90,068 results match your criteria: "Chile; FONDAP Center for Genome Regulation[Affiliation]"

Background/objectives: recent studies have suggested that components typical of the Mediterranean diet (MedDiet) are associated with depression and anxiety prevention. In this sense, the main objective of this study was to analyse the associations between adherence to the MedDiet and depression and anxiety symptoms and to examine whether this relationship is mediated by lean mass and the muscle strength index (MSI).

Methods: a cross-sectional study (based on data obtained from the Nuts4Brain-Z study) was conducted from 2023-2024, involving 428 university students, aged 18-30 years, from a Spanish public university.

View Article and Find Full Text PDF

Introduction: Nutritional issues, including overweight and obesity, along with the rising number of immigrants facing their own nutritional problems, continue to keep Chile on alert.

Objective: To evaluate the epidemiological and nutritional status changes among Chilean and immigrant boys, girls, and adolescents (BGA) in schools evaluated by the National Board of School Aid and Scholarships (JUNAEB) from 2013 to 2023.

Methods: This descriptive study analyzed individual, anonymous, and de-identified data on the nutritional status of BGA in pre-kindergarten, kindergarten, first grade, fifth grade, and the first year of high school using the JUNAEB Nutritional Map.

View Article and Find Full Text PDF

Unlabelled: Dental caries remains a prevalent chronic disease driven by dysbiosis in the oral biofilm, with playing a central role in its pathogenesis.

Objective: This study aimed to assess the effect of D-tagatose on cariogenic risk by analyzing randomized clinical trials (RCTs).

Methods: A systematic literature review was conducted targeting RCTs published up to 2024 in eight databases and two gray literature sources.

View Article and Find Full Text PDF

Brucite (Mg(OH)) is a typical precipitate in the mining industry that adversely affects processes such as flotation and thickening. Gaining insights into the physicochemical properties of this mineral is critical for developing strategies to mitigate these challenges and improve operational efficiency. Additionally, incorporating natural-origin polymers aligns with the shift toward more sustainable mining practices.

View Article and Find Full Text PDF

Improving Sensitivity and Resolution of Dendrimer Identification in MALDI-TOF Mass Spectrometry Using Varied Matrix Combinations.

Polymers (Basel)

January 2025

Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a well-known technique for polymer analysis, particularly for determining the molecular weight and structural details of dendrimers. In this study, we evaluated the performance of various matrices, such as 2',4',6'-trihydroxyacetophenone (THAP), α-cyano-4-hydroxycinnamic acid (HCCA), and sinapinic acid (SA), and their combinations, on the sensitivity and resolution of poly(amidoamine) (PAMAM) dendrimers of different generations (G3.0, G4.

View Article and Find Full Text PDF

Novel Co-Polyamides Containing Pendant Phenyl/Pyridinyl Groups with Potential Application in Water Desalination Processes.

Polymers (Basel)

January 2025

Centro de Nanotecnología Aplicada, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Camino La Pirámide 5750, Huechuraba 8580745, Chile.

This study explores the development and evaluation of a novel series of aromatic co-polyamides featuring diverse pendant groups, including phenyl and pyridinyl derivatives, designed for water desalination membrane applications. These co-polyamides, synthesized with a combination of hexafluoroisopropyl, oxyether, phenyl, and amide groups, exhibited excellent solubility in polar aprotic solvents, thermal stability exceeding 350 °C, and the ability to form robust, flexible films. Membranes prepared via phase inversion demonstrated variable water permeability and NaCl rejection rates, significantly influenced by the pendant group chemistry.

View Article and Find Full Text PDF

A Simple Machine Learning-Based Quantitative Structure-Activity Relationship Model for Predicting pIC Inhibition Values of FLT3 Tyrosine Kinase.

Pharmaceuticals (Basel)

January 2025

Centro de Química Médica, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.

Acute myeloid leukemia (AML) presents significant therapeutic challenges, particularly in cases driven by mutations in the FLT3 tyrosine kinase. This study aimed to develop a robust and user-friendly machine learning-based quantitative structure-activity relationship (QSAR) model to predict the inhibitory potency (pIC values) of FLT3 inhibitors, addressing the limitations of previous models in dataset size, diversity, and predictive accuracy. Using a dataset which was 14 times larger than those employed in prior studies (1350 compounds with 1269 molecular descriptors), we trained a random forest regressor, chosen due to its superior predictive performance and resistance to overfitting.

View Article and Find Full Text PDF

Gastrointestinal nematodes (GINs) inflict significant economic losses on sheep and goat farming globally due to reduced productivity and the development of anthelmintic resistance. Sustainable control strategies are urgently needed including the exploration of medicinal plants as safer alternatives to chemical anthelmintics. This genus of plants is used for anti-inflammatory, antioxidant, and antimicrobial activities.

