Enhancing Diabetic Oral Wound Healing with miR-132 Delivered Through Tetrahedral DNA Nanostructures.

Oral mucosal injuries are commonly caused by factors such as trauma, infection, or inflammation, especially in diabetic patients where healing is difficult and significantly affects quality of life. In this study, a nanocarrier system based on DNA tetrahedrons (TDN) is developed, which serve as ideal vectors due to their excellent intracellular uptake and drug delivery capabilities. By efficiently delivering miR132 into cells, the proliferation and migration of human oral mucosal fibroblasts (HOMFs) and human umbilical vein endothelial cells (HUVECs) are regulated, along with the modulation of inflammation and antioxidant processes.

TPMS-Gyroid Scaffold-Mediated Up-Regulation of ITGB1 for Enhanced Cell Adhesion and Immune-Modulatory Osteogenesis.

The porous structure is crucial in bone tissue engineering for promoting osseointegration. Among various structures, triply periodic minimal surfaces (TPMS) -Gyroid has been extensively studied due to its superior mechanical and biological properties. However, previous studies have given limited attention to the impact of unit cell size on the biological performance of scaffolds.

The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes.

Angiostrongylus cantonensis (AC) is the leading cause of eosinophilic meningoencephalitis worldwide. The neuroimmune interactions between peripheral and central immune systems in angiostrongyliasis remain unclear. In this study, significant infiltration of eosinophils, myeloid cells, macrophages, neutrophils, and Ly6C monocytes is observed in the brains of AC-infected mice, with macrophages being the most abundant.

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation.

Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization of corneal stroma is challenging. In this study, humanized corneal stroma-like adhesive patches (HCSPs) are prepared through a multi-step process.

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis.

Platelets play crucial roles in multiple pathophysiological processes after energy-dependent activation. It is puzzling how such a small cellular debris has abundant energy supply. In this study, it is shown that insulin-regulated aminopeptidase (IRAP), a type II transmembrane protein, is a key regulator for platelet activation by promoting energy regeneration during septic thrombosis.

Internal Nanocavity Regulation of Embedded Rare Earth Up-Conversion Nanoparticles for HO Production Operable at Up to 780 nm.

Semiconductor photocatalysts embedded with rare earth upconversion nanoparticles (REUPs) are a promising strategy to improve their photoresponse range, but their photocatalytic performance within the near-infrared (NIR) region is far from satisfactory. Here, a method is reported to improve the photocatalytic activity by adjusting the nanocavity of upconversion nanoparticles inside a semiconductor. Two types of CdS embedded with NaYF:Yb,Er photocatalysts with core-shell structure (no cavity) (NYE/CdS) and yolk-shell structure (empty cavity) (NYE@CdS) are synthesized by different methods.

Electrooxidation of Ethylene Glycol to Glycolic Acid with Pt-Ni(OH)2 Catalysts: High Efficiency and Selectivity for PET Plastics Upgrading.

The electroconversion of polyethylene terephthalate (PET) into C2 fine chemicals and hydrogen (H2) presents a promising solution for advancing the circular plastics economy. In this study, we report the electrooxidation of ethylene glycol (EG) to glycolic acid (GA) using a Pt-Ni(OH)2 catalyst, achieving a high Faraday efficiency (>90%) even at high current densities (250 mA cm-2 at 0.8 V vs.

Potential Biomarkers for Predicting the Risk of Developing Into Long COVID After COVID-19 Infection.

Background: Long COVID, a heterogeneous condition characterized by a range of physical and neuropsychiatric presentations, can be presented with a proportion of COVID-19-infected individuals.

Methods: Transcriptomic data sets of those within gene expression profiles of COVID-19, long COVID, and healthy controls were retrieved from the GEO database. Differentially expressed genes (DEGs) falling under COVID-19 and long COVID were identified with R packages, and contemporaneously conducted module detection was performed with the Modular Pharmacology Platform (http://112.

