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Article Synopsis
- Protein replacement therapies effectively treat conditions like diabetes and hemophilia, but recombinant proteins are not always available due to stability and cost issues.
- Gene therapy offers a promising alternative for rare inherited diseases, utilizing adipose tissue as a source of proliferative cells for these treatments.
- Recent advancements have focused on ceiling culture-derived proliferative adipocytes (ccdPAs) for gene therapy, specifically targeting lecithin:cholesterol acyltransferase (LCAT) deficiency, and developing novel strategies for using adipose tissue in treating various protein deficiencies.