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Chiba Institute of Technology.[Affiliat... Publications | LitMetric

634 results match your criteria: "Chiba Institute of Technology.[Affiliation]"

Recent studies focusing on neural activity captured by neuroimaging modalities have provided various metrics for elucidating the functional networks and dynamics of the entire brain. Functional magnetic resonance imaging (fMRI) can depict spatiotemporal functional neural networks and dynamic characteristics due to its excellent spatial resolution. However, its temporal resolution is limited.

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New on-site color test to discriminate cocaine and cathinone derivatives.

Sci Justice

November 2024

Department of Chemistry and Biochemistry, Advanced Science and Engineering, Waseda University, Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. Electronic address:

Color tests are advantageous for the field detection of illicit drugs because of their simplicity, low cost, and rapidity. The Scott test has been widely used as a color test for cocaine; however, it has the disadvantage of reacting with cathinone derivatives. To develop a more discriminating field-testing procedure, we evaluated the Cupric Reducing Antioxidant Capacity (CUPRAC) and bicinchoninic acid (BCA) tests for cathinones, to discriminate between cocaine and cathinones.

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Article Synopsis
  • * This study focuses on Besshi-type volcanogenic massive sulphide (VMS) deposits from Japan, determining their ages using Re-Os isochron dating, yielding ages of 89.4 ± 1.2 Ma and 48.2 ± 0.9 Ma.
  • * The findings suggest that these VMS deposits were formed in a sediment-covered mid-ocean ridge environment just before the subduction of the Izanagi-Pacific Ridge beneath ancient Japanese Islands.
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Unlabelled: Aspects of the Quaternary sedimentary geology of South-East Asia have proven problematic in terms of interpretation as to the origins and relationships of the surface sediment layers. The MIS 20 large meteorite impact (., 788 to 785 ka) occurred within mainland South-East Asia, evident from the well-researched 'Australasian Tektite Strewn Field' which extends over at least one tenth of the surface of the Earth.

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Bio-Based Self-Healing Epoxy Vitrimers with Dynamic Imine and Disulfide Bonds Derived from Vanillin, Cystamine, and Dimer Diamine.

Molecules

October 2024

Department of Applied Chemistry, Faculty of Engineering, Chiba Institute of Technology, 2-17-1, Tsudanuma, Narashino 275-0016, Chiba, Japan.

The condensation reactions of 4,4'-(ethane-1,2-diylbis (oxy)) bis(3-methoxybenzaldehyde) (VV) with cystamine, 1,6-hexamenthylene diamine, and a dimer diamine (Priamine 1075) produced three types of vanillin-derived imine-and disulfide-containing diamines (VC, VH, and VD, respectively). Thermal curing reactions of polyglycerol polyglycidyl ether with VD and mixtures of VC/VD and VH/VD produced bio-based epoxy vitrimers (BEV-VD, BEV-VC/VD, and BEV-VH/VD, respectively). The degree of swelling and gel fraction tests revealed the formation of a network structure, and the crosslinking density increased with a decreasing VD fraction.

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Allele-specific, monoallelic expression in diploid organisms represents an extreme case of allelic imbalance resulting from incompatibility between cis- and trans-elements. Due to haploinsufficiency, such monoallelic expression can lead to sporadic genetic diseases. In mice, allelic imbalances can be introduced into F1 offspring from inbred strains.

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This study compared the associations among motor competence, health-related fitness, and physical activity measured by gold standard and field-based methods in children. A total of 248 first-grade children (153 boys) aged 6-7 years participated in the study. Motor competence was assessed using the Test of Gross Motor Development, Second Edition (TGMD -2).

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Crystal structure of guanosine 5'-monophosphate synthetase from the thermophilic bacterium Thermus thermophilus HB8.

Acta Crystallogr F Struct Biol Commun

October 2024

Graduate School of Informatics and Engineering, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan.

