Anal Sphincter Reconstruction Using the Posterior Sagittal Approach for Pediatric Perineal Trauma.

Traumatic perineal injuries are rare but can result in significant morbidity, particularly when the anal sphincter is injured. The management of such injuries in the pediatric population is rarely noted in the literature. We aimed to describe reconstruction in such patients using lessons learned in reoperative anorectal malformation surgery.

Early Continuous Electroencephalography, Clinical Parameters, and Short-Term Functional Outcomes in Pediatric Traumatic Brain Injury: Single-Center, Retrospective Cohort, 2010-2020.

Objectives: Traumatic brain injury (TBI) is a leading cause of pediatric morbidity and mortality. This study first investigates clinical characteristics and continuous electroencephalography (cEEG) parameters associated with short-term functional outcomes in pediatric patients following TBI. Second, we use these data for a hypothesis-generating model about outcomes.

Misinformation and Readability of Social Media Content on Pediatric Ankyloglossia and Other Oral Ties.

Importance: Diagnosis of pediatric ankyloglossia and other oral ties is increasing in part due to social media, leading to more frenotomies and excess medicalization of often normal anatomy.

Objective: To assess the accuracy and readability of social media content on pediatric ankyloglossia and other oral ties.

Design, Setting, And Participants: In this cross-sectional study, the top 200 posts on an image-based social media platform tagged with #tonguetie, #liptie, or #buccaltie were collected using a de novo account on March 27, 2023.

A Dangerous Hiding Spot: The Unrecognized Danger Posed by Child-Sized Helium Balloons.

Anticipatory guidance on balloons typically highlights the danger of choking on uninflated balloon fragments. One type of balloon injury that is not widely discussed is suffocation due to crawling inside a large foil helium-containing balloon. A six-year-old female presented to a community hospital emergency department (ED) after being found on the floor inside a 50-inch foil balloon in the shape of the number "7.

Surgical Efficacy Analysis of Traumatic Posterior Fossa Epidural Hematoma in Children.

Objective: To investigate the treatment effect and prognosis of posterior fossa epidural hematoma in children by different surgical methods.

Methods: The clinical data of 41 children with traumatic posterior fossa epidural hematoma treated by surgery in the Department of Neurosurgery from June 2015 to October 2023 were retrospectively analyzed. Among them, 32 cases underwent minimally invasive skull trepanation and drainage and 9 cases underwent craniotomy and hematoma removal.

Controversies in Artificial Intelligence in Neurosurgery.

Artificial intelligence (AI) has evolved from science fiction to a technology infiltrating everyday life. In neurosurgery, clinicians and researchers are exploring ways to implement this powerful tool to improve the safety and efficiency of the perioperative process. Current applications include preoperative diagnosis, intraoperative detection and recommendations, and technical skills assessment and feedback.

Expert opinion on use of vagus nerve stimulation therapy in the management of pediatric epilepsy: A Delphi consensus study.

Purpose: To provide consensus-based recommendations for use of vagus nerve stimulation (VNS) therapy in the management of pediatric epilepsy.

Methods: Delphi methodology with two rounds of online survey was used to build consensus. A steering committee developed 43 statements related to pediatric epilepsy and the use of VNS therapy, which were evaluated by a panel of 12 neurologists/neurosurgeons with expertise in pediatric epilepsy, who graded their agreement with each statement on a scale of 1 ("I do not agree at all") to 5 ("I strongly agree").

Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy. An Official American Thoracic Society Clinical Practice Guideline.

Background: Pulmonary hypertension in children often progresses despite optimal therapy. This document provides an evidence-based clinical practice guideline for the management of children with progressive pulmonary hypertension despite optimal therapy.

Methods: A multidisciplinary panel identified pertinent questions regarding the management of children with pulmonary hypertension that has progressed despite optimal therapy, conducted systematic reviews of the relevant literature, and applied the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach to develop clinical recommendations.

Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.

Study Objectives: Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.

The PPP - Perineal Body Preserving PSARP (Posterior Sagittal Anorectoplasty) for Anorectal Malformation with Rectovestibular Fistula in Females-Report of Early Outcomes.

Introduction:  The perineal body preserving posterior sagittal anorectoplasty (PSARP) (PPP) is a novel modification of the original PSARP for female patients with rectovestibular fistulas designed to eliminate the risk of perineal body dehiscence. This study aims to examine the outcomes following PPP.

Methods:  A retrospective, single-institution study was performed examining female patients with rectovestibular fistula who underwent PPP between January /2020 and December 2023.

Change in striatal functional connectivity networks across 2 years due to stimulant exposure in childhood ADHD: results from the ABCD sample.

Widely prescribed for Attention-Deficit/Hyperactivity Disorder (ADHD), stimulants (e.g., methylphenidate) have been studied for their chronic effects on the brain in prospective designs controlling dosage and adherence.

Negative effect of treatment with mGluR5 negative allosteric modulator AFQ056 on blood biomarkers in young individuals with Fragile X syndrome.

Background: Fragile X syndrome, with an approximate incidence rate of 1 in 4000 males to 1 in 8000 females, is the most prevalent genetic cause of heritable intellectual disability and the most common monogenic cause of autism spectrum disorder. The full mutation of the Fragile X Messenger Ribonucleoprotein-1 gene, characterized by an expansion of CGG trinucleotide repeats (>200 CGG repeats), leads to fragile X syndrome. Currently, there are no targeted treatments available for fragile X syndrome.

Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease.

Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2-years after biologic assignment to a Donor or No Donor (SOC) Arm based on the availability of an HLA-matched sibling or unrelated donor (BMTCTN 1503; NCT02766465). A donor search was commenced after eligibility confirmation.