5,253 results match your criteria: "Children's Hospital "Pan. & Aglaia Kyriakou"[Affiliation]"
Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs.
Invest Ophthalmol Vis Sci
October 2024
The State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou Medical University, Wenzhou, China.
Article Synopsis
- The study aims to create induced microglia-like cells (iMG) from stem cells in a controlled environment and enhance their functionality by coculturing them with retinal organoids.
- Researchers established iMG production conditions, stimulated these cells, and compared their characteristics with a standard microglia cell line (HMC3) to understand their immune responses and maturation.
- The results showed that iMG closely resemble primary human microglia in immune functions, and further maturation with retinal organoids (CC-iMG) led to significant improvements in their cellular activities and properties, potentially aiding future research and therapies related to microglial functions.*
Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial.
Drug Des Devel Ther
October 2024
Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Key Laboratory of Pediatric Anesthesiology of Ministry of Education, Wenzhou, Zhejiang Province, People's Republic of China.
Article Synopsis
- The study investigated how different doses of fentanyl affect the required dose of ciprofol for smooth insertion of a laryngeal mask airway (LMA) in healthy preschool children undergoing surgery.
- 90 patients were divided into three groups, receiving either ciprofol alone or ciprofol with varying doses of fentanyl, with the main outcome being the effective dose of ciprofol needed for LMA insertion.
- Results showed that higher doses of fentanyl significantly reduced the amount of ciprofol needed and decreased the time to loss of consciousness, with minimal side effects reported among the groups.
Epidermal second-hit mutation in gene associated with linear porokeratosis.
Genes Dis
January 2025
Department of Dermatology, The Children's Hospital of Fudan University, Shanghai 201102, China.
Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors.
J Exp Clin Cancer Res
October 2024
Department of Hematology, Children's Hospital of Soochow University, SIP, No.92 Zhongnan Street, Suzhou, Jiangsu, China.
Article Synopsis
- Pediatric T-cell acute lymphoblastic leukemia (T-ALL) still poses significant challenges, including treatment resistance and recurrence, despite advances in prognosis, with LIM domain-binding protein 1 (LDB1) playing a crucial role in this context.
- * Researchers utilized techniques like shRNA, RNA-Seq, and CUT&Tag to analyze LDB1's function in T-ALL cell lines and uncovered its cooperation with key transcription factors (ERG, ETV6, IRF1) to regulate downstream targets.
- * The study concludes that LDB1 is essential for T-ALL cell proliferation and survival, specifically regulating the significant target gene MYB, thus providing insights into its role in T-ALL progression.*
Vision transformer introduces a new vitality to the classification of renal pathology.
BMC Nephrol
October 2024
Department of Nephrology, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang, PR China.
Article Synopsis
- Recent advancements in AI, particularly in computer vision, are being applied to medical fields, but classifying renal pathology is still challenging due to subtle differences in types.
- The study developed a Vision Transformer (ViT) model using 1861 stained renal histopathology images from 635 patients, categorizing them into 14 different classes.
- Results showed that the ViT model significantly outperformed traditional CNN models in accuracy (0.96-0.99) and demonstrated an ability to highlight important pathological structures, aiding in the diagnosis and treatment of renal diseases.
Chromosome 8 Inversion Mutation in Congenital Generalized Hypertrichosis: Precise Breakpoints Localization.
Br J Dermatol
October 2024
Department of Dermatology, The Children's Hospital of Fudan University, Shanghai 201102, China.
SLAMF8 regulates osteogenesis and adipogenesis of bone marrow mesenchymal stem cells via S100A6/Wnt/β-catenin signaling pathway.
Stem Cell Res Ther
October 2024
Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Article Synopsis
- The study investigates the role of SLAMF8 in bone healing by analyzing its effects on inflammatory responses and osteogenesis in mouse bone marrow mesenchymal stem cells (mBMSCs).
