A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation.

Colorectal cancer (CRC), one of the diseases posing a threat to global health, according to the latest data, is the third most common cancer globally and the second leading cause of cancer-related deaths. The development and refinement of novel structures of small molecular compounds play a crucial role in tumor treatment and overcoming drug resistance. In this study, our objective was to screen and characterize novel compounds for overcoming drug resistance via the B Lymphoma Mo-MLV insertion region 1 (Bmi-1) reporter screen assay.

Anaphylaxis definition, overview, and clinical support tool: 2024 consensus report.

Background: The 2006 National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network (NIAID/FAAN) anaphylaxis criteria are widely used in clinical care and research. In 2020, the World Allergy Organization (WAO) published modified criteria that have not been uniformly adopted. Different criteria contribute to inconsistent care and research outcomes.

Screening and Preparation of Nanobodies for SIGLEC-15 Detection.

As an important member of the Siglec family, SIGLEC-15 plays an important role in osteoclast differentiation, bone remodeling, and tumor immune evasion. In the tumor microenvironment, SIGLEC-15 functions independently of the B7-H1/PD-1 pathway. In this study, the SIGLEC-15 fusion protein (SIGLEC-15-Fc) was successfully expressed and purified using a eukaryotic expression system.

Abnormal glymphatic system in patients with autoimmune encephalitis: relationship with cognitive performance.

Objectives: We aimed to explore the impact of glymphatic function in patients diagnosed with autoimmune encephalitis (AE).

Methods: In this prospective longitudinal study, patients were recruited from Xijing Hospital between June 2020 and January 2024. Glymphatic function was evaluated using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS).

KDiffered brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients.

Purpose: To investigate the differences in brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis (ALS-L and ALS-B, respectively) patients using resting-state functional MRI (rs-fMRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).

Materials And Methods: The rs-fMRI data were collected from 41 ALS patients (11 ALS-B and 30 ALS-L) and 25 healthy controls (HC). ALFF and ReHo values were calculated, and group differences were assessed using one-way ANCOVA and two-sample t-tests.

Midterm Outcomes of Common Femoral Patch Angioplasty in Iliofemoral Occlusive Diseases: Bovine Pericardial Patch versus Great Saphenous Vein Patch.

Objective: To assess the mid-term outcomes of utilizing bovine pericardium patch (BPP) compared to great saphenous vein patch (GSVP) in femoral angioplasty for iliofemoral occlusive diseases.

Methods: A retrospective study was carried out at the First Medical Center of the Chinese PLA General Hospital from January 2013 to July 2023 to assess the efficacy of femoral angioplasty in patients with iliofemoral occlusive disease. Technical success, early outcomes, 24-month primary patency, and freedom from restenosis at the patch site were evaluated.

Burden of Nasopharyngeal Carcinoma in Asia from 1990 to 2021.

Objectives: The study aimed to investigate the disease burden of nasopharyngeal carcinoma (NPC) in Asia.

Material And Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 data evaluated NPC metrics by sex, and age in Asia. Estimated annual percentage changes (EAPCs) were calculated to assess the trends of NPC burden.

Executive dysfunction in Parkinson's disease: From neurochemistry to circuits, genetics and neuroimaging.

Cognitive decline is one of the most significant non-motor symptoms of Parkinson's disease (PD), with executive dysfunction (EDF) being the most prominent characteristic of PD-associated cognitive deficits. Currently, lack of uniformity in the conceptualization and assessment scales for executive functions impedes the early and accurate diagnosis of executive dysfunction in PD. The neurobiological mechanisms of executive dysfunction in PD remain poorly understood.

Bifunctional performance of cellulose nanofibers grafted with polyhexamethylene guanidine in Pickering emulsion: Antibacterial activity and interfacial stability.

This study developed the multifunctional cellulose nanofibers (CNFs) as emulsifier for preparation of antibacterial, ultrastable and non-toxic emulsion. To achieve these properties, CNFs were oxidated using sodium periodate to introduce aldehyde groups, which served as Schiff-base reaction sites for amino groups of polyhexamethylene guanidine (PHMG), yielding PHMG-grafted CNFs (PCNFs). The modified CNFs retained good emulsification ability while acquiring antibacterial properties.

