14 results match your criteria: "Children's Hospital Colorado Denver[Affiliation]"

Background: Cow's milk allergy (CMA) is the most complex and common food allergy in infants. Elimination of cow's milk from the diet and replacement with a specialized formula for infants with cow's milk allergy who cannot be breastfed is an established approach to minimize the risk of severe allergic reactions while avoiding nutritional deficiencies. Given the availability of multiple options, such as extensively hydrolyzed cow's milk-based formula (eHF-CM), aminoacid formula (AAF), hydrolyzed rice formula (HRF), and soy formula (SF), there is some uncertainty regarding which formula might represent the most suitable choice with respect to health outcomes.

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Objective: We examined post-concussion symptom presentation, exercise, and sleep among pediatric athletes who sustained concussion during the school year vs. summer months.

Methods: We evaluated athletes 6-18 years old within 21-days of concussion.

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Background: Pediatric dilated cardiomyopathy often leads to death or cardiac transplantation. We sought to determine whether changes in left ventricular (LV) end-diastolic dimension (LVEDD), LV end-diastolic posterior wall thickness, and LV fractional shortening (LVFS) over time may help predict adverse outcomes.

Methods And Results: We studied children up to 18 years old with dilated cardiomyopathy, enrolled between 1990 and 2009 in the Pediatric Cardiomyopathy Registry.

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Article Synopsis
  • IGFBPs are growth factor modifiers linked to pulmonary arterial hypertension (PAH) survival, with IGFBP7 being a key player in stimulating prostacyclin production.
  • Serum levels of IGFBP7 are notably higher in PAH patients compared to healthy controls and relate to worse exercise capacity and elevated heart pressure.
  • Increased IGFBP7 levels are associated with reduced survival rates in PAH, suggesting it could be a valuable target for future therapies.
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  • A proteomic study showed that patients with pulmonary arterial hypertension (PAH) have high levels of insulin-like growth factor binding protein 4 (IGFBP4), especially in connective tissue and idiopathic PAH subtypes.
  • Elevated IGFBP4 levels were significantly linked to worsening PAH severity, indicated by lower 6-minute walk distances, higher functional class, and greater right atrial pressures.
  • The study identified IGFBP4 as an independent predictor of survival in PAH patients, suggesting that the dysregulation of the insulin-like growth factor axis may impact the disease's progression and severity.
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Background Transplacental fetal treatment of immune-mediated fetal heart disease, including third-degree atrioventricular block (AVB III) and endocardial fibroelastosis, is controversial. Methods and Results To study the impact of routine transplacental fetal treatment, we reviewed 130 consecutive cases, including 108 with AVB III and 22 with other diagnoses (first-degree/second-degree atrioventricular block [n=10]; isolated endocardial fibroelastosis [n=9]; atrial bradycardia [n=3]). Dexamethasone was started at a median of 22.

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Article Synopsis
  • Pediatric cardiomyopathy is a serious heart condition in children with genetic diversity, and there's a need for consistent genetic testing across practices due to significant variations in testing rates.
  • A study involving 152 children revealed that 41% had a family history of cardiomyopathy, and 48% of those who had prior testing received positive results.
  • The research indicated that genetic testing can uncover the causes of cardiomyopathy in many children, suggesting routine testing may improve diagnosis and management.
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Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment) study was done to compare vascular function in patients with coarctation of the aorta treated with surgery, balloon dilation (BD), or stent implantation.

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Asthma imposes tremendous burden on children, families, and society. Successful management requires coordinated care among children, families, health providers, and schools. Building Bridges for Asthma Care Program, a school-centered program to coordinate care for successful asthma management, was developed, implemented, and evaluated.

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Background: Children with asthma are at increased risk for experiencing health and educational disparities because of increased school absence. School nurses are well positioned to support asthma management and improve school attendance.

Objective: We sought to implement and assess the effect of the Building Bridges for Asthma Care Program on improving school attendance and measures of asthma control.

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The term "children's interstitial lung disease" (chILD) refers to a heterogeneous group of rare and diffuse lung diseases associated with significant morbidity and mortality. These disorders include neuroendocrine cell hyperplasia of infancy, pulmonary interstitial glycogenosis, surfactant dysfunction mutations, and alveolar capillary dysplasia with misalignment of pulmonary veins. Diagnosis can be challenging, which may lead to a delay in recognition and treatment of these disorders.

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