Degradation of 15 halogenated hydrocarbons by 5 unactivated chemical oxidation oxidants.

Oxidants used in the ISCO technology usually require activation by activators to degrade contaminants. However, this study investigated degradation of 15 typical halogenated hydrocarbons by five common ISCO oxidants (PS, PMS, HO, KMnO, SPC) without activation in both pure water and real groundwater. Unactivated PS could degrade 14 halogenated hydrocarbons, excluding tetrachloromethane.

An Incognito Standardized Patient Approach for Measuring and Reducing Intersectional Healthcare Stigma: A Pilot Cluster Randomized Control Trial.

Background: Consistent evidence shows stigma impedes healthcare access in people living with HIV (PLWH) and men who have sex with men (MSM). We evaluated the impact of a stigma reduction training for providers whose design was informed by direct observation of their clinical behaviors obtained through visits by incognito standardized patient (SP).

Setting: We conducted this study in in sexually transmitted infection clinics in Guangzhou, China.

Enhanced remediation of oil-contaminated mineral sand by the controlled release of a surfactant from calcium alginate capsules.

The remediation of oil-contaminated soil poses significant environmental challenges, often necessitating innovative approaches for effective and sustainable solutions. This study focuses on the synthesis, characterisation, and application of biodegradable capsules loaded with surfactant for enhanced oil remediation of a clean sand. By controlling the release properties of capsules, the research aims to overcome the limitations of conventional surfactant-based remediation methods, such as rapid washout and reduced efficacy over time.

Study of PEG-rhG-CSF for the prevention of neutropenia in concurrent chemoradiotherapy for nasopharyngeal carcinoma.

Background: To study the efficacy and safety of Polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in the prevention of neutropenia during concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC).

Methods: This is a single-center, prospective, randomized controlled study conducted from June 1, 2021, to October 31, 2022 on patients diagnosed with locally advanced NPC. Participants were divided into an experimental group and a control group.

Effects of different tennis racket string tension on forehand stroke effect and racket dynamic impact.

This study investigates the effect of varying tennis racket string tension on stroke effect and the dynamic response of the racket. Using the YSV dynamic acceleration signal acquisition system and a portable radar speed gun collect data on racket acceleration, stress-strain signals, and ball speed from 15 male athletes. Stroke accuracy and depth were assessed according to the International Tennis Number.

The value co-creation mechanism of Public Cultural Services ecosystem in China based on "public value" theory.

The establishment of China's public cultural service system has been explored for nearly two decades, but there is still a significant gap in achieving the goal of equalising and eliminating differences in public value, and it is urgent to systematically explore the public value governance issues contained in it. This paper presents a localised theoretical analysis framework based on the strategic triangle model of public value, with the objective of exploring the endogenous mechanism of China's public cultural services ecosystem (PCSE). Furthermore, it constructs a panel vector autoregression (PVAR) model from a dynamic endogenous perspective, employing the STATA 16.

Perspective on Flexible Organic Solar Cells for Self-Powered Wearable Applications.

The growing advancement of wearable technologies and sophisticated sensors has driven the need for environmentally friendly and reliable energy sources with robust mechanical stability. Flexible organic solar cells (OSCs) have become promising substitutes for traditional energy solutions thanks to their remarkable mechanical flexibility and high power conversion efficiency (PCE). These unique properties allow flexible OSCs to seamlessly integrate with diverse devices and substrates, making them an excellent choice for powering various electronic devices by efficiently harvesting solar energy.

Enhanced Discovery of Alternative Proteins (AltProts) in Mouse Cardiac Development Using Data-Independent Acquisition (DIA) Proteomics.

Alternative proteins (AltProts) are a class of proteins encoded by DNA sequences previously classified as noncoding. Despite their historically being overlooked, recent studies have highlighted their widespread presence and distinctive biological roles. So far, direct detection of AltProt has been relying on data-dependent acquisition (DDA) mass spectrometry (MS).

Numerical testing method and mechanical property evaluation of large particle size asphalt mixture.

