Transparent cellulose-lignin films containing Fe with high UV absorption for thermal management.

In this paper, cellulose-lignin films containing Fe were prepared by the codissolution-precipitation method, and the films have high transparency as well as high UV absorption. In this process, kraft lignin chelates with Fe and then bonds with cellulose through hydrogen bonding, evenly distributing within the film. The morphological results showed that the kraft lignin chelated with Fe bound tightly linked to cellulose within the Fe@cellulose-lignin composite films.

A "cyclodextrin-salicylic acid-chitosan" bifunctional monomer magnetic hydrophilic imprinted sandwich gel for targeted adsorption and slow release of ginkgolic acid.

This study aims to address the challenge of detoxifying ginkgolic acid and transform it from waste into a valuable resource. By using pseudo-template molecular imprinting technology to chemically modify polysaccharide materials, we developed a polysaccharide-based molecular imprinted material (MMCC-CD/CS-MIP) for the targeted separation and controlled release of ginkgolic acid. Under optimal conditions, MMCC-CD/CS-MIP demonstrated excellent adsorption performance (Q = 47.

Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent eczematous lesions and severe itching, for which clinical treatments are limited. Selectively inhibiting Janus Kinase 3 (JAK3) and tyrosine kinase expressed in hepatocellular carcinoma (TEC) family kinases is proposed as a promising strategy to treat AD with possible reduced side effects and enhanced efficacy. In this study, we developed a dual JAK3/TEC family kinase inhibitor ZZB, which demonstrated potent inhibitory activity with IC values of 0.

Multifractal dynamic changes of spontaneous brain activity in psychiatric disorders: Adult attention deficit-hyperactivity disorder, bipolar disorder, and schizophrenia.

It is one of the strategies to study the complexity of spontaneous fluctuation of brain neurons based on resting-state functional magnetic resonance imaging (rs-fMRI), but the multifractal characteristics of spontaneous fluctuation of brain neurons in psychiatric diseases need to be studied. Therefore, this paper will study the multifractal spontaneous brain activity changes in psychiatric disorders using the multifractal detrended fluctuation analysis algorithm based on the UCLA datasets. Specifically: (1) multifractal characteristics in adult attention deficit-hyperactivity disorder (ADHD), bipolar disorder (BP), and schizophrenia (SCHZ); (2) the source of those multifractal characteristics.

Advances and applications of peripheral optogenetics in animal models.

Peripheral optogenetics is an emerging neuromodulation technique that regulates the activity of the nervous system outside the brain through the expression of photosensitive proteins and the application of photic stimulation. This article reviews recent advances in applying optogenetics to the spinal cord and peripheral nerves, offering a comprehensive understanding of functions and regulatory mechanisms of the peripheral nervous system through the modulation of specific neuronal activities. By showcasing novel opportunities for disease treatment, this technique opens new avenues in the field of psychophysiological research and neural regulation therapy.

SENP3: Cancers and diseases.

SUMOylation is a protein modification process that involves the covalent attachment of a small ubiquitin-like modifier (SUMO) to a specific lysine residue on the target protein. This modification can influence the function, localization, stability, and interactions of proteins, thereby regulating various cellular processes. Altering the SUMOylation of certain proteins is expected to be a potential approach for treating specific cancers and diseases.

SLC35C2 promotes stemness and progression in hepatocellular carcinoma by activating lipogenesis.

Metabolic reprogramming plays a critical role in in tumorigenesis and progression, including hepatocellular carcinoma (HCC). The Solute Carriers (SLCs) family is responsible for the transport of a range of nutrients and has been linked to various cancers. Cancer stem cells (CSC) are a contributing factor to the recurrence and metastasis of HCC.

Microbially mediated iron redox processes for carbon and nitrogen removal from wastewater: Recent advances.

