Visualization of Vestibular Aqueduct and Endolymphatic Hydrops in Meniere's Disease With 3D-Real IR.

Objectives: To investigate the association between the vestibular aqueduct (VA) and endolymphatic hydrops (EH) in patients with Meniere's disease (MD) using three-dimensional real inversion recovery (3D-real IR) sequences.

Methods: This retrospective study included patients diagnosed with unilateral MD who underwent computed tomography (CT) and 3D-real IR sequencing. The VA course was identified on CT, and its visibility was assessed using a 3D-real IR sequence.

Mechanistic Insights into the Reactive Uptake of Bromine Nitrate at the Air-Water Interface: Interplay between Halogen Bonding and Solvation.

The reactive uptake of bromine nitrate (BrONO) into aqueous aerosols is a pivotal process in atmospheric bromine chemistry. BrONO forms halogen bonds with adjacent water molecules, disrupting hydrogen-bond networks and potentially triggering unique chemical behaviors. However, the role of halogen bonds in interfacial reactions remains an open question.

Fabrication of Dialkyl Dithiophosphate-Functionalized Carbon Aerogel Microspheres for Enhanced Lubrication Performance.

Herein, functionalized carbon aerogel microspheres (CAMs) were successfully prepared by the pyrolysis of resorcinol-formaldehyde (RF) microspheres followed by surface modification. First, RF microspheres were carbonized to obtain CAMs. Afterward, the polyphenolic compound of epigallocatechin gallate (EGCG) was reacted with melamine to form a poly(EGCG) layer onto the CAM surface, followed by bonding the antiwear molecule dialkyl dithiophosphate (DDP) by the Michael addition, resulting in DDP-functionalized CAMs (DDP-CAMs).

Application of Wide, Adjustable External Traction Fixation in Conjunctival Approach Orbital Fat Reposition Surgery.

Background: The correction of tear trough deformities is a significant challenge. The aim of this study is to present a new technique of using wide, adjustable external traction fixation in conjunctival approach orbital fat reposition surgery.

Methods: This is a retrospective case series study conducted on 69 patients, aged 18 to 45 years, who underwent surgery for palpebral bags and tear trough deformities (TTD) between October 2022 and March 2024.

Strategy for Using Electrolyte Additives to Regulate Zinc-Ion Battery Anode Interfaces via Tautomerism.

The performance of zinc-ion batteries (ZIBs) is often hindered by issues such as dendrite formation, hydrogen evolution, and limited cycling stability. 1,3-Dihydroxyacetone (DHA) not only stabilizes the anode by modulating the anode/electrolyte interface (AEI) but also enhances the electrochemical performance of the battery through its spontaneous and reversible keto-enol tautomerization, reducing the concentration gradient on the anode surface. Using a combination of DFT calculations and experimental characterization, the regulation of the hydrated Zn structure and its adsorption at AEI by this additive is investigated.

A child who suffered from HSV encephalitis and AE with positive anti-MOG results: a case report.

Objective: To investigate the clinical manifestations of a pediatric case involving herpes simplex virus (HSV) encephalitis concurrent with autoimmune encephalitis (AE), which is characterized by a positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody status.

Results: A 12-year-old girl initially presented with symptoms of autoimmune encephalitis, including weakness and poor appetite, followed by headache, dizziness, and personality changes, which are indicative of disease progression. Cerebrospinal fluid routine biochemical tests demonstrated abnormal results.

Deep Learning Radiopathomics Models Based on Contrast-enhanced MRI and Pathologic Imaging for Predicting Vessels Encapsulating Tumor Clusters and Prognosis in Hepatocellular Carcinoma.

Purpose To develop deep learning (DL) radiopathomics models based on contrast-enhanced MRI and pathologic imaging to predict vessels encapsulating tumor clusters (VETC) and survival in hepatocellular carcinoma (HCC). Materials and Methods In this retrospective, multicenter study, 578 patients with HCC (mean age [±SD], 59 years ± 10; 442 male, 136 female) were divided into the training ( = 317), internal ( = 137), and external ( = 124) test sets. DL radiomics and pathomics models were developed to predict VETC using gadoxetic acid-enhanced MR and pathologic images.

Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease.