The large particle size asphalt mixture with nominal maximum aggregate size 53 mm(LSAM-50) has good technical and economic performance and will become an effective technical way to build a full-thick long-life asphalt pavement with Chinese characteristics. In order to reveal the mechanical properties and influencing factors of LSAM-50 in depth, a numerical test method for the mechanical properties of the large particle size LSAM-50 asphalt mixture was developed, and a reasonable specimen size for LSAM-50 performance test was proposed by combining the numerical test and the indoor test. The results show that: LSAM-50 numerical test conditions are the calculation time step 10-3 s/step, the loading rate is 2 mm/min (uniaxial compression numerical test) and 50 mm/min (splitting numerical test) when LSAM-50 numerical experiment calculation rate and numerical experiment accuracy are better; after the size of the specimen reaches 200×160mm, the influence of the size effect is eliminated.

CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation.

Monocytes are critical in controlling tissue infections and inflammation. Monocyte dysfunction contributes to the inflammatory pathogenesis of cystic fibrosis (CF) caused by CF transmembrane conductance regulator (CFTR) mutations, making CF a clinically relevant disease model for studying the contribution of monocytes to inflammation. Although CF monocytes exhibited adhesion defects, the precise mechanism is unclear.

Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities.

On the one hand, nature utilizes hierarchical assemblies to create complex biological binding pockets, enabling ultrastrong recognition toward substrates in aqueous solutions. On the other hand, chemists have been fervently pursuing high-affinity recognition by constructing covalently well-preorganized stereoelectronic cavities. The potential of noncovalent assembly, however, for enhancing molecular recognition has long been underestimated.

Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts.

Bacterial-fungal interaction (BFI) has significant implications for the health of host plants. While the diffusible antibiotic metabolite-mediated competition in BFI has been extensively characterized, the impact of intercellular contact remains largely elusive. Here, we demonstrate that the intercellular contact is a prevalent mode of interaction between beneficial soil bacteria and pathogenic filamentous fungi.

Dual modes of DNA N-methyladenine maintenance by distinct methyltransferase complexes.

Stable inheritance of DNA N-methyladenine (6mA) is crucial for its biological functions in eukaryotes. Here, we identify two distinct methyltransferase (MTase) complexes, both sharing the catalytic subunit AMT1, but featuring AMT6 and AMT7 as their unique components, respectively. While the two complexes are jointly responsible for 6mA maintenance methylation, they exhibit distinct enzymology, DNA/chromatin affinity, genomic distribution, and knockout phenotypes.

Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity.

Interferon regulatory factor 3 (IRF3) is the key transcription factor in the type I IFN signaling pathway, whose activation is regulated by multiple posttranslational modifications. Here, we identify SMYD3, a lysine methyltransferase, as a negative regulator of IRF3. SMYD3 interacts with IRF3 and catalyzes the dimethylation of IRF3 at lysine 39.

Hypochlorous Acid-Activatable NIR Fluorescence/Photoacoustic Dual-Modal Probe with High Signal-to-Background Ratios for Imaging of Liver Injury and Plasma Diagnosis of Sepsis.

Hypochlorous acid can be employed as a biomarker for blood infection (such as sepsis) and tissue damage (such as drug-induced liver injury, DILI), and the diagnosis of tissue damage or blood infection can be achieved through the detection of hypochlorous acid in relevant biological samples. Considering the complex environment and the diverse interferences in living organisms and blood plasma, developing new detection methods for HClO with high signal-to-background ratios is particularly important, and it can improve the accuracy of detection and quality of imaging based on a higher contrast, which makes the detection of HClO clearer and more accurate. Here, based on the advantages of the NIR fluorescence/photoacoustic dual-modal probe, we reported a hypochlorous acid-activatable NIR fluorescence/photoacoustic dual-modal probe (NIRF-PA-HClO) based on the spirolactam ring-opening strategy in this paper.

Warming accelerated phosphorus release from the sediment of Lake Chaohu during the decomposition of algal residues: A simulative study.

Algal decomposition plays an important role in affecting phosphorus (P) release from sediments in eutrophic lakes under global warming. Yet how rising air temperature affect endogenous P release from sediments during the algal decomposition is poorly understood. In this study, effect of increasing air temperature on endogenous P release was investigated.

Aligned membranes regulate wound healing via MMP12 secreted by macrophages.

