Core Outcome Set and Unique Outcomes of Nursing Interventions for Women With Lactational Mastitis: A Mixed Methods Study.

Aims: To develop the core outcome set and identify unique outcomes for the three stages and five types of nursing interventions, respectively, in lactational mastitis.

Design: A mixed methods study.

Methods: A systematic literature search, four semi-structured interviews for key stakeholders, two rounds of Delphi surveys and two online consensus meetings were conducted.

The 2024 APLAR Consensus on the Management of Lupus Nephritis.

The APLAR has published a set of recommendations on the management of systemic lupus erythematosus (SLE) in 2021. The current consensus paper supplements and updates specifically the treatment of lupus nephritis (LN) according to two rounds of Delphi exercise from members of the APLAR SLE special interest group, invited nephrologists, histopathologists, and lupus nephritis patients. For initial treatment of LN, we recommend a combination of glucocorticoids (GCs) with cyclophosphamide (CYC), mycophenolate mofetil (MMF), or the calcineurin inhibitors (CNIs) as first-line options.

Lignosulfonate as a versatile regulator for the mediated synthesis of Ag@AgCl nanocubes.

The remarkable catalytic activity, optical properties, and electrochemical behavior of nanomaterials based on noble metals (NM) are profoundly influenced by their physical characteristics, including particle size, morphology, and crystal structure. Effective regulation of these parameters necessitates a refined methodology. Lignin, a natural aromatic compound abundant in hydroxyl, carbonyl, carboxyl, and sulfonic acid groups, has emerged as an eco-friendly surfactant, reducing agent, and dispersant, offering the potential to precisely control the particle size and morphology of NM-based nanomaterials.

Association of Serum Uric Acid Level With Bone Mineral Density and the Risk of Osteoporosis: A Dose-Response Meta-Analysis.

Objective: Serum uric acid (SUA) may play positive roles in diseases associated with oxidative stress, such as osteoporosis (OP). Nevertheless, the specific impact of SUA levels on both bone mineral density (BMD) and the risk of OP remains uncertain. Considering such information crucial for clinicians when making decisions about urate-lowering therapy (ULT), we sought to fill this gap by conducting dose-response meta-analyses.

One-Step Epitaxy of Transition Metal Nitride Nanopillar Arrays with an Oxidation-Tunable Hyperbolic Dispersion.

The controllable synthesis of epitaxial nanopillar arrays is fundamentally important to the development of advanced electrical and optical devices. However, this fascinating growth method has rarely been applied to the bottom-up synthesis of plasmonic nanostructure arrays (PNAs) with many broad, important, and promising applications in optical sensing, nonlinear optics, surface-enhanced spectroscopies, photothermal conversion, photochemistry, etc. Here, a one-step epitaxial approach to single-crystalline NbTiN (NbTiN) nanopillar arrays based on the layer plus island growth mode is demonstrated by strain engineering.

Preparation, structural characterisation, absorption and calcium transport studies of walnut peptide calcium chelate.

In this study, a walnut peptide (WP) with calcium-binding capacity was prepared using a combination of alkalase and neutrase. The conditions for the preparation of walnut peptide calcium chelate (WP-Ca) were optimised (a peptide/calcium chloride ratio of 1 : 4 for 70 min at 50 °C and pH 9.5).

Construction of Full-Spectrum-Response BiOBr:Er@BiO S-Scheme Heterojunction With [Bi─O] Tetrahedral Sharing by Integrated Upconversion and Photothermal Effect Toward Optimized Photocatalytic Performance.

Designing and optimizing photocatalysts to maximize the use of sunlight and achieve fast charge transport remains a goal of photocatalysis technology. Herein, a full-spectrum-response BiOBr:Er@BiO core-shell S-scheme heterojunction is designed with [Bi─O] tetrahedral sharing using upconversion (UC) functionality, photothermal effects, and interfacial engineering. The UC function of Er and plasmon resonance effect of BiO greatly improves the utilization of sunlight.

Recent advances in the reactions of isatin-derived MBH carbonates for the synthesis of spirooxindoles.

As one of the main fragments in medical drugs, spirooxindole has received considerable attention from organic and medicinal chemists. In the past few decades, chemists have been searching for more straightforward and efficient methods to produce compounds containing a spirooxindole fragment. In this regard, isatin-derived Morita-Baylis-Hillman (MBH) carbonates have been widely used as versatile building blocks for the synthesis of spirooxindole structures.

