Continuous frusemide infusion versus intermittent bolus therapy in paediatric intensive care: A single centre retrospective study.

Objective: Frusemide is a common diuretic administered to critically ill children intravenously, by either continuous infusion (CI) or intermittent bolus (IB). We aim to describe the characteristics of children who receive intravenous frusemide, patterns of use, and incidence of acute kidney injury (AKI), and to investigate factors associated with commencing CI.

Design: Retrospective observational study.

Calculation of the Minimal Clinically Important Difference in Upper and Lower Limb Motor Assessment in Spinal Muscular Atrophy.

Objectives: Physical function assessments in patients with spinal muscular atrophy (SMA) are important indicators for assessing the effectiveness of treatment and changes over time in rehabilitation therapy. However, few reports exist on this indicator. This study calculated the minimal clinically important difference (MCID) for assessing motor function in the upper and lower limbs of individuals with SMA to estimate the degree of change within a functional score that is considered clinically meaningful.

Acceptance of Parents toward Hand-over-mouth Exercise and Other Behavior Management Techniques for Pediatric Dental Care in the 21st Century: A Systematic Review and Meta-analysis of Observational Studies.

Background: Hand-over-mouth exercise (HOME) is an aversive technique for child behavior management in a dental office. HOME has been omitted from various guidelines and certain teaching curricula due to legal and ethical issues. This systematic review meta-analysis (SRMA) was undertaken to understand the acceptance of parents toward HOME in comparison with that of other behavior management techniques (BMTs).

Comparison of Conventional Syringe with Camouflaged Syringe and Vibration-assisted Syringe for Pain and Fear Perception during Local Anesthetic Administration in Children: A Split-mouth Randomized Controlled Trial.

Aim And Background: Although local anesthesia (LA) eliminates pain and instills a positive dental attitude, the physical appearance of its syringe is highly fear provoking and often intolerable. Therefore, the purpose of this study was to evaluate the pain and fear perception in camouflaged syringe (CS) and vibration-assisted syringe (VA) when compared with conventional syringe and with each other (VACS) during local anesthetic administration in pediatric patients aged between 6 and 12 years.

Materials And Methods: Eighty-five subjects were randomly assigned into three groups: CS group ( = 7), VA group ( = 26), and VACS group ( = 27).

Survival of Silver Diamine Fluoride Varnish Treated Teeth among Children with Single/Multiple Applications: A Split-mouth Randomized Clinical Trial.

Introduction: Utilizing 38% silver diamine fluoride (SDF) has been demonstrated in clinical trials to prevent and halt early childhood caries (ECC). Based on a research evaluation, it has been found that 38% SDF can effectively prevent new tooth decay and stop existing tooth decay in children's primary teeth.

Objective: This study aimed to assess the survival of teeth treated with repeated applications of 38% SDF in children with ECC and to compare the outcomes between single and multiple applications.

Thaumaturgical Distraction as a Modality for Reducing Dental Anxiety in Children: A Systematic Review.

Background: Dental fear and anxiety have become a major obstacle for children to accept dental treatment. Dental anxiety ranks fifth among common fears.

Aim: The aim of this current systematic review is to assess the effect of thaumaturgical distraction in reducing anxiety in children undergoing dental procedures.

Angioedema in a 9-year-old Child after Dental Treatment: A Rare Complication Explored through a Case Report.

Aim And Background: Angioedema is a nonpruritic swelling that typically affects the skin, mucous membranes of the face, and perioral soft tissues. It can be life-threatening, but it is usually not and can be treated conservatively unless the airway is compromised. This paper seeks to illuminate a rare case of hereditary angioedema (HAE) onset following dental procedures in a 9-year-old Indian boy.

Comparing the Existence of Golden Proportion Using Maxillary Anterior Teeth Dimensions in Primary and Permanent Dentition: A Cross-sectional Study.

Aims And Background: The golden proportion is based on the premise that there is a link between natural beauty and mathematics. The study aimed to analyze the mesiodistal width of maxillary anterior teeth in primary and permanent dentition to determine whether a golden proportion exists among them.

Materials And Methods: Sixty subjects were randomly selected in accordance with inclusion and exclusion criteria.

Comparative Evaluation of Different Pain-alleviating Methods on Child's Dental Anxiety and Pain Perception during Local Anesthesia Administration: A Clinical Study.

Background: When it comes to reducing children's fear, anxiety, and discomfort during dental procedures, substantial local anesthetic delivery promotes adequate intervention. In the dental operatory, local anesthetic injections are the most anticipated or feared stimuli. The application of topical anesthetics, cryotherapy, and transcutaneous electrical nerve stimulation (TENS) to the oral mucosa prior to local anesthetic injections can alter pain perception in children.

Oral Myiasis in a 6-year-old Child with Cerebral Palsy: A Case Report.

Aims And Background: Myiasis is an infestation of live humans or animals with dipterous larvae that feed on the host's live or dead tissue. The incidence of oral myiasis is rare and even less common in children. Poor oral hygiene, neurological disabilities, bedridden or locomotor disabilities, low socioeconomic status, malnutrition, etc.

Comparative Evaluation of Clinical Anesthetic Efficacy of 4% Articaine with 24-Gauge Needle in Buccal Nerve Block Compared to 2% Lignocaine with 20-Gauge Needle in Inferior Alveolar Nerve Block in Children with Dentoalveolar Abscess.

Aims And Background: Local anesthetics play a crucial role in pain management in pediatric dentistry, where anxiety and fear are common among young patients. This study aimed to compare the anesthetic efficacy of 2% lignocaine with a 20-gauge needle in an inferior alveolar nerve block (IANB) and 4% articaine with a 24-gauge needle in a buccal nerve block (BNB) during the extraction of dentoalveolar abscesses in children aged 5-11 years.

