2,154 results match your criteria: "Children's Hospital Affiliated to Zhengzhou University; Henan Children's Hospital; Zhengzhou Children's Hospital[Affiliation]"
What Mice Can Teach Us about How to Stop Drug-Resistant Tuberculosis: Correct Chemotherapy Regimen and Patient Compliance are the Key.
Biomed Environ Sci
September 2024
Laboratory of Molecular Epidemiology and Evolutionary Genetics, St. Petersburg Pasteur Institute, St. Petersburg, 197101, Russia.
Editorial: The diversified role of mitochondria in cancer.
Front Genet
September 2024
Center of Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Application of intraoperative abdominal aortic balloon occlusion for bleeding during cesarean section in pernicious placenta previa.
Am J Transl Res
September 2024
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University Chengdu 610041, Sichuan, China.
Article Synopsis
- The study analyzed the effectiveness of abdominal active balloon closure during cesarean sections for patients with pernicious placenta previa (PPP), involving 140 patients from a specific hospital.
- The patients were split into two groups: one received intraoperative abdominal aortic balloon occlusion (IAABO) during surgery, while the other did not.
- Results showed that the IAABO group experienced significantly less blood loss, lower transfusion rates, fewer hysterectomies, and improved postoperative recovery compared to the routine group, indicating it’s a beneficial intervention for such patients.
Recent advances and current status of gene therapy for epilepsy.
World J Pediatr
November 2024
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Article Synopsis
- Epilepsy is a prevalent neurological disorder that often lacks effective treatment options, especially for those with refractory epilepsy; gene therapy emerges as a promising approach with positive preclinical results and some progressing to clinical studies.
- The review analyzed research from PubMed/MEDLINE, focusing on methodologies related to gene therapy technology, including CRISPR/Cas9 and various viral vectors, addressing how these can alleviate epilepsy symptoms.
- Despite advancements, significant challenges remain for clinical applications of gene therapy in epilepsy, such as issues with delivery vectors, model effectiveness, and ethical concerns, suggesting the need for tailored treatments and collaborative strategies in future research.
Integrating Contrast-enhanced US to O-RADS US for Classification of Adnexal Lesions with Solid Components: Time-intensity Curve Analysis versus Visual Assessment.
Radiol Imaging Cancer
November 2024
From the Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong, China (M.W., Y.W., M.S., L.H., X.Z.); Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, China (R.W.); Department of Ultrasound, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.S.); Department of Ultrasound, Children's Hospital of Shanxi (Women Health Center of Shanxi), Taiyuan, China (R.Z.); Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, China (L.M.); Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, China (L.X.); Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, China (H.W.); Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (T.L.); and Department of Ultrasound, The Third Hospital of BaoGang Group, Maternity Hospital of Bao Tou, Baotou, China (X.M.).
Article Synopsis
- The study aimed to evaluate how effective time-intensity curve (TIC) analysis and subjective visual assessment of contrast-enhanced ultrasound (CEUS) are when combined with the Ovarian-Adnexal Reporting and Data System (O-RADS) for diagnosing adnexal lesions with solid components.
- Conducted at multiple centers from September 2021 to December 2022, the study analyzed 180 lesions from 175 women, comparing diagnostic performances using receiver operating characteristic curves.
- Results showed that integrating CEUS with O-RADS significantly improved diagnostic accuracy (AUC 0.86) compared to O-RADS alone (AUC 0.78), and both CEUS assessment methods (TIC and subjective assessment
[Prediction of hemorrhage rate after tonsil surgery in children based on random forest model].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
October 2024
Article Synopsis
- Hemorrhage after tonsil surgery in children poses serious risks, leading to a study aimed at creating a risk warning model for predicting bleeding post-surgery.
- The study analyzed data from 8,854 children who underwent tonsillectomy, ultimately focusing on 2,724 cases, to distinguish between those who experienced bleeding and those who did not.
- Using a random forest algorithm, the model achieved a high prediction accuracy of 98.72% for postoperative bleeding, demonstrating potential for improving clinical decision-making despite needing to enhance the recall rate.
Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual aurora kinase A and B.
Eur J Med Chem
December 2024
Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China. Electronic address:
Article Synopsis
- Aurora kinases A and B are vital for cell division, and their abnormal activity can lead to cancer; thus, inhibitors targeting these kinases are being researched as potential cancer treatments.
- The study highlights a new compound, 6k, which showed strong cytotoxic effects against HeLa and HepG2 cancer cells, specifically inhibiting Aurora kinases A and B at very low concentrations.
- 6k was found to induce cell cycle arrest at the G2/M phase, increase signs of apoptosis, and demonstrated promising drug-like properties, suggesting it may be a candidate for further testing in cancer therapy.
Enzymatically Cyclic Activated Biosensor Based on a Tetrahedral DNA Framework for Precise Tumor Molecular Imaging.
ACS Sens
October 2024
Health Commission of Henan Province Key Laboratory for Precision Diagnosis and Treatment of Pediatric Tumor, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, China.
Article Synopsis
- - The study focuses on developing a sensitive and specific biosensor for tumor molecular imaging using a modified DNA framework that targets a specific enzyme called APE1, which is more active in cancer cells compared to normal cells.
- - This biosensor utilizes the unique ability of APE1 to cleave a specific site in the DNA framework, triggering a fluorescence signal that enhances the detection of tumor cells while minimizing noise from off-tumor signals.
- - The results show that this biosensor can accurately distinguish tumor cells and assess drug resistance in neuroblastoma, offering potential for better patient risk classification in clinical settings.
Clinical Analysis of Inhaled Nitric Oxide Therapy in Preterm Infants at Different Gestational Ages: A National Retrospective Multicenter Study.
Am J Perinatol
October 2024
Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Article Synopsis
- This study examined the use and effects of inhaled nitric oxide (iNO) in preterm infants under 34 weeks gestational age across eight hospitals in China over a span of ten years.
- A total of 434 infants were analyzed, categorized into three gestational age groups: extremely preterm (24-27 weeks), very preterm (28-31 weeks), and moderate preterm (32-33 weeks), focusing on treatment outcomes and complications.
- Findings indicated that extremely preterm infants had the highest rates of iNO treatment and associated complications, with mortality rates inversely related to gestational age and birth weight, underscoring the importance of iNO in managing severe respiratory issues in this population.
Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases.
Pediatr Res
October 2024
Department of Rheumatology and Immunology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Article Synopsis
- This study looked at how COVID-19 affects kids with rheumatic diseases in China.
- The researchers found that many kids showed symptoms like fever and cough, but most didn’t get very sick.
- Vaccinated kids had a quicker recovery time and were less likely to be hospitalized compared to those who weren’t vaccinated.
Gut microbiota causally impacts adrenal function: a two-sample mendelian randomization study.
Sci Rep
October 2024
Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, People's Republic of China.
Article Synopsis
- * A two-sample Mendelian randomization analysis was conducted using data from genome-wide association studies to investigate these causal relationships, yielding 27 identified connections between 23 types of gut microbiota and various regions of the adrenal gland.
- * Notable findings include the identification of Sellimonas, which enhances adrenal cortex function, while other bacteria like Parasutterella and Sutterella affect different adrenal areas; this research highlights the gut-microbiota-brain connection and has implications for diagnosing and treating adrenal diseases.
SARS-CoV-2 S protein harbors furin cleavage site located in a short loop between antiparallel β-strand.
Int J Biol Macromol
November 2024
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. Electronic address:
Furin cleavage site (FCS) of the SARS-CoV-2 S protein, which connects the S1/S2 junction, is essential for facilitating fusion with the host cells. Wild-type (Wt) SARS-CoV-2 S protein, PDB ID: 6yvb, lacks a sequence of amino acid residues, including the FCS that links the S1/S2 junction. For the first time, we demonstrated that a stretch of 14 amino acid residues (677QTNSPRRARSVASQ689) forms an antiparallel β-sheet comprising of PRRAR sequence in the FCS within a short loop.
