White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review.

Background: Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic review to identify the specific white matter lesions and DTI metrics strongly associated with various types of dysfunction in cerebral palsy.

Methods: We conducted a literature search of PubMed, Embase, Cochrane Library and Web of Science databases to identify trials published that had evaluated the correlation between DTI metrics in sensorimotor pathways and function scores in cerebral palsy.

Generative adversarial local density-based unsupervised anomaly detection.

Anomaly detection is crucial in areas such as financial fraud identification, cybersecurity defense, and health monitoring, as it directly affects the accuracy and security of decision-making. Existing generative adversarial nets (GANs)-based anomaly detection methods overlook the importance of local density, limiting their effectiveness in detecting anomaly objects in complex data distributions. To address this challenge, we introduce a generative adversarial local density-based anomaly detection (GALD) method, which combines the data distribution modeling capabilities of GANs with local synthetic density analysis.

Identification of hypertension gene expression biomarkers based on the DeepGCFS algorithm.

Hypertension is a critical risk factor and cause of mortality in cardiovascular diseases, and it remains a global public health issue. Therefore, understanding its mechanisms is essential for treating and preventing hypertension. Gene expression data is an important source for obtaining hypertension biomarkers.

Study on the evolution of the spatial patterns and driving factors of national agricultural cultural heritage in China.

The study analyzed the spatial distribution characteristics, evolution rules, and driving factors of 138 China's national agricultural cultural heritage sites from 2013 to 2021 at the overall and regional levels, using kernel density analysis, Centres for standard deviation ellipse analyses, spatial autocorrelation analysis, and geographical detector analysis.The results showed that: ①From an overall perspective, the spatial pattern of China's national agricultural cultural heritage changed greatly from 2013 to 2021, with a highly uneven spatial distribution, gradually showing a distribution pattern of "widely distributed, locally concentrated". The spatial distribution of China's national agricultural cultural heritage is increasingly evident, and the spatial distribution type has evolved from discrete to clustered.

Notch dimerization provides robustness against environmental insults and is required for vascular integrity.

The Notch intracellular domain (NICD) regulates gene expression during development and homeostasis in a transcription factor complex that binds DNA either as monomer, or cooperatively as dimers. Mice expressing Notch dimerization-deficient (NDD) alleles of Notch1 and Notch2 have defects in multiple tissues that are sensitized to environmental insults. Here, we report that cardiac phenotypes and DSS (Dextran Sodium Sulfate) sensitivity in NDD mice can be ameliorated by housing mice under hypo-allergenic conditions (food/bedding).

The status of China's international division of labour from Marx's theory of international value.

Based on Marx's theory of international value, this paper analyzes the carrier of unequal exchange and the path of international transfer of surplus value, constructs an international division of labour status index by comprehensively observing the organic composition of capital in the export and import sectors, and tries to accurately grasp the characteristics of the current international division of labour pattern coexisting between horizontal products and vertical products. At the same time, based on the data of all available HS92 six-digit code categories in various countries in the world from 1993 to 2016, the level of international division of labour in China is empirically analysed. The results show that: (1) there is no breakthrough in the situation of China's low status of international division of labour; (2) the high capital-organic composition of the import sector is the main reason for the low status of international division of labour; (3) the continuous decline in the absolute value of captured surplus is a global phenomenon; (4) WTO accession has not significantly improved the status of international division of labour.

Trace elements in fish species from the Punjnad headworks: Bioaccumulation and human health risk assessment.

Aquatic toxicology, as a result of industrial and agrieqcultural effluences, has become a global concern impacting not only the well-being of aquatic organisms but human health as well. The current study evaluated the impact of four toxic trace elements (TTEs) Cadmium (Cd), copper (Cu), lead (Pb), and nickel (Ni) in three organs (liver, gills, and muscles) of five fish species viz, Rita rita, Sperata sarwari, Wallago attu, Mastacembelus armatus, and Cirrhinus mrigala collected from right and left banks of Punjnad headworks during winter, spring, and summer. We investigated the accumulation (mg/kg) of these TTEs in fish in addition to the human health risk assessment.

Expanded non-invasive prenatal testing offers better detection of fetal copy number variations but not chromosomal aneuploidies.

