Recent Advances in Tetra-Coordinate Boron-Based Photoactive Molecules for Luminescent Sensing, Imaging, and Anticounterfeiting.

Tetra-coordinate boron-based fluorescent materials hold considerable promise across chemistry, biology and materials science due to their unique and precisely tunable optoelectronic properties. The incorporation of the heteroatom boron (B) enables these materials to exhibit high luminescence quantum yields, adjustable absorption and emission wavelengths, and exceptional photostability. This review examines the molecular design and applications of tetra-coordinate boron-based photoactive molecules, highlighting their roles in fluorescence sensing, anticounterfeiting, and imaging.

A lesson for post-COVID healthcare: assessment of physical and psychosocial risk factors on perceived pain intensity among urban individuals.

Background: Perceived pain intensity is an important determinant of health-related quality of life. A lack of studies has investigated the co-influences of physical and psychosocial risk factors on perceived pain intensity and the shifts in effects after pandemic. As a post-COVID symptom, it is important to re-assess the risk factors for post-COVID heath care.

Career calling and safety behavior among nurses: a cross-sectional study based on latent profile analysis.

Objective: This study aimed to clarify the subgroups of career calling among Chinese nurses, explore the factors correlated with the subgroups, and investigate the relationship between nurse safety behavior and different profiles of career calling.

Methods: A cross-sectional study of 2,567 nurses from 25 hospitals in China was conducted from February to September 2023. A latent profile model of nurses' career calling was analyzed using Mplus 7.

Validation of existential fulfillment scale in Chinese university students.

Introduction: This study aimed to assess the psychometric properties of the Existential Fulfillment Scale (EFS) in a Chinese university student sample, emphasizing the cultural fit of the scale.

Methods: A cohort of 1,600 undergraduate students from six universities in Fujian Province completed questionnaires including the EFS, Meaning of Life Questionnaire (MLQ), Index of Well-Being (IWB), and Self-Depression Scale (SDS). We conducted item analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and assessments of criterion-related validity, internal consistency, and test-retest reliability.

CO-loaded hemoglobin/EGCG nanoparticles functional coatings for inflammation modulation of vascular implants.

During the implantation process of cardiovascular implants, vascular damage caused by inflammation occurs, and the inflammatory process is accompanied by oxidative stress. Currently, carbon monoxide (CO) has been demonstrated to exhibit various biological effects including vasodilatation, antithrombotic, anti-inflammatory, apoptosis-inducing and antiproliferative properties. In this study, hemoglobin/epigallocatechin-3-gallate (EGCG) core-shell nanoparticle-containing coating on stainless steel was prepared for CO loading and inflammation modulation.

Semi-quantitative scoring criteria based on multiple staining methods combined with machine learning to evaluate residual nuclei in decellularized matrix.

The detection of residual nuclei in decellularized extracellular matrix (dECM) biomaterials is critical for ensuring their quality and biocompatibility. However, current evaluation methods have limitations in addressing impurity interference and providing intelligent analysis. In this study, we utilized four staining techniques-hematoxylin-eosin staining, acetocarmine staining, the Feulgen reaction and 4',6-diamidino-2-phenylindole staining-to detect residual nuclei in dECM biomaterials.

P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.

Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel that is expressed throughout the brain.

Inflammation biomarkers and Alzheimer's disease: A pilot study using NULISAseq.

Introduction: Increasing evidence links amyloid beta (Aβ) aggregation with inflammation. This pilot study investigated the use of an immunoassay panel to map biomarker changes in patients with Alzheimer's disease (AD). Furthermore, we evaluated the stability of protein quantification after multiple freeze-thaw cycles (FTCs).

Impact of sleep disruptions on gray matter structural covariance networks across the Alzheimer's disease continuum.

Background: This study explores the impact of sleep disturbances on gray matter structural covariance networks (SCNs) across the Alzheimer's disease (AD) continuum.

Methods: Amyloid-negative participants served as controls, whereas amyloid positive (A+) individuals were categorized into six groups based on cognitive status and sleep quality. SCNs for the default mode network (DMN), salience network (SN), and executive control network (ECN) were derived from T1-weighted magnetic resonance images.

Experimental Verification on Steering Flight of Honeybee by Electrical Stimulation.

The artificial locomotion control strategy is the fundamental technique to ensure the accomplishment of the preset assignments for cyborg insects. The existing research has recognized that the electrical stimulation applied to the optic lobes was an appropriate flight control strategy for small insects represented by honeybee. This control technique has been confirmed to be effective for honeybee flight initiation and cessation.

A Manta Ray-Inspired Biosyncretic Robot with Stable Controllability by Dynamic Electric Stimulation.

Biosyncretic robots, which are new nature-based robots in addition to bionic robots, that utilize biological materials to realize their core function, have been supposed to further promote the progress in robotics. Actuation as the main operation mechanism relates to the robotic overall performance. Therefore, biosyncretic robots actuated by living biological actuators have attracted increasing attention.

Recognition of Drivers' Hard and Soft Braking Intentions Based on Hybrid Brain-Computer Interfaces.

In this paper, we propose simultaneous and sequential hybrid brain-computer interfaces (hBCIs) that incorporate electroencephalography (EEG) and electromyography (EMG) signals to classify drivers' hard braking, soft braking, and normal driving intentions to better assist driving for the first time. The simultaneous hBCIs adopt a feature-level fusion strategy (hBCI-FL) and classifier-level fusion strategies (hBCIs-CL). The sequential hBCIs include the hBCI-SE1, where EEG signals are prioritized to detect hard braking, and hBCI-SE2, where EMG signals are prioritized to detect hard braking.

Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health.

Background: Whether medium-term increased water intake alone, or in combination with co-adjuvant nonexercise interventions aimed to expand blood volume (BV), improve the human cardiovascular phenotype and cardiorespiratory fitness remains unexplored.

Objectives: The purpose of this study was to determine the medium-term impact of increased (+40%) fluid (water) intake (IFI) or IFI plus head-up sleep (IFI + HUS) on BV and the cardiovascular phenotype in healthy individuals.

Methods: Healthy adults (n = 35, age 42 ± 18 years, 51% female) matched by sex, age, body composition, physical activity, and cardiorespiratory fitness were randomly allocated to IFI or IFI + HUS for 3 months.

Association between family economic decision-making power and survival outcomes among older adults in China: A population-based longitudinal study.

Objective: This study examines the association between family economic decision-making power and survival outcomes among older adults.

Methods: Data were drawn from the China Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2018. Family economic decision-making power was assessed based on participants' self-reported influence over household financial matters, categorized as: "making decisions on almost all household expenditures", "deciding on non-essential spending", "only deciding on personal expenditures", and "having no decision-making power over household spending".

Technology for sustainable living: The impact of digital inclusion on the health of China's elderly living alone.

Enhancing elderly health has become an important measure for coping with population ageing and building a healthy China. Among them, older adults living alone seem to suffer from greater loneliness and psychological stress. We analyzed data from the China Health and Retirement Longitudinal Study in 2015, 2018, and 2020, and carried out an empirical investigation into the impact of digital inclusion on the health of elderly individuals living alone, using two-way fixed effects models and two-stage least squares.

Lipid Metabolic Heterogeneity during Early Embryogenesis Revealed by Hyper-3D Stimulated Raman Imaging.

Studying embryogenesis is fundamental to understanding developmental biology and reproductive medicine. Its process requires precise spatiotemporal regulations in which lipid metabolism plays a crucial role. However, the spatial dynamics of lipid species at the subcellular level remains obscure due to technical limitations.

Fluorogenic Tetrazine Bioorthogonal Probes for Advanced Application in Bioimaging and Biomedicine.

A variety of bioorthogonal chemical tools have been developed and widely used in the study of biological phenomena in situ. Tetrazine bioorthogonal chemistry exhibits ultrafast reaction kinetics, excellent biocompatibility, and precise optical regulatory capabilities. Fluorogenic tetrazine bioorthogonal probes have achieved particularly diverse applications in bioimaging and disease diagnosis and treatment.

A new species of Tube-nosed Bat (Chiroptera: Vespertilionidae: ) from Qinghai-Tibet Plateau, China.

In 2018, an adult male of a small-sized Tube-nosed Bat (Chiroptera: Vespertilionidae: ) was captured at an arid cave located on the Qinghai-Tibet Plateau in Yushu City, Qinghai Province, China. Despite external morphological similarities with those of and , the individual in question displays explicit craniodental differences that distinguish it from either species. Morphological and morphometric evidence, coupled with phylogenetic analyses utilizing the mitochondrial gene, confirmed that it represents a distinct and still unknown species of , described herewith as sp.

alleviate Serovar Typhimurium-induced murine inflammatory/oxidative responses via the p62-Keap1-Nrf2 signaling pathway and cecal microbiota.

Background: Serovar Typhimurium (. Typhimurium) infection can cause inflammation and oxidative stress in the body, leading to gastroenteritis, fever and other diseases in humans and animals. More and more studies have emphasized the broad prospects of probiotics in improving inflammation and oxidative stress, but the ability and mechanism of (LA) to alleviate the inflammatory/oxidative reaction caused by pathogens are still unclear.

Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness.

Background: Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time in target range (TTR) for BP since childhood on the risk of arterial stiffness in midlife remains unclear.

Objectives: The purpose of this study was to determine the independent association of TTR for systolic blood pressure (SBP) from childhood to midlife with arterial stiffness in adulthood.

Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio: Post Hoc Analysis From FLAVOUR Trial.

Background: Coronary physiology measured by fractional flow reserve (FFR) is superior to angiography for assessing the efficacy of percutaneous coronary intervention (PCI). Yet, the clinical adoption of post-PCI FFR is limited. Murray law-based quantitative flow ratio (μQFR) may represent a promising alternative, as it can quickly compute FFR from a single angiographic view.

Cardiac Response Dynamics in Newly Diagnosed Light-Chain Amyloidosis Patients With Early and High-Quality Hematologic Response.

Background: The goal of hematological response has been well established in the treatment of systemic light chain amyloidosis. However, the pattern of cardiac response remains unknown.

Objectives: This study was designed to investigate the cardiac response dynamics in patients with an early and high-quality hematological response.

Sex and authorship in global cancer research.

Introduction: Research is an essential pillar of cancer control and key in shaping regional cancer control agendas. Imbalances in science and technology in terms of lack of female participation have been well documented. However, there is little evidence about country-level female participation in cancer research.

Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer.

Objective: Current biomarkers for predicting immunotherapy response in non-small-cell lung cancer (NSCLC) are derived from invasive procedures with limited predictive accuracy. Thus, identifying a non-invasive predictive biomarker would improve patient stratification and precision immunotherapy.

Methods And Analysis: In this retrospective multicohort study, the discovery cohort included 205 NSCLC patients screened from ORIENT-11 and an external validation (EV) cohort included 99 real-world NSCLC patients.