1 results match your criteria: "Chengdu University of Traditional Chinese Medicine Chengdu 611137 China ljaaa111@163.com dengyun@cdutcm.edu.cn taofeiyan@163.com.[Affiliation]"
Construction of multi-substituted pyrazoles potassium carbonate-mediated [3 + 2] cycloaddition of generated nitrile imines with cinnamic aldehydes.
RSC Adv
April 2022
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China
A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions has been developed. A plausible stepwise cycloaddition reaction mechanism is proposed. This protocol featured broad substrate coverage, good functional group tolerance, wide scalability, and operational simplicity, as well as conveniently constructed pyrazole scaffolds.
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