View Article and Find Full Text PDFThe impact of the COVID-19 pandemic on RSV outbreaks in children: A multicenter study from China.
Respir Med
November 2024
Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China. Electronic address:
Article Synopsis
- The study investigates how RSV (Respiratory Syncytial Virus) prevalence patterns in China were affected during the COVID-19 pandemic from 2019 to 2022.
- It analyzed data from over 872,000 children and found that while RSV detection rates rose during the pandemic, especially in children under 5, a notable decline occurred in 2022.
- The research concludes that the pandemic disrupted typical RSV seasonal patterns, resulting in increased year-long outbreaks and a lack of clear seasonal trends post-April 2022.
Association of neonatal outcome with birth weight for gestational age in Chinese very preterm infants: a retrospective cohort study.
Ital J Pediatr
October 2024
Division of Neonatology, The Affiliated Hospital of Qingdao University, NO. 16 Jiang Su Street, Qingdao, Shandong Province, 266000, China.
Article Synopsis
- The study investigated the neonatal outcomes of preterm infants (24-31 weeks gestational age) in 57 hospitals across China, focusing on how birth weight for gestational age affects health risks.
- It included 8,380 infants, finding that lower birth weight was linked to higher risks of serious health issues like mortality, necrotizing enterocolitis, and bronchopulmonary dysplasia.
- The research concluded that infants with birth weights below the 30th percentile face significantly higher risks for adverse outcomes, highlighting the need for close monitoring and early intervention for these vulnerable infants.
Genetic testing in pediatric kidney transplant recipients to promote informed choice and improve individualized monitoring.
Orphanet J Rare Dis
October 2024
Department of Renal Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Background: The growing body of research on kidney disease in children has identified a broad spectrum of genetic etiologies.
Methods: We conducted a prospective study to evaluate the efficacy of an optimized genetic test and subclinical changes in a real-world context before kidney transplantation. All cases involved recipients under the age of 18 who underwent whole exome sequencing (ES) between 2013 and 2022.
acFibroMASH Index for the Diagnosis of Fibrotic MASH and Prediction of Liver-related Events: An International Multicenter Study.
Clin Gastroenterol Hepatol
October 2024
MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, Zhejiang, China. Electronic address:
Article Synopsis
- Scientists studied a health problem called MASH, which affects people's livers, and worked on two tests to help doctors tell if someone has it.
- They looked at data from over 3,000 people to make sure their first test, called acMASH, worked well, and then created a new test called acFibroMASH to find more severe cases.
- The new acFibroMASH test was better at predicting who might have future liver problems compared to another test, showing it's a useful tool for doctors to keep patients healthy.
Formononetin Mitigates Liver Fibrosis via Promoting Hepatic Stellate Cell Senescence and Inhibiting EZH2/YAP Axis.
J Agric Food Chem
October 2024
Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou 450008, China.
Article Synopsis
- Formononetin (FMN) is a natural compound from certain plants that may help fight diseases, especially liver problems.
- This study showed that FMN protects mice from liver damage caused by specific chemicals and helps stop certain liver cells from turning bad.
- FMN works by changing the way certain proteins act in the liver, which helps older cells survive and reduces liver scarring.
Long noncoding RNA UCA1 inhibits epirubicin-induced apoptosis by activating PPARα-mediated lipid metabolism.
Exp Cell Res
October 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University and the Key Clinical Laboratory of Henan Province, Zhengzhou, China. Electronic address:
Metabolic reprogramming is a hallmark of cancer, and abnormal lipid metabolism is associated with drug resistance in bladder cancer cells. The long noncoding RNA (lncRNA) UCA1 is overexpressed in bladder cancer, but its functional contribution to lipid metabolism remains uncharacterized. In this study, we demonstrated that lncRNA UCA1 inhibits epirubicin-induced cell apoptosis by supporting abnormal lipid metabolism in bladder cancer cells.
View Article and Find Full Text PDFCharacteristics of oral mucosal pressure injuries in children with orotracheal intubation in intensive care units: An observational study.
