Analysis of Outcomes and Factors Influencing Community-Acquired Pressure Injury: A Retrospective Review of 413 Patients.

Purpose: The purpose of this study was to analyze the outcomes and influencing factors of patients with community-acquired pressure injuries (CAPIs) and provide insights for clinical practice.

Design: Retrospective cohort study.

Subjects And Setting: We reviewed medical records of 413 patients with a total of 522 CAPIs.

IL-21 and IL-33 May Be Effective Biomarkers to Predict the Efficacy of PD-1 Monoclonal Antibody for Advanced Cholangiocarcinoma.

Treatment options for patients with advanced biliary tract cancer (BTC) are limited. The programmed cell death protein-1 () inhibitors may have synergistic effects with chemotherapy. Therefore, the aim of our study was to provide real-world data on treatment outcomes in BTC patients receiving chemotherapy alone versus a combination of chemotherapy and inhibitors.

How I Do It: Management of Pleural-attached Pulmonary Nodules in Low-Dose CT Screening for Lung Cancer.

Lung cancer is the leading cause of cancer deaths globally. In various trials, the ability of low-dose CT screening to diagnose early lung cancers leads to high cure rates. It is widely accepted that the potential benefits of low-dose CT screening for lung cancer outweigh the harms.

Kinetics Difference-driven Organophosphorus Hydrolase-like Nanozyme-Coded Pattern for Identifying -Nitrophenyl Pesticides.

Organophosphorus pesticides (OPs) are widely used in agricultural production, posing a great threat to human health and the environment. Given that different OPs present different toxicology and toxicities, identifying individual pesticide residues becomes important for assessing food safety and environmental implications. In this work, a kinetics difference-driven analyte hydrolysis strategy is proposed for the first time and validated to identify -nitrophenyl pesticides by developing an organophosphorus hydrolase-like nanozyme-coded sensor array.

Tripartite organization of brain state dynamics underlying spoken narrative comprehension.

Speech comprehension involves the dynamic interplay of multiple cognitive processes, from basic sound perception, to linguistic encoding, and finally to complex semantic-conceptual interpretations. How the brain handles the diverse streams of information processing remains poorly understood. Applying Hidden Markov Modeling to fMRI data obtained during spoken narrative comprehension, we reveal that the whole brain networks predominantly oscillate within a tripartite latent state space.

Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study.

Background: The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real-world settings.

Methods: Patients with moderate-to-severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow-up period of at least 16 weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.

Relationship Between Intense Personal Celebrity Worship and Cosmetic Surgery Consideration Among Chinese Young Women: The Serial Mediating Effects of Body Dissatisfaction and Body Shame.

This study examined whether intense personal feelings toward celebrities are positively correlated with women's consideration of cosmetic surgery, and whether body dissatisfaction and body shame serve as possible mediators of this relationship. A sample of 605 Chinese female undergraduates completed questionnaires on celebrity worship, consideration of cosmetic surgery, body dissatisfaction, and body shame. The results revealed a significant positive correlation between intense personal feelings toward celebrities and the consideration of cosmetic surgery.

Real-time motion trajectory training and prediction using reservoir computing for intelligent sensing equipment.

Real-time moving target trajectory prediction is highly valuable in applications such as automatic driving, target tracking, and motion prediction. This paper examines the projection of three-dimensional random motion of an object in space onto a sensing plane as an illustrative example. Historical running trajectory data are used to train a reserve network.

A multi-band high-sensitivity microwave sensor for simultaneous detection of two dielectric materials.

A multi-band high-sensitivity microwave sensor is reported. The two resonance units are based on complementary square spiral resonators (CSSRs) and produce four measurement bands through parasitic resonances. The four frequency bands are 2.

Study on a compact pulse forming line-Marx type high voltage pulse generator.

High power pulse generators are moving in the direction of compact, solid-state, and stable working in a relatively long time. In this paper, a compact pulse forming line-Marx type high power pulse generator, based on a ceramic pulse forming line and a spark gap switch with carbide modified graphite electrodes, is studied numerically and experimentally. Specifically, a ceramic based pulse forming line with high relative permittivity was used to achieve long pulse duration in a limited dimension.

A novel overtone peak self-referencing fluorescent sensor based on a bipyridine-linked covalent organic framework for highly sensitive copper ion detection.

This study reports a novel ratiometric fluorescence sensor based on a tetraphenylethylene-bipyridine covalent organic framework (TPE-Bpy-COF) for the sensitive detection of Cu, leveraging the unique coordination properties of the bipyridine moieties. The interaction between Cu and the nitrogen atoms in the bipyridine units induces fluorescence quenching at 500 nm through an efficient host-guest electron transfer mechanism, where excited-state electrons from the COF framework are transferred to the vacant orbitals of Cu. Upon excitation at 410 nm, the sensor exhibits a primary emission peak at 500 nm, which is quenched in the presence of Cu, while an overtone peak at 820 nm remains stable, serving as an internal reference for ratiometric measurements and significantly enhancing the accuracy and reliability of the sensor.

A novel therapeutic strategy utilizing EpCAM aptamer-conjugated gemcitabine for targeting bladder cancer and cancer stem cells.