Selective Interface Engineering with Large π-Conjugated Molecules Enables Durable Zn Anodes.

Undesirable dendrite growth and side reactions at the electrical double layer (EDL) of Zn/electrolyte interface are critical challenges limiting the performance of aqueous zinc ion batteries. Through density functional theory calculations, we demonstrate that grafting large π-conjugated molecules (e.g.

Electrochemical Cyclopropanation of Unactivated Alkenes with Methylene Compounds.

Cyclopropanes are prevalent in natural products, pharmaceuticals, and bioactive compounds, functioning as a significant structural motif. Although a series of methods have been developed for the construction of the cyclopropane skeleton, the development of a direct and efficient strategy for the rapid synthesis of cyclopropanes from bench-stable starting materials with a broad substrate scope and functional group tolerance remains challenging and highly desirable. Herein, we present an electrochemical method for the direct cyclopropanation of unactivated alkenes using active methylene compounds.

A Versatile Dual-Responsive Shape-Memory Gripper via Additive Manufacturing Toward High-Performance Cross-Scale Objects Maneuvering.

Smart grippers serving as soft robotics have garnered extensive attentions owing to their great potentials in medical, biomedical, and industrial fields. Though a diversity of grippers that account for manipulating the small objects (e.g.

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice.

Background: To investigate the toxicity of N-n-butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes.

Methods: The acute median lethal dose (LD) of F2 was determined using the Bliss method following intravenous administration in mice. Routine surface electrocardiograms (ECGs) and arterial blood pressures (aBPs) were recorded under general anesthesia in untreated and pharmacologically vagotomized mice injected with F2.

Achieving Ultralow Lattice Thermal Conductivity and High Thermoelectric Performance in BiTeSe Alloys via Introducing Organic & Inorganic Nanoparticles.

N-type BiTeSe(BTS) is a state-of-the-art thermoelectric material owing to its excellent thermoelectric properties near room temperatures for commercial applications. However, its performance is restricted by its comparatively low figure of merit ZT. Here, it is shown that a 14% increase in power factor (PF) (at 300 K) can be reached through incorporation of inorganic GaAs nanoparticles due to enhanced thermopower originating from the energy-dependent carrier scattering.

Iron Drives Eosinophil Differentiation in Allergic Airway Inflammation Through Mitochondrial Metabolic Adaptation.

Eosinophils play a crucial role as effector cells in asthma pathogenesis, with their differentiation being tightly regulated by metabolic mechanisms. While the involvement of iron in various cellular processes is well known, its specific role in eosinophil differentiation has largely remained unexplored. This study demonstrates that iron levels are increased during the differentiation process from eosinophil progenitors to mature and activated eosinophils in the context of allergic airway inflammation.

Systematic Study of the Synthesis of Monodisperse CsPbI Perovskite Nanoplatelets for Efficient Color-Pure Light Emitting Diodes.

Metal halide perovskite nanoplatelets (NPls) possess ultra-narrow photoluminescence (PL) bands tunable over the entire visible spectral range, which makes them promising for utilization in light-emitting diodes (LEDs) with spectrally pure emission colors. This calls for development of synthetic methods toward perovskite NPls with a high degree of control over both their thickness and lateral dimensions. A general strategy is developed to obtain such monodisperse CsPbI NPls through the control over the halide-to-lead ratio during heating-up reaction.

Biotic and Abiotic Drivers of Ecosystem Temporal Stability in Herbaceous Wetlands in China.

Maintaining the stability of ecosystems is critical for supporting essential ecosystem services over time. However, our understanding of the contribution of the diverse biotic and abiotic factors to this stability in wetlands remains limited. Here, we combined data from a field vegetation survey of 725 herbaceous wetland sites in China with remote sensing information from the Enhanced Vegetation Index (EVI) from 2010 to 2020 to explore the contribution of biotic and abiotic factors to the temporal stability of primary productivity.

