Exosomes and non-coding RNAs: bridging the gap in Alzheimer's pathogenesis and therapeutics.

Alzheimer's disease (AD) is a neurodegenerative disease that primarily affects the elderly population and is the leading cause of dementia. Meanwhile, the vascular hypothesis suggests that vascular damage occurs in the early stages of the disease, leading to neurodegeneration and hindered waste clearance, which in turn triggers a series of events including the accumulation of amyloid plaques and Tau protein tangles. Non-coding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), have been found to be involved in the regulation of AD.

Comparison of short-term surgical outcomes between high and low tie ligation of the inferior mesenteric artery in robotic rectal cancer surgery: a propensity score matching analysis.

Robotic surgery is extensively used for rectal cancer treatment. Nonetheless, studies on whether to preserve the left colonic artery (LCA) during robotic rectal cancer surgery to reduce complications remain scarce and controversial. This study compared short-term outcomes of high tie (HT) and low tie (LT) ligation of the inferior mesenteric artery in 455 patients undergoing robotic rectal cancer surgery between May 2018 and July 2022.

Associations between stress hyperglycemia and outcomes in patients with ischemic stroke and TIA: the data comes from the Third China National Stroke Registry (CNSR-III).

In the acute stage of stroke, stress hyperglycemia is common in both diabetic and nondiabetic patients. The associations between stress hyperglycemia and functional outcomes, as well as stroke recurrence were heterogeneous in previous studies. We aimed to demonstrate these associations in a general population of patients with ischemic stroke and transient ischemic attack (TIA).

Mapping the knowledge landscape of the PET/MR domain: a multidimensional bibliometric analysis.

Objective: This study aims to conduct a bibliometric analysis to explore research trends, collaboration patterns, and emerging themes in the PET/MR field based on published literature from 2010 to 2024.

Methods: A detailed literature search was performed using the Web of Science Core Collection (WoSCC) database with keywords related to PET/MR. A total of 4,349 publications were retrieved and analyzed using various bibliometric tools, including VOSviewer and CiteSpace.

APOM Modulates the Glycolysis Process in Liver Cancer Cells by Controlling the Expression and Activity of HK2 via the Notch Pathway.

The metabolic pathway of aerobic glycolysis in tumor cells has garnered significant attention in tumor research because of its high activation in cancer cells. Previous research conducted by our team has demonstrated that Apolipoprotein M (APOM) exhibits potential as a factor against liver cancer. However, further investigations are needed to elucidate the precise approach and mechanism that are involved in this process.

Preserved but Un-Sustained Responses to Bids for Dyadic Engagement in School-Age Children with Autism.

Purpose: Dynamic eye-tracking paradigms are an engaging and increasingly used method to study social attention in autism. While prior research has focused primarily on younger populations, there is a need for developmentally appropriate tasks for older children.

Methods: This study introduces a novel eye-tracking task designed to assess school-aged children's attention to speakers involved in conversation.

Regulation of Glutamate Transporter Type 1 by TSA and the Antiepileptic Mechanism of TSA.

Epilepsy (EP) is a neurological disorder characterized by abnormal, sudden neuronal discharges. Seizures increase extracellular glutamate levels, causing excitotoxic damage. Glutamate transporter type 1 (GLT-1) and its human homologue excitatory amino acid transporter-2 (EAAT2) clear 95% of extracellular glutamate.

Precision tumor treatment utilizing bacteria: principles and future perspectives.

Bacteria-based tumor therapy, which releases therapeutic payloads or remodels the tumor's immune-suppressive microenvironment and directly kills tumor cells or initiates an anti-tumor immune response, is recently recognized as a promising strategy. Bacteria could be endowed with the capacities of tumor targeting, tumor cell killing, and anti-tumor immune activating by established gene engineering. Furthermore, the integration of synthetic biology and nanomedicine into these engineered bacteria could further enhance their efficacy and controllability.

Spatial distribution and driving factors of soil selenium on the Leizhou Peninsula, southern China.