Materials And Methods: A 12-month randomized controlled trial involving 100 healthy children was conducted following ethical standards.

Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer.

Resistance to the currently available treatment paradigms is one of the main factors that contributes to poor outcomes in patients with advanced cervical cancer. Novel targeted therapy approaches might enhance the patient's treatment outcome and are urgently needed for this malignancy. While chimeric-antigen receptor (CAR)-based adoptive immunotherapy displays a promising treatment strategy for liquid cancers, their use against cervical cancer is largely unexplored.

Window decompression surgery for a large radicular cyst in a 7-year-old patient: A case report.

Radicular cysts are rarely present in the primary dentition because of the distinct biological cycle of primary teeth. Cyst formation in children may cause bony expansion and resorption, malposition, delayed eruption, enamel defects, or damage to the developing permanent successors. Various treatment modalities for the management of radicular cysts have been reported in the literature.

Relationship Between ABO Blood Groups and Mental Disorders.

Previous research has unveiled an intriguing positive association between the AB blood group and mental disorders in general. In this study, we compared ABO blood groups with five major groups of mental disorders to attain a higher level of specificity. The analyses were conducted using data from the CoLaus|PsyCoLaus study (N=5111).

Comparing the Efficacy of Triamcinolone Acetonide Versus Bleomycin in Hypertrophic Scars in Burn Patients: A Clinical Trial.

Background: Treatment of hypertrophic burn scars is challenging. Intralesional injection of corticosteroids has been the first line of treatment. Triamcinolone Acetonide (TA) and Bleomycin (BLE) are standard therapeutic options.

The Effect of Mixed Articulation Therapy on Perceptual and Acoustic Features of Compensatory Errors in Children with Cleft Palate.

Background: Compensatory errors are a conventional part of an articulation disorder identified by speech pathologists in patients with Cleft palate (CP). This study aimed to evaluate the effect of new mixed articulation therapy on the perceptual and acoustic features of these errors.

Methods: The single-case experimental design, ABA design, was used in this study.

The Effect of Narrative Intervention on Spoken Narrative and Reading Comprehension Abilities in Farsi-Speaking Children with Autism Spectrum Disorders: A Randomized Clinical Trial.

Background: Children with autism spectrum disorders (ASD) show prominent deficits in pragmatic aspects of language such as spoken narrative. Deficits in spoken narrative in school years lead to deficits in reading comprehension. Therefore, this randomized clinical trial research examined the influence of narrative intervention on spoken narrative and reading comprehension abilities in children with ASD.

Features of Physical and Psychomotor Development in Children with Brain Ischemia.

Background: Brain ischemia is one of the leading causes of morbidity and mortality in infants. Currently, many factors influence the degree of development of ischemia and the consequences affecting the child's body. The purpose of this study was to find the characteristics of the physical and psychomotor development of children with brain ischemia.

A missense mutation in the gene in a patient with autism spectrum disorder and epilepsy.

The gene (OMIM: 608271) encodes the Microtubule-Actin Cross-Linking Factor 1 protein. Existing medical research shows that genetic mutations in the gene have been associated with neurodevelopmental and neurodegenerative disorders, with variants of unknown significance also linked to autism spectrum disorder (ASD). However, the number of reported autism disorder or epilepsy cases associated with mutations remains limited.

Training of medical coordinators for noncommunicable diseases based on Japanese experience.

Objective: The incidence of noncommunicable diseases (NCDs) is increasing in low- and middle-income countries and represents a major public health challenge. Herein, we present Japan's experience in training medical coordinators to combat NCDs, with a focus on hepatitis, early-onset dementia, and children with medical complexity. Coordinators play an important role in bridging the gap between patients and healthcare services.

Risk factor for difficult cases at the comprehensive consultation services about medical, welfare and legal problems.

Unlabelled: It is very important to cooperate with interprofessional personnel is in order to establish the community-based integrated care system, but this is very difficult. We have held comprehensive consultation services regarding medical, welfare, and legal problems to support the community.

Objectives: This study aimed to identify the associations between background factors (such as medical conditions, intractable diseases, welfare problems, disabilities, economic difficulties, legal problems, elderly adults, children, and foreign persons) and difficult cases to provide more thorough consultation services.

Efficacy of priming and commitment posters on urgent care patients' antibiotic expectations and knowledge: a cluster randomized trial.

Objective: Successfully educating urgent care patients on appropriate use and risks of antibiotics can be challenging. We assessed the conscious and subconscious impact various educational materials (informational handout, priming poster, and commitment poster) had on urgent care patients' knowledge and expectations regarding antibiotics.

Design: Stratified Block Randomized Control Trial.

Reducing antibiotic duration for acute otitis media: clinician, administrator, and parental insights to inform implementation of system-level interventions.

Objective: This qualitative study aimed to understand facilitators and barriers to implementation of interventions to improve guideline-concordant antibiotic duration prescribing for pediatric acute otitis media (AOM).

Design: Clinicians and clinic administrators participated in semi-structured qualitative interviews, and parents of children 2 years of age or older with a recent diagnosis of AOM participated in focus groups. The Practical Robust Implementation and Sustainability Model (PRISM) guided the study.

Going commando as part of a multifaceted intervention to reduce CAUTIs in critically ill children.

This project was initiated in a large pediatric intensive care unit to reduce catheter-associated urinary tract infections (CAUTIs). Implementing removal of diapers and a urine collection device that prevented urine backflow in March 2021 decreased the rate from 3.3 to 0.