1 results match your criteria: "Chiba University and Fukui University.[Affiliation]"
Development of novel DNA vaccine for VEGF in murine cancer model.
Sci Rep
November 2013
1] Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine [2] Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and Fukui University.
We developed DNA vaccine for vascular endothelial growth factor (VEGF), which may provide the therapeutic option instead of anti-VEGF antibody, bevacizumab. Plasmid containing VEGF mini-gene was constructed in the insertion of B-cell epitope of Hepatitis B core protein [HBc-VEGF], which was an epitope carrier. High titer of anti-VEGF antibody was observed in BALB/c mice which were intramuscularly immunized with HBc-VEGF by electropolator.
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