Aptamer-Driven Multifunctional Nanoplatform for Near-Infrared Fluorescence Imaging and Rapid Inactivation of .

() is a prominent pathogen responsible for intestinal infections, primarily transmitted through contaminated food and water. This underscores the critical need for precise and biocompatible technologies enabling early detection and intervention of bacterial colonization . Herein, a multifunctional nanoplatform (IR808-Au@ZIF-90-Apt) was designed, utilizing an -specific aptamer to initiate cascade responses triggered by intracellular ATP and GSH.

A novel hybrid deep learning framework based on biplanar X-ray radiography images for bone density prediction and classification.

Unlabelled: This study utilized deep learning for bone mineral density (BMD) prediction and classification using biplanar X-ray radiography (BPX) images from Huashan Hospital Medical Checkup Center. Results showed high accuracy and strong correlation with quantitative computed tomography (QCT) results. The proposed models offer potential for screening patients at a high risk of osteoporosis and reducing unnecessary radiation and costs.

Palladium-catalyzed allylic C-H alkylation of terminal olefins with 3-carboxamide oxindoles.

A novel palladium-catalyzed allylic C-H alkylation of terminal olefins with 3-carboxamide oxindoles is described. A variety of new 3-carboxamide-3-allylation oxindoles with an all-carbon quaternary center were obtained in moderate to good yields (up to 99%). In addition, the asymmetric version of this reaction was also explored, providing moderate enantioselectivity.

Complete genome sequence of strain SOCE 003, a marine bacterium isolated from the surface seawater of Dapeng Bay.

is a heterotrophic bacterium commonly found in diverse marine environments. Here, we report the complete genome sequence of strain SOCE 003, which is 5,154,101 bp long, encoding 5,524 annotated protein-coding genes, 39 tRNAs, and 8 rRNAs. This genome information will help us understand the ecology of .

A reciprocity calibration of hydrophones in a non-anechoic water tank: Method and realization.

To measure the electroacoustic parameters of transducers in the continuous sound field in a limited water area, a reciprocity calibration method of hydrophones using a spatial sampling average method in a non-anechoic tank was developed. The sound propagation in the non-anechoic tank under the impedance boundary condition, with a sound source producing continuous sound, is introduced based on the Helmholtz equation and Green's function. The reciprocity constant is given using the spatial sampling average sound pressure, and the three-transducer reciprocity calibration procedure was established.

A low-frequency broadband ring transducer driven by the flextensional structure.

The flextensional transducer (FT) is a typical low-frequency transmitting transducer that is capable of high-power operation due to its capacity for displacement amplification. This article uses the structural configuration of the class IV FT as the basis for designing a ring transducer, which is a circular structure comprising a multitude of class IV flextensional structures as well as circular acoustic radiation structures. The flextensional structure drives the circular acoustic radiation structure, which in turn generates sound waves at low frequencies.

Effects of leading-edge serration shape on noise reduction in rod-airfoil interactions.

Leading-edge serrations inspired by owls exhibit the capability to control airfoil-turbulence interaction noise, but the design principle of the serration shape is still an open issue. To this end, we designed five types of serration shapes with different combinations of curvature, namely, triangular, ogee, anti-ogee, feather-like, and anti-feather-like. These curves are applied to serrated modifications with different bluntness levels (sharp or blunt) and amplitudes (0.

Complete genome sequence of GL-4.

A cellulase-producing was previously isolated from the intestinal tract of domestic bamboo rat and identified as GL-4. In this study, we present the complete genome sequence of GL-4. The genome is 4,271,214 bp long, with a guanine-cytosine content of 43.

Side group topological structure modified orbital and condensed state characteristics enhance the electrical anti-breakdown performance of polyolefin.

As an effective method to enhance the dielectric performance of polyolefin materials, polar side group modification has been extensively applied in the insulation and energy storage materials of electrical and electronic systems. In this work, two side groups with different topological structures were adopted, namely, vinyl acetate (VAc, aliphatic chain) and -vinyl-pyrrolidone (NVP, saturated ring), to modify polypropylene (PP) chemical grafting, and the effects of structural topology of the polar side group on the microscopic and macroscopic characteristics of PP, particularly on its electrical anti-breakdown ability, were investigated. Experimental results showed that the side group structural topology directly affected the crystallization and thermal properties of PP.

WF2020 isolated from fermented pickles promotes longevity and health in JNK and p38 MAPK pathways.

, a potential probiotic for use in food and feed production, can exert anti-aging effects in a strain-specific manner. However, the molecular mechanisms underlying its anti-aging effects remain poorly understood. This study explored the effects of WF2020 (WF2020), isolated from Chinese fermented pickles, on longevity and health and investigated the underlying mechanisms in .

Apelin-13 inhibits ischemia-reperfusion mediated podocyte apoptosis by reducing m-TOR phosphorylation to enhance autophagy.

Podocytes are essential to maintain the normal filtration function of glomerular basement membrane, which could be injured by ischemia-reperfusion. As complicated function of autophagy in terminal differentiated podocytes, autophagy dysfunction might contribute to I/R induced renal dysfunction following glomerular filtration membrane (GFM) injuries. Meanwhile, apelin-13, an endogenous polypeptide, has been proved to be effective in regulating autophagy and apoptosis in podocytes.

A Serial MRI-based Deep Learning Model to Predict Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma.

Purpose To develop and evaluate a deep learning-based prognostic model for predicting survival in locoregionally- advanced nasopharyngeal carcinoma (LA-NPC) using serial MRI before and after induction chemotherapy (IC). Materials and Methods This multicenter retrospective study included 1039 LA-NPC patients (779 male, 260 female, mean age 44 [standard deviation: 11]) diagnosed between April 2009 and December 2015. A radiomics- clinical prognostic model (Model RC) was developed using pre-and post-IC MRI and other clinical factors using graph convolutional neural networks (GCN).