Pectins play a central role in enhancing Al tolerance of alfalfa via looseing fibre-microfiber arrangement of cell wall in root tips.

Cell wall greatly affects Al tolerance of plants, but the precise mechanisms by which the cell wall modulating Al tolerance remains largely unknown. In the present study, Al tolerant alfalfa varieties (WL525 and WL903) accumulated less Al in root tips, cell wall and pectins, averagely decreased by 23.8 %, 41.

Prospects and applications of efficient physical field processing technologies for polysaccharide extraction and quality improvement in edible mushrooms: A systematic review.

Edible mushroom-derived polysaccharides (EMPs) have been widely used in foods, medicine, and cosmetics due to theirs' diverse and versatile biological activities. Currently, many conventional extraction methods for extracting EMPs are struggling to meet the growing demand, and the produced EMPs with poor quality and low bioactivity. Novel physical field (e.

Konjac glucomannan-embedded corn starch-derived type 1 resistant starch: Physicochemical properties, in vitro digestibility and fermentation characteristics, and in vivo glucose response in mice.

Type 1 resistant starch (RS1) was prepared by high-pressure homogenization of corn starch (CS) embedded with 0.1 %, 0.3 %, 0.

Transcriptome-wide N-methyladenosinem modifications analysis of growth and fumonisins production in Fusarium proliferatum causing banana crown rot.

Crown rot caused by Fusarium proliferatum is a severe postharvest disease of banana fruit. The N-methyladenosine (mA) modification is the most common type of RNA modification and regulates gene expression in eukaryotes. Here, we analyzed transcriptome-wide changes in mA methylation to investigate post-transcriptional regulation mechanisms of growth and fumonisin biosynthesis of F.

An effective approach for lignin-based bamboo adhesive preparation via swelling crosslinking.

The preparation of lignin-based adhesives from sustainable lignin sources has garnered increasing attention from many researchers in recent years. However, developing high-performance and environmentally friendly lignin-based adhesives through a simple and efficient approach remains a significant challenge. In this study, aminated corn stover lignin (ACSL) was prepared by aminating corn stover lignin (CSL) using glutaraldehyde and ethylenediamine.

Global prevalence of fatigue in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Background: Fatigue is a common symptom in patients with chronic obstructive pulmonary disease (COPD). Published studies of fatigue among patients with COPD have presented diverse findings that may reflect variations in research methods as well as actual population differences.

Objective: To estimate the worldwide prevalence of fatigue in patients with COPD and its associated epidemiological characteristics.

Association between Executive Function and Food Addiction among Children and Adolescents with Attention Deficit Hyperactivity Disorder.

Objectives: To examine the prevalence of food addiction (FA) among children and adolescents with attention deficit hyperactivity disorder (ADHD), and to explore the association between executive function and FA.

Study Design: This is a cross-sectional study. A total of 1,021 children and adolescents aged 6-18 years and their parents participated in this study and completed the Vanderbilt ADHD Diagnostic Parent Rating Scale, Yale Food Addiction Scale and Executive Function Behavior Rating Scale.

Ability of the modified NUTRIC score to predict all-cause mortality among ICU patients with acute pancreatitis: A retrospective analysis using the MIMIC-IV database.

Background: Acute pancreatitis (AP) is a common acute abdominal condition that can lead to severe complications. Malnutrition significantly impacts the prognosis of patients with AP, so effective tools are needed to identify those at high nutritional risk. This study validated the ability of the modified NUTRIC score to predict all-cause mortality and identify nutritional risk in patients with acute pancreatitis in the ICU.

Associations of dietary factors with amyotrophic lateral sclerosis: A Mendelian randomization study.

Background: An inconsistent yet notable relationship between dietary habits and the risk of amyotrophic lateral sclerosis (ALS) has been previously established, with the causative nature of this relationship remaining uncertain. This study aims to explore the causal connections at a genetic level.