- Researchers utilized GEO datasets and various molecular techniques to assess how SLAMF8 influences genes related to bone formation (like RUNX2 and COL1A1) and fat formation (like PPARγ).
- Results showed that knocking down SLAMF8 reduced bone formation and increased fat formation in mBMSCs, while its overexpression enhanced bone healing in a femoral fracture model.
Pediatric Myelodysplastic Syndrome.
Arch Pathol Lab Med
October 2024
From the Center for Cancer and Blood Disorders (Inam, Diab, Schore, Vatsayan, Cheng), Children's National Hospital, Washington, DC.
Context.—: Myelodysplastic syndromes (MDSs) are rare in children and have unique clinical manifestations and implications.
Objective.
Implementation study of the CARRA Uveitis Consensus Treatment Plans: feasibility for clinical practice and applicability for research.
Pediatr Rheumatol Online J
October 2024
Division of Immunology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave, Fegan 6 Boston, Boston, MA, 02115, USA.
Article Synopsis
- Chronic anterior uveitis (CAU) can cause serious eye problems, so doctors created treatment plans to help kids with it.
- The study looked at how these treatment plans worked for kids with a type of arthritis-related eye condition, tracking their medicine and eye health over time.
- Results showed that most kids had good control of their uveitis after six months, and both treatment plans were successfully used in real-life doctor visits.
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Life Sci
November 2024
Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, PR China; Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, PR China. Electronic address:
Article Synopsis
- Scientists studied heart problems in patients with a condition called Tetralogy of Fallot (TOF) where the heart doesn't get enough oxygen, causing damage to heart cells.
- They found that a molecule called FOXO1 is very important in how these heart cells get hurt when there's not enough oxygen.
- By figuring out how FOXO1 works and what protects heart cells, researchers hope to find ways to help prevent heart damage in patients with TOF.
Colchicine prevents perioperative myocardial injury in cardiac surgery by inhibiting the formation of neutrophil extracellular traps: evidence from rat models.
Eur J Cardiothorac Surg
October 2024
Department of Cardiac Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Article Synopsis
- * In a study with male rats, colchicine treatment significantly decreased myocardial damage after cardiopulmonary bypass and ischemia/reperfusion injury, while also elevating NET levels in heart tissue.
- * The findings suggest that colchicine protects the heart during surgery by targeting NET formation, with one mechanism being the inhibition of an enzyme called peptidylarginine deiminase 4.
The Use of Remote Presence Robotic Tele-Presentation in Rural and Remote Canada: A Systematic Review.
Telemed J E Health
October 2024
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Article Synopsis
- Remote presence robotic tele-presentation is a technology that enables healthcare providers to treat patients remotely in rural and remote areas through robotic devices.
- A review of six studies indicated high satisfaction rates among patients and healthcare professionals, with many patients receiving care in their home communities instead of having to travel to urban centers.
- The evidence suggests that this approach is both safe and cost-effective, as it can reduce the need for patient transfers to larger hospitals while providing adequate medical services and imaging in certain cases.
Dual-energy computed tomography-based radiomics for differentiating patients with and without gout flares.
Clin Rheumatol
December 2024
Gout Laboratory, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
Article Synopsis
- This study aimed to develop and validate a dual-energy computed tomography-based radiomics model to differentiate between patients with gout flares and those without, addressing a current research gap.
- It involved analyzing data from 200 patients, including 150 with past gout flares, to extract and evaluate specific radiomic features related to tophi in the foot joints, utilizing advanced statistical methods for model development.
- The comprehensive model, which combined optimal radiomic features and key clinical factors like disease duration and hypertension, showed strong predictive performance, outperforming individual models in clinical relevance and accuracy.
Article Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
Impact of early continuous positive airway pressure in the delivery room (DR-CPAP) on neonates < 1500 g in a low-resource setting: a protocol for a pilot feasibility and acceptability randomized controlled trial.
Pilot Feasibility Stud
October 2024
Mbale Clinical Research Institute (MCRI), Mbale, Uganda.