Purpose: To evaluate the clinical performance of expanded non-invasive prenatal testing (NIPT-plus) and compare its effectiveness in screening for chromosomal aneuploidies with that of NIPT.

Methods: Screening results, confirmatory invasive testing results, and follow-up data from pregnant women who underwent either NIPT (6792 cases) or NIPT-Plus (5237 cases) testing at Luohe Central Hospital, China, from January 2019 to June 2023 were collected. The positive predictive value (PPV), sensitivity, specificity, and other indicators for different types of chromosomal abnormalities in NIPT/NIPT-plus screening were calculated.

What sustain Chinese adult second language (L2) learners' engagement in online classes? A sequential mix-methods study on the roles of L2 motivation and enjoyment.

Recent research has integrated positive psychology with the Second Language Motivational Self System (L2MMS) to explore how enjoyment, L2 self-guides (including ideal L2 self and ought-to L2 self), and engagement interact among school-aged second-language (L2) learners. However, there is a significant gap in understanding these dynamics among adult learners, particularly those who primarily learn a second language online-a group that has been largely overlooked. To address this gap, our study examined the underlying mechanisms connecting these constructs.

Low-resource MobileBERT for emotion recognition in imbalanced text datasets mitigating challenges with limited resources.

Modern dialogue systems rely on emotion recognition in conversation (ERC) as a core element enabling empathetic and human-like interactions. However, the weak correlation between emotions and semantics poses significant challenges to emotion recognition in dialogue. Semantically similar utterances can express different types of emotions, depending on the context or speaker.

A spatial interpolation method based on 3D-CNN for soil petroleum hydrocarbon pollution.

Petroleum hydrocarbon pollution causes significant damage to soil, so accurate prediction and early intervention are crucial for sustainable soil management. However, traditional soil analysis methods often rely on statistical methods, which means they always rely on specific assumptions and are sensitive to outliers. Existing machine learning based methods convert features containing spatial information into one-dimensional vectors, resulting in the loss of some spatial features of the data.

Probiotics interventions modulating gut microbiota composition in individuals with intestinal constipation: Protocol of a systemic review and meta-analysis of randomized controlled trials.

Introduction: Intestinal constipation is a substantive global health concern, significantly impairing patient quality of life. An emerging view is that the gut microbiota plays a critical role in intestinal function, and probiotics could offer therapeutic benefits. This study aims to consolidate evidence from randomized controlled trials (RCTs) that assess the effectiveness of probiotics in modulating microbiota and ameliorating symptoms of constipation.

Impact of mergers and acquisitions on firms' performance adjusted to business cycle fluctuations in China.

This research mainly explored the effects of mergers and acquisitions (M&As) on the financial performance of Chinese listed companies and the determinants of post-M&A financial performance of mergers by incorporating adjustments for business cycle fluctuations. The research was divided into two parts. The first part applied data envelopment analysis (DEA) models for the calculation of the financial performance scores of mergers and non-mergers in six major sectors before and after M&As.

Environmental judicature and firm productivity: Evidence from a quasi-natural experiment.

The impact of environmental governance on firm productivity has been widely discussed, but few studies have examined the function of environmental judicature. Using the establishment of environmental courts as a quasi-natural experiment, this paper examines the relationship between environmental judicature and firm productivity. Our findings show that environmental courts will reduce firm productivity in the short term, chiefly owing to the increased environmental violation costs, environmental reputation costs and environmental compliance costs.

The effects of preoperative glenohumeral osteoarthritis on rotator cuff repair: A systematic review and meta-analysis.

Purpose: This meta-analysis was carried out to evaluate the clinical effectiveness of rotator cuff repair surgery in treating rotator cuff tears in individuals with mild glenohumeral osteoarthritis (GHOA).

Methods: A computer-based search was conducted across multiple databases including PubMed, Embase, Web of Science, and Cochrane Library using the keywords "Shoulder Joints", "Osteoarthrosis", and "rotator cuff". Only studies focusing on patients with GHOA who underwent rotator cuff repair were considered for inclusion.

A missing link: The interdependence between sugar-sweetened beverage and cigarette consumption from China.

Sugar-sweetened beverages (SSBs) and cigarettes are addictive substances and addictive substances are often related in consumption with each other. However, the potential interdependence between SSB and cigarette consumption has not been explored in the literature. As SSB and cigarette consumption have posed a great threat to individual health, the knowledge of such interdependence is critical for policymakers to design and coordinate government interventions.

