Epigenetic Impacts of Non-Coding Mutations Deciphered Through Pre-Trained DNA Language Model at Single-Cell Resolution.

DNA methylation plays a critical role in gene regulation, affecting cellular differentiation and disease progression, particularly in non-coding regions. However, predicting the epigenetic consequences of non-coding mutations at single-cell resolution remains a challenge. Existing tools have limited prediction capacity and struggle to capture dynamic, cell-type-specific regulatory changes that are crucial for understanding disease mechanisms.

Broadband Near-Infrared Fibers Derived from Nanocrystal-Glass Composites for Miniature Arrays Light Sources.

Broadband near-infrared (NIR) fiber arrays are highly desirable for multiplexed fluorescence endoscopic, however, there is a challenge for the development of miniature light sources with highly efficient broadband NIR emissions. Here the synthesis of a MgAlO:Cr nanocrystal-glass composite (NGC) with an Cr-clusters-induced broadband NIR emission possessing is presented and external quantum efficiency of 44% and a full width at half maximum of 297 nm, and the NGC fiber is further fabricated through a template solidification strategy, resulting in the construction of an all-fiber coupling system by fusing them with commercial quartz fiber that achieves an optical coupling efficiency of 95.2%.

Triggered "On/off" Luminescent Polypeptide Bowl-Shaped Nanoparticles for Selective Lighting of Tumor Cells.

Functional polymeric nanoparticles, especially those with anisotropic structures, have shown significant potential and advantages in biomedical applications including detecting, bioimaging, antimicrobial and anticancer. Herein, tetraphenylethylene (TPE) and azobenzene modified polypeptides of poly((-glutamic acid) tetraphenylethylene-stat-(-glutamic acid)) (P(GATPE-stat-GA)) and poly((-glutamic acid) azobenzene-stat-(-glutamic acid)) (P(GAAzo-stat-GA) are synthesized, which self-assemble into bowl-shaped nanoparticles (BNPs) with controlled diameter, opening size and fluorescent property individually, or by co-assembly. Due to the quenching effect of azobenzene, the fluorescence of the coassembled BNPs is completely inhibited.

Non-Substituted Aromatic Pyridine N-Oxide Additives with an Intrinsic N →O Acceptor for Ultra-Long-Life Zn||MnO2 Batteries.

Various organic and inorganic reagents containing N/O functional groups have been developed as additives to aqueous electrolytes (e.g., ZnSO4, ZS) of zinc-ion batteries (ZIBs).

Dual Breaking of Electron Cloud and Space Structure Symmetry Induced Microscopic Split-phase Interface for High-rate and Long-term Aqueous Zinc Batteries.

Weak dipole interactions between highly symmetric H2O molecules and SO42- species are the root cause of unstable electric double layer (EDL), which triggers the hydrogen evolution reaction and Zn dendrite formation, significantly impeding the commercialization of aqueous zinc-ion batteries. Herein, we designed a microscopic split-phase interface (MSPI) by dual breaking of electron cloud and space structure symmetry to suppress interfacial side reactions and achieve uniform Zn deposition. The structurally asymmetric methylurea (MU) molecules possess both hydrophobic methyl and hydrophilic amino groups, which disrupt the continuity of H-bonding network and the aggregation state of H2O molecules, resulting in peculiar nanoscale core-shell-like clusters.

Platinum-Nickel Oxide Cluster-Cluster Heterostructure Enabling Fast Hydrogen Evolution for Anion Exchange Membrane Water Electrolyzers.

Carbon black has been extensively employed as the support for noble metal catalysts for electrocatalysis applications. However, the nearly catalytic inertness and weak interaction with metal species of carbon black are two major obstacles that hinder the further improvement of the catalytic performance. Herein, we report a surface functionalization strategy by decorating transition metal oxide clusters on the commercial carbon black to offer specific catalytic activity and enhanced interaction with metal species.

Reliability and Validity of the Consultation and Relational Empathy (CARE) Scale.

Background: The patient's perception of physician empathy has a positive influence on patient behavior and treatment effects. The scale of Consultation and Relational Empathy (CARE) scale has been widely used to measure patients' perceptions of doctor empathy. However, the CARE scale lacks a standardized Mandarin version.

Investigation of Substance Basis and Pharmacodynamics of Qingzao Jiefei Decoction in Lung Cancer based on Serum Pharmacochemistry and Proteomics.

Qingzao Jiufei Decoction (QD) is a renowned prescription for nourishing lung Yin to treat lung related diseases in ancient and modern times. It has been reported that QD can effectively inhibit the growth of lung cancer, but the material basis and mechanism of its treatment of LC remain to be further studied. In this experiment, we combined serum pharmacochemistry and proteomics to study the pharmacodynamic material basis and mechanism of QD against lung cancer.

