924 results match your criteria: "Children's Heart Center[Affiliation]"

Introduction: Fetuses with hypoplastic left heart syndrome (HLHS) and intact atrial septum (IAS) have an overall poor prognosis and a high risk of neonatal death due to severe secondary lung damage. Intrauterine stenting of the atrial septum was introduced in these patients to enable survival.

Case Presentation: We present a case of a HLHS fetus with IAS and signs of incipient nutmeg lung, in whom at 30 weeks gestation an atrial stent was successfully placed but continuously developed subtotal stent-obstruction over the next weeks.

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A new perspective on atrial tachycardia-induced cardiomyopathy: The misdiagnosis of epigastric pain in an 11-year-old girl.

Radiol Case Rep

December 2024

The Children's Heart Center, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, 100 Hongkong Road, Jiangan District, Wuhan, Hubei, China.

Article Synopsis
  • * An 11-year-old girl was first misdiagnosed with acute gastritis, highlighting the importance of accurate diagnosis.
  • * Early detection and intervention can significantly improve patient outcomes and prevent serious complications.
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A novel format of TNF-α binding affibody molecule ameliorate coronary artery endothelial injury in a mouse model of Kawasaki disease.

Int J Biol Macromol

November 2024

Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Structural Malformations in Children of Zhejiang Province, 325027 Wenzhou, Zhejiang, China; Children's Heart Center, Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Article Synopsis
  • Kawasaki disease (KD) is an autoimmune condition that affects blood vessels and can lead to heart issues, prompting research into new treatment methods like anti-TNFα monoclonal antibodies.
  • A novel therapeutic agent, an affibody designed to target TNF-α, was developed and showed strong binding and neutralizing effects against TNF-α, differentiating it from traditional mAbs.
  • The engineered affibody, known as ZTAT, demonstrated effectiveness in treating KD-related endothelial injury, showcasing potential as a cost-effective therapeutic option with a longer serum half-life.
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Hereditary connective tissue diseases have different risks of aortic dissection depending on the causative gene. We report a family with no extravascular phenotype and a clinical diagnosis of familial thoracic aortic aneurysm and dissection, but genetic testing confirmed p.Tyr470Cys in , which is typically the responsible gene for Loeys-Dietz syndrome.

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Objectives: Pulse oximetry screening of newborns detects critical congenital heart disease (CCHD). Rural birth location is known to affect timing and management of when infants with CHD undergo surgery, but its association with CCHD screening is unknown. We assess the relationship between rural location and postnatal CCHD diagnosis and describe lesion-specific modes of diagnosis.

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MYC deregulation occurs in the majority of multiple myeloma cases and is associated with progression and worse prognosis. Enhanced MYC expression occurs in about 70% of patients with multiple myeloma, but it is known to be driven by translocation or amplification events in only ∼40% of myelomas. Here, we used CRISPR interference to uncover an epigenetic mechanism of MYC regulation whereby increased accessibility of a plasma cell-type-specific enhancer leads to increased MYC expression.

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To evaluate the association between initial management strategy of neonatal symptomatic Tetralogy of Fallot (sTOF) and later health-related quality of life (HRQOL) outcomes. We performed a multicenter, cross-sectional evaluation of a previously assembled cohort of infants with sTOF who underwent initial intervention at ≤ 30 days of age, between 2005 and 2017. Eligible patients' parents/guardians completed an age-appropriate Pediatric Quality of Life Inventory, a Pediatric Quality of Life Inventory Cardiac Module Heart Disease Symptoms Scale, and a parental survey.

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Double-outlet Right Atrium with Double-orifice Tricuspid Valve: Report of a Rare Case and Review of the Literature.

Pediatr Cardiol

September 2024

Department of Pediatrics and Adolescent Medicine, Children's Heart Center, American University of Beirut Medical Center, Riad-El Solh1107 2020, PO Box 11-0236, Beirut, Lebanon.

Double-outlet right atrium is an extremely rare congenital cardiac defect, in which the right atrium drains into both ventricles. Here in, we present a peculiar case involving an 8-year-old female with double-outlet right atrium characterized by three distinct atrioventricular valves and a membranous ventricular septal defect. This is associated with right atrium to left ventricular flow through the accessory atrioventricular valve while maintaining adequate size of the right ventricle.

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Background: Previous observational studies have suggested that there appears to be a close association between mitochondrial function and psychiatric disorders, but whether a causal role exists remains unclear.

Methods: We extracted genetic instruments for 67 mitochondrial-related proteins and 10 psychiatric disorders from publicly available genome-wide association studies, and employed five distinct MR methods and false discovery rate correction to detect causal associations between them. Additionally, we conducted a series of sensitivity tests and additional model analysis to ensure the robustness of the results.

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Background: The association between exposure to cadmium (Cd) and cardiovascular health (CVH) has received considerable scientific interest. However, findings thus far have been inconclusive, particularly regarding sex-specific effects and dose-response relationships. The aim of our study was to investigate the relationships of blood Cd levels with the overall and component CVH scores.

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Article Synopsis
  • Major advances have been made in understanding the cellular and molecular mechanisms involved in various types of pulmonary hypertension, but survival rates are still low, highlighting the need for better healthcare interventions.
  • Recent discussions from the 7th World Symposium on Pulmonary Hypertension emphasize the importance of new findings in pathology and pathophysiology, questioning their relevance to different forms of the condition.
  • The exploration of omics and technological advancements aims to improve our understanding of pulmonary vascular remodelling and to enhance patient care, drug development, and research in this area.
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Receptor-interacting protein kinase 1 confers autophagic promotion of gasdermin E-mediated pyroptosis in aristolochic acid-induced acute kidney injury.

