Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics.

Pancreatic cancer is a highly fatal malignancy due to poor early detection rate and resistance to conventional therapies. This review examines the potential for liquid biopsy as a transformative technology to identify diagnostic and therapeutic targets in pancreatic cancer. Specifically, we explore emerging biomarkers such as exosomal non-coding RNAs (ncRNAs), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs).

Coastal Lagoon's dual role as a sink and source for microplastics: A case study from India.

Coastal lagoons, acting as transitional zones, are increasingly threatened by microplastic (MP) pollution. This study investigates the spatio-seasonal distribution of MPs in Chilika Lagoon sediments to propose effective mitigation measures. MPs were extracted using density flotation and wet peroxide oxidation, followed by quantitative analysis with a stereomicroscope and qualitative analysis with micro-Fourier Transform Infrared (μ-FTIR) spectroscopy.

Environmental performance improvement of ammonium hydroxide-diesel blends via carbon nanotube catalysis and electrostatic nanoparticle filtration.

This study explores the integration of ammonium hydroxide with diesel fuel, focusing on enhancing combustion efficiency and reducing emissions. The research addresses the challenge of ammonia's high activation energy during decomposition by introducing a carbon nanotube catalyst, which significantly improves catalytic performance. Additionally, an electrostatic precipitator (ESP) was developed to capture nanoparticles from engine exhaust, preventing their release into the atmosphere.

Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders - a review.

Neurodegeneration refers to the gradual loss of neurons and extensive changes in glial cells like tau inclusions in astrocytes and oligodendrocytes, α-synuclein inclusions in oligodendrocytes and SOD1 aggregates in astrocytes along with deterioration in the motor, cognition, learning, and behavior. Common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), spinocerebellar ataxia (SCA), and supranuclear palsy. There is a lack of effective treatment for neurodegenerative diseases, and scientists are putting their efforts into developing therapies against them.

Coleus vettiveroides Root Extract Protects Against Thioacetamide-Induced Chronic Liver Injury by Inhibiting NF-κB Signaling Pathway.

The roots of Coleus vettiveroides (CV) have been traditionally used in Indian medicinal systems such as Ayurveda and Siddha for its antioxidant, anti-inflammatory, and antidiabetic effects. This study examines the antifibrotic potential of CV ethanolic root extract (CVERE) against thioacetamide (TAA)-induced liver fibrosis in Wistar rats. TAA was administered via i.

Biogenesis and functional implications of extracellular vesicles in cancer metastasis.

Extracellular vesicles (EVs) play a crucial role in the complex process of cancer metastasis by facilitating cellular communication and influencing the microenvironment to promote the spread and establishment of cancer cells in distant locations. This paper explores the process of EV biogenesis, explaining their various sources that range from endosomal compartments to plasma membrane shedding. It also discusses the complex mechanisms that control the sorting of cargo within EVs, determining their chemical makeup.

A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line.

Introduction: The changes in histone modifications are linked to the progression of benign and normal tissue to malignancy. Thus, numerous findings suggest that targeting epigenetic factors might be a focus for anti-cancer treatment. In this study, we tested the hypothesis that telomerase activator might be a potential epigenetic regulator in combatting skin cancer cell proliferation.

Histopathological Assessment of Tricalcium Aluminate-free Mineral Trioxide Aggregate and Two Antibacterial Enhanced Mineral Trioxide Aggregates As Pulpotomy Agents in Rat Model.

Objective: To evaluate the effect of a newly developed MTA-based material and two antibacterial-enhanced MTAs as pulp capping materials in immature permanent dental elements underwent full pulpotomy.

Methods: The present animal study included 20 Wistar albino rats that, after full pulpotomy, were randomly divided into 4 groups receiving different MTA formulations as pulp capping materials: conventional MTA, Tricalcium aluminate (TCA)- free MTA, and MTA enhanced with metronidazole or doxycycline. Histopathological assessments were carried out at 7- and 28-days post-treatment to evaluate dentinal bridge formation, inflammatory reactions, pulp tissue necrosis and internal resorption.