A "Flexible" Solvent Molecule Enabling High-Performance Lithium Metal Batteries.

Localized high-concentration electrolytes (LHCEs) exhibit good performance in lithium metal batteries. However, understanding how the intermolecular interactions between solvents and diluents regulate the solvation structure and interfacial layer structure remains limited. Here, we reported an LHCE in which strong hydrogen bonding between diluents and solvents alters the conformation and polarity of "flexible" solvent molecules, thereby effectively regulating the solvation structure of Li+ ion and promoting the formation of robust electrode interfaces.

Aggregation-induced Electrochemiluminescence of AgNCs Enhanced with Ti3C2Tx AuNPs@MXene Composites for Ultrasensitive Detection of microRNA.

MXene, a two-dimensional nanomaterial, has metal conductivity, high electronegativity, functionalized with surface groups, which makes them has wide applications in catalysis and biosensing. However, studies on the principle of enhanced electro-chemiluminescence (ECL) by MXene composites and the improvement of their performance in catalyzing the ECL reaction are still in their infancy. In this study, gold nanoparticles (AuNPs) are obtained by mild reductive reduction and loaded in situ on the Ti3C2Tx MXene surface to form the composites (AuNPs@MXene).

Chemically Patterning Lithiophilic Interphase to Harmonize Spatial Electrons and Thermal Catalysis Dynamics for Safe Lithium Metal Batteries.

Lithium metal batteries have garnered significant attention as promising energy storage solutions. However, their performance is often compromised by the risks associated with highly active metallic lithium, unrestricted electrode expansion, and excessive dendrites growth. Here we introduce an advanced lithiophilic anode substrate designed by chemically patterning technology for multiple security enhancements.

Covalent Organic Frameworks for Green Energy: Synthesis, Properties, and Applications.

Covalent organic frameworks (COFs) are a new type of porous organic crystalline material, which have become an emerging platform for promoting the development of green energy technology due to their high surface area, adjustable pores, low skeleton density, and easy functionalization. In recent years, with the continuous advancement of synthesis technology, the synthesis efficiency and sustainability of COFs have been significantly improved, from traditional solvothermal methods to the emergence of various green synthesis strategies such as ion thermal, mechanochemical, and ultrasound assisted methods. This article reviews the main synthesis methods of COFs and explores their applications in the field of green energy, such as photocatalysis, gas adsorption and separation, electrocatalysis, battery, supercapacitor and Proton exchange membrane fuel cell.

Assessment of the Properties and Mechanism of Three Lotus (Nelumbo nucifera Gaertn.) Parts for Sleep Improvement.

Lotus leaves (LL), petals (LP), and seeds (LS) are believed to have properties that can improve sleep. However, their efficacy in improving sleep has not been fully validated. This study aimed to investigate the multitarget mechanisms of extracts from these lotus parts for sleep improvement using chemical analysis, bioactivity assessment, meta-analysis, network pharmacology evaluation, and molecular docking.

Epiberberine Improves Hyperglycemia and Ameliorates Insulin Sensitivity in Type 2 Diabetic Mice.

Aim: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterised by absolute or relative insufficiency of insulin secretion. The alkaloids from Rhizoma coptidis have potential hypoglycemic effects. Epiberberine (EPI), a protoberberine alkaloid extracted from Rhizome coptidis, has been found to regulate lipid metabolism.

Lewis and Brønsted Acids Synergy in Photocatalytic Aerobic Alcohol Oxidations.

Photocatalytic chemical transformations for green organic synthesis has attracted much interest. However, their development is greatly hampered by the lack of sufficient reactive sites on the photocatalyst surface for the adsorption and activation of substrate molecules. Herein, we demonstrate that the introduction of well-defined Lewis and Brønsted acid sites coexisting on the surface of TiO2 (SO42-/N-TiO2) creates abundant active adsorption sites for photoredox reactions.

Predictive Value of Preoperative Nutritional Risk Index for Screw Loosening After Lumbar Interbody Fusion in Elderly Patients With Lumbar Spine Diseases.

Objective: Pedicle screw loosening is one of the common complications in elderly patients undergoing transforaminal lumbar interbody fusion (TLIF) for lumbar spine disease. Malnutrition, prevalent among elderly patients, has been shown to be associated with increased complications. The Geriatric Nutritional Risk Index (GNRI) serves as a simple indicator of nutritional status.

Development of pH-Responsive SA/PEGDA/AS-POSS Hydrogels via Michael Addition for Controlled Drug Release and Enhanced Mechanical Properties.

