671 results match your criteria: "Chettinad Hospital and Research Institute[Affiliation]"

A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line.

Mol Biol Rep

December 2024

Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamilnadu, 600113, India.

Introduction: The changes in histone modifications are linked to the progression of benign and normal tissue to malignancy. Thus, numerous findings suggest that targeting epigenetic factors might be a focus for anti-cancer treatment. In this study, we tested the hypothesis that telomerase activator might be a potential epigenetic regulator in combatting skin cancer cell proliferation.

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Recent advances on artificial intelligence-based approaches for food adulteration and fraud detection in the food industry: Challenges and opportunities.

Food Chem

December 2024

Nano-biotechnology and Translational Knowledge Laboratory, Department of Applied Biology, School of Biological Sciences, University of Science and Technology Meghalaya, Techno City, 9(th) Mile, Baridua, 793101, India; Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam 603103, India. Electronic address:

Food adulteration is the deceitful practice of misleading consumers about food to profit from it. The threat to public health and food quality or nutritional valuable make it a major issue. Food origin and adulteration should be considered to safeguard customers against fraud.

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Chiral Au@Pt nanoparticles (NPs) with optically plasmonic and catalytic active surfaces were sustainably prepared to serve as label-free surface enhanced Raman scattering (SERS) platform to distinguish D- and L-enantiomers of alanine and tartaric acid. Surface morphologies were characterized by high-angle annular dark-field imaging-scanning transmission electron microscopy (HADDF-STEM) and selected area energy diffraction (SAED) patterns. The amounts of Pt on chiral Au NPs were estimated by the inductively coupled plasma-optical emission spectrometer (ICP-OES) and X-ray diffraction (XRD).

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Introduction: Proximal humerus fractures are prevalent, especially among the elderly, and pose significant challenges in treatment, particularly for displaced fractures. Despite the availability of various surgical techniques, outcomes remain inconsistent, often due to poor anatomical reduction and fixation. This study examines the correlation between specific radiographic parameters and functional outcomes, aiming to identify key predictors of recovery.

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Introduction: Carpal tunnel syndrome (CTS) is the most common compressive neuropathy, often leading to significant impairment, especially in patients with bilateral involvement. When conservative trials fail, surgical options such as open, mini-open, and endoscopic carpal tunnel release are considered. This report highlights the use of single-stage bilateral mini-open carpal tunnel release, emphasizing its efficiency, reduced recovery time, and cost-effectiveness.

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COVID-19 has become one of the deadliest epidemics in the past years. In efforts to combat the deadly disease besides vaccines, drug therapies, and facemasks, significant focus has been on designing specific methods for the sensitive and accurate detection of SARS-CoV-2. Of these, surface-enhanced Raman scattering (SERS) is an attractive analytical tool for the identification of SARS-CoV-2.

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Association of Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-analysis.

Gynecol Minim Invasive Ther

September 2024

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.

Objectives: Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder affecting reproductive-aged women. Genetic factors play a significant role in its development. This meta-analysis assesses the associations between specific gene polymorphisms (Vitamin D receptor [VDR] and adiponectin [ADIPOQ]) and PCOS susceptibility.

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Roles of the gut microbiota in human neurodevelopment and adult brain disorders.

Front Neurosci

November 2024

Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Article Synopsis
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Evaluating the impact of gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment.

J Turk Ger Gynecol Assoc

December 2024

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.

Objective: Polycystic ovary syndrome (PCOS) is prevalent among reproductive-aged women and is categorized by hormonal imbalances, irregular menstrual cycles, and challenges with fertility. PCOS affects approximately 3.6% of women globally, with prevalence varying by region.

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Retraction notice to "Adsorption of terbutaline β-agonists from wastewater by mechano-synthesized iron oxide nanoparticles modified copper (II) isonicotinate metal-organic framework" [Environ. Res. 258 (2024) 119413].

Environ Res

January 2025

HICoE-Centre for Biofuel and Biochemical Research, Institute of Sustainable Energy, Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, 32610, Seri Iskandar, Perak Darul Ridzuan, Malaysia; Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

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Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis.