Discovery of SARS-CoV-2 Mpro inhibitors through rational design of novel fluorinated 1,3,4-oxadiazole amide derivatives: An in-silico study.

The main protease (Mpro) of SARS-CoV-2 is an evolutionarily conserved drug discovery target. The present study mainly focused on chemoinformatics computational methods to investigate the efficacy of our newly designed trifluoromethyl-1,3,4-oxadiazole amide derivatives as SARS-CoV-2 Mpro inhibitors. Drug-likeness ADMET analysis, molecular docking simulation, density functional theory (DFT) and molecular dynamics simulation methods were included.

Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, but effective therapeutic drugs are still lacking. Dihydrotanshinone I (DHTS), a natural product isolated from Salvia miltiorrhiza, has been shown to have ameliorative effects on NAFLD. The aim of this study was to investigate the hepatoprotective effect of DHTS on NAFLD and its mechanism.

Ischemic Myocardium Targeting Peptide-Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction.

Coronary microvascular dysfunction (CMD) refers to clinical symptoms caused by structural and functional damage to coronary microcirculation. The timely and precise diagnosis of CMD-related myocardial ischemia is essential for improving patient prognosis. This study describes a method for the multimodal (fluorescence, ultrasonic, and photoacoustic) noninvasive imaging and treatment of CMD based on ischemic myocardium-targeting peptide (IMTP)-guided nanobubbles functionalized with indocyanine green (IMTP/ICG NBs) and characterizes their basic characteristics and in vitro imaging and targeting abilities.

A20 as a Potential Therapeutic Target for COVID-19.

Background: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major concern due to its astonishing prevalence and high fatality rate, especially among elderly people. Patients suffering from COVID-19 may exhibit immunosuppression in the initial stage of infection, while a cytokine storm can occur when the disease progresses to a severe stage. This inopportune immune rhythm not only makes patients more susceptible to the virus but also leads to numerous complications resulting from the excessive production of inflammatory factors.

Turning Waste into Treasure: Functionalized Biomass-Derived Carbon Dots for Superselective Visualization and Eradication of Gram-Positive Bacteria.

Gram-positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, the study utilizes purple rice lixivium to synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin-like residues for precisely targeting Gram-positive bacteria.

α-Glucosidase inhibitory activities of polyphenols from Mesua ferrea L. leaves.

Mesua ferrea L. is used in Ayurvedic and Thai medicine for treating various diseases, including diabetes. This study aimed to isolate and identify the bioactive constituents from M.

Comprehensive Analysis of Conventional and Bioactive Compositions of the Exocarp of Five Mainly-Planted Ginkgo Biloba Varieties.

Ginkgo biloba (G. biloba) exocarp, a by-product of seed production, is produced in an amount of over 75,000 tons annually in China. However, due to the lack of suitable processing methods, it is predominantly discarded as agricultural waste, resulting in substantial waste of resource.

Insights on Fabrication Strategies and Energy Storage Mechanisms of Transition Metal Dichalcogenides Cathodes for Aqueous Zn-Based Batteries.

Aqueous zinc-based batteries (AZBs) are gaining widespread attention owing to their intrinsic safety, relatively low electrode potential, and high theoretical capacity. Transition metal dichalcogenides (TMDs) have convenient 2D ion diffusion channels, so they have been identified as promising host materials for AZBs, but face several key challenges such as the narrow interlayer spacing and the lack of in-deep understanding energy storage mechanisms. This review presents a comprehensive summary and discussion of the intrinsic structure, charge storage mechanisms, and key fabrication strategies of TMD-based cathodes for AZBs.

Is cranial anatomy indicative of fossoriality? A case study of the mammaliaform Hadrocodium wui.

Determining the ecology of fossil species presents considerable challenges due to the often fragmentary preservation of specimens. The mammaliaform Hadrocodium wui from the Jurassic of China is known only from the cranium and mandible but may have had a fossorial lifestyle. It shares morphological similarities with talpid moles and soricid shrews and is closely related to other fossorial mammaliaforms.