In Vitro Evaluation of Bacterial Adhesion of Streptococcus mutans and Enterococcus faecalis on Sand-Blasted, Acid-Etched, and Anodized Titanium Dental Implants.

Although the surface modifications of the implant have been widely proposed to enhance the osseointegration, their impact on microbial adhesion is still not explored. The present in vitro study was done to compare the bacterial adhesion of S. mutans and Enterococcus faecalis on sand-blasted acid-etched and anodized titanium dental implants.

Classifying Alzheimer's Disease Using a Finite Basis Physics Neural Network.

The disease amyloid plaques, neurofibrillary tangles, synaptic dysfunction, and neuronal death gradually accumulate throughout Alzheimer's disease (AD), resulting in cognitive decline and functional disability. The challenges of dataset quality, interpretability, ethical integration, population variety, and picture standardization must be addressed using deep learning for the functional magnetic resonance imaging (MRI) classification of AD in order to guarantee a trustworthy and practical therapeutic application. In this manuscript Classifying AD using a finite basis physics neural network (CAD-FBPINN) is proposed.

Fabrication of a novel "all in one glove"- a functional tool for oral hygiene maintenance and the assessment of its effectiveness on plaque control in spastic cerebral palsy patients.

Background & Objective: Spastic Cerebral Palsy (CP) is a neurological disorder from non-progressive brain injury or malformation during development, severely impairing movement, coordination, reflexes, posture, balance, and motor skills. Individuals with spastic CP experience limb spasticity, complicating tasks like precise gripping, particularly with toothbrushes. This study proposed a novel "all-in-one glove" for oral hygiene, assessing its efficacy and comparing it to conventional toothbrushes for spastic CP patients.

The role of combined problem-based learning (PBL) and case-based learning (CBL) teaching methodologies in dental education.

Background: Innovative methods of teaching such as problem-based learning (PBL) and case-based learning (CBL) have shown promising results in academic understanding and application and enable one to manage their patients in a better manner. The study aimed to analyze the role of a combination of PBL and CBL teaching methodologies in a dental teaching institute in India.

Materials And Methods: This prospective, cross-sectional randomized study comprised 500 students divided into two study groups, each consisting of 250 participants.

Telemedicine and information technology in health care management: Perspectives and barriers among the nursing students.

Background: Telemedicine refers to using electronic information and telecommunication technologies to support numerous aspects of healthcare, including clinical care, patient and professional education and training, public health, and health administration. However, many challenges hinder the widespread adoption of telemedicine by healthcare providers. This study aimed to assess the perspectives and barriers in telemedicine and information technology in health care management among nursing students.

Burden of neurologic diseases in BRICS countries (1990 to 2021): an analysis of 2021 Global Burden of Disease Study.

Background: Neurological disorders are a major global health concern, especially in BRICS nations (Brazil, Russia, India, China, South Africa), where demographic and socio-economic changes have amplified their impact. This study evaluates trends in incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) associated with neurological diseases in these countries from 1990 to 2021, focusing on sex disparities and key risk factors.

Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 database.

Clinical Profile and Outcomes of Pediatric Snakebite Envenomation: A Three-Year Retrospective Study From a Rural Tertiary Care Center in South India.

Background Snakebite envenomation remains a significant public health challenge in tropical countries, particularly affecting the pediatric population. Children are especially vulnerable because of their smaller body mass, outdoor activities, and delayed presentation to healthcare facilities. This study aimed to analyze the clinical profile, demographic patterns, and envenomation characteristics of snakebites in children aged 1-16 years presenting to a tertiary care center.

Identifying the Prognostic Factors Affecting the Conversion From Laparoscopic Cholecystectomy to Open Cholecystectomy in Acute Cholecystitis.