In this study, thiolated sodium alginate (SA) and hydrophilic, polymerizable Janus-type polyhedral oligomeric silsesquioxane (AS-POSS) are synthesized by introducing thiol and sulfonic acid groups, respectively. A series of pH-responsive SA/PEGDA/AS-POSS nanocomposite hydrogels are successfully prepared through Michael addition reactions between the thiol groups of thiolated sodium alginate and the double bonds in the molecular chains of AS-POSS and poly(ethylene glycol) diacrylate (PEGDA). This reaction proceeds rapidly under physiological conditions without requiring initiators or catalysts.

Nanocrystals with Aggregate Anionic Structure Enable Ion Transport Decoupling of Chain Segment Movement in Poly(ethylene oxide) Electrolytes.

All-solid-state polymer electrolytes are promising for lithium batteries, but Li+ transport in these electrolytes relies on amorphous chain segment movement, leading to low Li+ mobility and poor mechanical strength. Here we propose a novel Li+ transport mechanism mediated by PEO3:LiBF4 nanocrystals (NCPB) with the aggregate (AGG) anionic structure, which enables a change from amorphous to crystalline phase dominated ion transport in all-solid-state PEO/LiBF4 electrolyte. Experiments and simulations reveal that the interaction between Li+ and F in NCPB with AGG anionic structure simultaneously restricts anion transport and reorients anions within the free volume of NCPB, resulting in a three-coordination intermediate to facilitate Li+ transport.

Efficient Blue Electroluminescence Based on A Donor-π-acceptor with Pyrene Bridge: Weak Charge-transfer (CT) For High Luminescence and Considerable Exciton Utilization.

Blue emitters are crucial in the organic light emitting diode (OLED) industry and scientific field. In this work, we prepared a novel donor-π-acceptor (D-π-A) molecular PCZ-P-PY using pyrene as a bridge to construct hybrid local and charge-transfer (HLCT) state with weak charge-transfer (CT) property. This excited state design give rise to the high photoluminescent quantum yield (PLQY), more importantly, it is also responsible for the high exciton utilization efficiency (EUE) by constructing efficient hot-exciton channel.

Data-Driven Accelerated Discovery Coupled with Precise Synthesis of Single-Atom Catalysts for Robust and Efficient Water Purification.

The development of advanced catalysts frequently employs trial-and-error methods and is lack of highly controlled synthesis, resulting in unsatisfactory development efficiency and performance. Here we propose a data-driven prediction coupled with precise synthesis strategy to accelerate the development of single-atom catalysts (SACs) for efficient water purification. The data-driven approach enables the rapid screening and prediction of high-performance SACs from 43 metals-N4 structures comprising transition and main group metal elements, followed by validation and structural modulation for improved performance through a highly controllable hard-template method.

APAGE Position Statements on Green and Sustainability in Gastroenterology, Hepatology, and Gastrointestinal Endoscopy.

Background And Aim: The APAGE Position Statements aimed to provide guidance to healthcare practitioners on clinical practices aligned with climate sustainability.

Methods: A taskforce convened by APAGE proposed provisional statements. Twenty-two gastroenterologists from the Asian Pacific region participated in online voting and consensus was assessed through an anonymized and iterative Delphi process.

Deep Learning for Staging Periodontitis Using Panoramic Radiographs.

Objectives: Utilizing a deep learning approach is an emerging trend to improve the efficiency of periodontitis diagnosis and classification. This study aimed to use an object detection model to automatically annotate the anatomic structure and subsequently classify the stages of radiographic bone loss (RBL).

Materials And Methods: In all, 558 panoramic radiographs were cropped to 7359 pieces of individual teeth.

A Bifunctional Lysosome-Targeting Chimera Nanoplatform for Tumor-Selective Protein Degradation and Enhanced Cancer Immunotherapy.

Lysosome-targeting chimeras (LYTACs) have recently emerged as a promising therapeutic strategy for degrading extracellular and membrane-associated pathogenic proteins by hijacking lysosome-targeting receptors. However, the antitumor performance of LYTAC is limited by its insufficient tumor accumulation and nonspecific activation. Additionally, the synergistic effects of LYTACs and other therapeutic modalities are crucial.

Development and Validation of a Prediction Model for Enteral Feeding Intolerance in Critical Ill Patients: A Retrospective Cohort Study.

Aim: To construct and validate a prediction model for enteral feeding intolerance in critically ill patients during the first 7 days of enteral feeding.

Design: A retrospective cohort study.

Methods: We reviewed the medical records of two intensive care units from January 2015 to August 2023, to develop a prediction model by univariate analysis and logistic regression analysis.