Aligned electrospinning membranes (Align) have demonstrated the potential to enhance wound healing by establishing a regenerative microenvironment surrounding the wound; However, the precise mechanism underlying its facilitation of healing remains unclear. To elucidate aligned electrospun fiber membrane's role in accelerating wound healing and improving its quality, we conducted a comprehensive analysis. Firstly, in vivo experiments confirmed that Align promotes wound healing.

A novel multi-user collaborative cognitive radio spectrum sensing model: Based on a CNN-LSTM model.

Cognitive Radio (CR) technology enables wireless devices to learn about their surrounding spectrum environment through sensing capabilities, thereby facilitating efficient spectrum utilization without interfering with the normal operation of licensed users. This study aims to enhance spectrum sensing in multi-user cooperative cognitive radio systems by leveraging a hybrid model that combines Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) networks. A novel multi-user cooperative spectrum sensing model is developed, utilizing CNN's local feature extraction capability and LSTM's advantage in handling sequential data to optimize sensing accuracy and efficiency.

Noncatalytic Reduction of Nitrogen Oxide and Soot Inhibition during Cocombustion with Biotar: The Molecular Dynamics Modeling Approach.

Cocombustion with biomass tar is a potential method for NO reduction during fossil fuel combustion. In this work, the molecular dynamic method based on the reactive force field was used to study the NO reduction by phenol, which is a typical tar model compound. Results indicate that phenol undergoes significant decomposition at 3000 K, resulting in the formation of small molecular fragments accompanied by the generation of large molecular, network-structured soot particles.

Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity.

The main protease (M) of SARS-CoV-2 is a key drug target for the development of antiviral therapeutics. Here, we designed and synthesized a series of small-molecule peptidomimetics with various cysteine-reactive electrophiles. Several compounds were identified as potent SARS-CoV-2 M inhibitors, including compounds (IC = 0.

Spatiotemporal evolution of hedging effects in Asia-Pacific countries amid Sino-US competition: Insights from massive event data.

Facing the pressure of Sino-US strategic competition, countries in the Asia-Pacific region often adopt hedging strategies to minimize risk and protect their interests. If implemented, these strategies could impact relationships between countries and lead to political instability. Owing to a lack of theoretical evaluation frameworks and methods, few studies have examined the implementation effects of hedging strategies adopted by Asia-Pacific countries amid Sino-US competition.

Do higher educated people feel happier?-Evidence of Han and minority nationalities from China.

Based on the data of China General Social Survey (CGSS), this study adopts empirical analysis method to explore the impact of education on residents' subjective well-being and its differentiated mechanism in different ethnic groups. The results show that, first of all, education significantly improves residents' subjective well-being, and the conclusion is still robust after controlling for endogenous problems. Secondly, compared with Han nationality, education has a more significant effect on the subjective well-being of ethnic minority residents.

Unprecedented Ultraviolet Circularly Polarized Light-Dependent Anomalous Photovoltaics in Chiral Hybrid Perovskites.

Circularly Polarized Light (CPL)-dependent anomalous photovoltaic effect (APVE), characterized by light helicity-manipulated steady photocurrent and above-bandgap photovoltage, has demonstrated significant potential in the fields of photoelectronic and photovoltaics. However, exploiting CPL-dependent APVE in chiral hybrid perovskites, a promising family with intrinsic chiroptical activity and non-centrosymmetric structure, remains challenging. Here, leveraging the flexible structural design of chiral alternating cations intercalation-type perovskites, CPL-dependent APV, for the first time, is achieved in chiral perovskites.

Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis. The natural compound pristimerin has shown promising anti-tumor effect. Here, it is found that pristimerin significantly triggered the activation of autophagy initiation and induced apoptosis in TNBC.

Functional proteins/peptides targeting to clear Amyloid-β for Alzheimer's disease therapy.

Alzheimer's disease (AD) is a significant neurodegenerative disorder primarily affecting individuals over the age of 65. It is characterized by impairments in memory, thinking, analytical judgment, visuospatial recognition, and mood. In recent years, the development of protein and peptide drugs targeting amyloid-beta (Aβ) has gained momentum, with several therapies entering clinical trials and even receiving marketing approval.