Efficient synthesis of α-aminophosphonates using magnetically retrievable ionic nanocatalysts under ultrasound acceleration.

Magnetic supported ionic liquids are a unique subclass of ionic liquids that possess the ability to respond to external magnetic fields, combining the advantageous properties of traditional ILs with this magnetic responsiveness. A novel magnetic ionic nanocatalyst of FeO@SiO@CPTMS-DTPA was prepared by anchoring an ionic liquid, CPTMS-DTPA, onto the surface of silica-modified FeO. The morphology, chemical structure and magnetic property of the magnetic ionic nanocatalyst structure was characterized using scanning electron microscopy, X-ray powder diffraction, Fourier transformation infrared spectroscopy, vibrating sample magnetometer, and thermogravimetric analysis.

Acrylamide/Alyssum campestre seed gum hydrogels enhanced with titanium carbide: Rheological insights for cardiac tissue engineering.

This study investigates the use of acrylamide and Alyssum campestre seed gum (ACSG) to create hydrogel composites with enhanced electrical and mechanical properties by incorporating titanium carbide (TiC). The composites were analyzed through techniques such as FTIR, SEM, TEM, TGA, swelling, rheology, tensile, electrical conductivity, antibacterial, and MTT assays. XRD analysis showed that 0.

Sulfonated asphaltene as a highly efficient catalyst for the Mannich reaction with excellent diastereoselectivity and recyclability.

This study investigates the repurposing of asphaltene, a petroleum waste product, as a catalyst for organic reactions. Sulfonated asphaltene was synthesized and evaluated for its efficacy in catalyzing the Mannich reaction, displaying notable diastereoselectivity and operating effectively under mild conditions. Characterization of the catalyst's chemical composition, structure, and thermal stability was conducted using FT-IR, TGA, XRD, CHN, BET-BJH, SEM, and EDS analyses.

Repurposing raltegravir for reducing inflammation and treating cancer: a bioinformatics analysis.

Inflammation is a defensive mechanism that safeguards the human body against detrimental stimuli. Within this intricate process, ADAM17, a zinc-dependent metalloprotease, emerges as an indispensable element, fostering the activation of diverse inflammatory and growth factors within the organism. Nonetheless, ADAM17 malfunctions can augment the rate of growth, inflammatory factors, and subsequent damage.

-Sulfonatocalix[4]arene turns peptide aggregates into an efficient cell-penetrating peptide.

A novel cell-penetrating peptide (CPP) called -YR, with as a fluorescent probe, was developed. Initially, we aimed to use Y as a supramolecular host for water-insoluble drugs, with R driving the complex into cells. However, an unexpected hurdle was discovered; the peptide self-assembled into amorphous aggregates, rendering it ineffective for our intended purpose.

An Invisible Dermal Nanotattoo-Based Smart Wearable Sensor for eDiagnostics of Jaundice.

Despite substantial progress in the diagnosis of jaundice/hyperbilirubinemia as the most common disease and cause of hospitalization of newborns, on the eve of Industry/Healthcare 5.0, the development of accurate and reliable wearable diagnostic sensors for noninvasive smart monitoring of bilirubin (BIL) is still in high demand. Aiming to fabricate a smart wearable sensor for early diagnosis of neonatal jaundice and its therapeutic monitoring, we here report a fluorescent dermal nanotattoo that further coupled with an IoT-integrated wearable optoelectronic reader for minimally invasive, continuous, and real-time monitoring of BIL in interstitial fluid.

Impact of spraying commercial Bentonite Nanoclay on fortification of the mortar as Nano Sprying Technique (NST) in heritages and historical buildings.

Spraying Bentonite NanoClay as an innovative idea satisfied an urgent need for conservation of historical brick constructions. This research explores the application of Nanotechnology as a Nano-Geotechnics (NaG) and Nano Ground Improvement (NGI) techniques for fortifying the mortar between bricks in historical buildings against some environmental erosive factors. Bentonite Nanoparticles were selected because of their compatibility with mortar.

