Sjogren's Syndrome Complicated by Naso-Orbito-Cerebral Mucormycosis: A Case Report.

Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by exocrine gland dysfunction. Mucormycosis is a rare yet life-threatening opportunistic fungal infection caused by species, with a high mortality rate. In patients undergoing long-term immunosuppressive therapy or corticosteroid use, especially when compounded by conditions such as diabetes or hyperlipidemia, Mucor can become pathogenic.

Development and validation of an integrated model for the diagnosis of liver cirrhosis with portal vein thrombosis combined with endoscopic characters and blood biochemistry data: a retrospective propensity score matching (PSM) cohort study.

Background: Liver cirrhosis complicated by portal vein thrombosis (PVT) is a fatal complication with no specific manifestations but often misdiagnosed, it crucially increases the mortality worldwide. This study aimed to identify risk factors and establish a predictive model for diagnosis of venous thrombosis clinical by routine blood tests and endoscopic characteristics.

Methods: Patients from Gansu Provincial Hospital from October 2019 to December 2023 were enrolled.

Combination of reverse shock index and simplified motor score as a strong discriminator of trauma outcomes.

Background: The reverse shock index multiplied by simplified motor score (rSI-sMS) is a novel and rapid measure for assessing injury severity in patients with trauma in prehospital settings; however, its discriminant ability requires further validation.

Methods: A retrospective cohort study was conducted from trauma database of Taipei Tzu Chi Hospital to compare the accuracy of the rSI-sMS with that of the shock index, modified shock index, reverse shock index multiplied by the Glasgow Coma Scale (rSI-GCS), and the reverse shock index multiplied by GCS motor subscale (rSI-GCSM) for discriminating in-hospital mortality, intensive care unit (ICU) admissions, prolonged ICU stays ≥14 days, and prolonged hospital stays ≥30 days in patients with trauma.

Results: A total of 11,760 patients from the trauma database were included.

Selective Liquid Chemical Production in Waste Polyolefin Photorefinery by Controlling Reactive Species.

Photocatalytic upcycling of waste polyolefins into value-added chemicals provides promise in plastic waste management and resource utilization. Previous works demonstrate that polyolefins can be converted into carboxylic acids, with CO as the final oxidation product. It is still challenging to explore more transformation products, particularly mild-oxidation products such as alcohols, because of their instability compared with polymer substrates, which are prone to oxidation during catalytic reactions.

Deciphering the Dynamic Interplay between Rhizobacteria and Root Exudates via Cerium Oxide Nanomaterials Modulation for Promoting Soybean Yield and Quality.

The interplay between root exudates and rhizobacteria is essential for enhancing agricultural productivity. Herein, the impacts of cerium dioxide nanomaterials (CeO NMs) on these interactions in soybean plants were investigated. Following 3-5 weeks of exposure to 5 mg·kg CeO NMs, the composition of root exudates changed over time, with isoflavone levels increasing by 6.

Bioinspired Chestnut Burr-like Polyaniline: Achieving Superhydrophobicity and Excellent Microwave Transparency through Controlled Polymerization.

Achieving dual functionalities of hydrophobicity and excellent microwave transmission in a single material remains a significant challenge, especially for advanced applications in aerospace, telecommunications, and navigation engineering. Inspired by natural designs like chestnut burrs, bioinspired polyaniline (PANI) particles with tunable micro-/nanostructures through a facile template-free polymerization process have been developed. By regulating the polarity of the reaction system, temperature, and reaction time, various hierarchical structures, including cross-linked nanosheets, chestnut burr-like spheres, and starburst flower-like structures, are synthesized.

Polygenic risk score, dietary inflammatory potential, and incident coronary heart disease.

Aims: Dietary inflammatory potential and genetic factors are reported as being linked to coronary heart disease (CHD). We aimed to investigate their joint association with CHD incidence.

Methods And Results: We included 51 889 British participants from the UK Biobank who completed the 24-h dietary assessment at baseline.

Liver injury related to vascular endothelial growth factor tyrosine kinase inhibitors: a pharmacovigilance analysis of the USA FDA adverse event reporting system (FAERS) database.

Background: While vascular endothelial growth factor tyrosine kinase inhibitors (VEGFR-TKIs) are known to cause adverse events like cardiotoxicity and haematotoxicity, their impact on liver injury remains understudied. This study evaluates the association between VEGFR-TKIs and liver injury using data from the FDA Adverse Event Reporting System (FAERS) database from 2006 to 2024.

