1,565 results match your criteria: "Children's hospital of Soochow University[Affiliation]"

Article Synopsis
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) using umbilical cord blood is a promising treatment for pediatric patients with acute leukemia, but acute graft-versus-host disease (aGVHD) is a significant complication.
  • A study of 71 patients found that 32.4% experienced aGVHD, with higher severity leading to worse overall survival rates at 5 years.
  • Post-transplant serum ferritin levels above 1650 ng/mL within two weeks were identified as a potential biomarker for an increased risk of severe aGVHD, highlighting its importance in patient monitoring.
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Article Synopsis
  • Prior antibiotic exposure, particularly to carbapenems and vancomycin, is linked to a higher incidence of Ventilator-Associated Pneumonia (VAP) in children on mechanical ventilation, with VAP affecting about 21.94% of the studied population.
  • The VAP group demonstrated significantly longer hospital and PICU stays, as well as increased mechanical ventilation duration compared to the non-VAP group, along with higher mortality rates (36.07% vs. 21.82%).
  • Factors such as prolonged carbapenem use (≥7 days), repeated intubations, and tracheostomy emerge as independent risk factors for VAP occurrence, highlighting the need for further research on antibiotic regimes.
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Contrasting presentations of children with ADHD and subthreshold ADHD.

Pediatr Res

August 2024

Suzhou Key Laboratory of Children's Structural Deformities, Suzhou, China.

Article Synopsis
  • * Both ADHD and subthreshold ADHD children face significant social functional impairments and have higher comorbidity rates than their healthy peers, underscoring the complexity of their mental health challenges.
  • * Factors such as inattention and anxiety/depression elevate the risk of functional impairments in ADHD, while a higher fat-free mass index may offer some protective benefits.
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  • Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal death and is linked to oxidative stress, which increases the risk of a cell death process called ferroptosis due to immature antioxidant defenses in neonates.
  • Researchers studied how mitophagy, a process that removes damaged mitochondria, can help prevent ferroptosis in a neonatal rat model of HIE using mitophagy activators and inhibitors.
  • The findings showed that a mitophagy activator (Tat-SPK2 peptide) reduced mitochondrial damage and ferroptosis, while inhibitors aggravated the condition, suggesting that enhancing mitophagy could be a potential therapeutic approach for HIE.
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Bladder fibrosis is the final common pathway of neurogenic bladder (NB), and its underlying mechanisms are not fully understood. The current study aims to evaluate the involvement of Piezo1, a mechanosensitive channel, in bladder fibrosis. A full-thickness bladder specimen was taken during ileocystoplasty or ureteral reimplantation from the surgical cut's edge.

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Background: Indoor environmental factors, such as pet ownership, presence of cockroaches, mattress quality, fuel usage (gas or electricity), use of biomass for cooking and heating, exposure to tobacco smoke or household molds can significantly affect the sleep quality of children with chronic cough. However, data regarding the effects of indoor environmental conditions on sleep in this population are limited. This study aimed to assess the prevalence of abnormal sleep behaviors and to establish associations between indoor environmental factors and sleep behaviors among children with chronic cough in Wuxi, China.

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Association of ultraprocessed food consumption with risk of rheumatoid arthritis: a retrospective cohort study in the UK Biobank.

Am J Clin Nutr

October 2024

Pediatric Clinical Research Institute, Children's Hospital of Soochow University, Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China. Electronic address:

Background: Limited studies explored the association between consumption of ultraprocessed food (UPF) and rheumatoid arthritis (RA).

Objectives: This study aimed to examine the association between UPF consumption and RA risk and explore the potential mediating effects of RA-related biomarkers.

Methods: This retrospective cohort study included 207,012 participants without RA at recruitment and completed 24-h dietary recalls.

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Manganese (Mn) play a crucial role in various biological processes in the body. Studies have primarily focused on their ability to enhance immune cell function and activation against tumors, particularly in dendritic cells (DCs), macrophages, and T cells. Tumor-associated macrophages (TAMs) are often the most abundant immune cell population present in the tumor microenvironment (TME).