Ecotoxicol Environ Saf

October 2024

Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, 7 Weiwu Road, Jinshui District, Zhengzhou, Henan 450053, China. Electronic address:

Article Synopsis
  • Aristolochic acid (AA) is harmful to our kidneys and can cause a serious condition known as acute kidney injury (AKI).
  • In the study, scientists found that a protein called Gasdermin E (GSDME) plays a big role in kidney cell death and inflammatory responses when exposed to AA.
  • The research also showed that controlling certain proteins involved in cell processes can help reduce the damage caused by AA, offering new ideas on how to treat or prevent kidney problems from AA exposure.
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The Pediatric Heart Center Melting Pot: Sharing Recipes for Success: Proceedings from the 8th World Congress of Pediatric Cardiology and Cardiac Surgery.

World J Pediatr Congenit Heart Surg

November 2024

Division of Pediatric Cardiology and Division of Cardiac Critical Care, Department of Pediatrics, Children's National Hospital, Washington, DC, USA.

The challenges of present-day healthcare are urgent; there is a shortage of clinicians, patient care is increasingly complex, resources are limited, clinician turnover seems ever-increasing, and the expectations of providers and patients are monumental. To transform problems into innovative opportunities, diverse perspectives and a sense of possibility are needed. The following is a collaborative manuscript authored by the speakers of the 8th World Congress of Pediatric Cardiology and Cardiac Surgery session, "Teamwork, Culture Change, and Strategy.

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Mediastinal lipoblastomatosis invading the trachea in a 4-month-old girl: A rare cause of airway obstruction.

JTCVS Tech

August 2024

Department of Pediatric Cardiovascular Surgery, Children's Heart Center, West China Second University Hospital, Sichuan University, Chengdu, China.

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Background: Young people with congenital heart disease (CHD) are frequently affected by discontinued follow-up when transferring from paediatric to adult care. Identified predictors for discontinuation include mostly patient-related factors, and further knowledge of hospital and healthcare system factors is needed.

Aim: This study aims to explore patient-related, hospital-related and healthcare system-related factors affecting continued follow-up care after transfer, as perceived and experienced by paediatric cardiology and adult CHD (ACHD) healthcare providers (HCPs) in Sweden and Belgium.

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Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity.

Cell Genom

September 2024

Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science - HiLIFE, University of Helsinki, Helsinki, Finland; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

Article Synopsis
  • * A meta-analysis identified eight genetic loci linked to Raynaud's syndrome, with specific genes like ADRA2A, NOS3, and IRX1 showing important roles in blood vessel behavior and gene expression.
  • * The research utilized CRISPR gene editing and functional assays, revealing how these genes influence blood vessel contraction in response to cold, emphasizing the complexity of genes in understanding this syndrome.
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Introduction: In this study, we investigated the effect of depression on the interaction between lung disease and cardiovascular health (CVH).

Methods: Utilising data from the National Health and Nutrition Examination Survey (2013-2018), we employed multivariate regression and bootstrap mediation analysis to explore the relationships among lung diseases, depression, and CVH scores.

Results: Complex and significant associations were identified among lung diseases, depression, and CVH scores, with depression mediating 9.

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Human cytomegalovirus pUL135 protein affects endothelial cell function via CD2AP in Kawasaki disease.

Int J Cardiol

October 2024

Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325027, Wenzhou, Zhejiang, China; Key Laboratory of Structural Malformations in Childern of Zhejiang Province, 325027, Wenzhou, Zhejiang, China; Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325027 Wenzhou, China. Electronic address:

Background: Kawasaki disease (KD) is a kind of pediatric vasculitis, whose pathogenesis has not been elucidated until now. Many scholars believe that KD is one type of infectious diseases in the susceptible groups. However, no recognized pathogens are confirmed.

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The 3-year follow-up of a fully biodegradable implantable device closure for perimembranous ventricular septal defects in children using echocardiography.

Front Cardiovasc Med

July 2024

Department of Children's Heart Center, Fuwai Central China Cardiovascular Hospital, Fuwai Central China Hospital of Zhengzhou University, Henan Provincial People's Hospital Heart Center, Zhengzhou, Henan, China.

Objects: The aim of this study was to investigate the morphologic changes of a novel fully biodegradable implantable device after closing a perimembranous ventricular septal defect (Pm-VSD) and to evaluate the effect of the occluder on the myocardial function in patients during a 3-year follow-up period.

Methods: One-year, 2-year, and 3-year follow-ups were carried out after implantation with a total of 30 Pm-VSD patients who had successful closure by the fully biodegradable occluder. In total, 30 healthy children were enrolled as controls.

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Article Synopsis
  • Long non-coding RNA MIPRL is highly expressed in ischemic hearts and is conserved in both humans and mice, indicating its potential significance in heart conditions.
  • Research showed that MIPRL knockout mice experienced worse cardiac outcomes after a myocardial infarction, while reintroducing MIPRL improved these conditions.
  • MIPRL was found to enhance the stability of HSPB8 mRNA, a target gene, contributing to its protective effects against apoptosis in heart cells, suggesting MIPRL could be a novel therapeutic target for ischemic heart diseases.
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Bicuspid aortic valve (BAV) is the most common congenital heart defect. It can be accompanied by aortic regurgitation or stenosis with aortopathies. Studies in adults showed a sex difference, but there are limited number of reports in the pediatric population.

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