Selenium (Se) is an essential element for humans, playing a critical role in the functioning of the immune system. The global prevalence of dietary Se deficiency is a significant public health concern, largely attributed to the low levels of Se present in crops. The sufficient Se in plants and humans is determined by the presence of stable Se sources in the soil.

Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy.

To investigate the role of silent information regulator 6 (SIRT6) in regulating podocyte injury in diabetic nephropathy (DN) through autophagy mediated by Notch signaling pathway. A blank control group (group A), a diabetic nephropathy group (group B), and a Sirt6 intervention group (group C) were established. The group A cells were human normal glomerular podocyte cell lines (HGPCs) without any treatment.

Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson's Disease: Insights from Signaling Pathways Mediated by Insulin Receptors.

Parkinson's disease (PD), a chronic and common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-synuclein. Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by chronic insulin resistance and deficiency in insulin secretion. Extensive evidence has confirmed shared pathogenic mechanisms underlying PD and T2DM, such as oxidative stress caused by insulin resistance, mitochondrial dysfunction, inflammation, and disorders of energy metabolism.

Sorghum grain as a bio-template: emerging, cost-effective, and metal-free synthesis of C-doped g-CN for photo-degradation of antibiotic, bisphenol A (BPA), and phenol under solar light irradiation.

Due to the industry's rapid growth, the presence of organic pollutants, especially antibiotics, in water and wastewater resources is the main concern for wildlife and human health. Therefore, these days, a significant challenge is developing an efficient, sustainable, and eco-friendly photocatalyst. Natural biological models have numerous advantages compared to artificial model materials.

Ecotoxicology of cephalopod early life phases: review and perspectives.

The present review provides the first analysis and synthesis of the available scientific information on the effects of anthropogenic contaminants on cephalopod embryos, paralarvae, and juveniles. We evaluated 46 articles published between 1970 and 2023 that focused on trace elements (69%), pharmaceutical compounds (11%), persistent organic compounds (11%), and plastics (9%). To date, the greatest scientific effort has originated from Europe and Asia (France [57%], China [9%], Italy [7%], and Spain [4%]), with few reports available from the rest of the world.

Synergistic effects of Au nanoparticles in SiO@Au@Polyaniline system for improved photothermal performance.

A SiO@Au@Polyaniline (SiO@Au@PAN) system has been successfully fabricated leveraging the synergistic effects of gold nanoparticles (AuNPs) to realize enhanced photothermal performance. The SiO@Au@PAN exhibited strong near-infrared (NIR) absorbance, excellent photothermal conversion efficiency, good dispersibility, and outstanding photostability. The SiO nanospheres as the template provided numerous binding sites for coating of AuNPs.

The link between eye movements and cognitive function in mild to moderate Alzheimer's disease.

This study investigated the relationship between eye movement parameters and cognitive function in patients with mild to moderate Alzheimer's disease (AD). A total of 80 patients with AD (mild and moderate) and 34 normal controls (NC) participated. Neuropsychological assessments were conducted using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), while eye movements were recorded using eye-tracking technology.

Increased parietal operculum functional connectivity following vestibular rehabilitation in benign paroxysmal positional vertigo patients with residual dizziness: a randomized controlled resting-state fMRI study.

Introduction: Residual dizziness (RD) is common in patients with benign paroxysmal positional vertigo (BPPV) after successful canalith repositioning procedures. This study aimed to investigate the therapeutic effects of vestibular rehabilitation (VR) on BPPV patients experiencing RD, and to explore the impact of VR on functional connectivity (FC), specifically focusing on the bilateral parietal operculum (OP) cortex.

Methods: Seventy patients with RD were randomly assigned to either a four-week VR group or a control group that received no treatment.

Diagnostic accuracy of Xpert MTB/RIF Ultra for detecting pulmonary tuberculosis and rifampicin resistance: a systematic review and meta-analysis.

Background: Public health issues related to tuberculosis still exist. Because Xpert MTB/RIF Ultra is more effective than conventional TB diagnostic techniques are, it is now regarded as an emerging technology. The diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculosis was assessed in this systematic study.