Solvent extraction of lithium from brines with high magnesium/lithium ratios: investigation on parameter interactions.

Solvent extraction of lithium from brine with a high Mg/Li ratio was investigated. Tributyl phosphate (TBP), ferric chloride (FeCl), and kerosene were used as the extractant, co-extractant, and diluent, respectively. The mechanism of the extraction process was studied by LC-MS, UV-VIS, and FT-IR analyses.

Effect of geometric isomerism on the anticancer property of new platinum complexes with glycine derivatives as asymmetric N, O donate ligands against human cancer.

In this project, to fallow the anticancer ability of new Pt drugs, several new Pt complexes were synthesized with the asymmetric bidentate glycine derivatives, as named propyl- and hexyl glycine (L), in the general formula: [Pt(NH)(L)]NO, and cis- and trans-[Pt(L)]. The structure of two cis- and trans-[Pt(propylgly)] complexes was proved by single crystallography analysis. However, all complex structures were characterized by various methods of H NMR, C NMR, Pt NMR, FTIR, LC-Mass, and Raman spectroscopy.

Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1.

Taspase 1 is a unique protease not only pivotal for embryonic development but also implicated in leukemias and solid tumors. As such, this enzyme is a promising while still challenging therapeutic target, and with its protein structure featuring a flexible loop preceding the active site a versatile model system for drug development. Supramolecular ligands provide a promising complementary approach to traditional small-molecule inhibitors.

Spicy Recipe for At-Home Diagnostics: Smart Salivary Sensors for Point-of-Care Diagnosis of Jaundice.

Even though significant advances have been made, there is still a lack of reliable sensors capable of noninvasively monitoring bilirubin and diagnosing jaundice as the most common neonatal disease, particularly at the point-of-care (POC) where blood sampling from infants is accompanied by serious challenges and concerns. Herein, for the first time, using an easy-to-fabricate/use assay, we demonstrate the capability of curcumin embedded within paper for noninvasive optical monitoring of bilirubin in saliva. The highly selective sensing of the developed sensor toward bilirubin is attributed to bilirubin photoisomerization under blue light exposure, which can selectively restore the bilirubin-induced quenched fluorescence of curcumin.

Efficient and promising oxidative desulfurization of fuel using Fenton like deep eutectic solvent.

Oxidative desulfurization (ODS) has emerged as a prominent technique for the removal of sulfur compounds from fuels, aiming to comply with stringent environmental regulations and minimize sulfur dioxide emissions. Herein, Fenton-like deep eutectic solvents (DESs) were synthesized as a catalyst and reaction medium and their application for the ODS process was investigated. The study encompassed the optimization of DES composition, reaction conditions, and the influence of different parameters on the desulfurization efficiency.

Selective Upcycling of Polyethylene over Ru/H-ZSM-5 Bifunctional Catalyst into High-Quality Liquid Fuel at Mild Conditions.

It has been known that plastics with undegradability and long half-times have caused serious environmental and ecological issues. Considering the devastating effects, the development of efficient plastic upcycling technologies with low energy consumption is absolutely imperative. Catalytic hydrogenolysis of single-use polyethylene over Ru-based catalysts to produce high-quality liquid fuel has been one of the current top priority strategies, but it is restricted by some tough challenges, such as the tendency towards methanation resulting from terminal C-C cleavage.

Ultrafast and efficient continuous flow organic synthesis with a modified extruder-grinder system.

The study introduces a groundbreaking continuous system that combines an extruder and grinder to enable catalyst-free and solvent-free reactions under mild conditions. This temperature-controlled system facilitates the synthesis of highly functionalized chromenes, which have valuable applications in generating combinatorial libraries and complex target molecules. The newly developed mill extruder machine offers several advantages for industrial production on a large scale.

Exploring the potential of silymarin-loaded nanovesicles as an effective drug delivery system for cancer therapy: in vivo, in vitro, and in silico experiments.