Ann Indian Acad Neurol

November 2024

Human Cytogenetics and Genomics Laboratory, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.

Background And Objectives: Toll-like receptor ( TLR2 ) gene plays an important role in the pathogenesis of bacterial meningitis (such as meningococcal meningitis and pneumococcal meningitis). The association between TLR4 rs4986790 polymorphism and the susceptibility to bacterial meningitis has been extensively studied. However, the results of these studies remain inconsistent.

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Genetic Variability of Polymorphisms in Non-Syndromic Cleft Lip/Palate: A Meta-Analysis Across Diverse Populations.

Cleft Palate Craniofac J

November 2024

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, India.

Article Synopsis
  • Orofacial clefts, such as cleft lip and palate, are common congenital defects that pose significant global health challenges due to their medical and socioeconomic effects.
  • A meta-analysis investigated the genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P) by analyzing specific genetic polymorphisms across diverse populations, including groups from China, Brazil, and Iran.
  • The study found significant associations with certain SNPs (rs2235371 and rs2235373) in some ethnic groups, while others showed no significant links, indicating genetic differences in NSCL/P susceptibility and highlighting the need for more research on genetic and environmental interactions.
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Article Synopsis
  • - The study focused on recovering oil from discarded lemon peel biomass and testing it as a gasoline substitute in engine blends at different volume ratios (10%, 20%, and 30%) using steam distillation for oil extraction.
  • - Using an endoscopic visualization approach, the research found that a 10% lemon peel oil blend offered higher thermal efficiency and lower emissions, while premixed combustion produced better combustion characteristics, leading to increased cylinder pressure.
  • - To enhance performance, a ceramic coating was applied to the piston using the micro-arc oxidation technique, which improved thermal efficiency by 3% and 4.69% for the 20% lemon peel oil blend compared to uncoated and pure gasoline engines, while also reducing hydrocarbon
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  • Nomophobia, the fear of losing access to mobile phones, is examined among college students in Chengalpattu, Tamil Nadu, revealing its prevalence and impact on mental health.
  • The study surveyed 207 students aged 18-26 using the NMP-Q questionnaire, finding that 3.4% had no nomophobia, while 27.5% had mild, 59.4% moderate, and 9.7% severe nomophobia, with females being more affected than males.
  • The research highlights that nomophobia poses risks to students' physical, emotional, and social well-being, suggesting a need for better smartphone usage practices among students.
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A Rare Case Report of Nasal Schwannoma.

Indian J Otolaryngol Head Neck Surg

December 2024

Department Of Otorhinolaryngology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, 603103 India.

Schwannoma is a rare mass that is benign. It develops from the Schwann cells found in the peripheral nerves. Schwannomas consists of spindle cells exhibiting two unique histological patterns, which may be combined: Antoni type A and type B.

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Teacher's Competence in First-Aid Management of Epistaxis in Schools.

Indian J Otolaryngol Head Neck Surg

December 2024

Department Of Community Medicine, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu India.

Introduction: Epistaxis is commonly referred to as nosebleeds. The age range in which it most frequently manifests itself is three to eight years old. One of the primary settings for pediatric epistaxis is schools since kids can get accidental injuries while playing.

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Comparing the Efficacy of Acetic Acid vs Gentian Violet in Chronic Discharging Ears.

Indian J Otolaryngol Head Neck Surg

December 2024

Department Of Otorhinolaryngology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103 India.

Chronic suppurative otitis media is a prolonged and chronic condition. It is a prevalent bacterial infection in the field of otolaryngology that has substantial consequences. Prior to surgical intervention, it is crucial to implement medical treatment to make the ears dry in cases of chronic suppurative otitis media.

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Influence of Interleukin Polymorphisms on the Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-analysis.

J Hum Reprod Sci

September 2024

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.