View Article and Find Full Text PDF

The most widely used radiance sensor for monitoring Night Sky Brightness (NSB) is the Sky Quality Meter (SQM), making its measurement stability fundamental. A method using the Sun as a calibrator was applied to analyse the quality of the measures recorded in the Veneto Region (Italy) and at La Silla (Chile). The analysis mainly revealed a tendency toward reductions in measured NSB due to both instrument ageing and atmospheric variations.

View Article and Find Full Text PDF

: This study aims to describe and analyze the indications and clinical results of total TMJ replacement in participants with degenerative and/or inflammatory joint diseases, defining patient and intervention conditions. : A systematic review was conducted according to the Cochrane Handbook for Systematic Reviews of Intervention and reported according to the PRISMA Items update. The search strategy was from 1997 to July 2024 in Pubmed, Embase, Scopus, and Web of Science.

View Article and Find Full Text PDF

To determine whether 448 kHz capacitive-resistive monopolar radiofrequency (CRMR) after platelet-rich-plasma (PRP) injections can further reduce pain sensation within the first 72 h in an active population with patellar chondropathy. One-hundred fifty-three active patients with patellar chondropathy grade II-III were followed for three days after PRP injections with and without CRMR under a control-placebo study. They were clinically evaluated for pain sensation using a visual analog scale ranging from zero (no pain sensation) to ten (highest pain sensation).

View Article and Find Full Text PDF

Phenolic compounds have antiglycation activity, but the changes occurring during thermal treatment (TT) in these activities are not completely understood. The effects of the extraction conditions of (poly)phenols from fruits, before and after TT, on their antioxidant and antiglycation effects were assessed. (Poly)phenol-enriched extracts (PEEs) from raw and TT (90 °C, 1 h) were extracted using three solvent mixtures (ethanol/water/acetic acid) with increasing water content (0, 24, and 49%) and three solvent-to-solid ratios (5, 10, and 20 mL/g).

View Article and Find Full Text PDF

This study evaluates the effectiveness of Total Reflection X-ray Fluorescence for multi-element analysis in mussels, focusing on sensitivity, precision, and detection limits. Additionally, it offers a cross-regional comparison of elemental composition in mussels from aquaculture farms in Italy, Spain, and Chile. TXRF, using suspensions of mussel samples, proved effective in detecting minor and trace elements, with recovery rates over 80% for Fe, Cu, Zn, As, and Sr.

View Article and Find Full Text PDF

Histology Assessment of Chitosan-Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles.

Molecules

January 2025

Grupo Biomateriales Dentales, Escuela de Odontología, Universidad del Valle, Calle 4B # 36-00, Cali 760001, Colombia.

Scaffolds for regenerative therapy can be made from natural or synthetic polymers, each offering distinct benefits. Natural biopolymers like chitosan (CS) are biocompatible and biodegradable, supporting cell interactions, but lack mechanical strength. Synthetic polymers like polyvinyl alcohol (PVA) provide superior mechanical strength and cost efficiency but are not biodegradable or supportive of cell adhesion.

View Article and Find Full Text PDF

Mine tailings are a byproduct of mineral extraction and often pose an environmental challenge due to the contamination of soil and water bodies with dissolved metals. However, this type of waste offers the opportunity for the recovery of valuable metals such as silver (Ag). In the present investigation, an integral analysis of a sample of tailings was carried out, addressing granulometry, elemental composition, neutralization potential (NP), and acid potential (AP), as well as mineralogy, for the dissolution of silver from this type of waste.

View Article and Find Full Text PDF

Inconel 718 (IN718) is a polycrystalline nickel-based superalloy and one of the most widely used materials in the aerospace industry owing to its excellent mechanical performances at high temperatures, including creep resistance. Interest in additively manufactured components in aerospace is greatly increasing due to their ability to reduce material consumption, to manufacture complex parts, and to produce out-of-equilibrium microstructures, which can be beneficial for mechanical behavior. IN718's properties are, however, very sensitive to microstructural features, which strongly depend on the manufacturing process and subsequent heat treatments.

View Article and Find Full Text PDF

Stable Reusability of Nanocellulose Aerogels with Amino Group Modification in Adsorption/Desorption Cycles for CO Capture.

Materials (Basel)

January 2025

Departamento de Química Ambiental, Universidad Católica de la Santísima Concepción, Concepción 4070129, Chile.

This study evaluated the stability and reusability of amino-functionalized nanocellulose aerogels as CO-adsorbent materials. The modified aerogels, synthesized via a controlled silylation using N-[3-(trimethoxysilyl) propyl] ethylenediamine (DAMO), demonstrated excellent thermal stability up to 250 °C (TGA) and efficient CO adsorption through chemisorption, which was the main adsorption mechanism. The performance of the aerogels was assessed using both adsorption isotherms and the decay pressure technique, revealing that CO adsorption capacity increased with higher amino group loading (4.