Introduction Acute cholecystitis, commonly caused by gallstones, is a prevalent surgical emergency worldwide. Laparoscopic cholecystectomy (LC) is the gold standard for treatment, but the timing is crucial, with early surgery (within seven days) reducing complications. Identifying prognostic factors such as age, sex, white blood cell (WBC) count, C-reactive protein (CRP), and gallbladder wall thickness can help predict outcomes and reduce the need for conversion to open surgery.

Overcoming Giant Verruca Vulgaris Treatment Obstacles With Siddha Medicine: A Case Report.

Verrucae vulgaris are infectious keratotic lesions caused by the human papillomavirus (HPV), frequently impairing an individual's quality of life, mainly when situated on the facial region. Verruca vulgaris constitutes a prevalent dermatological issue with diverse repercussions for those affected. The interaction among HPV, the immune system, and treatment methods requires a sophisticated comprehension of this illness.

Photonic Inks with Dual-Layer Security Features by Encapsulation of Color Tunable Fluorescent Dyes in PMMA Colloidal Microspheres.

To counter economic terrorism by preventing counterfeit currency, documents and high-value commercial products, new-generation security inks with multiple safety features are required. Herein, color-tunable pyrylium and pyridinium dye-encapsulated polymethyl methacrylate (PMMA) colloidal microspheres are reported to exhibiting brilliant emission and photonic properties. A combination of the PMMA colloidal photonic ink having structural color variation and the dye-encapsulated colloidal photonic ink with fluorescence modulation is used for security labeling.

Effects of Congestion in Human Lung Investigated Using Dual-Scale Porous Medium Models.

Chronic obstructive pulmonary disease (COPD) is a primary chronic respiratory disease associated with pulmonary congestion that restricts airflow and thereby affects the exchange of gases between the alveoli and the blood capillaries in the lungs. Dual scale-global and local-porous medium models have been developed and reported in this work, to study the effects of air-side congestion on the blood-oxygen content in the alveolar region of the human lung. The human lung is model as a global, equivalent, heterogeneous porous medium comprising three zones with distinct permeabilities related to their progressively complex branching structure.

Spatial analysis and mapping of malaria risk areas using geospatial technology in the case of Nekemte City, western Ethiopia.

Background: Malaria is a major public health issue in Nekemte City, western Ethiopia, with various environmental and social factors influencing transmission patterns. Effective control and prevention strategies require precise identification of high-risk areas. This study aims to map malaria risk zones in Nekemte City using geospatial technologies, including remote sensing and Geographic Information Systems (GIS), to support targeted interventions and resource allocation.

Assessing correlation between different temporary restorative materials for microleakage following endodontic treatment: an in-vitro study.

Background: Coronal microleakage, the passage of fluids and bacteria through the interface between the temporary restoration and the tooth structure, can potentially result in endodontic treatment failure.

Purpose: This study evaluated and compared the sealing efficacy of various temporary restorative materials utilized during endodontic procedures.

Methods: All seventy premolar teeth were extracted, measured, and restored, except for the negative control group, where the teeth were left whole.

Invention of Enmetazobactam: An Indian Triumph in Antimicrobial Drug Discovery.

The discovery of antimicrobials was an inflection point in human existence since it contributed enormously to the extension of the human lifespan. Among others, the invention of Enmetazobactam marks a significant milestone in the field of antimicrobial development, especially for India. It is a novel beta-lactamase inhibitor invented by scientists at Orchid Pharma in Chennai, India, and has garnered international attention for its potential to address antimicrobial resistance.

Microbial disintegration of wool: An effective and sustainable approach for keratin extraction.

Keratin is an important biopolymer used to develop biomaterials for biomedical and industrial applications. Traditional keratin extraction methods involve the removal of surface lipids using organic solvents, detergents, and energy-intensive processes that often compromise the purity of the extracted keratin. In the present study, wool fibers were microbially disintegrated to isolate cortical cells, achieving a maximum yield of 61.