Research Design And Methods: Nine VEGFR-TKIs (Axitinib, Vandetanib, Cabozantinib, Lenvatinib, Pazopanib, Ponatinib, Regorafenib, Sunitinib, Sorafenib) were analyzed.

Chiral Primary Amine-Catalyzed Asymmetric Photochemical Reactions of Pyridotriazoles with Boronic Acids to Access Triarylmethanes.

Imine-containing azaarene-based triarylmethanes are vital molecular motifs that are prevalent in a wide array of bioactive compounds. Recognizing the limitations of current synthetic methodologies─marked by a scarcity of examples and difficulties in flexible functional group modulation─we have developed an efficient and modular asymmetric photochemical strategy employing pyridotriazoles and boronic acids as substrates. Utilizing novel chiral diamine-derived pyrroles and primary amines as catalysts, we successfully synthesized a diverse range of triarylmethanes with high yields and excellent enantioselectivities.

68Ga-FAPI-04 Versus 18F-FDG PET/CT in Duodenal Synovial Sarcoma.

A previously healthy 18-year-old man with a 9-month history of upper abdominal pain and significant weight loss underwent gastroscopy, revealing an ulcerative lesion in the duodenal bulb. Enrolled in a clinical trial, both 18F-FDG and 68Ga-FAPI-04 PET/CT demonstrated similar metabolic activity, though 68Ga-FAPI-04 offered superior lesion delineation. Pathology confirmed synovial sarcoma.

Prohibitins in infection: potential therapeutic targets.

Prohibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes. Recent studies have demonstrated that both PHB1 and PHB2 can act as a complex or independently to participate in the pathogen infection process.

Synergistic effects of quaternary ammonium compounds and antibiotics on the evolution of antibiotic resistance.

The usage of quaternary ammonium compounds (QACs) as disinfectants has surged dramatically during the COVID-19 pandemic and thereafter. QACs can promote antimicrobial resistance, but the combined effects of QACs and antibiotics in driving resistance evolution were yet revealed. This study aimed to evaluate antibiotic resistance of wastewater microorganisms under coexposure to typical antibiotics and the most widely used QAC, dodecyl dimethyl benzyl ammonium chloride (DDBAC).

Highly efficient removal of per- and polyfluoroalkyl substances by extrusion-regenerated aminated polyurethane sponges.

Per- and polyfluoroalkyl substances (PFAS) are a class of persistent organic compounds widely detected in the environments. Due to their chemical stability, physical adsorption has emerged as one of the most promising techniques for remediating PFAS-containing wastewater, while some newly synthesized functional absorbents in powder form suffer from separation issues. Inspired by mussel biology, we have successfully synthesized a porous spongy absorbent termed aminated polyurethane (PU-PDA-PANI) with over 99.

Hydrogen production by suspension self-rotation enhanced pyrolysis of sludge particles in cyclone.

The challenges faced by sludge pyrolysis units, including poor heat transfer efficiency and uneven heating of material groups, significantly hinder the green and low-carbon transformation and sustainable development of sludge treatment. The suspension self-rotation of sludge particles in a cyclone enhances particle heat transfer, thereby improving the pyrolysis process. In this study, we developed a novel method for sludge pyrolysis using Cyclone Suspension Self-Rotation Pyrolysis Reactor (CSSPR).

Research on mixed sample test for the rapid detection of rice stripe virus and southern rice black-streaked dwarf virus in vector.

Rice is a staple food in East and Southeast Asian countries, rice disease surveillance and warning is particularly important. Rice stripe disease and southern rice black-streaked dwarf virus disease are the insect-borne viral diseases that easily break out and quickly become epidemic. It is important to improve the efficiency of the virus detection method.

Comparison of hook wire and microcoil preoperative localisation in subsolid pulmonary nodules: a retrospective analysis.

Aim: Subsolid nodules are increasingly detected during physical examinations with computed tomography (CT) scan and video-assisted thoracoscopic surgery (VATS) is the standard treatment. This study compared the effectiveness of preoperative localisation of subsolid pulmonary nodules using a hook-wire and a microcoil under CT guidance prior to VATS.

Materials And Methods: Patients with solitary subsolid pulmonary nodules (n = 342) underwent percutaneous puncture localisation guided by CT before VATS.