View Article and Find Full Text PDF

The poplar moth, (Lepidoptera: Lyonetiidae), is widely distributed across Europe, Asia, and parts of Africa. It was first identified in Chile in 2015 and has since become a significant pest in the agricultural sector. Additionally, economic losses are further aggravated by the presence of pupae in nearby fruit orchards.

View Article and Find Full Text PDF

The Use of Novel Alginate Capsules in a Monitoring System for in a Cherry Orchard in the Region of La Araucanía, Chile.

Insects

December 2024

Applied Entomology Laboratory, Facultad de Ciencias Agropecuarias y Medioambiente, Universidad de La Frontera, Temuco 4811230, Chile.

Spotted wing drosophila (SWD) is a pest that causes damage due to the female laying eggs under the skin of ripe fruit, from which a larva emerges, causing its collapse and reducing its commercial value. Due to the importance of this pest, monitoring its population is the starting point for any control program; however, there is no early monitoring plan within management tasks, nor are there studies on behavior, the optimization of traps, or their baits. This research proposes the evaluation of a monitoring system with encapsulated baits and adhesive traps that allow effective control.

View Article and Find Full Text PDF

Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases.

Int J Mol Sci

January 2025

Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.

Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity and metabolic syndrome (MetS), which subsequently increase palmitic acid (PA) levels. At high concentrations, PA induces lipotoxicity through several mechanisms involving endoplasmic reticulum (ER) stress, mitochondrial dysfunction, inflammation and cell death. Nevertheless, there are endogenous strategies to mitigate PA-induced lipotoxicity through its unsaturation and elongation and its channeling and storage in lipid droplets (LDs), which plays a crucial role in sequestering oxidized lipids, thereby reducing oxidative damage to lipid membranes.

View Article and Find Full Text PDF

Consumption of phytosterols is a nutritional strategy employed to reduce cholesterol absorption, but recent research shows that their biological activity might go beyond cholesterol reduction for the treatment of metabolic dysfunction-associated fatty liver disease (MAFLD), and novel phytosterol formulations, such as submicron dispersions, could improve these effects. We explored the therapeutic activity of phytosterols, either formulated as submicron dispersions of phytosterols (SDPs) or conventional phytosterol esters (PEs), in a mouse model of MAFLD. MAFLD was induced in mice by atherogenic diet (AD) feeding.

View Article and Find Full Text PDF

Differential Activity and Expression of Proteasome in Seminiferous Epithelium During Mouse Spermatogenesis.

Int J Mol Sci

January 2025

Laboratorio de Biología de la Reproducción, Departamento Biomédico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1240000, Chile.

Proteasome-mediated protein degradation is essential for maintaining cellular homeostasis, particularly during spermatogenesis, where extensive cellular transformations, such as spermatid differentiation, require precise protein turnover. A key player in this process is the ubiquitin-proteasome system (UPS). This study aimed to investigate proteasome enzymatic activity at different stages of the spermatogenic cycle within the seminiferous tubules of mice and explore the regulatory mechanisms that influence its proteolytic function.

View Article and Find Full Text PDF

This study aims to provide evidence that when testing cellulose paper modified with copper particles (CuPs), the particle size and the analysis method influence the antimicrobial activity observed by this material. Commercial CuPs of nanometric size (2.7 nm, CuNPs) and micrometric size (2.

View Article and Find Full Text PDF

Cardiac Hemodynamics, Tissue Oxygenation, and Functional Capacity in Post-COVID-19 Patients.

Medicina (Kaunas)

January 2025

Laboratório de Inovação Tecnológica em Reabilitação, Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte (UFRN), Campus Universitário Central, Natal 59078970, RN, Brazil.

: This study aimed to evaluate and compare the functional capacity of post-COVID-19 patients with a control group and analyze cardiac hemodynamics and muscle tissue oxygenation responses during assessment protocols in both groups. : A cross-sectional study was conducted involving patients with COVID-19 and a control group who were all aged ≥18 years. Participants underwent two functional capacity tests: the one-minute sit-stand test (1-STS) and the six-minute walk test (6MWT).

View Article and Find Full Text PDF

Gate dielectrics are essential components in nanoscale field-effect transistors (FETs), but they often face significant instabilities when exposed to harsh environments, such as radioactive conditions, leading to unreliable device performance. In this paper, we evaluate the performance of ultrascaled transition metal dichalcogenide (TMD) FETs equipped with vacuum gate dielectric (VGD) as a means to circumvent oxide-related instabilities. The nanodevice is computationally assessed using a quantum simulation approach based on the self-consistent solutions of the Poisson equation and the quantum transport equation under the ballistic transport regime.

View Article and Find Full Text PDF