Pharmacomicrobiomics: a new field contributing to optimizing drug therapy in Parkinson's disease.

Gut microbiota, which act as a determinant of pharmacokinetics, have long been overlooked. In recent years, a growing body of evidence indicates that the gut microbiota influence drug metabolism and efficacy. Conversely, drugs also exert a substantial influence on the function and composition of the gut microbiota.

From fear to empowerment: the impact of employees AI awareness on workplace well-being - a new insight from the JD-R model.

Purpose: The primary purpose of the study was to explore the impact of health workers' awareness of artificial intelligence (AI) on their workplace well-being, addressing a critical gap in the literature. By examining this relationship through the lens of the Job demands-resources (JD-R) model, the study aimed to provide insights into how health workers' perceptions of AI integration in their jobs and careers could influence their informal learning behaviour and, consequently, their overall well-being in the workplace. The study's findings could inform strategies for supporting healthcare workers during technological transformations.

Design, Structure Optimization, and Preclinical Characterization of JAB-21822, a Covalent Inhibitor of KRAS.

KRAS is the most frequently mutated driver oncogene in human cancer, and KRAS mutation is commonly found in non-small-cell lung cancer (NSCLC), colorectal cancer (CRC), and pancreatic ductal adenocarcinoma (PDAC). Inhibitors that covalently modify the mutated codon 12 cysteine have completed proof-of-concept studies in the clinic. Here, we describe structure-based design and cocrystal-aided drug optimization of a series of compounds with the 1,8-naphthyridine-3-carbonitrile scaffold.

Bias-Induced Ga-O-Ir Interface Breaks the Limits of Adsorption-Energy Scaling Relationships for High-Performing Proton Exchange Membrane Electrolyzers.

Rationally manipulating the in-situ formed catalytically active surface of catalysts remains a significant challenge for achieving highly efficient water electrolysis. Herein, we present a bias-induced activation strategy to modulate in-situ Ga leaching and trigger the dynamic surface restructuring of lamellar Ir@Ga2O3 for the electrochemical oxygen evolution reaction. The in-situ reconstructed Ga-O-Ir interface sustains high water oxidation rates at OER overpotentials.

Radical Homopolymerization of α-Olefins to Synthesize Polysulfones - a "SO2-free" Approach.

Traditionally, α-olefins have been regarded as non-homopolymerizable substrates in textbook examples. However, they have the ability to copolymerize with sulfur dioxide, leading to the creation of alternating copolymers. These commodity poly(olefin sulfone)s exhibite a wide array of applications.

Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation.

The cyclic GMP-AMP synthase (cGAS)-stimulator of the interferon genes (STING) pathway plays a key role in triggering interferon and inflammatory responses against microbial invasion or tumor. However, aberrant activation of the cGAS-STING pathway is associated with a variety of inflammatory and autoimmune diseases, and thus inhibition of STING is regarded as a potential new approach to treating these diseases. Herein, we report a series of novel indolyl-urea derivatives as STING inhibitors.

Transcription and epigenetic factor dynamics in neuronal activity-dependent gene regulation.

Neuronal activity, including sensory-evoked and spontaneous firing, regulates the expression of a subset of genes known as activity-dependent genes. A key issue in this process is the activation and accumulation of transcription factors (TFs), which bind to cis-elements at specific enhancers and promoters, ultimately driving RNA synthesis through transcription machinery. Epigenetic factors such as histone modifiers also play a crucial role in facilitating the specific binding of TFs.

The two action mechanisms of plant cryptochromes.

Plant cryptochromes (CRYs) are photolyase-like blue-light receptors that contain a flavin adenine dinucleotide (FAD) chromophore. In plants grown in darkness, CRYs are present as monomers. Photoexcited CRYs oligomerize to form homo-tetramers.

Identification of Gingival Inflammation Surface Image Features Using Intraoral Scanning and Deep Learning.

Introduction And Aim: The assessment of gingival inflammation surface features mainly depends on subjective judgment and lacks quantifiable and reproducible indicators. Therefore, it is a need to acquire objective identification information for accurate monitoring and diagnosis of gingival inflammation. This study aims to develop an automated method combining intraoral scanning (IOS) and deep learning algorithms to identify the surface features of gingival inflammation and evaluate its accuracy and correlation with clinical indicators.

Effect of TKI Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation on Recurrence of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia p190 and p210 Transcripts: A Multicentre Study.

Objective: To analyze the impact of tyrosine kinase inhibitor (TKI) maintenance therapy following allogeneic hematopoietic stem cell transplantation (HSCT) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) on recurrence rates and prognosis for the 2 transcripts, p190 and p210.

Methods: We conducted a retrospective analysis of clinical data from 58 patients diagnosed with Ph + ALL who underwent HSCT. All patients received TKI maintenance therapy following hematopoietic reconstruction post-transplantation.

Predefined-time adaptive neural network decentralized control for large-scale interconnected systems with input hysteresis.

This study endeavors to develop a predefined-time adaptive neural network decentralized controller for large-scale interconnected nonlinear systems with input hysteresis. Within the framework of the backstepping technique, the proposed control scheme guarantees that the tracking error converges to a small bounded set within a predefined settling time. The upper limit of this convergence time is determined by a single adjustable control parameter.

Hierarchical braking accurate control of electrohydraulic composite braking system for electric vehicles.

For the electrohydraulic composite braking system, the general total braking force calculation strategy frequently ignores the resist forces, thereby cannot track the braking intention of driver perfectly. Moreover, the torque allocation process reduces the control reliability and energy recovery effect. In this research, a novel hierarchical braking accurate control (HBAC) algorithm is designed to achieve both the control accuracy and the ideal energy recovery efficiency.

Prediction-based rapid force control of a single-acting pneumatic cylinder under hysteresis nonlinearity.

Hysteresis characteristics widely affects the performance and reliability of pneumatic systems across various industrial applications. Addressing this challenge can significantly enhance system efficiency and precision. This paper aims to develop a rapid and accurate method for controlling the actuating force of a Single-Acting Pneumatic Cylinder (SAPC), considering hysteresis characteristic.

Potential risk of heavy metals release in sediments and soils of the Yellow River Basin (Henan section): A perspective on bioavailability and bioaccessibility.

The ecology of watersheds plays an important role in regulating regional climate and human activities. The sediment-soil system in the middle and lower reaches of the Yellow River Basin (Henan section) was explored. The spatial distribution characteristics of heavy metals (HMs) showed that tributaries, which are affected by anthropogenic activities, contain higher concentrations of HMs than the main channel.

Impact of variations in airborne microbiota on pneumonia infection: An exploratory study.

Background: Previous studies showed airborne bacteria affect pneumonia incidence, but specific impacts of bacterial communities on Klebsiella pneumoniae infection were unknown.

Methods: Five different ratios of bacterial community structures were randomly generated. Mice were divided into control, artificial bacterial community exposure, and corresponding Klebsiella pneumoniae challenge groups.

Dietary protein intake and PM on ovarian cancer survival: A prospective cohort study.

Background: Evolving evidence suggests both protein consumption and particulate matter less than 2.5 micrometers (PM) might be related to ovarian cancer (OC) mortality. However, no epidemiological studies have explored their potential interaction.

Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study.

Environmental pollutants have been implicated in various detrimental health effects. However, the specific relationship between environmental pollutant exposure and the risk of cerebrovascular disease mortality remains uncertain. This study aimed to comprehensively explore the potential relationship between environmental pollutant exposure and risk of cerebrovascular disease mortality in the U.