One-pot isothermal CRISPR/Dx system for specific and sensitive detection of microRNA.

MicroRNA (miRNA) is a promising biomarker for the early diagnosis of pancreatic cancer. To enable sensitive and reliable miRNA detection, we have developed a one-pot isothermal CRISPR/Dx detection system by combining rolling circle amplification (RCA) and CRISPR/Cas12a. RCA and CRISPR/Cas12a reactions are carried out in a single closed tube, bypassing the transferring step.

Fluorination of Aza-BODIPY for Cancer Cell Plasma Membrane-Targeted Imaging and Therapy.

Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional PSs specifically designed for cancer PDT by fluorinating aza-BODIPY with perfluoro--butoxymethyl (PFBM) groups.

Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip.

Improper use of antibiotics has led to the development of antimicrobial resistance, or "superbugs," outpacing the discovery of new antibiotics. The lack of rapid, high-throughput screening methods is a major bottleneck in discovery novel antibiotics. Traditional methods consume significant amounts of samples, making it challenging to discover new antibiotics from limited natural product extracts.

Ultrasound-Controllable Release of Carbon Monoxide in Multifunctional Polymer Coating for Synergetic Treatment of Catheter-Related Infections.

Medical catheters are susceptible to biological contamination and pathogen invasion, leading to infection and inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited biological functionality and the incompatibility between bactericidal properties and biosafety remain great challenges.

Boosting Hot Electron Generation in Energy Center Embedded Metal-Organic Frameworks for Photocatalysis.

The ligands in metal-organic framework (MOF) play as light absorption center and transfer photogenerated electrons to metal node through ligand-to-metal charge transfer (LMCT) during photocatalysis, and energy utilization efficiency is strongly restricted by the light inertness of ligands. Herein, a ligand updating strategy is proposed by inserting energy centers to MOFs to activate the inherent ligands, realizing boosting hot electron generation and photocatalytic activities via the cascaded proceeding of energy transfer and charge transfer. By taking PCN-777 (a zeotype mesoporous Zr-containing MOF) as an example, this study shows that the embedded energy center of 1-pyrenecarboxylic acid (PCA) can activate the inherent ligand of PCN-777 through triplet-triplet energy transfer, where triplet excitons would dissociate into photocarriers migrating to the Zr metal cluster via LMCT process.

Enhanced Protein Immobilization Capacity through Grafting of Poly(sodium methacrylate) onto Magnetic Bead Surface.

This study aims to improve the signal-to-noise ratio (SNR) of chemiluminescence immunoassay (CLIA) by increasing the amount of protein immobilized on the surface of the magnetic bead (MB). Proteins are macromolecules with three-dimensional structures, and merely increasing the density of functional groups on the two-dimensional surface of the MB cannot significantly enhance protein immobilization. Therefore, we grafted spatially extended functional polymer to not only increase the density of functional groups on the MB surface but also expand their distribution in three-dimensional space, ultimately increasing protein immobilization.

Emerging 0D Hybrid Metal Halide Luminescent Glasses.

0D hybrid metal halide (HMH) luminescent glasses have garnered significant attentions for its chemical diversity in optoelectronic applications and it also retains the skeleton connectivity and coordination mode of the crystalline counterparts while exhibiting various physics/chemistry characteristics distinct from the crystalline states. However, understanding of the glass-forming ability and the specific structural origins underpinning the luminescent properties of 0D HMH glasses remains elusive. In this review, it is started from the solid-liquid phase transition and thermodynamic analysis of 0D HMHs formed through melt-quenching, and summarize the current compounds capable of stably forming glassy phases via chemical structural design.

Dupilumab induced ocular surface diseases: an analysis of FAERS database, literature review and disease-gene interaction networks.

Background: Adverse events (AE) in dupilumab induced ocular surface diseases (DIOSD) have raised concerns regarding its safety. The objective of this study was to evaluate DIOSD by employing database analysis and clinical case review, along with mechanism analysis.

Research Design And Methods: Database AE data were extracted from FAERS from 2017 Quarter 1 (Q1) to 2023 Q1.

Regulation of the valleytronic properties in single-layer NbSeCl.