Dynamic characteristics of high-risk HPV infection in women with low-grade cervical intraepithelial neoplasia, based on a community longitudinal study.

Background: High-risk human papillomavirus (HR-HPV) infection is the primary cause of cervical cancer and precancerous lesions. Approximately 35% of women with low-grade cervical intraepithelial neoplasia (CIN1) may experience persistence or progression to high-grade lesions. Yet, the dynamic characteristics of HR-HPV infection in women with CIN1 remain unclear.

Alzheimer's disease and diabetes-associated cognitive dysfunction: the microglia link?

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques and the aggregation of tau protein, resulting in intense memory loss and dementia. Diabetes-associated cognitive dysfunction (DACD) is a complication of diabetes mellitus, which is associated with decreased cognitive function and impaired memory. A growing body of literature emphasize the involvement of microglia in AD and DACD.

Health system responsiveness: comparison of different levels of medical institutions in Kunshan City, China.

Background: Evaluation of health system responsiveness (HSR) can improve patient satisfaction, promote health equity and enhance the quality of health services.

Objectives: To explore the differences in HSR among medical institutions at different levels and in various domains.

Methods: A multi-stage stratified sampling method was used to select 820 participants aged 18 years and older from Kunshan City, China.

Chiral Nanostructures from Artificial Helical Polymers: Recent Advances in Synthesis, Regulation, and Functions.

Helical structures such as right-handed double helix for DNA and left-handed α-helix for proteins in biological systems are inherently chiral. Importantly, chirality at the nanoscopic level plays a vital role in their macroscopic chiral functionalities. In order to mimic the structures and functions of natural chiral nanoarchitectures, a variety of chiral nanostructures obtained from artificial helical polymers are prepared, which can be directly observed by atomic force microscopy (AFM), scanning tunneling microscopy (STM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

High-Performance Thermoelectric Composite of BiTe Nanosheets and Carbon Aerogel for Harvesting of Environmental Electromagnetic Energy.

Intensifying the severity of electromagnetic (EM) pollution in the environment represents a significant threat to human health and results in considerable energy wastage. Here, we provide a strategy for electricity generation from heat generated by electromagnetic wave radiation captured from the surrounding environment that can reduce the level of electromagnetic pollution while alleviating the energy crisis. We prepared a porous, elastomeric, and lightweight BiTe/carbon aerogel (CN@BiTe) by a simple strategy of induced in situ growth of BiTe nanosheets with three-dimensional (3D) carbon structure, realizing the coupling of electromagnetic wave absorption (EMA) and thermoelectric (TE) properties.

Anisotropic Plasmon Resonance in TiCT MXene Enables Site-Selective Plasmonic Catalysis.

The ever-growing interest in MXenes has been driven by their distinct electrical, thermal, mechanical, and optical properties. In this context, further revealing their physicochemical attributes remains the key frontier of MXene materials. Herein, we report the anisotropic localized surface plasmon resonance (LSPR) features in TiCT MXene as well as site-selective photocatalysis enabled by the photophysical anisotropy.

Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy.

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due to their defects in inducing potent ICD signaling. Here, we report a dual-enzyme-instructed peptide self-assembly platform of (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) to promote ICD and engage systemic adaptive immunity for tumor rejection.

A Zero-gap Electrolyzer Enables Supporting Electrolyte-free Seawater Splitting for Energy-saving Hydrogen Production.

Membrane-assisted direct seawater splitting (DSS) technologies are actively studied as a promising route to produce green hydrogen (H2), whereas the indispensable use of supporting electrolytes that help to extract water and provide electrochemically-accelerated reaction media results in a severe energy penalty, consuming up to 12.5% of energy input when using a typical KOH electrolyte. We bypass this issue by designing a zero-gap electrolyzer configuration based on the integration of cation exchange membrane and bipolar membrane assemblies, which protects stable DSS operation against the precipitates and corrosion in the absence of additional supporting electrolytes.