574 results match your criteria: "Chemotherapy-Induced Oral Mucositis"
The effect of honey in oral care intervention against chemotherapy-induced mucositis in pediatric cancer patients: a pilot study.
BMC Complement Med Ther
December 2024
Department of Pediatric Nursing, Faculty of Nursing, Universitas Padjadjaran, Jalan Ir. Soekarno KM. 21, Jatinangor, Sumedang, West Java, 45363, Indonesia.
Objective: Mucositis is one of the common side effects of chemotherapy. This study aimed to identify the effects of honey on oral care interventions to reduce mucositis scores among children undergoing chemotherapy.
Methods: This pilot study was quasi-experimental with pre-post intervention with the control group.
Cancer treatment-induced ulcerative mucositis serves as a significant predictor of burden of illness including dysphagia, and associated disparities among hospitalized cancer patients.
Support Care Cancer
December 2024
Department of Medicine, Division of Hematology and Oncology, University at Buffalo, Buffalo, NY, 14203, USA.
Article Synopsis
- The study investigates the link between oral ulcerative mucositis (both chemotherapy and radiotherapy-induced) and the burden of illness, dysphagia, and disparities in patients with cancers of the oral cavity and those undergoing stem cell transplants.
- Using national data, the research found that chemotherapy-induced oral ulcerative mucositis is associated with longer hospital stays and a higher likelihood of dysphagia in both cancer and transplant patients, while radiotherapy-induced mucositis only increased hospital stays without impacting dysphagia.
- The findings stress the importance of better screening and prevention strategies for oral mucositis, particularly focusing on vulnerable groups, and suggest future studies explore AI for predicting mucositis outcomes.
The Study Progress and Analysis of Preventive Measures of Nursing Care for Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Hematologic Malignancies: A Retrospective Study.
J Multidiscip Healthc
November 2024
Department of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Objective: To analyze the preventive and therapeutic effects of comprehensive nursing interventions on chemotherapy-induced oral mucositis in pediatric patients with hematologic malignancies.
Methods: A retrospective analysis was conducted, and 80 pediatric patients with hematologic malignancies who underwent chemotherapy in our hospital from January 2020 to December 2023 were selected as the research subjects. According to different nursing intervention methods, the patients were divided into an experimental group (45 cases) and a control group (35 cases).
Photodynamic therapy for oral mucositis in cancer patients- a systematic review and meta-analysis.
Photodiagnosis Photodyn Ther
December 2024
Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Department of Oral Diseases, Karolinska Institutet, Huddinge, Sweden.
Aim: This systematic review aimed to evaluate the efficacy of photodynamic therapy (PDT) in reducing the severity of chemotherapy-induced oral mucositis, and associated symptoms in cancer patients compared to standard care or other interventions.
Materials And Methods: A comprehensive literature search identified seven relevant studies (randomized controlled trials and non-randomized clinical trials) published between January 1, 2000, and May 31, 2024. The data analysis was carried out using the standardized mean difference as the outcome measure.
Influence of Tryptophan Metabolism on the Protective Effect of Weissella paramesenteroides WpK4 in a Murine Model of Chemotherapy-Induced Intestinal Mucositis.
Probiotics Antimicrob Proteins
November 2024
Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Minas Gerais, 31270-901, Belo Horizonte, Brazil.
Article Synopsis
- * In a study, mice treated with W. paramesenteroides WpK4 showed increased intestinal mucus production, better villi regeneration, and 100% survival, compared to 60% survival in the control group after chemotherapy with 5-fluorouracil (5-FU).
- * The probiotic strain can produce and metabolize tryptophan, and its protective effects are associated with increased expression of tryptophan-related molecules in the mice, but these benefits are negated when an AhR inhibitor is
Prevalence and risk factors of chemotherapy-induced taste alterations among cancer patients: A systematic review and meta-analysis.
Eur J Oncol Nurs
November 2024
School of Nursing, Sun Yat-sen University, Guangzhou, China. Electronic address:
Article Synopsis
- This study investigates the prevalence and risk factors of chemotherapy-induced taste alterations (CiTA) among cancer patients, which can lead to gastrointestinal issues and malnutrition.
