3,327,867 results match your criteria: "China; Freshwater Fisheries Research Center of Chinese Academy of Fishery Sciences[Affiliation]"

Crystalline Covalent Triazine Frameworks and 2D Triazine Polymers: Synthesis and Applications.

Acc Chem Res

January 2025

School of Engineering, Westlake University, Hangzhou 310024, Zhejiang Province, China.

ConspectusCovalent triazine frameworks (CTFs) are a novel class of nitrogen-rich conjugated porous organic materials constructed by robust and functional triazine linkages, which possess unique structures and excellent physicochemical properties. They have demonstrated broad application prospects in gas/molecular adsorption and separation, catalysis, energy conversion and storage, etc. In particular, crystalline CTFs with well-defined periodic molecular network structures and regular pore channels can maximize the utilization of the features of CTFs and promote a deep understanding of the structure-property relationship.

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Quantum anomalous Hall effect in a nonmagnetic bismuth monolayer with a high Chern number.

Mater Horiz

January 2025

School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.

The quantum anomalous Hall effect (QAHE) with a high Chern number hosts multiple dissipationless chiral edge channels, which is of fundamental interest and promising for applications in spintronics. However, QAHE is currently limited in two-dimensional (2D) ferromagnets with Chern number . Using a tight-binding model, we put forward that Floquet engineering offers a strategy to achieve QAHE in 2D nonmagnets, and, in contrast to generally reported QAHE in 2D ferromagnets, a high-Chern-number is obtained accompanied by the emergence of two chiral edge states.

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Synergistic Enhancement of Ferroptosis via Mitochondrial Accumulation and Photodynamic-Controlled Release of an Organogold(I) Cluster Prodrug.

J Am Chem Soc

January 2025

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.

Effective delivery and controlled release of metallo-prodrugs with sustained activation and rapid response feed the needs of precise medicine in metal chemotherapeutics. However, gold-based anticancer drugs often suffer from detoxification binding and extracellular transfer by sulfur-containing peptides. To address this challenge, we integrate a thiol-activated prodrug strategy of newly prepared hypercoordinated carbon-centered gold(I) clusters (HCGCs) with their photosensitization character to augment the mitochondrial release of Au(I) in tumors.

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Ultralow Power Cold-Fuse Memory Based on Metal-Oxide-CNT Structure.

Nano Lett

January 2025

Key Lab for the Physics and Chemistry of Nanodevices and Center for Carbon-based Electronics, School of Electronics, Peking University, Beijing 100871, China.

One-time programmable (OTP) memory is an essential component in chips, which has extremely high security to protect the stored critical information from being altered. However, traditional OTP memory based on the thermal breakdown of the dielectric has a large programming current, which leads to high power consumption. Here, we report a gate tunneling-induced "cold" breakdown phenomenon in carbon nanotube (CNT) field-effect transistors, and based on this we construct a "cold" fuse (C-fuse) memory where applying a mild gate voltage can break down the CNT channel without damaging the gate dielectric.

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Parkinson's disease (PD) is a limb movement disorder caused by the degeneration of brain neurons and seriously affects the quality of life of the elderly. However, the current drugs are symptomatic treatments that cannot prevent or delay the development of the disease. Targeted therapy for pathogenesis may be the direction of development in the future.

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Access to Chiral Bridged Biaryls via Brønsted Acid-Catalyzed Asymmetric Addition of Alcohols to Fluoroalkylated Biaryl Oxazepines.

Org Lett

January 2025

Key Laboratory of Chemical Biology and Traditional Chinese Medicine (Ministry of Educational of China), Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.

We disclose herein a chiral phosphoric-acid-catalyzed enantioselective addition reaction of alcohols to fluoroalkylated biaryl 1,3-oxoazepines, which furnished a wide range of bridged biaryls bearing a fluoroalkylated quaternary carbon stereocenter on the seven-membered ring in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). Our method can be used for the modification of several natural products and bioactive molecules. Preliminary studies revealed that the products obtained in this reaction exhibit good in vitro bioactivities against two plant pathogens.

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In a previous report, we showed that voltage-gated K+ (Kv) Kv1 and Kv2 channels are involved in cAMP-induced neuritogenesis of mouse neuronal N2A cells. In this report, we examined the effects of tannic acid (TA) on Kv channels and neuritogenesis in N2A cells. TA (15 μM) mildly enhanced Kv currents at -30 to -20 mV but strongly inhibited Kv currents at higher voltages, causing a preferential activation of currents at low voltages.