Article Synopsis
  • Guanosine 5'-monophosphate (GMP) synthetase (GuaA) is an enzyme that converts xanthine 5'-monophosphate (XMP) into GMP, a key step in purine nucleotide synthesis, using Gln and ATP as reactants.* -
  • The study provided the crystal structure of an XMP-bound GuaA from the thermophilic bacterium Thermus thermophilus at high resolution, revealing its homodimeric form and characteristic three-domain structure.* -
  • Molecular-dynamics simulations were conducted to analyze the structural dynamics of the TtGuaA dimer and the interactions at the active site, incorporating disordered regions predicted by AlphaFold2.*
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Effects of hyperbaric oxygen pre-exposure on the motor learning acquisition phase.

Behav Brain Res

January 2025

Laboratory of Motor Learning and Motor Control, Faculty of Creative Engineering, Chiba Institute of Technology, Chiba, Japan. Electronic address:

Hyperbaric oxygen (HBO) exposure has recently been reported to be effective in spatial learning and memory. Additionally, HBO exposure considerably improves performance on motor tasks. These findings suggest that HBO exposure may facilitate motor learning.

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Inverse Correlation between -Carrying Abundance in Colorectal Cancer Liver Metastases and the Number of Organs Involved in Recurrence.

Cancers (Basel)

August 2024

Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research (JFCR), 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.

Colibactin, a genotoxin produced by strains harboring the polyketide synthetase () gene cluster, causes DNA damage and somatic mutations. is enriched in primary colorectal cancer (CRC) and is associated with clonal driver mutations, but its role in CRC liver metastasis is unclear. We assessed the association of in CRC liver metastasis tissues with systemic and local immune responses and the number of organs involved in recurrence using specimens and clinicopathological data from 239 patients with CRC liver metastasis who underwent metastasectomy.

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Article Synopsis
  • This study investigates how ferroelectric catalysts can change their catalytic activities by switching electric polarizations, using layered bismuth oxyselenide (L-BiOSe) microreactors.
  • It introduces a new method called selective-area ionic liquid gating to control the direction of dipole orientation in L-BiOSe, leading to variations in catalytic reactions, with upward polarization favoring oxygen evolution and downward polarization favoring hydrogen evolution.
  • The research demonstrates that by integrating L-BiOSe microreactors with different polarizations, it is possible to achieve overall water splitting, highlighting the potential for designing catalysts that can switch surface polarizations.
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The presence of Fusobacterium nucleatum is associated with an immunosuppressive tumor immune microenvironment (TIM) in primary colorectal cancer (CRC), contributing to tumor progression. Its persistence in CRC liver metastasis tissues raises questions about its role in modulating local and systemic immune responses and influencing recurrence patterns. This retrospective cohort study of 218 patients with CRC liver metastasis investigated the association of F.

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The social amoeba Polysphondylium violaceum uses chemoattractants different from those of Dictyoctelium discoideum for cell aggregation. However, the detailed mechanisms in P. violaceum remain unknown.

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Introduction: The deep echo state network (Deep-ESN) architecture, which comprises a multi-layered reservoir layer, exhibits superior performance compared to conventional echo state networks (ESNs) owing to the divergent layer-specific time-scale responses in the Deep-ESN. Although researchers have attempted to use experimental trial-and-error grid searches and Bayesian optimization methods to adjust the hyperparameters, suitable guidelines for setting hyperparameters to adjust the time scale of the dynamics in each layer from the perspective of dynamical characteristics have not been established. In this context, we hypothesized that evaluating the dependence of the multi-time-scale dynamical response on the leaking rate as a typical hyperparameter of the time scale in each neuron would help to achieve a guideline for optimizing the hyperparameters of the Deep-ESN.

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Charge-Enhanced Reactivity of Esters by a Cationic Substituent.

Org Lett

July 2024

Department of Applied Chemistry, Graduate School of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan.

In this study, the high electrophilicity of carbonyl carbons attached to cationic heterocycles was observed. Triazolium-substituted esters underwent catalyst-free amidation with aliphatic amines at -50 °C and reduction with NaBH at -100 °C. The origin and generality of the high reactivity of these esters were systematically investigated.