- The analysis included 30 studies with over 15,000 participants, finding that 70% of patients experience CiTA, with prevalence varying widely between 21% and 100%.
- Key risk factors identified for developing CiTA include being female, having xerostomia or oral mucositis/ulcers, and undergoing at least two chemotherapy cycles; these findings suggest a need for targeted interventions in healthcare.
Article Synopsis
Mitigation of chemotherapy-induced experimental intestinal mucositis through postbiotic lactate.
Lett Appl Microbiol
November 2024
Department of Nutrition, School of Nursing, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Postbiotic lactate modulates the immune system in inflammatory bowel diseases. However, its role in experimental intestinal mucositis (IM) has not been elucidated. This study aimed to evaluate the effects of lactate supplementation (1 and 2 × 10-1 mol/l) in a 5-fluorouracil (5-FU)-induced IM model.
View Article and Find Full Text PDFEvaluation of high-power laser therapy as treatment of chemotherapy-induced oral mucositis in paediatric patients with oncohematological diseases-Dr Morankar.
Int J Paediatr Dent
January 2025
Dentistry section, Department of Neuroscience, University of Padua, Padua, Italy.
Evaluating high power laser therapy (HPLT) as treatment for chemotherapy-induced oral mucositis in paediatric patients with oncohematological diseases- Dr Jin.
Int J Paediatr Dent
January 2025
Dentistry section, Department of Neuroscience, University of Padua, Padua, Italy.
Efficacy of Mucosamin Spray as an Adjunct for Prevention of Oral Mucositis in Children under Chemotherapy: A Two-Center Randomized Clinical Trial.
J Dent (Shiraz)
September 2024
Dept. of Pediatric Dentistry, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Article Synopsis
- Chemotherapy-induced mucositis is a common and painful side effect in cancer treatment, necessitating effective solutions to alleviate its severity and duration.
- This study investigated the effectiveness of Mucosamin spray as an additional preventive measure against oral mucositis in pediatric patients undergoing chemotherapy.
- Results showed no significant difference in the incidence or severity of mucositis between the groups, but the intervention group experienced a significantly shorter healing time.
A randomized phase III study evaluating dexamethasone-based mouthwash to prevent chemotherapy-induced stomatitis in patients with breast cancer.
Jpn J Clin Oncol
October 2024
Department of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
Article Synopsis
- A multicenter phase III trial is being conducted to evaluate a dexamethasone-based mouthwash for preventing chemotherapy-induced stomatitis in early breast cancer patients.
- The study will involve 230 patients, randomly assigned to either the dexamethasone mouthwash group or a control group using tap water as mouthwash.
- The main goal is to measure the effectiveness of the mouthwash in reducing the incidence of stomatitis, tracked through electronic patient-reported outcomes.
Effects of Curcumin on Radiation/Chemotherapy-Induced Oral Mucositis: Combined Meta-Analysis, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.
Curr Issues Mol Biol
September 2024
College of Stomatology, Guangxi Medical University, Nanning 530021, China.
Article Synopsis
- The study investigates how curcumin can alleviate oral mucositis caused by radiation and chemotherapy and examines its underlying mechanisms.
- It includes a meta-analysis of 12 studies with 565 patients, revealing that curcumin significantly reduces both the incidence and severity of the condition.
- Molecular docking and dynamics simulations suggest curcumin interacts strongly with target proteins like MAPK3, SRC, and TNF, indicating potential pathways for its therapeutic effects.
Photobiomodulation therapy on chemo- and radiotherapy induced oral conditions: an umbrella review.
BMC Oral Health
September 2024
Egas Moniz School of Health & Science, Egas Moniz Center for Interdisciplinary Research (CiiEM), Caparica, 2829-511, Portugal.
Article Synopsis
- Photobiomodulation (PBM) is a laser therapy aimed at healing tissue and reducing pain, and has been specially examined for treating oral mucositis (OM) caused by chemotherapy and radiotherapy.
- *Out of 1201 systematic reviews (SRs) studied, only 21 met the criteria, with 71.4% showing critically low quality in evidence, and most meta-analyses were considered weak, despite 87.5% showing significant results.