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Background: Pectus carinatum (PC) mainly present at the growth spurt time of the early teenage years or the puberty. Poor outer appearance is a major reason for seeking help for surgeons to increase self-confidence and self-esteem. At present, minimally invasive repair (MIR) is one of effective ways to correct the chest wall deformity.

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Background: Osteosarcoma is the most common mesenchymal cell malignancy, 10% of which is fibroblastic osteosarcoma (FOS). Due to the low incidence of osteosarcoma, the impact of many pathological factors on survival is still unclear, especially FOS. The goal of this study was to assess the latest survival rates for FOS and the risk factors affecting survival using the Surveillance, Epidemiology, and End Results (SEER) database.

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Background: The current early warning model for organ damage in critically ill patients has certain limitations. Based on the pathological mechanism, the establishment of an early warning system for organ damage in critically ill children using cytokines profile has not been explored. The aim of this study is to explore the predicting value of cytokines in critically ill patients.

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Article Synopsis
  • Synovial sarcomas (SSs) are rare malignant tumors mostly affecting teenagers and young adults, accounting for 5% to 10% of soft tissue sarcomas, and this study aimed to evaluate survival rates and risk factors for children with SS using the SEER database.
  • The analysis included various factors such as age, sex, SEER stage, and treatment methods, finding that age, male sex, lack of surgery, chemotherapy use, and advanced SEER stage correlated with worse survival outcomes.
  • The study concluded that chemotherapy and advanced SEER stage are significant indicators of poor prognosis, and a nomogram was developed to predict patient survival rates over time, showing strong alignment with actual survival data.
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Background: This study aimed to analyze the clinical features of children with lobar pneumonia caused by (MP) infection, to explore the independent risk factors for bronchoscopic intervention in children with lobar pneumonia caused by MP infection. There is a lack of objective assessment tools to guide the use of bronchoscopy in clinical practice. For children with lobar pneumonia caused by MP infection, whether line shall be actively bronchoscope intervention therapy remains to be further defined.

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.

World J Pediatr

September 2024

Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

Article Synopsis
  • * The increasing prevalence of MRMP, particularly noted in East Asia since 2000, results in extended hospitalization, poor treatment responses, and higher use of glucocorticoids and alternative antibiotics.
  • * A group of 29 experts from China developed the first global consensus on diagnosing and treating pediatric MRMP pneumonia, emphasizing the importance of early identification and appropriate treatment strategies based on current evidence.
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Objectives: Both obesity and non-alcoholic fatty liver disease (NAFLD) increase the risk of metabolic abnormalities. However, the metabolic status of children suffering from NAFLD and exhibiting various subtypes of obesity is currently unclear. We aimed to explore the association between NAFLD and metabolic abnormalities in children with different weight statuses.

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Introduction: cGMP-dependent protein kinase 1 (PRKG1) has shown to be associated with some tumorigenesis, while the role of PRKG1 in bladder cancer is unclear.

Methods: To investigate the biological and clinical significance of PRKG1 in bladder cancer, we detected the expression of PRKG1 and explored the function of PRKG1 in bladder cancer cells. The PRKG1 transcripts data was downloaded from The Cancer Genome Atlas (TCGA) database, and immunohistochemistry staining was conducted on formalin-fixed paraffin-embedded (FFPE) sample tissues.

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Delineation of features, responses, outcomes, and prognostic factors in pediatric PDGFRB-positive acute lymphoblastic leukemia patients: A retrospective multicenter study.

Cancer

November 2024

Department of Pediatrics, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Article Synopsis
  • PDGFRB fusions in pediatric acute lymphoblastic leukemia (ALL) are rare, accounting for only 0.8% of tested cases.
  • A study involving 6457 patients over seven years identified 28 with PDGFRB-positive ALL, revealing a median age of 10 and a varied response to treatment.
  • The results highlighted that while chemotherapy with tyrosine-kinase inhibitors (TKIs) improved complete remission rates, high levels of measurable residual disease (≥0.01%) were linked to poorer outcomes, suggesting a need for tailored treatment strategies to improve survival.
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Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional mA modification in the nucleus.