Gemcitabine (GEM) is a first line chemotherapy drug for bladder cancer (BCa). GEM's lack of specificity has led to disadvantages, resulting in low efficiency, especially when combined with the targeted treatment of BCa stem cells (CSCs), which is considered the cause of BCa recurrence and progression. To enhance the anti-cancer effect and reduce the side effects of GEM targeting of BCa cells/CSCs, an aptamer drug conjugate (ApDC) targeted delivery system was used to improve the efficiency of GEM in BCa therapy using EpCAM aptamer-GEM conjugates based on the epithelial cell adhesion molecule (EpCAM), which is highly expressed on the cell membrane of BCa cells/CSCs.

The potential of dynamic plants for attention and stress recovery in indoor environment.

This study simulates the natural movement of plants in indoor environments to investigate whether these plants can effectively facilitate psychological, physiological, and emotional recovery from fatigue caused by short vigilance tasks. A total of 63 participants completed baseline assessments of emotional and physiological stress as well as attention and memory (including the POMS-SF, blood pressure, pulse, and Digit Span Backward). They then performed a vigilance task to induce fatigue, followed by a second measurement of stress and cognition.

The effect of atomic vibration on thermal transport in diatomic semiconductors investigated molecular dynamics.

Based on the molecular dynamics (AIMD), the temperature and velocity statistics of diatomic semiconductors were proposed to be classified by atomic species. The phase differences resulting from lattice vibrations of different atoms indicated the presence of anharmonicity at finite atomic temperatures. To further explore the electronic properties, the effect of temperature on electrostatic potential field vibrations in semiconductors was studied, and the concept of electrostatic potential oscillation (EPO) at finite atomic temperature was introduced.

Thermal- and Rate-Regulated Fast Switchable Adhesion within Glass Transition Zone of an Epoxy Polymer.

Thermoresponsive shape memory polymer (SMP) adhesives have demonstrated a high adhesion strength and large switching ratios on different substrates. However, a long response time to switch adhesion on or off is generally encountered. This study provides a fast adhesion switching method based on the temperature and rate dependence of adhesion within the glass-transition zone of an epoxy polymer.

Photoredox-Catalyzed Three-Component Sulfonaminoalkynylation of Alkenes via a Radial/Polar Crossover.

We report a photoredox-catalyzed three-component sulfonaminoalkynylation of alkenes with -aminopyridine salts and potassium alkynyltrifluoroborate salts. This aminoalkylation reaction underwent a radial/polar crossover mechanism, which was distinguished from the previous reports. A variety of β-alkynylated sulfonamides were obtained in moderate to excellent yields.

Abrupt transformation of west Greenland lakes following compound climate extremes associated with atmospheric rivers.

Arctic ecosystems are affected by accelerated warming as well as the intensification of the hydrologic cycle, yet understanding of the impacts of compound climate extremes (e.g., simultaneous extreme heat and rainfall) remains limited, despite their high potential to alter ecosystems.

Advancing forecasting capabilities: A contrastive learning model for forecasting tropical cyclone rapid intensification.

Tropical cyclones (TCs), particularly those that rapidly intensify (RI), pose a significant threat due to the uncertainty in forecasting them. RI TC periods, which intensify by at least 13 m/s within 24 h, remain challenging to forecast accurately. Existing models achieve a probability of detection (POD) of 82.

Global urban greening and its implication for urban heat mitigation.

Urban vegetation provides essential ecosystem services and benefits to support biodiversity and human well-being in urban areas. However, the dynamic trends, driving factors, and their implications to urban heat mitigation at the global scale remain largely unclear. Here, we used a high-resolution enhanced vegetation index (EVI) dataset to examine the vegetation dynamics in 11,235 urban areas worldwide, identify the driving factors behind its changes, and estimate the potential urban heat mitigation benefits of these changes.

Postdoc publications and citations link to academic retention and faculty success.

Postdoctoral training is a career stage often described as a demanding and anxiety-laden time when many promising PhDs see their academic dreams slip away due to circumstances beyond their control. We use a unique dataset of academic publishing and careers to chart the more or less successful postdoctoral paths. We build a measure of academic success on the citation patterns two to five years into a faculty career.

CircZmMED16 delays plant flowering by negatively regulating starch content through its binding to ZmAPS1.

Circular RNAs (circRNAs), a type of head-to-tail closed RNA molecules, have been implicated in various aspects of plant development and stress responses through transcriptome sequencing; however, the precise functional roles of circRNAs in plants remain poorly understood. In this study, we identified a highly expressed circular RNA, circZmMED16, derived from exon 8 of the mediator complex subunit 16 (ZmMED16) across different maize (Zea mays L.) inbred lines using circRNA-seq analysis.

A synthetic biology approach for identifying de-SUMOylation enzymes of substrates.

A synthetic biology approach using a robust reconstitution system in Escherichia coli enables the identification of plant ubiquitin-like proteases responsible for removing the small ubiquitin-like modifier (SUMO) post-translational modifications from specific protein substrates.

Comparative Analysis of CXCR5 Circulating DNA Methylation Levels in Autoimmune Rheumatic Diseases.

Objective: To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features.

Methods: Targeted methylation sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), 30 ankylosing spondylitis (AS), 30 psoriatic arthritis (PsA), 24 Sjögren's syndrome (SS) patients, and 30 healthy controls (HC).

Results: Significant differences in CXCR5 cg19599951 methylation were found between RA and HC, as well as AS and SLE.