Nurs Crit Care
September 2024
Nursing Department, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Background: Tracheal intubation can be used for ventilation to ensure an unobstructed respiratory tract, and it is the most common respiratory support technique used in paediatric intensive care unit (PICU) patients. Orotracheal intubation is usually the preferred method of tracheal intubation. However, it can cause stress-related damage to the oral mucosa.
View Article and Find Full Text PDFA multicentre, randomized, double-blind, placebo-controlled trial of topical oestradiol gel for endometrial regeneration after induced abortion.
Hum Reprod
November 2024
Department of Obstetrics and Gynaecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
Study Question: Is topical oestradiol gel effective in promoting endometrial regeneration after a surgical abortion?
Summary Answer: Topical oestradiol gel is effective in promoting endometrial regeneration after a surgical abortion with few side-effects.
What Is Known Already: Oestrogen is effective in promoting endometrial regeneration. Transdermal oestrogen has been widely used in clinical practice for endometrial regeneration after induced abortion, but high-level evidence is limited.
[Clinical characteristics and genetic analysis of a child with Cantú syndrome due to variant of ABCC9 gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2024
Henan Provincial Neurodevelopment Engineering Research Center for Children, Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan 450066, China.
Article Synopsis
- * The child showed distinctive symptoms like excessive body hair and facial abnormalities, along with a heart defect identified prior to the study.
- * Genetic analysis revealed a likely pathogenic variant in the ABCC9 gene that is believed to contribute to the child’s condition, supporting its role in Cantú syndrome.
Discovery of a potent, Highly selective, and In vivo anti-inflammatory Efficacious, P2YR antagonist with a novel quinoline-pyrazole scaffold.
Eur J Med Chem
December 2024
Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, 450018, China. Electronic address:
The P2Y receptor (P2YR), as a crucial member of the purine family, is a potential therapeutic target for the treatment of intestinal inflammation, tracheal inflammation and diabetes. We first discovered the hit compound (5a, IC = 168.5 nM against P2YR) through our in-house library screening.
View Article and Find Full Text PDFConsensus on the monitoring, treatment, and prevention of leukaemia relapse after allogeneic haematopoietic stem cell transplantation in China: 2024 update.
Cancer Lett
November 2024
Peking University People's Hospital & Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, PR China; Peking-Tsinghua Center for Life Sciences, Beijing, PR China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China. Electronic address:
Article Synopsis
- In 2018, the Chinese Society of Haematology established guidelines for monitoring and treating leukaemia relapse after stem cell transplantation, enhancing China's clinical practices and global integration.
- Recently, experts updated the consensus to include a strategy focused on measurable residual disease (MRD) and improved therapies, emphasizing haploidentical HSCT for high-risk patients.
- The updated guidelines promote advancements in MRD detection methods and explore new targeted treatment options, underscoring a significant progression in managing post-transplant leukaemia relapses.
Case Report: Clinical manifestations and treatment of two Chinese patients with FINCA syndrome carrying a novel variant of .
Front Pediatr
September 2024
Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
Article Synopsis
- FINCA syndrome is a rare genetic disorder caused by mutations in the NHL-repeat-containing protein 2 (NHLRC2) gene, leading to issues like fibrosis and neurodegeneration.
- A case study of two Chinese siblings illustrates the severe symptoms they experienced, including interstitial lung disease (ILD) and similar chest CT scans, highlighting the severity of the condition.
- While the elder brother tragically passed away due to respiratory failure, the younger brother's health improved significantly with long-term glucocorticoid treatment, suggesting that anti-inflammatory therapies could help manage ILD symptoms in FINCA syndrome.
Pickle water ameliorates castor oil-induced diarrhea in mice by regulating the homeostasis of the gut microbiota and intestinal mucosal barrier.
Front Nutr
September 2024
School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Introduction: Diarrhea is a common clinical condition that can potentially be fatal. Current treatment options often have side effects, such as constipation and vomiting, and there remains a need for more effective therapies. Pickled vegetables, a famous traditional food in China, have been suggested in clinical studies to alleviate diarrhea in children, particularly through the use of pickle water (PW).
View Article and Find Full Text PDF