Modification of the Se/MoO Rear Interface for Efficient Wide-Band-Gap Trigonal Selenium Solar Cells.

Trigonal selenium (t-Se) is a promising wide-band-gap photovoltaic material with a high absorption coefficient, abundant resources, simple composition, nontoxicity, and a low melting point, making it suitable for absorbers in advanced indoor and tandem photovoltaic applications. However, severe electrical losses at the rear interface of the t-Se absorber, caused by work function and lattice mismatches, limit the voltage output and overall performance. In this study, a strategy to enhance carrier transport and collection by modifying interfacial chemical interactions is proposed.

Biofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel ().

Unlabelled: Global aquaculture production faces the challenge of biologically cycling nitrogenous waste. Biofloc technology (BFT) systems offer the potential to reduce water consumption and eliminate waste products by using beneficial microorganisms to convert waste into usable nutrients or non-toxic molecules. Unlike flow-through systems (FTS), which depend on continuous water exchange and result in higher operational costs as well as limited microbiome stability, BFT operates without the need for constant water exchange.

NR1D1 Inhibition Enhances Autophagy and Mitophagy in Alzheimer's Disease Models.

Alzheimer's disease (AD) is marked by extracellular beta-amyloid (Aβ) plaques and intracellular Tau tangles, leading to progressive cognitive decline and neuronal dysfunction. Impaired autophagy, a process by which a cell breaks down and destroys damaged or abnormal proteins and other substances, contributes to AD progression. This study investigated Nuclear Receptor Subfamily 1 Group D Member 1 (NR1D1) as a potential therapeutic target for modulating autophagy.

Decoding the Multiple Identities and Crosstalk of Organokines in Obesity-Related Type 2 Diabetes Mellitus.

Obesity causes an imbalance in the expression and secretion of several organokines, which in turn contributes to the development of metabolic disorders such as type 2 diabetes mellitus. Organokines are produced by corresponding organs and affect systemic metabolic homeostasis. Diverse organokines play a crucial role in the communication between adipose tissue, skeletal muscle and other organs.

Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence.

Circadian rhythm is the internal homeostatic physiological clock that regulates the 24-hour sleep/wake cycle. This biological clock helps to adapt to environmental changes such as light, dark, temperature, and behaviors. Aging, on the other hand, is a process of physiological changes that results in a progressive decline in cells, tissues, and other vital systems of the body.

Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease.

Increased entropy is a common cause of disease and aging. Lifespan entropy is the overall increase in disorder caused by a person over their lifetime. Aging leads to the excessive production of reactive oxygen species (ROS), which damage the antioxidant system and disrupt redox balance.

TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer's Disease.

Autophagy in microglia is essential for the clearance of amyloid-beta (Aβ) and amyloid plaques in Alzheimer's disease. However, reports regarding the levels of autophagy in microglia have been inconsistent; some studies indicate an early enhancement followed by a subsequent reduction, while others describe a persistently weakened state. Notably, there is a lack of systematic studies documenting the temporal changes in microglial autophagy.

Dipole-Modulated Carrier Dynamics and Charge Transport Behavior of Ligand-Protected Metal Chalcogenide Nanoclusters.

Atomically precise nanoclusters, distinguished by their unique nuclearity- and structure-dependent properties, hold great promise for applications of energy conversion and electronic transport. However, the relationship between ligands and their properties remains a mystery yet to be unrevealed. Here, the influence of ligands on the electronic structures, optical properties, excited-state dynamics, and transport behavior of ReS dimer clusters with different ligands is explored using density functional theory combined with time-domain nonadiabatic molecular dynamic simulations.

Constructing a Polyoxometalate-Based Metal-Organic Framework for Photocatalytic Oxidation of Thioethers to Sulfoxides Utilizing In Situ-Generated Superoxide Radicals.

Developing new photocatalysts for the selective oxidation of thioethers to high-value-added sulfoxides under low-oxygen mild conditions is a promising but challenging strategy. Here, a new polyoxometalate-based metal-organic framework (POMOF), , was successfully synthesized, wherein continuous π···π stacking interactions and direct coordination bonds not only strengthen the framework's stability but also accelerate electron transfer. A series of experiments and theoretical studies, including control experiments, kinetic studies, electrochemical spectroscopic analyses, and electron paramagnetic resonance, revealed the synergistic catalytic effect among Co(II) metal centers, BWO, and the photosensitizer TPT.

Research on high-performance, real-time periodic signal detection method based on field-programmable gate arrays (FPGAs).

Long-Time Coherent Integration (LTCI) utilizes digital integration to combine multiple coherent cycles, thereby improving the signal-to-noise ratio (SNR). Our previous work introduced single-bit LTCI, an approach optimized for FPGA implementation, but faced challenges of output saturation at high SNR levels and inherent limitations in SNR gain (SNRG), which are insufficient for certain applications. This paper presents a threshold tracking method that improves the performance of single-bit LTCI in high-SNR scenarios.

Innovative applications of bio-inspired technology in bio-based food packaging.

Traditionally, food packaging was used to extend the shelf life of food or to monitor its condition. Inspired by many biological structures found in nature, bio-inspired functional materials for bio-based food packaging have been shown to have significantly improved capabilities over traditional bio-based food packaging materials in various aspects and to attract consumers through novel freshness preservation features. This review synthesizes recent advances in bio-inspired bio-based food packaging materials that mimic the structure of natural organisms with specific functionalities, with examples of specific biomimetics in different enhancement areas.