Prognostic values of intracellular cell-related genes in esophageal cancer and their regulatory mechanisms.

Esophageal cancer is a grave malignant condition. While radiotherapy, often in conjunction with chemotherapy, serves as a cornerstone in the management of locally advanced or metastatic cases, patient tolerance and treatment resistance frequently hinder its efficacy. Cell-in-cell structures, prevalent in various tumors, have been linked to prognosis.

Accessibility and TB patient satisfaction in Nigeria.

Nigeria ranks first in Africa and sixth among countries with a high Tuberculosis burden globally. The increasing incidence of drug resistance following poor treatment adherence among drug-susceptible TB (DS-TB) patients necessitates reviewing TB services in Nigeria. This study explored accessibility and patient-reported experiences in newly established TB treatment facilities.

Letter from the UK: Developing the ecosystem for career advancement of women.

Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russel and Kathleen O Lindell See related Editorial.

Prologue: Leading women in respiratory clinical sciences.

Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russell and Kathleen O Lindell See related Letter.

The New Bharatiya Nyaya Sanhita Laws: Progress or Pitfall for Doctors?

The Indian Penal Code (IPC), a relic of British colonial rule, was recently replaced by the Bharatiya Nyaya Sanhita (BNS) in July 2024. While the overhaul of the IPC was largely welcomed, it has sparked significant concern among the medical community, primarily due to Section 106 of the BNS. This section mandates imprisonment for doctors involved in deaths caused by rash or negligent acts during medical procedures, which many in the profession fear could lead to a climate of fear and hesitancy in performing critical medical interventions.

Swallowing the Litigation Pill: The Future of Medical Lawsuits in India.

As the tide of medical lawsuits rises, doctors in India find themselves navigating increasingly treacherous waters. What drives this surge in litigation? Can we chart a course through these challenging times, or are we destined to face relentless legal battles? In this editorial, we unravel the complexities of this pressing issue and glimpse what lies on the horizon for India's medical community.

Pill Pushers or Partners in Progress: Should Pharmaceutical Companies Be Allowed to Sponsor Continuing Medical Education (CME)?

This article explores a timely and contentious issue within the Indian medical community: the relationship between doctors and pharmaceutical companies, particularly the sponsorship of continuing medical education (CME) events. Triggered by the National Medical Council's proposed guidelines in August 2023, which sought to ban such sponsorships, the article revisits the longstanding debate over potential conflicts of interest. While critics argue that these relationships could compromise medical ethics, the article questions whether this assumption holds up under scrutiny.

Revolutionizing Healthcare: The Emerging Role of Quantum Computing in Enhancing Medical Technology and Treatment.

The healthcare sector faces complex challenges that call for innovative solutions to improve diagnostic accuracy, treatment efficacy, and data management. Quantum computing, with its unique capabilities, holds the potential to revolutionize various aspects of healthcare. This narrative review critically examines the existing literature on the application of quantum computing in healthcare, focusing on its utility in enhancing diagnostics, data processing, and treatment planning.

Isolated Tuberculosis of the Radius in an Immunocompetent Indian Male Without Pulmonary Involvement: A Report of a Rare Case.

Extrapulmonary tuberculosis is less commonly reported, and isolated tuberculous involvement of bones such as the radius, without any pulmonary lesions, is extremely rare. Diagnosing this condition can be challenging due to ambiguous clinical features and non-specific radiological findings in the early stages. The present case describes a rare instance of isolated tuberculosis of the radius in an immunocompetent Indian male with no pulmonary involvement.

Spina Ventosa of the Left Ring Finger With Tuberculous Pyomyositis in the Forearm Muscles in a Young Immunocompetent Indian Male With No Pulmonary Involvement: A First Report of Its Type.