Mol Cell

October 2024

College of Life Sciences, TaiKang Center for Life and Medical Sciences, Hubei Key Laboratory of Cell Homeostasis, RNA Institute, Wuhan University, Wuhan, China; Institute of Advanced Studies, Wuhan University, Wuhan, China; Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology, Wuhan University, Wuhan, China. Electronic address:

N-methyladenosine (mA) modification is deemed to be co-transcriptionally installed on pre-mRNAs, thereby influencing various downstream RNA metabolism events. However, the causal relationship between mA modification and RNA processing is often unclear, resulting in premature or even misleading generalizations on the function of mA modification. Here, we develop 4sU-coupled mA-level and isoform-characterization sequencing (4sU-mA-LAIC-seq) and 4sU-GLORI to quantify the mA levels for both newly synthesized and steady-state RNAs at transcript and single-base-resolution levels, respectively, which enable dissecting the relationship between mA modification and alternative RNA polyadenylation.

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Background: This study aimed to investigate the clinical characteristics of pediatric patients hospitalized with community-acquired pneumonia (CAP) and concomitant cytomegalovirus (CMV) infection.

Methods: This cross-sectional study enrolled consecutive pediatric patients admitted with CAP who tested positive for CMV DNA in bronchoalveolar lavage fluid (BALF). Flexible fiberoptic bronchoscopy was performed when routine treatment for CAP proved ineffective.

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The Epidemiologic and Clinical Features of Radiographic-Confirmed Community-Acquired Pneumonia Among Chinese Children: A Retrospective Hospital-Based Study.

Pediatr Infect Dis J

August 2024

From the Department of Epidemiology, School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.

Background: To help understand the disease burden of vaccine-preventable bacterial disease, we delineated the epidemiologic and clinical characteristics of radiographic-confirmed community-acquired pneumonia (CXR-CAP) among Chinese children.

Methods: We retrospectively screened the electronic database of the hospital information system to identify all pediatric CAP cases admitted to the Children's Hospital of Soochow University between 2010 and 2014. Radiographic findings and clinical data were extracted from the medical charts through individual chart reviews.

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Aims: To explore the distressing experiences of Chinese parents of children with cancer from the perspective of psychological inflexibility.

Design: A qualitative study using a descriptive qualitative approach based on the model of psychological inflexibility was adopted.

Methods: Individual semi-structured interviews through synchronized online video were conducted with 21 Chinese parents of children with cancer from October 2020 to May 2021.

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Asthma is a prevalent respiratory condition with multifaceted pathomechanisms, presenting challenges for therapeutic development. The SLC (Solute Carrier) gene family, encompassing diverse membrane transport proteins, plays pivotal roles in various human diseases by facilitating solute movement across biological membranes. These solutes include ions, sugars, amino acids, neurotransmitters, and drugs.

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Background: Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been reported to play a crucial role in osteosarcoma growth and metastasis. Therefore, there is an urgent need to identify specific targeted inhibitors of SEs to assist clinical therapy.

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Introduction: Congenital disorders of glycosylation (CDG) refer to monogenetic diseases characterized by defective glycosylation of proteins or lipids causing multi-organ disorders. Here, we investigate the clinical features and genetic variants of -CDG and conduct a preliminary investigation of its pathogenesis.

Methods: We retrospectively report the clinical data of a male infant with early life respiratory distress, congenital diaphragmatic eventration, cosmetic deformities, and moderate growth retardation.

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Article Synopsis
  • - The study evaluated a commercial AI-powered X-ray bone age analyzer's effectiveness compared to the Tanner-Whitehouse 3 (TW-3) method, finding that the AI system is both accurate and efficient in assessing bone age in children and adolescents.
  • - It used radiographs from 900 patients across 30 centers in China, with six doctors independently assessing the images alongside the AI, which performed better on average than one of the raters and matched performance with others in terms of accuracy.
  • - The AI analyzer achieved an impressive mean absolute error (MAE) of around 0.48 years for bone age estimates, suggesting it could enhance clinical workflow by significantly reducing the time required for evaluations.
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