We aimed to perform a comprehensive study on the development and characterization of silymarin (Syl)-loaded niosomes as potential drug delivery systems. The results demonstrate significant novelty and promising outcomes in terms of morphology, size distribution, encapsulation efficiency, in vitro release behavior, free energy profiles of Syl across the niosome bilayer, hydrogen bonding interactions, antimicrobial properties, cytotoxicity, and in vivo evaluations. The physical appearance, size, and morphology assessment of free niosomes and Syl-loaded niosomes indicated stable and well-formed vesicular structures suitable for drug delivery.

Metallosalen modified carbon nitride a versatile and reusable catalyst for environmentally friendly aldehyde oxidation.

The development of environmentally friendly catalysts for organic transformations is of great importance in the field of green chemistry. Aldehyde oxidation reactions play a crucial role in various industrial processes, including the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. This paper presents the synthesis and evaluation of a new metallosalen carbon nitride catalyst named Co(salen)@g-CN.

Non-target screening in water analysis: recent trends of data evaluation, quality assurance, and their future perspectives.

This trend article provides an overview of recent advancements in Non-Target Screening (NTS) for water quality assessment, focusing on new methods in data evaluation, qualification, quantification, and quality assurance (QA/QC). It highlights the evolution in NTS data processing, where open-source platforms address challenges in result comparability and data complexity. Advanced chemometrics and machine learning (ML) are pivotal for trend identification and correlation analysis, with a growing emphasis on automated workflows and robust classification models.

Enhanced efficiency of MS/MS all-ion fragmentation for non-targeted analysis of trace contaminants in surface water using multivariate curve resolution and data fusion.

Data-independent acquisition-all-ion fragmentation (DIA-AIF) mode of mass spectrometry can facilitate wide-scope non-target analysis of contaminants in surface water due to comprehensive spectral identification. However, because of the complexity of the resulting MS AIF spectra, identifying unknown pollutants remains a significant challenge, with a significant bottleneck in translating non-targeted chemical signatures into environmental impacts. The present study proposes to process fused MS and MS data sets obtained from LC-HRMS/MS measurements in non-targeted AIF workflows on surface water samples using multivariate curve resolution-alternating least squares (MCR-ALS).

Isatin-Schiff base functionalized graphene oxide as a highly selective turn-on fluorescent probe for the detection of Pd(II) via photoinduced electron transfer pathway.

We investigated the use of isatin-Schiff base functionalized graphene oxide (ISBGO) as a selective fluorescent chemosensor for the detection of palladium ions. Selectivity tests indicated that over 23 metal ions tested, ISBGO (λ = 340 nm, λ = 504 nm) showed the highest affinity for Pd(II), displaying a 10.1-fold enhancement.

Improving protein-ligand docking results using the Semiempirical quantum mechanics: testing on the PDBbind 2016 core set.

Molecular docking techniques are routinely employed for predicting ligand binding conformations and affinities in the phase of the drug design and development process. In this study, a reliable semiempirical quantum mechanics (SQM) method, PM7, was employed for geometry optimization of top-ranked poses obtained from two widely used docking programs, AutoDock4 and AutoDock Vina. The PDBbind core set (version 2016), which contains high-quality crystal protein - ligand complexes with their corresponding experimental binding affinities, was used as an initial dataset in this research.

New insight into highly efficient CSA@g-CN for photocatalytic oxidation of benzyl alcohol and thioanisole: NAEDS as a promoter of photoactivity under blue LED irradiation.

An open new perspective has been established toward synthesizing eco-friendly CSA@g-CN employing surface engineering. The carbon nitride modified through camphorsulfonic acid was designed and developed in a category of the new generation of photocatalysts for the oxidation of benzyl alcohol and thioanisole in the existence of a natural deep eutectic solvent (NADES). In comparison with pure g-CN, not only does CSA@g-CN exhibit an extraordinarily higher ability for harvesting visible light stemming from declining the recombination rate of electrons/holes dependent on PL results but it also reveals notable photocatalytic oxidation capability in the transformation of alcohols as well as thiols into relevant compounds.