Iron is the most abundant redox-active metal on Earth. The microbially mediated iron redox processes, including dissimilatory iron reduction (DIR), ammonium oxidation coupled with Fe(III) reduction (Feammox), Fe(III) dependent anaerobic oxidation of methane (Fe(III)-AOM), nitrate-reducing Fe(II) oxidation (NDFO), and Fe(II) dependent dissimilatory nitrate reduction to ammonium (Fe(II)-DNRA), play important parts in carbon and nitrogen biogeochemical cycling globally. In this review, the reaction mechanisms, electron transfer pathways, functional microorganisms, and characteristics of these processes are summarized; the prospective applications for carbon and nitrogen removal from wastewater are reviewed and discussed; and the research gaps and future directions of these processes for the treatment of wastewater are also underlined.

O-Arm Navigation-Guided Unilateral Biportal Endoscopic Decompression of Far-Out Syndrome.

The main aim of this video article is to demonstrate the combined use of O-arm navigation and unilateral biportal endoscopy (UBE) to manage far-out syndrome (FOS). In FOS there is entrapment and compression of the fifth lumbar nerve beyond the foramen and between L5 transverse process and the sacral ala at the lumbosacral junction. Conventional microscopic decompression using a paraspinal approach had been the gold standard for its management.

Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice.

Lactate has emerged as a central metabolic fuel and an important signaling molecule. Its availability participates in various brain functions. Although lactate homeostasis is vital for adult hippocampal neurogenesis and cognition, it is still unknown how shuttles lactate across the plasma membrane of neural stem cells (NSCs) to control their activity and neurogenic potential.

Forecasting O and NO concentrations with spatiotemporally continuous coverage in southeastern China using a Machine learning approach.

Ozone (O) is a significant contributor to air pollution and the main constituent ofphotochemical smog that plagues China. Nitrogen dioxide (NO) is a significant air pollutant and a critical trace gas in the Earth's atmosphere. The presence of O and NO has detrimental effects on human health, the ecosystem, and agricultural production.

Decoding the trajectory of antibiotic resistance genes in saline and alkaline soils: Insights from different fertilization regimes.

The soil salinity and alkalinity play an important role in the occurrence and proliferation of antibiotic resistance genes (ARGs). Yet, little is known the underlying mechanism by which soil salinity and alkalinity affect antibiotic resistance evolution. Here we investigated the ARGs variation in soil salinity and alkalinity environments created by different fertilization, and explored the biological mechanisms that salinity and alkalinity alter the evolutionary paradigm of antibiotic resistance.

Chicken hnRNPK suppresses interferon production, thereby enhancing IBDV replication.

Heterogeneous ribonucleoprotein K (hnRNPK) is a well-known RNA-binding protein initially identified for its role in inhibiting the growth of various human tumors. Members of the hnRNP family have also been implicated in both interferon production and RNA virus replication. However, the role of chicken hnRNPK (chhnRNPK) in the replication of Infectious Bursal Disease Virus (IBDV) remains unclear.

Exploring the potential mechanism of action of Wutou-Guizhi decoction in the treatment of rheumatoid arthritis through network pharmacology analysis.

As a widely recognized traditional Chinese medicine (TCM) decoction prescription in China, numerous studies have shown that Wutou-Guizhi decoction (WTGZD) exhibits significant therapeutic efficacy for Rheumatoid arthritis (RA). Nevertheless, the underlying molecular mechanisms have yet to be fully elucidated. This study aims to establish a database of active ingredients for WTGZD and identify RA-related target genes.

Vertical migration characteristics of polychlorinated biphenyls (PCBs) in estuarine and coastal zones under complex environmental conditions.

As a transitional zone where rivers meet the sea, estuaries are influenced by river transport and ocean tides, resulting in complex variations in parameters such as organic matter content, pH, and sediment salinity. This paper primarily explores the vertical migration patterns of polychlorinated biphenyls (PCBs) under complex conditions, focusing on the soil sediments in the Dagu River estuary area. We designed an indoor soil column leaching experiment to investigate how soil organic matter content, pH, and salinity affect the vertical migration of PCBs in soil.

Genomic insights into the specialisation and selection of the Jinding duck.