Tuberculous infection of the extrapulmonary sites, especially the small bones, is a seldom reported entity even in endemic countries. Moreover, simultaneous involvement of the forearm muscles is a very rare presentation with no such case reported showing concurrent involvement of the two sites. The diagnosis is challenging due to the paucibacillary nature of the disease, a lack of awareness among primary clinicians, and ambiguity in clinical features with other musculoskeletal disorders, especially when there is no pulmonary involvement.

Regulatory Challenges and Frameworks for Fog Computing in Healthcare.

The integration of fog computing into healthcare promises significant advancements in real-time data analytics and patient care by decentralizing data processing closer to the source. This shift, however, introduces complex regulatory, privacy, and security challenges that are not adequately addressed by existing frameworks designed for centralized systems. The distributed nature of fog computing complicates the uniform application of security measures and compliance with diverse international regulations, raising concerns about data privacy, security vulnerabilities, and legal accountability.

White Coats Under Fire: Understanding the Epidemic of Violence Against Doctors.

The doctor-patient relationship, once grounded in trust and mutual respect, is increasingly marred by incidents of violence against healthcare providers. This alarming trend not only threatens the safety of doctors but also undermines the integrity of medical care. This article delves into the multifaceted reasons behind such violence, exploring emotional, financial, societal, and systemic factors that contribute to this disturbing phenomenon.

The Theatre of Surgery: The Ethical and Legal Implications of Live Surgeries.

Surgical training has long emphasized learning through direct observation, allowing young surgeons to gain practical insights from experienced surgeons. The advent of live surgical demonstrations has extended this learning method, providing real-time broadcasts of surgeries to wider audiences. Live surgery is a surgery that is broadcasted in real time to an audience.

Exploring New Horizons: Advancements in Cartilage Tissue Engineering Under Space Microgravity.

Novel investigations of how microgravity affects cellular and tissue development have recently been made possible by the multidisciplinary fusion of tissue engineering and space science. This review examines the intersection of cartilage tissue engineering (CTE) and space science, focusing on how microgravity affects cartilage development. Space microgravity induces distinct physiological changes in chondrocytes, including a 20-30% increase in cell diameter, a 1.

Blood Money: Is it Time to Incentivize Blood Donation in India?

Blood donation, a fundamental act of altruism, has undergone significant evolution over the centuries. Despite medical progress, the persistent challenge lies in securing an adequate supply of blood and its derivatives. This article critically examines the proposal to introduce monetary incentives for blood donation, delving into ethical, legal, and pragmatic dimensions.

Applications of Fog Computing in Healthcare.

Fog computing is a decentralized computing infrastructure that processes data at or near its source, reducing latency and bandwidth usage. This technology is gaining traction in healthcare due to its potential to enhance real-time data processing and decision-making capabilities in critical medical scenarios. A systematic review of existing literature on fog computing in healthcare was conducted.

Isoniazid resistance in Rifampicin sensitive pulmonary tuberculosis in children and adolescents.

Background: Isoniazid (INH) and Rifampicin (RIF) are two crucial drugs used in antitubercular therapy. INH is known for its potent bactericidal effects and has a relatively higher prevalence of resistance compared to RIF. However, RIF resistance has been the subject of more extensive research.

Nikshay Mitra: A Remarkable Initiative in Efforts Against Tuberculosis.

Tuberculosis continues to haunt the fragile healthcare systems in the developing world. It is a disease that is not only limited to the illness due to the bacterial infection but is associated with a number of other impacts, like social and psychological ones. Eliminating tuberculosis is an arduous task and requires a number of initiatives that were taken by the national governments and collaborating partners.

Tuberculosis of the Femur With Intramedullary Abscesses and No Pulmonary Foci in an Immunocompetent Male: A Rare Case.

Tuberculosis of the long bones/femur, especially in an immunocompetent person, is a challenging diagnosis. It is a rare entity, even in endemic settings. The non-specific clinical features, backed by a low suspicion about such presentations even in endemic settings, may result in delayed diagnosis and often unfavorable treatment outcomes.