7 results match your criteria: "Children's Hospital Los Angles[Affiliation]"
Prevalence of alternative lengthening of telomeres in pediatric sarcomas determined by the telomeric DNA C-circle assay.
Front Oncol
August 2024
Department of Pediatrics, Texas Tech University Health Sciences Center School of Medicine Cancer Center, Lubbock, TX, United States.
Article Synopsis
- Alternative lengthening of telomeres (ALT) is found in sarcomas, and this study investigates its frequency in Ewing's family sarcoma (EFS), rhabdomyosarcoma (RMS), and osteosarcoma (OS) using a specific PCR assay to detect telomeric DNA C-circles.
- After analyzing DNA from 273 primary tumor samples, results showed ALT in 0% of EFS, 2.7% of RMS, and 71% of OS, indicating a significant variability in ALT presence among these cancers.
- The findings suggest that the C-circle assay (CCA) is an effective method for identifying ALT in sarcomas and could serve as a valuable tool
Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease.
Circ Genom Precis Med
April 2023
Department of Medicine (M.J.L., B.K., W.K.C.), Columbia University Irving Medical Center, New York.
Improvement in sinonasal quality-of-life indicators for pediatric patients with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor.
Int Forum Allergy Rhinol
January 2023
Caruso Department of Otolaryngology - Head & Neck Surgery, Keck Medicine of University of Southern California, Los Angeles, USA.
Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations.
Emerg Microbes Infect
December 2021
Children's Hospital Los Angles, Department of Pathology and Laboratory Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
The SARS-CoV-2 B.1.1.
View Article and Find Full Text PDFEmerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications.
Emerg Microbes Infect
December 2021
Children's Hospital Los Angles, Department of Pathology and Laboratory Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Mutations in the SARS-CoV-2 Membrane (M) gene are relatively uncommon. The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate proteoglycan, viral protein assembly in conjunction with the N and E genes, and enhanced glucose transport. We have identified a recent spike in the frequency of reported SARS-CoV-2 genomes carrying M gene mutations.
View Article and Find Full Text PDFDoes Pain Intensity Matter? The Relation between Coping and Quality of Life in Pediatric Patients with Chronic Pain.
J Pediatr Nurs
October 2018
Department of Anesthesiology Critical Care Medicine, Children's Hospital Los Angeles, USA; University of Southern California University Center of Excellence for Developmental Disabilities, Children's Hospital Los Angeles, USA; Keck School of Medicine, Departments of Anesthesiology, Pediatrics, and Psychiatry & Behavioral Sciences, Children's Hospital Los Angles, Department of Anesthesiology Critical Care Medicine, USA. Electronic address:
Purpose: Chronic pain is a complex and debilitating chronic health condition that negatively impacts a child's daily function. Previous investigations of coping behaviors in youth with chronic illness have suggested that secondary control/accommodative coping may be more adaptive than primary control/active coping or disengagement/passive coping. However, studies have not considered how pain intensity may change the effect of various coping strategies on functioning in this pediatric population.
View Article and Find Full Text PDFThe use of TheraTogs versus twister cables in the treatment of in-toeing during gait in a child with spina bifida.
Pediatr Phys Ther
February 2013
Department of Rehabilitation Services, Children's Hospital Los Angles, Los Angeles, California, USA.
Purpose: To present the effects of TheraTogs and twister cables (TCs) on in-toeing during gait in a child with spina bifida while comparing overall parent and patient satisfaction.
Case Description: The participant was a 2-year-old girl with L4 spina bifida with bilateral in-toeing during gait.
Intervention: The child was given a 6-week intervention of TheraTogs followed by 6 weeks of TCs.