Background: Preterm birth is the leading cause of childhood mortality, and respiratory distress syndrome is the predominant cause of these deaths. Early continuous positive airway pressure is effective in high-resource settings, reducing the rate of continuous positive airway pressure failure, and the need for mechanical ventilation and surfactant. However, most deaths in preterm infants occur in low-resource settings without access to mechanical ventilation or surfactant.
View Article and Find Full Text PDFAssociation of neonatal outcome with birth weight for gestational age in Chinese very preterm infants: a retrospective cohort study.
Ital J Pediatr
October 2024
Division of Neonatology, The Affiliated Hospital of Qingdao University, NO. 16 Jiang Su Street, Qingdao, Shandong Province, 266000, China.
Article Synopsis
- The study investigated the neonatal outcomes of preterm infants (24-31 weeks gestational age) in 57 hospitals across China, focusing on how birth weight for gestational age affects health risks.
- It included 8,380 infants, finding that lower birth weight was linked to higher risks of serious health issues like mortality, necrotizing enterocolitis, and bronchopulmonary dysplasia.
- The research concluded that infants with birth weights below the 30th percentile face significantly higher risks for adverse outcomes, highlighting the need for close monitoring and early intervention for these vulnerable infants.
Trends in antimicrobial resistance amongst Salmonella Typhi in Bangladesh: A 24-year retrospective observational study (1999-2022).
PLoS Negl Trop Dis
October 2024
Child Health Research Foundation, Dhaka, Bangladesh.
Article Synopsis
- Rising antimicrobial resistance (AMR) in Salmonella Typhi poses a significant threat to typhoid treatment, especially in high-burden countries like Bangladesh, where long-term data is lacking.
- The study analyzed typhoid cases in Dhaka from 1999 to 2022, finding a decrease in multidrug resistance (MDR) from 38% to 17% and a drop in cotrimoxazole consumption, while resistance to ciprofloxacin remained high (>90%).
- With a noted decline in MDR, the research suggests that first-line antibiotics may be safely reintroduced for treating typhoid fever, pending further decreases in resistance rates.
Pediatric RVOT reconstruction with ePTFE trileaflet valved conduits: a dual-center Chinese study.
Front Cardiovasc Med
September 2024
Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Heart Center, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Objective: This study aims to assess the early to mid-term clinical efficacy of expanded polytetrafluoroethylene (ePTFE) trileaflet valved conduits in pediatric right ventricular outflow tract reconstruction for congenital heart disease.
Methods: We conducted a retrospective analysis of pediatric patients who underwent right ventricular outflow tract (RVOT) reconstruction using ePTFE trileaflet valved conduits at two cardiac centers in China, between January 2017 and June 2023. The main assessment criterion was the functionality of the prosthetic pulmonary valve conduit.
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas.
Nat Commun
October 2024
Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.
Article Synopsis
- Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a diverse and challenging type of cancer that often has poor outcomes, especially in younger patients lacking the SMARCB1 protein.
- Research indicated that human and mouse PTCL-NOS exhibit similar DNA changes, including the hypermethylation of T-cell genes and the hypomethylation of myeloid development genes, contributing to a complicated tumor ecosystem.
- A study found that histone deacetylase inhibitors (HDACi), like SAHA, can effectively treat PTCL-NOS by modifying the tumor's microenvironment and improving immune function, paving the way for potential combination therapies.
A multivalent mRNA-LNP vaccine protects against infection.
Science
October 2024
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Clostridium difficile infection (CDI) poses a significant public health risk, with few prevention methods available.* -
- Researchers developed a multivalent mRNA-lipid nanoparticle vaccine that stimulates strong immune responses in various animal models, unaffected by gut microbiota changes.* -
- The vaccine effectively protects mice from severe CDI and enhances the elimination of harmful bacteria from the gut, highlighting mRNA-LNP technology as a potential new treatment avenue.*
Curriculum Innovation: Design and Implementation of Synchronous and Asynchronous Curricula to Enhance Residents' EEG Knowledge and Experience.
