[Adrenal tumors in pediatric patients treated with minimally invasive surgery].

Unlabelled: Adrenal tumors in children are frequently neoplastic and malignant, and surgical resection is the first management option. Minimally invasive surgery (MIS) has proven to be a safe management alternative and is suggested as a preferred alternative approach.

Objective: To report the surgical outcomes of patients with adrenal tumors treated by MIS.

[Posterior reversible encephalopathy syndrome (PRES) and hemolytic anemia: two severe and unusual complications of acute post-streptococcal glomerulonephritis].

Unlabelled: The most frequent cause of nephritic syndrome in the pediatric population is acute post-infectious glomerulonephritis (PIGN). A rare complication is posterior reversible encephalopathy syndrome (PRES), characterized by subcortical vasogenic cerebral edema associated with variable neurological symptoms. The development of autoimmune hemolytic anemia is an atypical clinical presentation.

[Prognostic factors for survival in children with cancer and febrile neutropenia].

Unlabelled: Cancer remains one of the most important diseases in public health.

Objective: To estimate 5-year survival in pediatric cancer patients affected by FN, according to clinical-demographic variables.

Patients And Method: Survival, prognostic, and analytical study with historical cohort.

[Prolonged treatment of patent ductus arteriosus with paracetamol in very low birth weight preterm infants].

Unlabelled: Hemodynamically significant patent ductus arteriosus (hs-PDA) in very low birth weight (VLBW) infants continues to be an issue of research regarding the timing of treatment and which would be the most appropriate drug.

Objective: To assess the outcome of prolonged treatment with paracetamol in the closure of hemodynamically significant patent ductus arteriosus in preterm newborns.

Patients And Method: Retrospective study in VLBW infants with echocardiographic and clinical diagnosis of hs-PDA who received treatment with intravenous paracetamol at 15 mg/kg every 6 hours for 6 days.

[Impact of the coronavirus SARS-CoV-2 pandemic on the presentation and management of acute appendicitis in children].

Unlabelled: Acute appendicitis (AA) is the most frequent cause of acute surgical abdomen in pediatrics. During the COVID-19 pandemic, lockdown slowed surgical processes, delaying medical consultations.

Objective: To analyze the impact of the pandemic on the presentation and management of acute appendicitis.

[Screening in Cystic Fibrosis in the Chilean population. Pilot project for screening in newborns].

Unlabelled: Neonatal screening has been implemented internationally with different protocols and has become the routine method in the preclinical stage. Late diagnosis is associated with more severe symptoms with decreased survival and higher treatment costs.

Objectives: To estimate the incidence of cystic fibrosis; to evaluate the performance of the screening algorithms Immunoreactive Trypsinogen and Pancreatitis-Associated Protein (IRT/PAP) and the IRTxPAP product; to analyze the cut-off value for IRT, PAP, and IRTxPAP, and to establish a methodology for its ongoing evaluation; finally, to evaluate the quality of IRT and PAP measurements.

[Micronutrients intake in patients with refractory epilepsy with ketogenic diet treatment].

Unlabelled: The Ketogenic Diet (KD) is a non-pharmacological strategy for drug-resistant epilepsy (DRE) and inborn errors of metabolism (Glut-1 deficiency) management. KD is characterized by being restrictive, affecting micronutrient intake. There are different modalities of KD in which food intake and nutritional deficiencies vary.

[Can CPAP prevent the progression of pediatric acute respiratory distress syndrome? A decade of experience in a Reference Center].

Viral infections are the main cause of acute respiratory failure in infants, which can progress to acute respiratory distress syndrome (ARDS), with high morbidity and mortality, so it is essential to imple ment strategies that prevent this progression. Recently, it has been proposed that increased work of breathing would not only be a warning symptom during the evolution of acute respiratory failure, but also a mechanism for the progression of injury, both lungs and diaphragm, coining the concept of patient self-inflicted lung injury. Since the first reports of ARDS, the usefulness of the use of con tinuous positive airway pressure (CPAP) has been raised, a non-invasive respiratory support therapy with wide access and low cost, capable of improving oxygenation and work of breathing.

[Pseudohiponatremia secondary to hypertriglyceridemia during the treatment of lymphoblastic lymphoma with corticoids and L-asparaginase].

Unlabelled: L-asparaginase (L-asp) is an antineoplastic drug used in Leukemia and Lymphoma treatment protocols. Alterations in lipid metabolism have been reported in 10-50% of children treated with L-Asp.

Objective: To report an unusual complication of lipid metabolism associated with the use of L-Asp.

[Benefits of home-based administration of palivizumab in high-risk groups].

Unlabelled: Palivizumab, a humanized monoclonal antibody against the respiratory syncytial virus (RSV), currently is indicated in groups at higher risk of developing severe RSV disease, such as extreme premature infants and patients with hemodynamically significant heart disease. In Chile, this strategy is guaranteed by Law 20850 (Ricarte Soto Law). Nevertheless, barriers to its administration included the need to transfer these labile patients and exposure to other users, with the risk of contagion in waiting rooms.

[Validation and cross-cultural adaptation of the Pediatric Sleep Questionnaire Sleep-Related Breathing Disorder Scale (PSQ-SRBD) to spanish language].

Unlabelled: In the Chilean pediatric population, to date, there is no validated screening instrument for sleep-related breathing disorders (SRBD).

Objective: to develop and validate a cross-cultural adaptation of the Pediatric Sleep Questionnaire - sleep-related breathing disorder scale (PSQ-SRBD), by creating the Chilean Spanish version (PSQ-CL).

Patients And Method: The PSQ-SRBD was translated from English into Chilean Spanish, obtaining the PSQ-CL, which was subsequently validated.

[Exploring the sexual and reproductive health of migrant adolescents in Chile: insights from the 10th National Youth Survey].

Unlabelled: Migration is a phenomenon with an impact on the health of adolescents. Barriers to accessing health services expose them to risks such as sexual violence, unwanted pregnancies, and sexually transmitted infections/HIV.

Objective: To analyze variables of sexual and reproductive health in migrant and Chilean adolescents.

[Health Related Quality of Life in retinoblastoma patients].

Unlabelled: Retinoblastoma (Rb) is the most common intraocular cancer in children and, along with its treatment, can negatively impact the Quality of Life (QoL). Few studies have explored this subject in these patients; none in Latin America.

Objective: To evaluate the general, physical, emotional, social, and school quality of life of patients treated for Rb and to analyze which patient, disease, or treatment factors are associated with worse outcomes.

[Estimation of cardiorespiratory fitness from the Six-Minute Walk Test in schoolchildren].

Unlabelled: Cardiorespiratory fitness can be assessed by direct, indirect, maximal, and moderate effort, running, cycling, or walking methods.

Objective: To predict maximum oxygen consumption (V O2max) from the six-minute walk test in schoolchildren.

Patients And Method: 459 students were included, 215 were male and 244 were female, aged 11.

[Properties of the Test of Early Learning and Development, second edition "TADI", in the context of scale validation policies for children under 6 years of age in Chile and Latin America].

Unlabelled: In Latin America, scales have been built to assess Early Child Development (EChD), most of them for direct evaluations. In Chile, the Psychomotor Development Evaluation Scale (EEDP) and the Test of Psychomotor Development (TEPSI) were developed in the 70's and 80's and are still used in different Spanish-speaking countries, but have not been updated or revalidated. In response to the need for a new instrument built in Chile for the evaluation of EChD on a large scale, the Test of Early Learning and Development (TADI-2, for its acronym in Spanish) was built and standardized between 2009 and 2012.