Stigma, colorectal cancer knowledge and self-efficacy among colorectal cancer survivors: A cross-sectional study based on random forest analysis.

Purpose: To assess the stigma levels among colorectal cancer (CRC) survivors, identify determinants, examine correlations with CRC knowledge and self-efficacy, and quantify the relative influence of various contributing factors.

Methods: In total, 301 CRC survivors were enrolled from a tertiary oncology center in southern China. The participants completed the Social Impact Scale (SIS), Bowel Cancer Awareness Measure (Bowel CAM), General Self-Efficacy Scale (GSES), and a demographic and disease-related questionnaire.

Family participation in geriatric decision-making: Marginalization of older patients' autonomy in Chinese outpatient consultation.

Family participation is regarded as crucial for promoting patient well-being, particularly in geriatric care, where patients often face greater challenges and require additional support in making medical decisions. The importance of family participation is frequently framed within a cultural context that acknowledges differing conceptions of autonomy. However, it remains unclear how family members are actually prompted or discouraged in their participation in medical decision-making.

Peptoniphilus vaginalis bacteremia in a patient with diabetic foot infection: First reported case and literature review.

Background: Peptoniphilus vaginalis, a Gram-positive anaerobic coccus, is a recently characterized species within the Peptoniphilus genus. No studies have detailed its features. This report documents the first case of P.

Non-invasive diagnosis of pulmonary tuberculosis and predictive potential for treatment outcomes via miR-146a and miR-155 levels.

Use of microRNAs is a promising area for non-invasive diagnosis of pulmonary tuberculosis (TB). Herein, we aimed to investigate the diagnostic potential of miR-146a and miR-155 in pulmonary TB and their predictive potential for patient treatment outcomes. The study included 60 patients with active TB, 50 patients with latent TB, and 50 individuals without TB infection.

Efficient synthesis, stability-guided optimization and anticancer evaluation of bee venom peptide Melittin.

Natural cytotoxic peptides (NCPs) are emerging sources of novel anticancer chemotherapeutics. Especially, Melittin, which is the major component of bee venom and the first-in-class NCP, has been considered as a promising anticancer scaffold. Nevertheless, as a classical linear, cationic, amphipathic, and membrane-lytic peptide, Melittin may be easily degraded by proteases, suffering from poor stability, moderate anticancer durability, and severe hemolysis.

Prodigiosin inhibits proliferation and induces apoptosis through influencing amino acid metabolism in multiple myeloma.

The recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treatment for MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cell proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC range of MM cells.

Local salient location-aware anomaly mask synthesis for pulmonary disease anomaly detection and lesion localization in CT images.

Automated pulmonary anomaly detection using computed tomography (CT) examinations is important for the early warning of pulmonary diseases and can support clinical diagnosis and decision-making. Most training of existing pulmonary disease detection and lesion segmentation models requires expert annotations, which is time-consuming and labour-intensive, and struggles to generalize across atypical diseases. In contrast, unsupervised anomaly detection alleviates the demand for dataset annotation and is more generalizable than supervised methods in detecting rare pathologies.

Targeting TRAP1-dependent metabolic reprogramming to overcome doxorubicin resistance in quiescent breast cancer.

Aims: TRAP1 is involved in metabolic reprogramming and promotes drug resistance. We aimed to explore whether a novel HSP90 inhibitor, C210, overcomes doxorubicin (DOX) resistance of quiescent breast cancer cells by targeting TRAP1.

Methods: Breast cancer cells were induced to quiescence by hypoxia and low glucose.

Caryophyllene oxide from bioassay-guided fractionation of Toona sinensis essential oil shows insecticidal activity against poultry red mite (Dermanyssus gallinae).

The widespread distribution and ecumenical abundance of the poultry red mite, Dermanyssus gallinae (De Geer), in chicken houses, has been bringing about one intractable challenge for the egg-laying hens. However, because of the appearance of drug resistance and the animal safety legislation, the search for some effective insecticidal agents is necessary. In the present investigation, the essential oil extracted from the tender shoots and young leaflets of Toona sinensis (Chinese toon, TSEO) were demonstrated to be not only display significant antioxidant effect, but also revealed prominent insecticidal activity against the poultry red mite.