Evolutionary analysis of landscape ecological risk in Baili Rhododendron National Forest Park.

It is significant to research the ecological risk of land use landscape to promote ecological conservation and restoration. The characteristics of land use dynamic change in Baili Rhododendron National Forest Park were analyzed based on GlobeLand30 data for three periods in 2000, 2010 and 2020. With the support of the landscape ecological risk evaluation model and spatial analysis methods, the features of spatial and temporal differentiation of ecological risk and its spatial correlation in the study area were evaluated.

Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival.

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and lacks effective therapeutic options. Cancer cells frequently become more dependent on splicing factors than normal cells due to increased rates of transcription. Terminal uridylyltransferase 1 (TUT1) is a specific terminal uridylyltransferase for U6 small nuclear RNA (snRNA), which plays a catalytic role in the spliceosome.

Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression.

Intrahepatic cholangiocarcinoma (iCCA) is a lethal malignancy affecting the liver and biliary system. Enhanced understanding of the pathogenic mechanisms underlying iCCA tumorigenesis and the discovery of appropriate therapeutic targets are imperative to improve patient outcomes. Here, we investigated the functions and regulations of solute carrier family 16 member 3 (SLC16A3), which has been reported to be a biomarker of poor prognosis in iCCA.

Maize quality detection based on MConv-SwinT high-precision model.

The traditional method of corn quality detection relies heavily on the subjective judgment of inspectors and suffers from a high error rate. To address these issues, this study employs the Swin Transformer as an enhanced base model, integrating machine vision and deep learning techniques for corn quality assessment. Initially, images of high-quality, moldy, and broken corn were collected.

MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway.

Legg-Calvé-Perthes disease (LCPD) involves femoral head osteonecrosis caused by disrupted blood supply, leading to joint deformity and early osteoarthritis. This study investigates the role of miRNA-223-5p in regulating hypoxia-induced apoptosis and enhancing osteogenesis in bone marrow mesenchymal stem cells (BMSCs). Utilizing a juvenile New Zealand white rabbit model of LCPD established through femoral neck ligation, we transfected BMSCs with miR-223-5p mimics, inhibitors, and controls, followed by hypoxic exposure.

Tumor Microenvironment-Responsive Lipid Nanoparticle for Blocking Mitosis and Reducing Drug Resistance in NSCLC.

Blocking mitosis is a promising strategy to induce tumor cell death. However, AMPK- and PFKFB3-mediated glycolysis can maintain ATP supply and help tumor cells overcome antimitotic drugs. Inhibiting glycolysis provides an opportunity to decrease the resistance of tumor cells to antimitotic drugs.

Regioselective Suzuki-Miyarua Cross-Coupling for Substituted 2,4-Dibromopyridines Catalyzed by -Symmetric Tripalladium Clusters.

Multipalladium clusters possess peculiar structures and synergistic effects for reactivity and selectivity. Herein, -symmetric tripalladium clusters (, 0.5 mol %) afford C-regioselective SMCC of 2,4-dibromopyridine with phenylboronic acids or pinacol esters (C:C up to 98:1), in contrast to Pd(OAc) in ligand-free conditions.

Asymptotic BLSCP models in uncertain and asymmetric environments-Take the charging station location problem.

The rapid development of the field of vehicles exposes many problems of charging station, the most common is the uncertainty and asymmetry of its task volume, so the flexibility of location and scale design is crucial. This paper proposes the asymptotic BLSCP model, suitable for uncertain and asymmetric environments, which balances facility workload and minimizes cost through the forward or backward asymptotic methods of candidate center locations and flexible allocation of jurisdictions. Additionally, the findings suggest these methods possess considerable potential for application and generalization.

Unraveling the transcriptomic effects of leucine supplementation on muscle growth and performance in basketball athletes.

Leucine has gained recognition as an athletic dietary supplement in recent years due to its various benefits; however, the underlying molecular mechanisms remain unclear. In this study, 20 basketball players were recruited and randomly assigned to two groups. Baseline exercise performance-assessed through a 282-foot sprint, free throws, three-point field goals, and self-rated practice assessments-was measured prior to leucine supplementation.