Article Synopsis
  • - The study investigates the link between genetic variations in interleukin (IL) genes and the risk of recurrent pregnancy loss (RPL), finding significant associations with specific IL gene variants in a large meta-analysis of 58 studies involving 13,696 participants.
  • - Key findings indicate that variations in IL-1β, IL-6, and IL-10 genes are associated with increased RPL risk, particularly in Asian populations.
  • - Limitations include focusing on single-factor studies and not accounting for other factors like age or lifestyle, which could also influence RPL susceptibility.
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Enhancing Wound Healing with Nanohydrogel-Entrapped Plant Extracts and Nanosilver: An In Vitro Investigation.

Molecules

October 2024

Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam, Chennai 603103, India.

Wound healing is a complex process that can be improved through advanced biomedical approaches. Incorporating nanopolymers and plant extracts into wound dressings offers a favorable strategy for promoting tissue repair. Nanopolymers provide a controlled environment for sustained drug release while also protecting the wound from external contaminants.

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Background: The choice of the ideal antiseptic is not only based on its efficacy but also on safety and skin-friendliness. There are no standard recommendations regarding ideal skin preparation in neonates.

Methods: This was a prospective cohort study to evaluate the efficacy of 3 antiseptics[10% Povidone Iodine(PI), 70% isopropyl alcohol(AL), 2% chlorhexidine in 70% alcohol(CHG-IPA)] in disinfecting the skin before venipuncture in term neonates as assessed by logarithmic reduction in skin bacterial colony counts post-application.

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Background: Inpatients are at higher risk of Drug Therapy Related Problems (DTRPs), and early identification and management of these DTRPs is crucial for optimal treatment outcomes and ensuring rational drug therapy.

Objective: This study aims to assess DTRPs in a general medicine ward of a tertiary care hospital in eastern Nepal.

Methods: A three-month prospective observational study was conducted on inpatients admitted to the general medicine ward of the hospital.

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Genetic variants in ( and ) and stroke susceptibility: a case-control analysis in South India.

Ann Hum Biol

February 2024

Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India.

Article Synopsis
  • Stroke is a condition where the blood supply to the brain is interrupted, risking cell death and is influenced by various factors like genetics and environment.
  • This study explored how specific genetic variations in the BDNF gene affect stroke risk among a sample of South Indian individuals.
  • Results indicated that one genetic variant is linked to a lower risk of stroke, while another variant is associated with a higher risk, suggesting a potential genetic influence on stroke susceptibility in this population.*
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Catalytic co-pyrolysis of plastic pyrolyzed and biooil over Ni-modified ZSM-5 hierarchical structures.

Environ Res

October 2023

Fuel Cell Institute, Universiti Kebangsaan Malaysia, 43600, UKM, Bangi, Selangor, Malaysia; Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, India. Electronic address:

Hierarchical designing of (10 wt% - 70 wt%) nickel over HZSM-5 zeolite was done using wet-impregnation method. The material formation was established by XRD, BET, TPD and TEM studies. Optimization of reaction parameters for mixture of LDPE derived oil and waste cooking oil was found to be 450 °C, 4.

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Mitigating persistent organic pollutants from marine plastics through enhanced recycling: A review.

Environ Res

October 2023

Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, Taiwan; Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, India. Electronic address:

The escalating crisis of marine plastic waste pose threats to the marine ecosystems. Statistics revealed that a staggering 8 MMT of plastic inundates the marine atmosphere annually. This review delves into a pivotal aspect of this issue, examining the release of additives like brominated flame retardants, phthalates, and bisphenol A from plastic into the environment.

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Unlocking the potential of environmentally friendly adsorbent derived from industrial wastes: A review.

Chemosphere

November 2024

Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, India. Electronic address:

With increasing urbanization and industrialization, growing amounts of industrial waste, such as red mud (RM), fly ash (FA), blast furnace slag (BFS), steel slag (SS), and sludge, are being produced, exposing substantial threats to the environment and human health. Given that numerous researchers associate with conventional adsorbents, developing and utilizing industrial wastes derived from adsorption technology still has received limited attention. Utilizing this waste contributes to developing alternative materials with superior performance and significantly reduces the volume of solid waste.

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