5 results match your criteria: "Chengdu General Hospital of Chengdu Military Area Command[Affiliation]"
Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury.
Sci Rep
December 2015
Division of Nephrology and Selzman Institute for Kidney Health/Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury. Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides cytoprotection; hence, we hypothesized that STC1 will inhibit thrombin/PAR1 signaling and protect from bleomycin-induced pneumonitis. We determined thrombin level and activity, thrombin-induced PAR-1-mediated signaling, superoxide generation and lung pathology after intra-tracheal administration of bleomycin to WT and STC1 Tg mice.
View Article and Find Full Text PDFSevere Nephrotoxic Nephritis following Conditional and Kidney-Specific Knockdown of Stanniocalcin-1.
PLoS One
June 2016
Division of Nephrology/Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America.
Article Synopsis
- - The study investigates the effects of knocking down Stanniocalcin-1 (STC1) in the kidneys of transgenic mice to understand its role in nephrotoxic nephritis, a condition marked by inflammation in the kidneys.
- - Results showed that while serum and urinary parameters were similar across groups, mice with reduced STC1 exhibited severe kidney damage, including extensive tubular and glomerular necrosis, compared to mild injury in control mice.
- - The severe kidney damage in STC1 knockdown mice occurred despite a lower inflammatory response, indicating that the protective role of STC1 may involve promoting survival factors that mitigate kidney injury.
Therapeutic effect and mechanism of electroacupuncture at Zusanli on plasticity of interstitial cells of Cajal: a study of rat ileum.
BMC Complement Altern Med
June 2014
Center of General Surgery, Chengdu General Hospital of Chengdu Military Area Command, 270 Rongdu Rd,,Tianhui Town, Jinniu District, Chengdu 610083, China.
Background: Electroacupuncture (EA) is one of the techniques of acupuncture and is believed to be an effective alternative and complementary treatment in many disorders. The aims of this study were to investigate the effects and mechanisms of EA at acupoint Zusanli (ST36) on the plasticity of interstitial cells of Cajal (ICCs) in partial bowel obstruction.
Methods: A Sprague Dawley rat model of partial bowel obstruction was established and EA was conducted at Zusanli (ST36) and Yinglingquan (SP9) in test and control groups, respectively.
Association of vascular endothelial growth factor -2578C/A gene polymorphism in Chinese patients with colon cancer.
Genet Test Mol Biomarkers
March 2011
Center of General Surgery, Chengdu General Hospital of Chengdu Military Area Command, Chengdu, China.
The vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in the process of angiogenesis, a crucial phase in tumor growth and metastasis. We carried out a case-control study to evaluate whether VEGF -2578C/A gene polymorphism modulates the risk of developing colon cancer. A total of 110 colon cancer patients and 110 cancer-free healthy people were recruited in the Chinese population.
View Article and Find Full Text PDFPercutaneous catheter drainage in combination with choledochoscope-guided debridement in treatment of peripancreatic infection.
World J Gastroenterol
January 2010
Center of General Surgery, Chengdu General Hospital of Chengdu Military Area Command, Chengdu 610083, Sichuan Province, China.
Aim: To introduce and evaluate the new method used in treatment of pancreatic and peripancreatic infections secondary to severe acute pancreatitis (SAP).
Methods: A total of 42 SAP patients initially underwent ultrasound-guided percutaneous puncture and catheterization. An 8-Fr drainage catheter was used to drain the infected peripancreatic necrotic foci for 3-5 d.