A Cost-Effective Approach to Creating Large Silicone Rubber Molds Using Advanced Rigid Polyurethane Foam.

In practical applications, polyurethane (PU) foam must be rigid to meet the demands of various industries and provide comfort and protection in everyday life. PU foam components are extensively used in structural foam, thermal insulation, decorative panels, packaging, imitation wood, and floral foam, as well as in models and prototypes. Conventional technology for producing PU foam parts often leads to defects such as deformation, short shots, entrapped air, warpage, flash, micro-bubbles, weld lines, and voids.

Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression.

Melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream prometastatic gene regulatory networks (GRNs). Appropriate therapeutic manipulation of the E2F1-governed GRNs holds the potential to prevent metastasis however, these networks entail complex feedback and feedforward regulatory motifs among various regulatory layers, which make it difficult to identify druggable components.

Exploring potential of diacerin nanogel for topical application in arthritis: Formulation development, QbD based optimization and pre-clinical evaluation.

Diacerein (DCN) is a chondroprotective agent which shows inadequate oral bioavailability along with gastrointestinal side effects. This study is intended to develop a topical novel DCN delivery system. DCN nanogel was prepared by emulsion solvent diffusion technique.

Structure-function relationships explain CTCF zinc finger mutation phenotypes in cancer.

CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutations have not been examined. We performed molecular and structural characterisation of five cancer-specific CTCF missense zinc finger (ZF) mutations occurring within key intra- and inter-ZF residues.

Investigation of MicroRNA and transcription factor mediated regulatory network for silicosis using systems biology approach.

Silicosis is a major health issue among workers exposed to crystalline silica. Genetic susceptibility has been implicated in silicosis. The present research demonstrates key regulatory targets and propagated network of gene/miRNA/transcription factor (TF) with interactions responsible for silicosis by integrating publicly available microarray data using a systems biology approach.

An integrative network-driven pipeline for systematic identification of lncRNA-associated regulatory network motifs in metastatic melanoma.

Background: Melanoma phenotype and the dynamics underlying its progression are determined by a complex interplay between different types of regulatory molecules. In particular, transcription factors (TFs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) interact in layers that coalesce into large molecular interaction networks. Our goal here is to study molecules associated with the cross-talk between various network layers, and their impact on tumor progression.

Integrative workflows for network analysis.

Due to genetic heterogeneity across patients, the identification of effective disease signatures and therapeutic targets is challenging. Addressing this challenge, we have previously developed a network-based approach, which integrates heterogeneous sources of biological information to identify disease specific core-regulatory networks. In particular, our workflow uses a multi-objective optimization function to calculate a ranking score for network components (e.

Metatranscriptome Analysis Deciphers Multifunctional Genes and Enzymes Linked With the Degradation of Aromatic Compounds and Pesticides in the Wheat Rhizosphere.

Agricultural soils are becoming contaminated with synthetic chemicals like polyaromatic compounds, petroleum hydrocarbons, polychlorinated biphenyls (PCBs), phenols, herbicides, insecticides and fungicides due to excessive dependency of crop production systems on the chemical inputs. Microbial degradation of organic pollutants in the agricultural soils is a continuous process due to the metabolic multifunctionalities and enzymatic capabilities of the soil associated communities. The plant rhizosphere with its complex microbial inhabitants and their multiple functions, is amongst the most live and dynamic component of agricultural soils.

Recent advancement in the early detection of melanoma using computerized tools: An image analysis perspective.

Background: The paper reviews the advancement of tools and current technologies for the detection of melanoma. We discussed several computational strategies from pre- to postprocessing image operations, descriptors, and popular classifiers to diagnose a suspected skin lesion based on its virtual similarity to the malignant lesion with known histopathology. We reviewed the current state of smart phone-based apps as diagnostic tools for screening.

A Network-Based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression.

Unraveling mechanisms underlying diseases has motivated the development of systems biology approaches. The key challenges for the development of mathematical models and computational tool are (1) the size of molecular networks, (2) the nonlinear nature of spatio-temporal interactions, and (3) feedback loops in the structure of interaction networks. We here propose an integrative workflow that combines structural analyses of networks, high-throughput data, and mechanistic modeling.

