Genetic diversity and intercontinental dispersal of temperate and subarctic populations of Dibothriocephalus dendriticus (Cestoda; Diphyllobothriidea), a causative agent of dibothriocephalosis.

The diphyllobothriid tapeworm Dibothriocephalus dendriticus, one of the causative agents of the fish-borne zoonosis dibothriocephalosis, is mainly distributed in the Arctic/subarctic and temperate zones of the Northern Hemisphere (Europe, North America, and Asia), but also in the southern cone region of South America (Patagonia). The genetic structure and gene flow among 589 individuals of D. dendriticus, representing 20 populations, were studied using the mitochondrial cox1 gene as the first choice marker and 10 polymorphic nuclear microsatellite loci as a dominant molecular tool.

Intranasal delivery of extracellular vesicles: A promising new approach for treating neurological and respiratory disorders.

Background: Extracellular vesicles (EVs) are membrane vesicles secreted by all types of cells, including bacteria, animals, and plants. These vesicles contain proteins, nucleic acids, and lipids from their parent cells and can transfer these components between cells. EVs have attracted attention for their potential use in diagnosis and therapy due to their natural properties, such as low immunogenicity, high biocompatibility, and ability to cross the blood-brain barrier.

Microscale intertidal habitats modulate shell break resistance of the prey; Implications for prey selection.

Intertidal microhabitats provide special conditions to the organisms that inhabit them and to some of their morpho-protective characteristics. Tidal pools, under the influence of acidified freshwater, may affect the characteristics of the protective shells of prey and have repercussions on predation. The shells of Perumytilus purpuratus from such tidepools are more fragile than those of their counterparts from the vertical intertidal walls of the same area.

Exploring the relationship between upwelling intensity and socio-ecological attributes of marine exploitation areas for benthic resources (MEABRs), along the southern Humboldt Current system.

The Eastern Boundary Upwelling Systems (EBUS) sustains some of the most productive marine systems on Earth. Within each of these systems, the upwelling process exhibits spatial and temporal variation resulting in marked differences in upwelling intensity and seasonality along extensive coastlines. The study of this variation is well needed, given the magnitude of the services provided by upwelling, and the impending impacts of global warming on EBUS.

Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.

Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) are part of a spectrum of diseases that share several causative genes, resulting in a combinatory of motor and cognitive symptoms and abnormal protein aggregation. Multiple unbiased studies have revealed that proteostasis impairment at the level of the endoplasmic reticulum (ER) is a transversal pathogenic feature of ALS/FTD. The transcription factor XBP1s is a master regulator of the unfolded protein response (UPR), the main adaptive pathway to cope with ER stress.

Japi 2.0, a gaming platform to stimulate cognitive and non-cognitive skills in early childhood: protocol for a pilot randomized controlled trial.

Background: Mental health disorders are one of the leading causes of illness globally. The importance of psychosocial skills acquired in early childhood, such as executive functions, inhibitory control, emotional regulation, and social problem-solving, in preventing mental disorders has been reported. Furthermore, mental health care delivery is evolving, and mobile technology is becoming the medium for assessment and intervention.

Isotemporal substitution of physical activity patterns and sitting time with obesity indicators among workers in São Paulo.

This study aimed to evaluate the association between substituting 10, 30, and 60 min/day of physical activity and sitting time with obesity indicators among workers. It is a cross-sectional study involving 394 adults (76.6% women) from São Paulo, Brazil.

Specific activity of mouse liver desaturases and elongases: Time course effects using n-3 and n-6 PUFA substrates and inhibitory responses of delta-6 desaturase.

The synthesis of n-3 and n-6 polyunsaturated acids (PUFAs) is associated with physiological functions in mammals, being catalyzed by Δ-5D and Δ-6D desaturases and elongases Elovl-2 and Elovl-5. In this context, we aimed to study the chief kinetic features of PUFA liver anabolism, looking upon (i) the time-dependency for the specific activity of Δ-6D, Δ-5D, Elovl2, Elovl2/5 and Elovl5, using n-3 and n-6 precursors between 0 and 240 min ex vivo in mouse liver.; and (ii) the specific activity-substrate (α-linolenic acid; ALA) concentration responses of Δ-6D in the absence and presence of linoleic acid (LA), arachidonic acid (ARA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), an enzyme regarded as the rate-limiting step in PUFA anabolism.

Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults.

Background: There are no studies examining the prospective joint association of device-based measures of sedentary time and physical activity (PA) with cancer mortality. We examined the joint associations of sedentary time and intensity-specific PA with cancer mortality in 72,458 adults from UK Biobank.

Methods: Participants wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days (with at least 1 weekend day).

Transport mechanisms of the anthropogenic contaminant sulfamethoxazole in volcanic ash soils at equilibrium pH evaluated using the HYDRUS-1D model.

The volcanic soils in Chile, where a significant portion of agricultural activities take place, are impacted by the presence of veterinary drugs, including sulfamethoxazole (SMX). The study examines how different soil types influence the movement and retention of sulfamethoxazole (SMX) across four regions of Chile, focusing on conditions at a neutral pH of 7.0.

goChem: A Composable Library for Multi-Scale Computational Chemistry Data Analysis.

Data analysis is a major task for Computational Chemists. The diversity of modeling tools currently available in Computational Chemistry requires the development of flexible analysis tools that can adapt to different systems and output formats. As a contribution to this need, we report the implementation of goChem, a versatile open-source library for multiscale analysis of computational chemistry data.

Plasmon-Enhanced Luminescence of Gold Nanoclusters by Using Silver and Gold Metal Nanostructures.