Emergency multimodality imaging for a giant cystic renal artery aneurysm in a lung adenocarcinoma patient with iodinated contrast media allergy: A case report.

Introduction And Importance: Renal artery aneurysm (RAA) is a rare, but potentially life-threatening condition. The rarity of malignancy-associated RAAs limits our understanding of their natural history, morphological characteristics, intervention criteria, and available treatment options. When these aneurysms manifest as large cystic formations, they may mimic renal masses or cysts.

Efficacy of Acellular Dermal Matrix in Improving Clinical Outcomes in Pediatric Burns: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: This latest systematic review and meta-analysis aim to examine the efficacy of acellular dermal matrix (ADM) in pediatric burns.

Methods: Relevant articles were retrieved from Pubmed, Embase, Cochrane, Web of science, China National Knowledge Infrastructureris, VIP Database for Chinese Technical Periodicals and Wanfang database. The primary outcome was the healing time, and secondary outcomes were the skin graft survival rate, reoperation, complications, numbers of dressing change, incidence of scarring, scar areas and scar scores.

Clinical Efficacy of Arthroscopic Minimally Invasive Treatment in Children With Congenital Muscular Torticollis: A Retrospective Study.

Objectives: The purpose of the study was to assess the clinical efficacy of arthroscopic treatment strategy in children with congenital muscular torticollis (CMT).

Methods: A retrospective study was carried out in patients diagnosed with CMT from October 2020 to March 2023, of the 98 subjects who met the inclusion criteria, 52 subjects underwent arthroscope-assisted treatment and 46 subjects treated with traditional open operation were recruited for the study. Clinical follow-up evaluation was evaluated using the modified Cheng scoring.

Prevalence of frailty and prefrailty in systemic lupus erythematosus: A systematic review and meta-analysis.

Objective: Frailty is associated with mortality in systemic lupus erythematosus (SLE), but the prevalence is unclear. The aim of this systematic review and meta-analysis was to investigate the prevalence of frailty and prefrailty in SLE patients.

Methods: Four databases, namely PubMed, Cochrane, EMBASE, and Web of Science, were systematically searched from their inception to November 2024 to identify studies that fulfilled the predefined a priori inclusion criteria for systematic review and meta-analysis, and that specifically investigated frailty and prefrailty in patients with SLE.

Stocking filter-feeder in fed fish aquaculture pond: Unexpected Aggravation of nitrous oxide emission.

Intensive farming of fed fish could produce large amounts of uneaten feed and feces, potentially leading to increased nitrous oxide (NO) emissions. Filter-feeding fish can ingest residual feed and feces, but it is unclear whether introducing them into fed fish farming ponds could reduce NO emissions. This study employed monoculture of fed largemouth bass (Micropterus salmoides, LB) and polyculture of LB with filter-feeding silver carp (Hypophthalmichthys molitrix, SC) at density ratios of 18:1, 9:1 and 4.

Unravelling riverine dissolved organic matter sources using molecular fingerprints and FEAST model in a multi-tributary mountain river basin.

Revealing the sources, composition and fate of riverine dissolved organic matter (DOM) is fundamental to understanding the biogeochemical cycles of aquatic ecosystems. This study aimed to reveal the impact of land uses and wastewater treatment plants (WWTPs) on riverine DOM. Spatiotemporal variations in molecular characteristics of riverine DOM in the river network containing 15 tributaries in the mainstream of upper Hanjiang River were studied.

A comparative study of reactive manganese species and electron transfer pathway in oxidation efficiency and environmental impact: Which activation route for potassium permanganate is optimal?

Various methods have been explored to activate potassium permanganate (Mn(VII)) for the elimination of organic compounds, typically by generating highly-reactive manganese species (RMnS) or mediated by electron transfer process (ETP). However, the oxidation selectivity, transformation pathways, toxicity byproduct potential, and efficacy in complicated water matrices associated with RMnS and ETP have not been comprehensively evaluated and compared, which is important for selecting a fit-of-purpose mechanism for water remediation. This study selected Mn(VII)/graphite process and ultraviolet (UV)/Mn(VII) process as the model ETP-dominated system and RMnS-dominated system, respectively.