Pyridine influence on a sequential anaerobic-anoxic-aerobic FMBR system for phenol, thiocyanate and ammonia removal.

A synthetic wastewater containing various pyridine concentrations (25-250 mg/L) was treated in a sequential anaerobic(B1)-anoxic(B2)-aerobic(B3) fed batch moving bed reactor (FMBR) system. Pyridine was associated with phenol (1500 mg/L), SCN- (800 mg/L), chemical oxygen demand (COD) (5400-5430 mg/L) and NH4+-N (500 mg/L) at hydraulic retention time (HRT) of 6 (B1: 3 days; B2 and B3: 1.5 days each) days.

Toxicity and Safety Profiles of Methanolic Extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar Rats.

Objectives: The goals of this research were to evaluate acute (single-dose) and sub-acute (repeated-dose) toxicity profiles of methanolic extract of J. L. Stewart ex Brandis (PI) for Wistar rats and to assess the safety profile of PI by observing physiological changes, mortality, changes in body weight, the histopathology of body organs, the hematology and the biochemistry of the animals.

Artocarpus gomezianus aided green synthesis of ZnO nanoparticles: luminescence, photocatalytic and antioxidant properties.

We report green synthesis of multifunctional ZnO nanoparticles (NPs) using Artocarpus gomezianus (AG) extract as fuel by solution combustion synthesis. The formation of NPs was confirmed by powder XRD, SEM, TEM and UV-Visible studies. The NPs were subjected for photoluminescence, photodegradative and antioxidant studies.

Role of flux on morphology and luminescence properties of Sm(3+) doped Y2SiO5 nanopowders for WLEDs.

The study involves preparation of samarium doped Y2SiO5 (YSO) nano powders by solution combustion method using urea as a fuel for the first time. Effect of different fluxes on the crystallization behavior, morphology and photoluminescence (PL) properties of YSO:Sm(3+) (1-9 mol%) were investigated. The final product was characterized by Powder X-ray diffraction (PXRD), Scanning Electron Microscopy (SEM) and UV-Vis spectroscopy.

Zn2TiO4:Eu(3+) nanophosphor: self explosive route and its near UV excited photoluminescence properties for WLEDs.

A simple and low-cost solution combustion method was used to prepare Eu(3+) (1-11mol%) doped Zn2TiO4 nanophosphors at 500°C using zinc nitrates as precursors and oxalyl di-hydrazide (ODH) as fuel. The final product was calcined at 1100°C for 3h and then characterized by powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and UV-visible absorption (UV-Vis). The PXRD patterns of the sample calcined at 1100°C show pure cubic phase.

GdAlO3:Eu(3+):Bi(3+) nanophosphor: synthesis and enhancement of red emission for WLEDs.

GdAlO3, GdAlO3:Eu(3+) and GdAlO3:Eu(3+):Bi(3+) nanophosphors were synthesised by solution combustion technique. Pure orthorhombic phase was obtained from powder X-ray diffraction (PXRD) studies. Scanning electron microscopy (SEM) micrographs showed the porous, agglomerated and irregular shaped particles.

Synthesis and luminescence properties of Sm3+ doped CaTiO3 nanophosphor for application in white LED under NUV excitation.

CaTiO3:Sm(3+) (1-11 mol%) nanophosphors were successfully synthesized by a low temperature solution combustion method [LCS]. The structural and morphological properties of the phosphors were studied by using Powder X-ray diffractometer (PXRD), Fourier transform infrared (FTIR), X-ray photo electron spectroscopy (XPS), scanning electron microscope (SEM) and transmission electron microscopy (TEM). TEM studies indicate that the size of the phosphor is ∼20-35 nm.

Mathematical directions for curing the cancer disease: theory and practice.

In this paper, we present a mathematical direction for curing the cancer disease. To completely destroy the cancer cell is the maximum objective and to completely stop the increasing cancer cell is the minimum objective, these two are the main fundamental reason to the given this result. We observed that, if we scientifically and keen study of the algebraic and geometrical structure of the selected or identified cancer affected region then we find this result and we try to present this idea with the help of the important theorem.