Plasmonic materials can be utilized as effective platforms to enhance luminescent signals of luminescent metal nanoclusters (LMNCs). Both surface enhanced fluorescence (SEF) and shell-isolated nanoparticle-enhanced fluorescence (SHINEF) strategies take advantage of the localized and increased external electric field created around the plasmonic metal surface when excited at or near their characteristic plasmonic resonance. In this context, we present an experimental and computational study of different plasmonic composites, (Ag) Ag@SiO2 and (Au) Au@SiO2 nanoparticles, which were used to enhance the luminescent signal of Au nanoclusters coated with glutathione (GSH) molecule (Au25GSH NCs).

Generic Competencies in Dentistry: Students' and Teachers' Perceptions of Their Professional Relevance and Their Development in Undergraduate Studies at Universidad Diego Portales of Chile.

Introduction: Generic competencies are transferable skills, knowledge and attitudes essential for personal and professional development and not restricted to any particular field. Evidence shows the relevance of incorporating them into the dentistry curriculum. However, defining which competencies to prioritise is complex and requires input from the academic community.

Validation of an Eye-Foot Coordination Assessment Tool for Children in Dual-Task Condition.

: Eye-foot coordination is essential in sports and daily life, enabling the synchronization of vision and movement for tasks like ball control or crossing obstacles. This study aimed to examine both the validity and reliability of an innovative eye-foot coordination (EFC) test in a dual-task paradigm in children aged 6-11 years and the capacity of this test to discriminate between sex and age. : A total of 440 schoolchildren aged 6-11 years participated in this cross-sectional study.

Association Between Physical Fitness and Cardiovascular Health in Chilean Schoolchildren from the Metropolitan Region.

Cardiovascular diseases increasingly impact youth, with early development of risk factors such as obesity, hypertension, and inadequate nutrient intake. Proper nutrient intake and physical fitness are vital for reducing these risks, especially in pediatric populations. This study explores the connection between physical fitness, metabolic risk, and nutrient status among 1656 Chilean schoolchildren from diverse socio-economic backgrounds.

Effect of Cashew Nut Consumption on Biomarkers of Copper and Zinc Status in Adolescents with Obesity: A Randomized Controlled Trial.

Background: Children and adolescents with obesity have altered serum copper (Cu) and zinc (Zn) levels, which are associated with oxidative stress, inflammation, and health outcomes. The inclusion of cashew nuts in an adequate diet may provide health benefits and help improve the mineral status of individuals with obesity.

Objective: To evaluate the effects of cashew nut consumption on biomarkers of Cu and Zn status in adolescents with obesity.

Dietary Counseling: An Option to Malnutrition and Masticatory Deficiency in Patients with Total Protheses? A Scoping Review.

Unlabelled: Given the rising global population of older adults and their association with edentulism and the use of complete removable prostheses [CRP], it is imperative to pursue solutions for issues such as the relationship between poor diets and masticatory deficiency.

Objective: To examine the research on the efficacy of dietary counseling in enhancing mastication and nutrition in older adults with CRP.

Methods: A systematic literature review was performed in the PubMed, Trip, and Web of Science databases.

Effects of Maca ( Walp.) on Physical Performance in Animals and Humans: A Systematic Review and Meta-Analysis.

Background: Walp. (LmW), known as maca, has been shown to increase physical performance. However, the effect size (ES) of LmW on the different manifestations of physical performance has not yet been described.

Screening and Selection of Native Lactic Acid Bacteria Isolated from Chilean Grapes.

The aim of this study was investigating the biological diversity of lactic acid bacteria isolated from Chilean grapes and identifying potential candidates for use as malolactic fermentation starter cultures. The isolated bacteria underwent a comprehensive six-stage screening process, which was mutually exclusive except for the evaluation of tyramine production and citric acid intake. This process included morphological, metabolic, fermentation yield, and resistance tests to identify promising malolactic strains.

Healthy Lifestyle Motivators of Willingness to Consume Healthy Food Brands: An Integrative Model.

This study evaluated how healthy lifestyle motivators (MHLs) influence the Peruvian market's willingness to consume healthy food (WCHBF). The main objective was to analyze the relationship of variables, such as attitude (ATT), perceived behavioral control (PBC), self-identity (SI), and moral norms (MN) with the WCHBF. This study adopted a quantitative, non-experimental, and cross-sectional approach, using a self-administered questionnaire for data collection.

Proteomic Profile of in Response to Heavy Metal Pollution in Lakes of Northern Patagonia.

Over recent decades, Northern Patagonia in Chile has seen significant growth in agriculture, livestock, forestry, and aquaculture, disrupting lake ecosystems and threatening native species. These environmental changes offer a chance to explore how anthropization impacts zooplankton communities from a molecular-ecological perspective. This study assessed the anthropogenic impact on by comparing its proteomes from two lakes: Llanquihue (anthropized) and Icalma (oligotrophic).

The Unexplored Role of Connexin Hemichannels in Promoting Facioscapulohumeral Muscular Dystrophy Progression.

DUX4 is typically a repressed transcription factor, but its aberrant activation in Facioscapulohumeral Muscular Dystrophy (FSHD) leads to cell death by disrupting muscle homeostasis. This disruption affects crucial processes such as myogenesis, sarcolemma integrity, gene regulation, oxidative stress, immune response, and many other biological pathways. Notably, these disrupted processes have been associated, in other pathological contexts, with the presence of connexin (Cx) hemichannels-transmembrane structures that mediate communication between the intracellular and extracellular environments.