Correlation of semi-quantitative analyses and visual scores in pulmonary perfusion SPECT/CT imaging with pulmonary function test parameters in patients with interstitial lung diseases.

Aim: To evaluate the correlation between semi-quantitative analyses and visual scores of pulmonary perfusion Single Photon Emission Computed Tomography (SPECT)/ Computed Tomography (CT) imaging and pulmonary function test parameters (PFTs) in patients with interstitial lung diseases (ILDs).

Materials And Methods: This retrospective study included 35 patients with ILDs from China-Japan Friendship Hospital between January 2020 and December 2022. All patients underwent pulmonary perfusion SPECT/CT imaging and a pulmonary function test.

A scoping review of somatosensory interaction design for mental health and well-being.

This study explores the efficacy of somatosensory interactions in enhancing mental health care by examining the deployment and impact of these technologies. Based on a scoping review of 46 research studies, our analysis reveals that traditional mental health interventions often fail to align with prevalent technological trends. However, somatosensory interactions bridge this gap by creating immersive and engaging experiences.

Green synthesis of silver nanoparticles from the endophytic fungus Panax notoginseng and their antioxidant and antimicrobial activities and effects on cherry tomato preservation.

This study investigated endophytic fungi isolated from the medicinal plant Panax notoginseng. Among these, the endophytic fungus SQ3, identified as Chaetomium globosum, was capable of reducing silver ions to form metallic silver nanoparticles. The green-synthesized silver nanoparticles (AgNPs) presented a distinct surface plasmon resonance peak at 424 nm, with particle sizes between 2.

HIF-1α/HO-1-Mediated Ferroptosis Participates in Polystyrene Nanoplastics-Induced Intergenerational Cardiotoxicity.

To explore the intergenerational cardiotoxicity of nanoplastics, maternal mice were exposed to 60 nm polystyrene nanoplastics (PS-NP) during pregnancy and lactation. The results showed that PS-NP can enter the hearts of offspring and induce myocardial fiber arrangement disorder, acidophilic degeneration of cardiomyocytes, and elevated creatine kinase isoenzymes (CK-MB) and lactate dehydrogenase (LDH) levels after maternal exposure to PS-NP at 100 mg/kg during pregnancy and lactation. Mechanistically, KEGG analysis of RNA sequencing showed the participation of hypoxia-inducible factor-1 (HIF-1) and ferroptosis in PS-NP-induced cardiotoxicity.

A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features.

Membrane-associated RING-CH8 (MARCH8) is a member of the recently discovered MARCH family of ubiquitin ligases. MARCH8 has been shown to participate in immune responses. However, the role of MARCH8 in prognosis and immunology in human cancers remains largely unknown.

Use of the FHTHWA Index as a Novel Approach for Predicting the Incidence of Diabetes in a Japanese Population Without Diabetes: Data Analysis Study.

Background: Many tools have been developed to predict the risk of diabetes in a population without diabetes; however, these tools have shortcomings that include the omission of race, inclusion of variables that are not readily available to patients, and low sensitivity or specificity.

Objective: We aimed to develop and validate an easy, systematic index for predicting diabetes risk in the Asian population.

Methods: We collected the data from the NAGALA (NAfld [nonalcoholic fatty liver disease] in the Gifu Area, Longitudinal Analysis) database.

Musculoskeletal adverse events associated with CDK4/6 inhibitors: a real-world study using FDA Adverse Event Reporting System (FAERS) database.

Objective: Cyclin-dependent kinase (CDK)-4/6 inhibitors have significantly improved outcomes in several cancers but can also induce various organ system toxicities, including musculoskeletal disorders. This study aimed to comprehensively characterize the musculoskeletal adverse events (MSAEs) associated with CDK4/6 inhibitors based on real-world data.

Methods: Reports of MSAEs linked to CDK4/6 inhibitors from the first quarter (Q1) of 2015 and 2023 Q4 were extracted from the FAERS.

EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes.

Myelodysplastic Syndromes (MDS) represent a group of heterogeneous myeloid clonal diseases derived from aberrant hematopoietic stem/progenitor cells. Enhancer of zeste homolog 2 (EZH2) is an important regulator in gene expression through methyltransferase-dependent or methyltransferase-independent mechanisms. Herein, we found EZH2 inhibition led to MDS cell pyroptosis through RNA Helicase A (RHA) down-regulation induced overexpression of S100A9, a key regulator of inflammasome activation and pyroptosis.