3 results match your criteria: "Chengdu Medical College Chengdu 610083[Affiliation]"

[Comparative study on anti-inflammatory effect of Lonicerae Japonicae Flos and Lonicerae Flos].

Zhongguo Zhong Yao Za Zhi

August 2020

Key Research Office for Biological Evaluation of Traditional Chinese Medicine Quality of the State Administration of Chinese Medicine, Sichuan Provincial Traditional Medicine System Development Engineering Technology Research Center, Sichuan Center for Transforming Chinese Medicine, Sichuan Academy of Traditional Chinese Medicine Chengdu 610041, China.

Article Synopsis
  • - The study investigated the anti-inflammatory effects and mechanisms of Lonicerae Japonicae Flos extract using both in vivo (mouse ear swelling model) and in vitro (LPS-induced RAW264.7 cell model) experiments.
  • - Results showed that both extracts significantly reduced ear swelling in mice, decreased lymphocyte and neutrophil infiltration, and inhibited the production of nitric oxide and inflammatory factors like IL-1β, IL-6, and TNF-α in RAW264.7 cells.
  • - The extracts lowered protein levels of iNOS and COX2, suggesting their anti-inflammatory action may work through inhibiting the NF-κB signaling pathway.
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Zha-xun is widely used in Tibetan medicine and is also an international traditional medicine. This study believes that the black organic matter constituting Zha-xun is mainly stored in the rocks. The exudation points of Zha-xun mostly distribute on the cliffs of high mountains, which makes it difficult to evaluate its resource distribution and storage area.

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Chemotherapy turns tumor cells into "tumor vaccines" by immunogenic cell death (ICD). However, it remains a challenge to exploit chemotherapy-induced "tumor vaccines" for solid cancer immunotherapy due to the inefficient effector T cells activation and tumor microenvironment immunosuppression. Here, a matrix metalloprotease 2 responsive liposome (PEG-FA-Lip) composed of cleavable PEG chains covering the folate (FA)-modified liposome is developed to deliver ICD inducer doxorubicin.

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