Methods: A two-sample Mendelian Randomization (MR) based analysis was conducted utilizing a comprehensive, publicly assessable Genome-wide association study (GWAS) database.

Development and testing the psychometric properties of 20 bolt-on items for the EQ-5D-5L across 31 rare diseases.

Objective: Our objective was to develop and assess the psychometric properties of relevant bolt-on items for the EQ-5D-5L in patients with rare diseases (RDs).

Methods: Nineteen new EQ-5D-5L bolt-ons were developed based on literature review, expert input and qualitative interviews and focus groups with patients, caregivers and representatives of patient associations. A nationwide, cross-sectional, web-based survey in China included patients or caregivers of patients with 31 RDs in China (n=9,190).

Robot-assisted Endodontic Retreatment: A Case Report with Clinical Considerations.

Introduction: Fiber posts present significant challenges for nonsurgical endodontic retreatment, as improper removal may result in iatrogenic root perforation or even root fracture. Recently, robotic technology has attracted considerable attention in dentistry and active dental robotic (ADR) systems can perform procedures based on preset instructions, minimizing reliance on the dentist's experience. This case report describes the application of an ADR system for fiber post removal through an existing zirconia crown.

Integration of MRI radiomics and clinical data for preoperative prediction of vascular invasion in breast cancer: A deep learning approach.

Background: Accurate preoperative prediction of vascular invasion in breast cancer is crucial for surgical planning and patient management. MRI radiomics has shown promise in enhancing diagnostic precision. This study aims to evaluate the effectiveness of integrating MRI radiomic features with clinical data using a deep learning approach to predict vascular invasion in breast cancer patients.

Carrier-free nanoparticles for cancer theranostics with dual-mode magnetic resonance imaging/fluorescence imaging and combination photothermal and chemodynamic therapy.

Both photothermal therapy (PTT) and chemodynamic therapy (CDT) are designed to focus their antitumor effect on only the tumor site, thereby minimizing unwanted severe damage to healthy tissue outside the tumor. However, each monotherapy is limited in achieving complete tumor eradication, resulting in tumor recurrence. The combination of multiple therapies may help to overcome the limitations of single therapy, improve the chances of complete tumor eradication, and reduce the risk of recurrence.

Rubicon siRNA-encapsulated liver-targeting nanoliposome is a promising therapeutic for non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disorder worldwide, and effective therapeutic strategies for its treatment remains limited. In this article, we introduced Glipo-siRubi, a hepatocytes-targeting RNA interference (RNAi) nanoliposome for suppression of Rubicon expression, aiming to achieve precise regulation of autophagy in NAFLD. Autophagy activation induced by Rubicon suppression resulted in reduced endoplasmic reticulum stress and intracellular lipid accumulation in vitro.

Iontophoresis-driven transdermal drug delivery system based on porous microneedles for hyperuricemia treatment.

An iontophoresis-driven porous microneedles (IPMNs) system has been developed for hyperuricemia management, which can be effectively prolong the anti-hyperuricemia effect. Porous microneedles (PMNs) with good biocompatibility, high porous volume, and excellent substance exchange capacity were firstly prepared for drug transdermal delivery and active iontophoresis.In vitro experiments showed that the transdermal delivery efficiency of anti-hyperuricemia drug (Allopurinol, AP) could be controlled using the iontophoresis current of IPMNs system.

Cas12a Is Competitive for Gene Editing in the Malaria parasites.

Malaria, caused by the Plasmodium parasites, has always been one of the worst infectious diseases that threaten human health, making it necessary for us to study the genetic function and physiological mechanisms of Plasmodium parasites from the molecular level to find more effective ways of addressing the increasingly pressing threat. The CRISPR (Clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated protein) is an RNA-guided adaptive immune system, which has been extensively developed and used as a genome editing tool in many organisms, including Plasmodium parasites. However, due to the physiological characteristics and special genomic characteristics of Plasmodium parasites, most of the tools currently used for genome editing of Plasmodium parasites have not met expectations.