- *The conclusion indicates that, while there is some support for PBM's effectiveness against chemo-induced OM, the existing evidence is of low quality and highlights the need for better future research.*
In situ gel-forming oil solubilizing α-lipoic acid as a physical shielding alleviated chemotherapy-induced oral mucositis via inhibiting oxidative stress.
Int J Pharm
November 2024
Department of Pharmaceutics, Key Laboratory of Novel Nuclide Technologies on Precision Diagnosis and Treatment & Clinical Transformation of Wenzhou City, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China. Electronic address:
Article Synopsis
- Oral mucositis (OM) is a serious side effect of cancer treatment, and existing management techniques offer limited healing.
- A new in situ gel-forming oil (LGF) has been developed to provide better treatment, featuring good adhesion and wetting properties on oral tissues, which helps it stay in place.
- The oil contains α-lipoic acid, which gradually releases to reduce oxidative stress, promotes healing in animal studies, and reduces harmful inflammation associated with OM.
Association between salivary inflammatory mediators and oral mucositis in patients with cancer undergoing chemotherapy.
Support Care Cancer
September 2024
Department of Drug Safety and Risk Management, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Article Synopsis
- - This study investigates the link between salivary inflammatory markers and oral mucositis in 167 patients receiving chemotherapy, emphasizing the impact of mucositis on cancer treatment.
- - Results show that interleukin-6 and tumor necrosis factor (TNF)-α levels were significantly higher in patients with severe oral mucositis, indicating a correlation with inflammation.
- - The findings suggest that saliva can be used to assess inflammation and that elevated TNF-α levels may predict the severity of oral mucositis in chemotherapy patients.
Safety assessment of neurokinin-1 receptor antagonist: real-world adverse event analysis from the FAERS database.
Front Pharmacol
July 2024
Department of General Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
Article Synopsis
- Aprepitant, fosaprepitant, and netupitant are neurokinin-1 receptor antagonists used to prevent nausea and vomiting from chemotherapy, and understanding their side effects can guide clinicians in treatment choices.!
- Data from the FDA Adverse Event Reporting System showed differing adverse event (AE) profiles for the three drugs; aprepitant was linked to joint deposits, fosaprepitant to seizure-like symptoms, and netupitant had a notable association with death among other unique AEs.!
- The study highlighted that AEs varied by gender, suggesting clinicians need to consider both common and new emerging AEs, alongside gender differences when prescribing these medications.!
Enhancing Standardized Practices for Oral Mucositis Prevention in Pediatric Hematopoietic Stem Cell Transplantation: A Best Practice Implementation Project.
Risk Manag Healthc Policy
August 2024
Department of Haematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, People's Republic of China.
Article Synopsis
- Oral mucositis (OM) is a significant issue for children undergoing hematopoietic stem cell transplantation (HSCT), highlighting a discrepancy between clinical practices and available evidence in nursing care.* -
- The study aims to integrate evidence-based practices to improve nurse compliance and prevent chemotherapy-induced OM, using a comprehensive model from the Joanna Briggs Institute.* -
- After implementing these evidence-based interventions, there was a notable improvement in compliance and a reduction in the incidence and severity of OM, leading to standardized oral care procedures for better patient outcomes.*
Unveiling the therapeutic potential of Taxifolin in Cancer: From molecular mechanisms to immune modulation and synergistic combinations.
Phytomedicine
October 2024
Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address:
Article Synopsis
- - Taxifolin (TAX), a natural flavonoid found in medicinal plants, shows potential in cancer therapy by inhibiting tumor growth and enhancing the effectiveness of traditional chemotherapy through various biological mechanisms.
- - The review analyzes TAX’s antitumor mechanisms, its synergistic effects with chemotherapeutic agents, and its ability to protect cells from chemotherapy-related toxicities, while also exploring its safety and pharmacokinetic challenges.
- - Research indicates that TAX can block tumor cell proliferation and invasion by targeting specific pathways, and it also has a beneficial role in improving immune responses against tumors, potentially enhancing the effectiveness of immune therapies.