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Single-cell RNA sequencing (scRNA-seq) offers remarkable insights into cellular development and differentiation by capturing the gene expression profiles of individual cells. The role of dimensionality reduction and visualization in the interpretation of scRNA-seq data has gained widely acceptance. However, current methods face several challenges, including incomplete structure-preserving strategies and high distortion in embeddings, which fail to effectively model complex cell trajectories with multiple branches.

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scMMAE: masked cross-attention network for single-cell multimodal omics fusion to enhance unimodal omics.

Brief Bioinform

November 2024

Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems, Great Bay University, No. 16 Daxue Rd, Songshanhu District, Dongguan, Guangdong, 523000, China.

Multimodal omics provide deeper insight into the biological processes and cellular functions, especially transcriptomics and proteomics. Computational methods have been proposed for the integration of single-cell multimodal omics of transcriptomics and proteomics. However, existing methods primarily concentrate on the alignment of different omics, overlooking the unique information inherent in each omics type.

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Co-blocking TIGIT and PVRIG using a novel bispecific antibody enhances anti-tumor immunity.

Mol Cancer Ther

January 2025

Jiangsu Hengrui Pharmaceutical Co. Ltd, Shanghai, China.

TIGIT and PVRIG are immune checkpoints co-expressed on activated T and NK cells, contributing to tumor immune evasion. Simultaneous blockade of these pathways may enhance therapeutic efficacy, positioning them as promising dual targets for cancer immunotherapy. This study aimed to develop a bispecific antibody (BsAb) to co-target TIGIT and PVRIG.

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Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis.

Emerg Microbes Infect

January 2025

Key Laboratory of Jiangxi Province for Transfusion Medicine, Department of Blood Transfusion, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China.

The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis of tuberculosis (TB) is still unclear. The objective of the present study was to evaluate the performance of the serum tsRNAs biosignature to distinguish between active TB, healthy controls, latent TB infection, and other respiratory diseases.

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Rotator cuff tears are the most common conditions in sports medicine and attract increasing attention. Scar tissue healing at the tendon-bone interface results in a high rate of retears, making it a major challenge to enhance the healing of the rotator cuff tendon-bone interface. Biomaterials currently employed for tendon-bone healing in rotator cuff tears still exhibit limited efficacy.

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Role of Ciliary Neurotrophic Factor in Angiotensin II-Induced Hypertension.

Hypertension

January 2025

Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.).

Background: Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have not been explored. Here, we examined the role of CNTF in AngII (angiotensin II)-induced hypertension.

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Flexible deformation and special interface structure in nanoparticle-stabilized Pickering bubbles strengthen the immunological response as adjuvant.

J Mater Chem B

January 2025

State Key Laboratory of Biopharmaceutical Preparation and Delivery, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Adjuvants can enhance an immunological response, which is an important part of vaccine research. Pickering bubbles have been a mega-hit for biomedical applications, including visualization and targeted drug delivery. However, there have been no studies on Pickering bubbles as an immunological adjuvant, and the special properties and structures of Pickering bubbles may play an important role in immunization.

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Dental Fluorosis (DF) is one of the negative outcomes of excessive fluoride (F) intake through food sources. This systematic review aimed to compare F content in two important food sources for infants, Mother's Milk (MoM) and Infant Formula (IF), and then evaluate the risk of DF related to F in those two types of food. For this purpose, 181 studies were initially found by searching the relevant keywords in widely recognized databases, including Google Scholar, Scopus, Science Direct, and PubMed.

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To investigate the safety of the tetravalent meningococcal conjugate vaccine (MPCV-ACYW) in combination with the inactivated poliomyelitis (IPV) vaccine and diphtheria-tetanus-acellular pertussis (DTaP) vaccine for infants aged 3-5 months and provide real-world evidence for the immunization strategy of vaccine combination. From June to October 2023, a total of 600 3-month-old infants were selected and divided into three groups: control group, mono-vaccination group and combined vaccination group. They were simultaneously or individually vaccinated with MPCV-ACYW, IPV and DTaP vaccines at 3, 4, and 5 months of age, respectively.

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Unveiling the electrochemical nitrogen reduction reaction mechanism in heteroatom-decorated-MoCS-MXene: the synergistic effect of single-atom Fe and heteroatom.