Introduction: Crohn's disease (CD) is a group of chronic transmural inflammation of gastrointestinal tract, which seriously harms the mental and physical health of adolescents. At present, there are still no specific markers that make the diagnosis of CD extremely difficult and poor prognosis. Iron deficiency is common in CD, yet the role of ferroptosis-related genes in CD has not been elucidated.

HLA-DQB1*03:01 and risk of Hepatitis B virus-related hepatocellular carcinoma.

Background Aims: The human leukocyte antigen (HLA) locus is implicated in hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers. We investigated associations of HLA variants, amino acid polymorphisms, zygosity, and evolutionary divergence (HED) with HBV-related HCC in Han Chinese and explored biological mechanisms.

Approach Results: We examined the associations of HLA variants (imputed 4-digit classical alleles and amino acid polymorphisms), zygosity, and HED with HBV-related HCC in a discovery set (706 HBV-related HCC cases, 6,197 chronic HBV carriers in Taiwan).

Socially Withdrawn or Socially Engaged? The Impacts of Caring for Grandchildren on Social Participation among Older Adults in China.

Objectives: Grandparents caring for grandchildren (i.e., grandparenting) is a key aspect of intergenerational family dynamics.

Pterostilbene Exhibited the Anticancer Effect Against 1, 2-Dimethylhydrazine (DMH)-Induced Colorectal Cancer via Alteration of Oxidative Stress, Inflammation and Gut Microbiota.

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. The current investigation aimed to assess the chemoprotective effects of pterostilbene against 1,2-dimethylhydrazine (DMH)-induced colorectal cancer in mice. An in-silico study was conducted to perform docking studies against nuclear factor kappa factor (NF-κB).

A wireless sensor for nanosecond transient electric field measurement based on asymptotic conical antenna and high-speed data acquisition technology.

The transient electromagnetic field generated by the operation of high-voltage switches in substations can cause electromagnetic interference to the communication and control electronic equipment in the substation. On the other hand, it can also reflect the working status of the high-voltage switch itself. Therefore, it is necessary to measure and study it.

Predictors of surgical outcomes in transcervical resection of myoma.

Objective: To verify identified predictors of surgical outcomes in transcervical resection of myoma (TCRM) in Filipino women.

Methods: A retrospective analytical cross-sectional study was done on 474 women who underwent TCRM between 2010 and 2020, in St Luke's Medical Center, Philippines. Ethical exemption was granted by the Institutional Ethics Committee.

Minigene assay for verifying the splicing effects of the rare variants in the SLC12A2 gene at c.2930-1G>a.

Background: Hearing loss (HL) is a prevalent sensory impairment with a genetic basis. The SLC12A2 gene, encoding NKCC1, is vital for inner ear ion balance. The c.

177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study.

Purpose: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts and certain tumor cells, making it a promising therapeutic target for various malignancies. This study evaluated the efficacy and safety of 177Lu-Evans blue-FAP inhibitor (177Lu-LNC1004) radioligand therapy (RLT) for treating end-stage metastatic tumors.

Patients And Methods: This single-arm, single-center, phase II trial included 28 patients with progressive metastatic malignancies (11 types) and high FAP expression (defined as a maximum standardized uptake value ≥10 in >50% of tumors) who had exhausted all approved therapies, screened between June 2022 and April 2024.

Intramolecular Halogen Bonds Assist in Activating Carbonyl Groups for the Catalytic Synthesis of Bis(indolyl)methanes.

Ortho-carboxyl-substitution increases the acidity of hypervalent diaryliodonium salts and makes them useful catalysts in the synthesis of bis(indolyl)methanes under mild conditions, with yields up to 98%. The halogen bond-assisted hydrogen bonding was demonstrated by crystal structure analysis. The interaction distance of 2.

Constructing a 3D Interconnected Carbon Network for Mg-Doped Porous LiMnFePO/C Cathode Materials.

Economical and high-safety LiMnFePO/C cathode materials have gained significant attention recently due to their theoretical specific energy advantage of 18% compared to LiFePO. However, their low electronic conductivity and sluggish diffusion kinetics limit the practical applications of LiMnFePO/C. This paper presents a simple solid-state synthesis of porous LMFMP-2C4P, which is doped with Mg and coated with composite carbon.