Oral Neuropathy Associated with Commonly used Chemotherapeutic Agents: A Narrative Review.
Curr Pain Headache Rep
July 2024
Paolo Procacci Foundation, Roma, Italy.
Article Synopsis
- Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of various chemotherapy drugs, with oral-and-perioral-CIPN (OCIPN) being less reported despite causing symptoms like jaw pain and numbness.* -
- A recent review analyzed data on OCIPN by examining literature from PubMed and Cochrane, excluding studies related to head and neck cancer treatment complications.* -
- Different types of chemotherapy agents, such as platinum-based drugs, taxanes, and vinca alkaloids, can lead to specific symptoms in the mouth and face, and it’s crucial for healthcare providers to recognize and document these effects.*
The Effect of Oral Care Intervention in Mucositis Management Among Pediatric Cancer Patients: An Updated Systematic Review.
J Multidiscip Healthc
July 2024
Pediatric Nursing Department, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Article Synopsis
- - Chemotherapy-induced mucositis can significantly harm pediatric cancer patients by causing oral inflammation, leading to financial strains, reduced quality of life, and potentially lower survival rates; effective oral care is essential to manage these symptoms.
- - A systematic review analyzed studies from 2014 to 2023 that explored oral care interventions for mucositis in children, employing rigorous appraisal methods to ensure the quality of the findings.
- - Eight studies indicated that interventions like tooth brushing and use of natural products (honey, olive oil, Aloe Vera) may alleviate mucositis symptoms, but the overall improvement in children's quality of life was not significant, while some products (Caphosol) showed no benefits.
cytoprotective and anti-oral mucositis effects of melatonin and its derivatives.
PeerJ
July 2024
Melatonin Research Group, Khon Kaen University, Khon Kaen, Thailand.
Article Synopsis
- A preliminary study examined the effects of melatonin and its derivatives, BBM and EBM, on preventing chemotherapy-induced inflammation, especially in the oral mucosa.
- BBM showed the most significant protective effects against oxidative stress and cell damage, outperforming melatonin and EBM at certain concentrations.
- The study indicates potential for developing BBM and EBM as effective treatments for oral mucositis related to chemotherapy, with BBM also promoting better recovery in mice.
Application of Mucoadhesive Hydrogel with Anti-Inflammatory and Pro-Repairing Dual Properties for the Treatment of Chemotherapy-Induced Oral Mucositis.
ACS Appl Mater Interfaces
July 2024
Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong 510280, P. R. China.
Article Synopsis
- * The study introduces a novel hydrogel system combining methacrylate-modified collagen, hyaluronic acid, and alginate to enhance adhesion, biocompatibility, and therapeutic effects.
- * This new hydrogel promotes healing by reducing inflammation, supporting blood vessel formation, and repairing tissue, making it a potentially effective treatment option for CIOM.
Chemotherapy-induced oral mucositis: hierarchical analysis of recurrence factors.
Eur Arch Paediatr Dent
August 2024
Clinical and Preventive Dentistry Department, Federal University of Pernambuco (UFPE), Professor Moraes Rego Avenue, 1235, Recife, Pernambuco, Brazil.
Article Synopsis
The Effect of Gastrointestinal Mucositis Care Training Given to Pediatric Leukemic Patients and Caregivers on Mucosal Barrier Injury.
Cancer Nurs
July 2024
Author Affiliations: Pediatric Nursing Department, Faculty of Nursing, Ege University (Dr Ardahan Sevgili), Izmir; and Department of Pediatric Nursing, Faculty of Health Sciences, Kütahya Health Sciences University (Dr Şenol), Turkey.
Article Synopsis
- The study examined the effects of mucositis care training for children with leukemia and their caregivers on various outcomes, including caregiver knowledge and mucositis development in children.
- The results showed that while the training significantly reduced the area of oral mucositis, it did not affect anal mucositis or the overall infection rate in the clinic.
- The conclusion emphasized the positive impact of caregiver training on improving knowledge and managing oral mucositis, suggesting that nurses should implement such training in clinical practice to enhance care outcomes.