Mater Horiz

January 2025

Institute of Biomass Engineering, Key Laboratory of Energy Plants Resource and Utilization, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, 510642, China.

Conversion of nitrogen (N) to ammonia (NH) is a significant process that occurs in environment and in the field of chemistry, but the traditional NH synthesis method requires high energy and pollutes the environment. In this work, the charge, orbital and spin order of the single-atom Fe loaded on heteroatom (X) doped-MoCS (X = B, N, O, F, P and Se) and its synergistic effect on electrochemical nitrogen reduction reaction (eNRR) were investigated using well-defined density functional theory (DFT) calculations. Results revealed that the X-element modified the charge loss capability of Fe atoms and thereby introduced a net spin through heteroatom doping, resulting in the magnetic moment modulation of Fe.

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Multi-label zero-shot learning (ML-ZSL) strives to recognize all objects in an image, regardless of whether they are present in the training data. Recent methods incorporate an attention mechanism to locate labels in the image and generate class-specific semantic information. However, the attention mechanism built on visual features treats label embeddings equally in the prediction score, leading to severe semantic ambiguity.

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Semiconductor photocatalytic antibacterial materials and their application for bone infection treatment.

Nanoscale Horiz

January 2025

State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.

Bacterial infection in bone tissue engineering is a severe clinical issue. Traditional antimicrobial methods usually cause problems such as bacterial resistance and biosecurity. Employing semiconductor photocatalytic antibacterial materials is a more controlled and safer strategy, wherein semiconductor photocatalytic materials generate reactive oxygen species under illumination for killing bacteria by destroying their cell membranes, proteins, DNA, In this review, P-type and N-type semiconductor photocatalytic materials and their antibacterial mechanisms are introduced.

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Niche shift and localized competitive dynamics influence the persistence and distribution of polyploids in the genus Achillea (Asteraceae).

Ann Bot

January 2025

Key Laboratory of Biodiversity Science and Ecological Engineering of the Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, China.

Background And Aims: Competition with sympatric diploid progenitor(s) hinders the persistence of polyploids. The hypothesis that polyploids escape from competition through niche shifts has been widely tested; however, niche escape is unlikely to completely avoid competition. Given species growing in less favorable environments likely have weaker competitive abilities, we hypothesize that polyploid populations tend to persist in areas where their progenitors with relatively low habitat suitability.

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Background: The aim of the present study was to investigate the willingness of elderly individuals regarding their choice of elderly care modes in underdeveloped regions of Western China and to identify the key factors influencing the willingness.

Methods: We distributed a total of 20 000 questionnaires using the multistage stratified cluster random sampling method, and successfully collected 19 460 of them. After conducting quality checks, we deemed 19 040 questionnaires valid for analysis.

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Objective: This study aims to explore the impact of physical exercise on feelings of inferiority among college students, focusing on the mediating roles of social support and emotional regulation ability. The research investigates both direct and indirect pathways to understand how physical exercise enhances psychological resilience and mitigates negative self-perceptions.

Methods: A sample of 2,036 college students from 15 provinces in China was surveyed using validated scales for physical exercise, feelings of inferiority, social support, and emotional regulation ability.

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Japanese-as-a-foreign-language acquisition affects native Chinese lexical processing among Chinese learners.

Front Psychol

January 2025

School of Japanese and International Studies, Beijing Centre for Japanese Studies, Beijing Foreign Studies University, Beijing, China.

Existing research has primarily focused on the influence of the native language on second language (L2) acquisition and processing, with less attention given to whether L2 acquisition affects native language processing. This study examines Chinese learners of Japanese, focusing on the orthographic and phonological similarities between two-character words in Chinese and Japanese. It investigates how these similarities affect native Chinese lexical processing at intermediate and advanced stages of Japanese learning and explores the predictive effect of L2 lexical processing efficiency on native language lexical processing efficiency at different stages of L2 learning.

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Introduction: The significance of music might be attributed to its role in social bonding, a function that has likely influenced the evolution of human musicality. Although there is substantial evidence for the relationship between prosocial songs and prosocial behavior, it remains unclear whether music alone, independent of lyrics, can influence prosocial behaviors. This study investigates whether music and the emotions it induces can influence prosocial decision-making, utilizing the classical two-dimensional model of emotion (mood and arousal).

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