Multi-functional high-entropy alloys and oxides for self-powered electrocatalytic nitrate reduction to ammonia.

High-entropy alloys (HEAs) show high activities toward oxygen reduction reaction (ORR), Zn-air batteries (ZABs) and nitrate reduction reaction (NO3-RR). In this work, FeNiCoMnRh HEA supported by N-doped carbon frameworks is prepared and showed excellent ORR performance with a half-wave potential (E1/2) of 0.89 V vs.

An study on the enhancement of tunneling magnetoresistance and spin injection in Ni/vacuum/Ni magnetic tunnel junctions by h-BN stacking.

This study investigates the spin-dependent transport properties of two different magnetic tunnel junctions (MTJs) with a slab with three Ni atomic layers: Ni(111)/vacuum/Ni(111) and Ni(111)-h-BN/h-BN/Ni(111)-h-BN. By combining density functional calculations and a nonequilibrium Greens function technique, we found that the Ni/vacuum/Ni MTJ has a low TMR ratio of only 3.4%.

Multitarget Natural Compounds for Ischemic Stroke Treatment: Integration of Deep Learning Prediction and Experimental Validation.

Ischemic stroke's complex pathophysiology demands therapeutic approaches targeting multiple pathways simultaneously, yet current treatments remain limited. We developed an innovative drug discovery pipeline combining a deep learning approach with experimental validation to identify natural compounds with comprehensive neuroprotective properties. Our computational framework integrated SELFormer, a transformer-based deep learning model, and multiple deep learning algorithms to predict NC bioactivity against seven crucial stroke-related targets (, and ).

Side-Functionalization of Poly(l-methionine) for Ice Control.

Controlling ice growth is crucial during the cryopreservation of cells, but the current application of small molecules as cryoprotectants still remains a challenge. Inspired by structures of natural antifreeze (glyco)proteins, in this work, functionalized poly(l-methionine)s (PMets) are synthesized with different side groups including hydroxyl, threonine-mimetic with both methyl and hydroxyl groups (PMet-MOH), zwitterion with carboxyl and sulfonium (PMet-COOH), glycerol, and trehalose pendants. Results suggest that these functionalized PMets tend to self-assemble into 100-300 nm nanoparticles with positive charges in water.

Maximum a posteriori underwater acoustic source localization based on time differences of arrival accounting for refraction.

Traditional underwater acoustic source localization methods based on time differences of arrival (TDOA) in the presence of refraction first estimate the source depth and range to each hydrophone and then estimate the horizontal location of the source. The accuracy of these methods is compromised by errors in range estimation. To address this, we propose a three-dimensional source localization method that utilizes TDOA measurements between direct and surface-reflected arrivals at N(N ≥3) hydrophones, taking into account refraction effects.

Context effects on lexical tone categorization in quiet and noisy conditions by young, middle-aged, and older individuals.

Previous studies focused on how contexts affect the recognition of lexical tones, primarily among healthy young adults in a quiet environment. However, little is known about how senescence and cognitive decline influence lexical tone normalization in adverse listening conditions. This study aims to explore how F0 shifts of the preceding context affect lexical tone identification across different age groups in quiet and noisy conditions.

Upconversion Nanoparticle-Delivery Flexible Optrodes for Long-Lasting Multichannel Electrophysiology and Transcranial NIR Optogenetics.

Near-infrared (NIR) activatable nanoparticles enable remote, cell-type-specific manipulation of neuronal activity, whereas flexible microelectrode arrays (FMAs) facilitate long-term, multichannel recording of neural signals. Despite the recent development of multifunctional neural probes, integrating these techniques into a single, minimally invasive device remains challenging. Here, we present a novel optrode that combines NIR-activatable upconversion nanoparticles (UCNPs) with FMAs.

Influence of microstructure on metal-ceramic bonding in SLM-manufactured titanium alloy crowns and bridges.

Objectives: This study focuses on the effect of microstructural surface characteristics on metal-ceramic bond strength for SLM-fabricated titanium alloy. This research seeks to improve metal-ceramic adhesion in SLM-produced parts.

Methods: Inspired by the hydrophilic structure of Calathea zebrina, bioinspired microstructures were designed on titanium alloy surfaces.