Benign Giant Phyllodes Tumours Presenting as Fungating Breast Masses.

Breast masses presenting as fungating growths usually represent advanced malignancy. One remarkable exception is a benign phyllodes tumour. These tumours of stromal origin often exhibit rapid growth, resulting in pressure necrosis at the summit of the tumor causing fungation.

Two Interesting Cases of Thyroid Gland Tuberculosis.

Tuberculosis involving the thyroid gland is an exceptionally rare condition with varied clinical presentations, often leading to diagnostic challenges. We report two cases: a 9-year-old male with necrotic tuberculous cervical lymphadenopathy secondarily involving the thyroid gland, and a 40-year-old male with disseminated tuberculosis affecting multiple organ systems, including the thyroid gland. Both cases presented with swelling over the neck region and were evaluated using ultrasonography and contrast-enhanced computed tomography (CECT), which revealed characteristic imaging findings of thyroid involvement.

Kocuria rosea Sepsis in an Immunocompromised Patient: A Case Report.

species, classified within the phylum , class , order  family , are Gram-positive coccoid bacteria. They bear morphological resemblance to and which often leads to misidentification and oversight as contaminants, given their presence as normal flora on human and animal skin and mucous membranes. Accurate identification of these organisms typically relies on automated systems such as MALDI-TOF-MS, Vitek-2 System, and 16S rRNA studies.

Mangrove tree aerial root extract mediated green synthesis of Ag/FeO/rGO nanocomposite and its application as a catalyst for one pot synthesis of 7-phenyl-6H,7H-benzo[4,5]imidazo[2,1-b]chromeno[4,3-d][1,3]thiazin-6-one derivatives.

In this study, we report the green preparation of magnetically separable Ag/FeO/rGO nanocomposites using mangrove tree aerial root extract as a stabilising agent. The morphology, size, chemical composition, magnetic property and other characteristic parameters of synthesised Ag/FeO/rGO nanocomposite were determined by analytical techniques like Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The results proved that mangrove tree aerial root extract has the ability to reduce Ag ions, graphene oxide (GO) to Ag nanoparticle and reduced graphene oxide (rGO), respectively.

COX-2 targeted therapy for diabetic foot ulcers using T7-enhanced CS-PVA membranes.

Diabetic foot ulcers can lead to severe complications, including infection, gangrene, and even amputation, significantly impacting patients' quality of life. The application of anti-inflammatory compounds loaded into chitosan membranes offers targeted therapeutic effects, reducing inflammation and promoting tissue regeneration. This study evaluates the therapeutic efficacy of T7, a selective COX-2 inhibitor, incorporated into chitosan-polyvinylalcohol (CS-PVA) membranes for diabetic wound treatment.

Pharmaceuticals and personal care products contamination in the rivers of Chennai city during the COVID-19 pandemic.

Pharmaceuticals and personal care products (PPCPs) monitoring in surface water is crucial to address the escalating threat of antimicrobial resistance and safeguard public health. This study aimed to investigate the occurrence of 21 different PPCPs, including wastewater chemical markers, antibiotics, and parabens in the surface water of Chennai city using Ultra Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UPLC-MS/MS) analysis. It is noteworthy that chemical markers viz.

Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis.

Background: Ashwagandha (Withania somnifera) is an adaptogenic herb used to prevent and treat psychosomatic disorders. This systematic review and meta-analysis evaluated the effects and safety of Ashwagandha on psychosomatic functions related to stress and anxiety among patients.

Methods: A comprehensive search was conducted in MEDLINE, EMBASE, PubMed, PsychINFO, and the Cochrane Library for articles published from January 2000 to January 2022.

Stress and Sleep Deprivation Experienced by Bus Drivers of Government Bus Depots in an Urban Area of Chengalpattu District in South India.

Background Driving a bus is far more stressful than other professions. Bus drivers also take more sick leave than other workers because of the physical and mental demands of their employment. Bus drivers are especially vulnerable because of their intense work environment, poor sleep, and poor food pattern.

Chitosan-based insecticide formulations for insect pest control management: A review of current trends and challenges.

Future agricultural practices necessitate green alternatives to replace hazardous insecticides while distinguishing between pests and beneficial insects. Chitosan, as a biological macromolecule derived from chitin, is biodegradable and exhibits low toxicity to non-target organisms, making it a sustainable alternative to synthetic pesticides. This review identifies chitosan-derivatives for insecticidal activity and highlights its efficacy including genotoxicity, defense mechanism, and disruption of insect's exoskeleton at different concentrations against several insect pests.

Self-Medication Practice and Associated Factors Among Pregnant Women Residing in Kattankulathur Block of Chengalpattu District in Tamil Nadu, India: A Cross-Sectional Study.