Modulating d-orbital electronic configuration of magnetic iron sulfide nanocrystals for maximized treatment efficiency of chromium-contaminated water.

Hexavalent chromium (Cr(VI)) is one of the most rigorously regulated contaminants frequently detected in surface and groundwater. Magnetic iron sulfides are naturally abundant, environmentally friendly materials ideal for the removal of Cr(VI) from contaminated water, but the high-spin states of Fe(III) ions limits their adsorption affinity. Herein, we develop a heteroatom-doping approach to boost the Cr(VI) removal efficacy of greigite.

Green and efficient disinfection of antibiotic-resistant bacteria via PI/HO homogeneous system.

The proliferation and spread of antibiotic-resistant bacteria (ARB) significantly threaten human health and ecosystem. Periodate (PI) based advanced oxidation process has potentials for water purification but is limited by complex activators or activation process. Herein, we demonstrated that HO could be used to activate PI, achieving efficient ARB disinfection performance.

Physiological and genetic responses of Chlorella sp. to nitrite accumulation in microalgal-bacterial consortium with partial nitrification treating municipal wastewater.

The integration of microalgal-bacterial consortium (MBC) with partial nitrification (PN-MBC) offers a promising strategy for low-carbon wastewater treatment. However, the gradually accumulated nitrite levels challenge microalgal activities and system stability. This study demonstrated the nitrite tolerance (10-300 mg/L) of Chlorella sp.

Exploring physiological differences in injury response by skin tone: A scoping review.

Aim: To explore existing literature examining physiological differences in pressure ulcer response among individuals with differing skin tones.

Methods: This was a scoping review. Articles meeting the inclusion criteria were retrieved from electronic databases including PubMed, CINAHL, Scopus, Cochrane, and EMBASE, using the keywords "pressure ulcer," "skin pigmentation," "melanin," and "risk factor.

Preparation of mixed-mode hydrophilic particle for efficient separation of common human milk oligosaccharides.

Human milk oligosaccharides (HMOs) are essential for babies' growth. The most commonly used method for HMOs analysis combines hydrophilic interaction liquid chromatography (HILIC) with ultra-performance liquid chromatography (UPLC). However, high-pressure operation and the cost of commercial HILIC columns limit progress in the HMOs research.

Construction of three-face recognition molecularly imprinted polymers for extraction and detection of melamine via specific hydrogen bonding.

Based on the principle that poly(thymine) ssDNA could recognize melamine (Mel) in aqueous media and the third face of Mel could be accessed by other hydrogen bonding molecules, UiO-66-NH was functionalized with poly(thymine) ssDNA and as the matrix to construct three-face recognition molecularly imprinted polymers (UDMIPs). The adsorption processes of UDMIPs towards Mel were accorded to Sips model and exhibited high adsorption capacity (Q=10.60 mg/g) and good imprinting factor (IF=2.

Infection-related mortality in hospitalized children: A multi-center study in China from 2016 to 2021.

Background: Hospitalized children experience mortality as a result of infections. Since the COVID-19 outbreak in early 2020, China's strict prevention measures have curbed pathogen transmission, altering infection-related epidemiology. The Futang Research Center of Pediatric Development has collected the face sheet of discharge medical records (FSMRs) data from 27 tertiary children's hospitals since January 2016, which facilitate us to investigate this issue.

Early differential diagnosis models of Talaromycosis and Tuberculosis in HIV-negative hosts using clinical data and machine learning.

Background: Talaromyces marneffei is an emerging pathogen, and the number of infections in HIV-negative individuals is increasing. In HIV-negative individuals, talaromycosis is usually misdiagnosed as another disease, especially tuberculosis (TB).

Methods: We retrospectively extracted the clinical data of HIV-negative patients with Talaromyces marneffei infection from 2018 to 2023, analyzed the differences between TB patients and talaromycosis patients and attempted to establish differential diagnosis models utilizing clinical prediction models for these two diseases.