Relationship between triglyceride glucose-body mass index baselines and variation with future cardiovascular diseases risk in the middle-aged and elderly individuals.

Background: Cardiovascular diseases (CVDs) are gradually becoming the leading cause of morbidity and mortality among chronic non-communicable diseases. Previous studies have found that the TyG index is an effective alternative indicator for insulin resistance (IR) and is associated with cardiovascular events. Additionally, obesity directly or indirectly increases the risk of developing CVDs.

Nucleoside reverse transcriptase inhibition enhances platelet production and megakaryocyte maturation in patients with COVID-19.

Coronavirus disease 2019 (COVID-19) is a systemic infection frequently involving the haematopoietic system. Thrombocytopenia is associated with increased risks of severe disease progression and mortality. Antiviral agents have shown much promise in decreasing viral load and shortening the time to the resolution of symptoms.

Association Between Body Image, Fear of Childbirth and Maternal-Fetal Attachment: The Relative Mediation Analysis.

Aims: To explore the association between body image, fear of childbirth and maternal-fetal attachment and the mediating effects of fear of childbirth among different body image profiles.

Design: A cross-sectional study.

Methods: Pregnant women were recruited from obstetric outpatient clinics between February 2022 and October 2023.

Methylase METTL3 regulates oxidative stress-induced osteoblast apoptosis through Wnt/β-catenin signaling pathway.

The latest research shows that the imbalance of reactive oxygen species (ROS) leads to oxidative stress-induced osteoblast apoptosis, which is an important factor in the development of osteoporosis. Methyltransferase like 3 (METTL3) is the most widely known methyltransferase, which has a marked effect on the cells of oxidative stress reaction. However, the precise mechanism through which METTL3 mediates oxidative stress-induced osteoblast apoptosis remains uncleared.

The chromatin remodeler Brg1 is essential for cochlear sensory epithelium differentiation and patterning.

Human genome analyses have revealed that abnormal BAF (BRG1/BRM-associated factor) complex is highly associated with hearing loss. However, the underlying pathogenesis remains largely unknown. Disrupted structure and function of the organ of Corti is the most prevalent cause of sensorineural hearing loss in mammals.

Cognitive impairments in first-episode psychosis patients with attenuated niacin response.

Background: Psychosis is a complex brain disorder with diverse biological subtypes influenced by various pathogenic mechanisms, which can affect treatment efficacy. The ANR(Attenuated Niacin Response) subtype is characterized by pronounced negative symptoms and functional impairments, suggesting a distinct clinical profile. However, research on the cognitive characteristics associated with the ANR subtype in drug-naïve first-episode psychosis(FEP) patients remains limited.

N-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.

Background: Acquired anlotinib resistance is still a key challenge in osteosarcoma treatment. Unravelling the mechanisms underlying anlotinib resistance is the key to optimising its efficacy for treating osteosarcoma. Previous studies have explored the pivotal function of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with regard to osteosarcoma chemoresistance.

Long-Term Exposure to Fine Particulate Matter (PM) Components and Precocious Puberty Among School-Aged Children: Cross-Sectional Study.

Background: The increasing incidence of precocious puberty is a major health challenge for Chinese children, while related risk factors remain less well explored. Exposure to ambient fine particulate matter (PM2.5) is a leading environmental hazard in China.

Automated detection of early-stage osteonecrosis of the femoral head in adult using YOLOv10: Multi-institutional validation.

Objectives: To develop a deep learning model based on the You Only Look Once version 10 (YOLOv10) for detecting early-stage ONFH in adult using radiographs.

Methods: A retrospective database study enrolled patients with ONFH classified as the stage I-II by the Association Research Circulation Osseous (ARCO) staging system based on MRI, and with Kellgren-Lawrence (KL) grade ≤ 1, as the positive group. In negative group, femoral head exhibited normal or KL grade 1 changes.

A novel missense mutation Smad4 V354L enhances the efficacy of docetaxel in non-small cell lung cancer.

NSCLC is a heterogeneous disease with unique combinations of somatic molecular alterations in individual patients. The different mutations in tumor oncogene and suppressors might be associated with the response to therapy. However, little is known about how Smad4 genomic alterations cause the therapeutic effect of docetaxel.

Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis.

Histone lactylation plays a crucial role in cancer progression, but its impact on breast cancer (BC) tumorigenesis is still unclear. We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules.

MK886 ameliorates Alzheimer's disease by activating the PRKCI/AKT signaling pathway.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, associated with oxidative stress, neuronal apoptosis, and the accumulation of amyloid-β (Aβ) plaques. Despite advances in understanding AD pathology, effective treatments remain limited. This study aimed to investigate the therapeutic efficacy and underlying molecular mechanisms of MK886, a selective inhibitor of the 5-lipoxygenase pathway, in the context of AD.

A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women.