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Tardigrades are small aquatic invertebrates known for their remarkable tolerance to diverse extreme stresses. To elucidate the in vivo mechanisms underlying this extraordinary resilience, methods for genetically manipulating tardigrades have long been desired. Despite our prior success in somatic cell gene editing by microinjecting Cas9 ribonucleoproteins (RNPs) into the body cavity of tardigrades, the generation of gene-edited individuals remained elusive.

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Aim: This study aimed to identify atypical hubs in the whole-brain networks of patients with schizophrenia (SZ) and examine the effects of antipsychotic medications, using electroencephalography (EEG) data.

Methods: We estimated the functional connectivity across all electrodes by applying the phase lag index to the EEG signals of 21 drug-naïve patients with SZ and 31 age-matched healthy controls. Betweenness centrality (BC), a measure of hub status, was calculated for each electrode and frequency band.

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Development of the 12-Base Short Dimeric Myogenetic Oligodeoxynucleotide That Induces Myogenic Differentiation.

BioTech (Basel)

April 2024

Department of Agricultural and Life Sciences, Faculty of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina 399-4598, Japan.

A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5'-AGA TTA GGG TGA GGG TGA-3'), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected to be a nucleic acid drug for the prevention of disease-associated muscle wasting. To improve the drug efficacy and synthesis cost of myoDN, shortening the sequence while maintaining its structure-based function is a major challenge. Here, we report the novel 12-base non-telomeric myoDN, iMyo01 (5'-TTG GGT GGG GAA-3'), which has comparable myogenic activity to iSN04.

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Characterization of Porous β-Type Tricalcium Phosphate Ceramics Formed via Physical Foaming with Freeze-Drying.

Int J Mol Sci

May 2024

Department of Applied Chemistry, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino-shi 275-0016, Chiba, Japan.

Porous β-tricalcium phosphate (Ca(PO); β-TCP) was prepared via freeze-drying and the effects of this process on pore shapes and sizes were investigated. Various samples were prepared by freezing β-TCP slurries above a liquid nitrogen surface at -180 °C with subsequent immersion in liquid nitrogen at -196 °C. These materials were then dried under reduced pressure in a freeze-dryer, after which they were sintered with heating.

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Selection and characterization of aptamers targeting the Vif-CBFβ-ELOB-ELOC-CUL5 complex.

J Biochem

September 2024

Department of Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan.

The viral infectivity factor (Vif) of human immunodeficiency virus 1 forms a complex with host proteins, designated as Vif-CBFβ-ELOB-ELOC-CUL5 (VβBCC), initiating the ubiquitination and subsequent proteasomal degradation of the human antiviral protein APOBEC3G (A3G), thereby negating its antiviral function. Whilst recent cryo-electron microscopy (cryo-EM) studies have implicated RNA molecules in the Vif-A3G interaction that leads to A3G ubiquitination, our findings indicated that the VβBCC complex can also directly impede A3G-mediated DNA deamination, bypassing the proteasomal degradation pathway. Employing the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method, we have identified RNA aptamers with high affinity for the VβBCC complex.

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The DESTINY(Demonstration and Experiment of Space Technology for INterplanetary voYage with Phaethon fLyby and dUst Science) Dust Analyser (DDA) is a state-of-the-art dust telescope for the analysis of cosmic dust particles. As the primary scientific payload of the DESTINY mission, it serves the purpose of characterizing the dust environment within the Earth-Moon system, investigating interplanetary and interstellar dust populations at 1 AU from the Sun and studying the dust cloud enveloping the asteroid (3200) Phaethon. DDA features a two-axis pointing platform for increasing the accessible fraction of the sky.

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The reaction of -alkyl--cinnamyl-2-ethynylaniline derivatives via annulation and aza-Claisen-type rearrangement easily afforded corresponding branch-type 3-allylindoles with high regioselectivities in good yields using π-allylpalladium chloride complex as a catalyst.

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Extraterrestrial minerals on the surface of airless Solar System bodies undergo gradual alteration processes known as space weathering over long periods of time. The signatures of space weathering help us understand the phenomena occurring in the Solar System. However, meteorites rarely retain the signatures, making it impossible to study the space weathering processes precisely.

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