[Seizure-induced brain injury in brain development and Zn2+ metastasis in hippocampus].

Zn2 + is a novel ionic mediator of neurotoxic injury in central nervous system. Zn2 + homeostasis in hippocampal Zinc-rich mossy fiber (MF) pathway is important in keeping the balance between excitatory and inhibitory system, and in maintaining cognitive functions of the brain. Abnormal Zn2+ metastasis occurred during MS sprouting induced by developmental seizures and influenced the function of hippocampus.

[Selective depletion of donor alloreactive T cells by using immuno-magnetic cell sorting].

This study was aimed to explore a new method of alleviating graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation through selective elimination of human alloreactive T cells expressing either CD25(+) or CD69(+) by immuno-magnetic cell sorting (MACS). Healthy donor peripheral blood mononuclear cells were cocultivated with bone marrow mononuclear cells from HLA-nonidentical leukemia recipient with remission in one-way mixed lymphocyte culture (OWMLC). After 3 days, both CD25(+) and CD69(+) lymphocytes were removed by MACS.