Neurol Educ
December 2023
From the Department of Neurology (A.F.), Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Department of Neurology (J.J.M.), Yale School of Medicine, New Haven, CT; Department of Neurology (D.B.H.), Children's National Medical Center, Washington, DC; Department of Neurology (R.M.G.), Washington University School of Medicine and St. Louis Childrens Hospital, MO; Department of Neurology (J.P.), University of Pennsylvania, Philadelphia; Minnesota Epilepsy Group, P.A. (N.A., K.S.), Roseville, MN; Division of Pediatric Neurology (J.M.C.), Connecticut Childrens, University of Connecticut School of Medicine, Hartford, CT; American Epilepsy Society (A.K.), Chicago, IL; Department of Neurology (F.A.L.), Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY; and Department of Neurology (D.J.W.), St. Louis University, MO.
Introduction And Problem Statement: There is a need for structured EEG education opportunities to enhance neurology resident education. To address this need, the American Epilepsy Society (AES) supported the development and implementation of both synchronous and asynchronous EEG courses.
Objectives: To produce EEG curricula that enhance resident EEG learning, increase interest in EEG and improve participants' knowledge, and to ensure that courses were highly used and available to the broadest range of learners.
Long noncoding RNA UCA1 inhibits epirubicin-induced apoptosis by activating PPARα-mediated lipid metabolism.
Exp Cell Res
October 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University and the Key Clinical Laboratory of Henan Province, Zhengzhou, China. Electronic address:
Metabolic reprogramming is a hallmark of cancer, and abnormal lipid metabolism is associated with drug resistance in bladder cancer cells. The long noncoding RNA (lncRNA) UCA1 is overexpressed in bladder cancer, but its functional contribution to lipid metabolism remains uncharacterized. In this study, we demonstrated that lncRNA UCA1 inhibits epirubicin-induced cell apoptosis by supporting abnormal lipid metabolism in bladder cancer cells.
View Article and Find Full Text PDFAnalysis on childhood fever health information seeking behaviors in online health community using a mixed-methods approach.
Digit Health
September 2024
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Objective: The primary aim of this study is to analyze health information seeking behaviors of users related to child fever within online health communities. The findings will serve as a foundation for the development of targeted interventions and resources for addressing the specific information needs related to child fever. Ultimately, this will enhance parental capabilities in managing fever in children and for improving the quality of communication between healthcare professionals and parents dealing with feverish children.
View Article and Find Full Text PDFDichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome.
Exp Mol Med
October 2024
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.
Article Synopsis
- This study explores how alternative cleavage and polyadenylation within introns (intronic APA) create shorter mRNA variants, revealing complex responses to mTOR activity that either increase or decrease intronic APA for different genes.
- Using RNA-seq data from The Cancer Genome Atlas, researchers found a consistent pattern of contrasting intronic APA in normal and cancerous tissues, indicating its significant role in transcriptomic processes.
- The analysis showed that protein length changes due to intronic APA could lead to functional differences, particularly in cancer contexts, suggesting that intronic APA is an important factor in shaping the cancer proteome and its functionality.
Current Status and Factors Influencing Mental Health Literacy in Patients With Coronary Heart Disease: A Cross-Sectional Study.
Nurs Health Sci
December 2024
Department of Nursing, Anhui Women and Children's Medical Center, Hefei, China.
This study aimed to investigate the current status of mental health literacy and related influencing factors in patients with coronary heart disease. Four hundred and thirty-five patients with coronary heart disease were recruited in this survey. Data collection was conducted using the General Information Questionnaire, the Chinese version of the Mental Health Literacy Scale, Coronary Artery Disease Self-Management Scale, Social Support Rating Scale, and Coronary Heart Disease Self-Efficacy Scale.
View Article and Find Full Text PDF