The regulation of the valleytronic properties of two-dimensional materials can contribute to the in-depth study of valley physics and improve its potential for applications in valleytronic devices. Herein, we systematically investigate the electronic properties and the modulation of the valleytronic properties in single-layer NbSeCl. Our results reveal that NbSeCl is a semiconductor with a 105.

Dynamic Redox Induced Localized Charge Accumulation Accelerating Proton Exchange Membrane Electrolysis.

The sluggish anodic oxygen evolution reaction (OER) in proton exchange membrane (PEM) electrolysis necessitates applied bias to facilitate electron transfer as well as bond cleavage and formation. Traditional electrocatalysis focuses on analyzing the effects of electron transfer, while the role of charge accumulation induced by the applied overpotential has not been thoroughly investigated. To explore the influence mechanism of bias-driven charge accumulation, capacitive Mn is incorporated into IrO to regulate the local electronic structure and the adsorption behavior.

In Situ Integration of Metallic Catalytic Sites and Photosensitive Centers within Covalent Organic Frameworks for the Enhanced Photocatalytic Reduction of CO.

Covalent organic frameworks (COFs) are a promising platform for heterogeneous photocatalysis due to their stability and design diversity, but their potential is often restricted by unmanageable targeted excitation and charge transfer. Herein, a bimetallic COF integrating photosensitizers and catalytic sites is designed to facilitate locally ultrafast charge transfer, aiming to improve the photocatalytic reduction of CO. The strategy uses a "one-pot" method to synthesize the bimetallic COF (termed PBCOF) through in situ Schiff-base condensation of Pyrene with MBpy (M = Ru, Re) units.

Machine Learning for Reaction Performance Prediction in Allylic Substitution Enhanced by Automatic Extraction of a Substrate-Aware Descriptor.

Despite remarkable advancements in the organic synthesis field facilitated by the use of machine learning (ML) techniques, the prediction of reaction outcomes, including yield estimation, catalyst optimization, and mechanism identification, continues to pose a significant challenge. This challenge arises primarily from the lack of appropriate descriptors capable of retaining crucial molecular information for accurate prediction while also ensuring computational efficiency. This study presents a successful application of ML for predicting the performance of Ir-catalyzed allylic substitution reactions.

Functionalized Microsphere Platform Combining Nutrient Restriction and Combination Therapy to Combat Bacterial Infections.

The escalating prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a critical global health crisis, undermining the efficacy of conventional antibiotic therapies. This pressing challenge necessitates the development of innovative strategies to combat MDR pathogens. Advances in multifunctional drug delivery systems offer promising solutions to reduce or eradicate MDR bacteria.

An Optoelectronic Sensing Real-Time Glucose Detection Film Using Photonic Crystal Enhanced Rare Earth Fluorescence and Additive Manufacturing.

In this research, a novel detection method employing rare-earth upconversion nanoparticle (UCNP) as the core, coated with MnO nanosheets is designed, which formed a color and fluorescence dual-responsive UCNP composite material, MnO-modified NaYF:Yb,Tm@NaYF. By enabling both colorimetric and fluorescence methods simultaneously, this composite material allows for the detection of glucose concentration under different conditions, while exhibiting strong resistance to environmental interference, chemical stability, and accuracy. To further enhance the sensitivity of the detection method, a photonic crystals (PCs)-PDMS array where polymethyl methacrylate PCs are deposited onto a substrate composed of PDMS-glass slice with hydrophobic surfaces is developed.

Slide-Ring Structured Stress-Electric Coupling Hydrogel Microspheres for Low-Loss Transduction Between Tissues.

High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane and conductive polypyrrole to construct stress-electric coupling hydrogel microspheres.

Comparative study of labour analgesia onset with injection of loading dose through epidural needle versus catheter: A prospective, double-blinded, randomised clinical trial.

Background: Rapid onset of epidural analgesia is an important concern for the parturient. Commonly, the local anaesthetic mixture is administered through the epidural catheter. Drugs administered through the epidural needle might decrease the onset time and enhance the spread of medication within the epidural space.

How AI competencies can make B2B marketing smarter: strategies to boost customer lifetime value.

There has been a rapid rise in utilization of artificial intelligence (AI) in many different sectors in the last several years. However, business-to-business (B2B) marketing is one of the more notable examples. The initial assessments emphasize the significant advantages of AI in B2B marketing, including its knack for yielding unique understandings into consumer behaviors, recognizing crucial market trends, and improving operational efficiency.