Background Self-medication is a prevalent phenomenon worldwide. The self-medication practiced by pregnant women, particularly during the first trimester, can have significant adverse consequences for both the developing fetus and the mother. Although self-medication during pregnancy has the potential to cause adverse effects, there is less information regarding the consequences among pregnant women in low-middle-income countries, such as India.

A novel brominated chalcone derivative as a promising multi-target inhibitor against multidrug-resistant Listeria monocytogenes.

Foodborne pathogens continue to challenge public health due to their ability to cause severe illness and their increasing resistance to current antimicrobial treatments. Listeria monocytogenes is a resilient foodborne pathogen that poses significant risks to vulnerable populations, leading to severe infections and high hospitalization rates. The emergence of antimicrobial-resistant (AMR) strains of L.

Prescribing Trend of Antibiotics Among the Patients Admitted in Intensive Medical Care Unit: A Prospective Observational Study.

Background: Intensive medical care units (IMCUs) usually admit patients who are in critical medical need and require the utmost attention of healthcare professionals, along with the best treatment options available. These patients are prone to infections and require various antibiotics for the treatment. Varying costs of antibiotics, variable dosage forms, and antibiotic resistance cause an economic burden on patients Methodology: This study was designed and conducted prospectively to evaluate the prescribing pattern of antibiotics at the IMCU in a tertiary care hospital.

Lived experiences of diabetes self-management among persons with disabilities in rural Tamil Nadu - a case study approach.

Background: People with disabilities have numerous challenges in diabetes self-management. Poor self-management leads to the worsening of disability and secondary complications of diabetes. This study was conducted to explore the challenges in diabetes self-management and the factors influencing diabetes self-management among people with disabilities.

Chitosan-chondroitin sulfate-daidzein nanoconjugate ameliorates glucocorticoid induced osteoporosis in vivo.

The use of nanotechnology and polymer-based carriers in osteoporosis treatment offers promising avenues for targeted drug delivery and enhanced therapeutic efficacy. In this study, we developed a novel nanoconjugate composed of Chitosan (CH), Chondroitin Sulfate (CS), and Daidzein (DZ) to treat glucocorticoid-induced osteoporosis in an in vivo zebrafish model. The CH-CS-DZ nanoconjugate were synthesized using the ionic gelation method, with a CH: CS ratio of 1:1 and a 3 % DZ concentration was identified as optimal for further analysis.

Establishing network pharmacology between natural polyphenols and Alzheimer's disease using bioinformatic tools - An advancement in Alzheimer's research.

Alzheimer's disease (AD) is a major cause of disability and one of the top causes of mortality globally. AD remains a major public health challenge due to its prevalence, impact on patients and caregivers, and the current lack of a cure. In recent years, polyphenols have garnered attention for their potential therapeutic effects on AD.

Development of a Questionnaire for Dental Utilization Based on the Andersen Model.

Background and aim Oral health is an integral part of overall general health. Understanding the variables that affect the use of dental services can help overcome the challenges and lessen disparities in oral health. There are no significant reliable questionnaires available for determining factors that influence dental care utilization.

Knowledge, Attitudes, and Practices of University Students Regarding the Impact of Smokeless Tobacco, Areca Nut, E-cigarette Use on Oral Health.

Background:  The prevalence of smokeless tobacco, areca nut, and e-cigarette use among university students has raised concerns regarding their potential impact on oral health. Assessing students' knowledge, attitudes, and practices toward these substances is necessary. Understanding these factors can inform targeted interventions and policies promoting oral health among this population.

Abdomen (A Pandora's Box): A Delayed Presentation of Blunt Abdominal Injury With a Mesenteric Tear Leading to Gangrenous Bowel.

In the emergency department, blunt trauma to the abdomen is frequently seen following a blunt injury. Road traffic accidents are the leading cause of this type of injury. This is a case presentation of a young adult male who presented to the emergency medicine department one week after he had a road traffic accident.

Amelanotic Malignant Melanoma With Atypical Divergent Neuroendocrine Differentiation: A Report of an Unusual and Rare Case of Anorectal Bleeding.

Melanocytes located between the anal transition zone and the dentate line of the anal canal can give rise to the uncommon malignant tumor known as anal melanoma. It has a fast-paced clinical course and can masquerade as several common anorectal symptoms, such as hemorrhoids or rectal ulcers. In melanoma, divergent differentiation is a very uncommon phenomenon.

A comprehensive guide to content-based image retrieval algorithms with visualsift ensembling.

Background: Content-based image retrieval (CBIR) systems are vital for managing the large volumes of data produced by medical imaging technologies. They enable efficient retrieval of relevant medical images from extensive databases, supporting clinical diagnosis, treatment planning, and medical research.

Objective: This study aims to enhance CBIR systems' effectiveness in medical image analysis by introducing the VisualSift Ensembling Integration with Attention Mechanisms (VEIAM).