The domestication of ducks represents a pivotal evolutionary shift from the unguided propagation of wild species to deliberate human-mediated selection, culminating in distinct behavioural, morphological, and physiological traits that differentiate domesticated ducks from their wild counterparts. This transition has yielded breeds with traits fine-tuned to specific economic roles, such as egg production, meat yield, or dual-purpose functionality. Duck domestication plays a significant role in poultry production globally, meeting the growing demand for eggs and meat in various regions.

Lacustrine groundwater discharge as an important hidden source of nutrients to a large eutrophic lake: Implications for eutrophication management.

Lake eutrophication driven by excessive nutrient inputs has become a global issue, but the potential impact of lacustrine groundwater discharge (LGD) as a nutrient source on lake eutrophication remains largely unknown. This study assessed the contribution of LGD-derived nutrient loads and revealed their potential impact on lake eutrophication in Taihu Lake, a typical large shallow and eutrophic lake in China, based on the segmented radon mass balance model and nutrient data. The total LGD flux was estimated to be 6.

Mapping the terrain of social media misinformation: A scientometric exploration of global research.

The rise of social media has enabled unrestricted information sharing, regardless of its accuracy. Unfortunately, this has also resulted in the widespread dissemination of misinformation. This study aims to provide a comprehensive scientometric analysis under the PRISMA paradigm to clarify the repetitive trajectory of misinformation on social media in the current digital age.

KPNA2/KPNB1 promotes the malignant progression of gastric cancer induced by M2 macrophage polarization.

Macrophages in the tumor microenvironment (TME) regulated gastric cancer progression, but the mechanism of macrophage polarization in gastric cancer progression remained unclear. This study mainly explored the molecular mechanism of macrophage polarization in the tumor microenvironment and its impact on the progression of gastric cancer. KPNA2 and KPNB1 expressions in cancer tissues and adjacent non-cancerous tissues were quantified via RT-qPCR and western blot.

IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.

Background: Telomere maintenance is an important feature of tumor cells. Telomeric-repeat binding factor 1 interaction nuclear protein 2 (TIN2), a key member of the shelterin proteins, functions in regulating telomere structure, length and function. Our work sought to investigate the role of TIN2 in controlling gastric cancer (GC) malignant biological behaviors.

SUMO1 modification reduces oxidative stress and SUMO1ylated AKAP4 degradation affects frozen-thawed boar sperm quality.

Low-temperature injury affects normal physiological function and viability of boar sperm during cryopreservation. Small ubiquitin-like modifier (SUMO) modification of proteins after translation is related to the cell stress response but the relationship between SUMO modification and oxidative stress in freeze-thawed sperm remains unclear. A-kinase ankyrin 4 (AKAP4) and its precursor proAKAP4 are two main proteins in mammalian sperm.

BcAMT1;2 interacts with BcLBD41 and BcMAMYB transcription factors during nitrogen metabolism in flowering Chinese cabbage.

Chinese cabbage is an important vegetable in southern China. Excessive nitrogen fertilizer application can lead to the accumulation of nitrate in edible organs, which affects food value. Hence, the cultivation of varieties with high nitrogen utilization efficiency (NUE) and low nitrate accumulation is essential for molecular breeding.

CtWD40-6 enhances the UV-B tolerance of safflower by regulating flavonoid accumulation.

Moderate UV-B promotes plant growth, but excessive UV-B inhibits plant development. The induction mechanism of how CtWD40-6 responds to UV-B is still unclear in safflower. Our results showed that CtWD40-6 is expressed at the top of safflower leaves and is strongly induced by UV-B.

Effects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity.

In this study, male Sprague-Dawley (SD) rats were exposed to bisphenol S (BPS) at environmentally relevant concentrations to investigate its reproductive toxicity and evaluate its effects on the gut-blood-testicular axis. After 28 days of exposure to BPS (0.05 and 20 mg/kg), the results showed a reduction in weight gain and the induction of reproductive toxicity in male rats, including decreased sperm parameters, lower sperm viability, and increased abnormal sperm density and mortality.