Background: Human papillomavirus (HPV) infection and osteoporosis (OP) are global health concerns, with higher prevalence observed in women compared to men. However, the impact of HPV infection on bone health remains uncertain.

Methods: This case-control study utilized data from the National Health and Nutrition Examination Survey (NHANES).

WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis.

Liver metastasis (LM) poses a significant challenge in cancer treatment, with limited available therapeutic options and poor prognosis. Understanding the dynamics of tumor microenvironment (TME) and immune interactions is crucial for developing effective treatments. We find that WNT11 promoted CD8 T-cell exclusion and suppression, which was correlated with poor prognosis in LM.

Unraveling the hydroxylation and methylation mechanism in polymethoxylated flavones biosynthesis in Dracocephalum moldavica.

Dracocephalum moldavica, which belongs to the Lamiaceae family, is an important medicinal plant rich in polymethoxylated flavones (PMFs). PMFs have multi-methoxy groups on the central flavone skeleton. Hydroxylation and methylation are important modifications in the biosynthesis of PMFs, but the corresponding mechanism and related enzymes have not yet been elucidated in D.

Evolutionary Trends and Research Focal Points on Port Wine Stains: A Scientometric and Meta-Analysis.

Background: Despite numerous studies over the past two decades, clinical treatment for port wine stains (PWS) has shown limited progress. Analyzing evolutionary trends and research focal points can illuminate current deficiencies and guide future investigations. We aim to conduct a scientometric analysis and meta-analysis to uncover the historical trajectory, research hotspots, and future directions of PWS.

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways.

Background: Breast cancer remains a leading cause of mortality among women worldwide, with existing therapeutic options often accompanied by significant side effects and a persistent risk of disease recurrence. This highlights the need for novel drug candidates with new mechanisms of action by targeting alternative signaling pathways. While hERG channel is notoriously regarded as an off-target due to drug-induced cardiotoxicity, its therapeutic potential as a drug target remains largely unexplored.

Study of absorbable dural sealant to improve complications after craniocerebral surgery and its application strategy and standardized operation procedure.

Background: Infection after craniocerebral operation has always been a very focused problem, and dural closure can reduce perioperative infection by reducing drainage volume and subcutaneous effusion, so how to effectively perform dural closure seems to be a small but not negligible problem.

Methods: We proposed a classification and grading system for dural incisions based on the type and degree of suture, and based on the system, a standardized operation process for ADS (absorbable dural sealant) was developed. Then, we conducted a retrospective study.

Impact of sand and dust storms on mortality in Jinan City, China.

Background: Sand and dust storms (SDSs) cause considerable health risks worldwide. China is a country seriously affected by SDSs, however only few studies researched the risk of SDS in China. The insufficient evidence on SDS hampers effective measures to mitigate its harm.

Longitudinal Relationships of Phubbing, Depression, and Anxiety in the Middle and High School Students: A Cross-Lagged Panel Network Analysis.

Introduction: Prior research has documented the associations among phubbing, depression, and anxiety, while the cross-sectional design failed to clarify the temporal directionality of the relationships between these mental disorders and behavioral issues. To bridge this gap, the present study utilizing longitudinal data aimed to articulate the temporal relationships between these mental disorders and behavioral issues.

Methods: A total of 3296 adolescents from China (54.

50 years of methylprednisolone application in spinal cord injury: a bibliometric analysis.

Purpose: Methylprednisolone (MP) is a synthetic glucocorticoid known for its anti-inflammatory and immunosuppressive effects, yet its application in global spinal cord injury (SCI) research has not been thoroughly summarized. This study aims to assess the current status and trends of methylprednisolone research in SCI, providing insights for future scholarly work.

Methods: Articles on methylprednisolone in SCI published from 1975 to 2023 were retrieved from the Web of Science database.

A program to enhance family resilience through improved family communication for young and middle-aged breast cancer survivors and their spouses: A feasibility study.

Purpose: This study aimed to assess the feasibility, acceptability, and preliminary efficacy of a Family Communication-focused Family Resilience-enhancing Program (FC-FRP) for young and middle-aged breast cancer survivors and their spouses.

Methods: A pre- and post-test single-group pilot study was conducted in China. Survivors and their spouses received 5-week online courses on the topic of family resilience as well as related tasks.

Laparoscopic repair of parahiatal hernia: surgical techniques and literature reviews.

Purpose: Parahiatal hernia (PHH) is a rare type of diaphragmatic hernia that protrudes through a defect adjacent to, but distinct from, the esophageal hiatus. Current literature on PHH is extremely limited. In this study, we present our experience with laparoscopic repair of PHH and provide a comprehensive review of existing literature.

The Combined Prognostic Value of F-FDG PET/CT Metabolic Parameters of Immune Organs and Hematological Immune-Related Markers in Patients With Locally Advanced Cervical Cancer.

Background: This study aimed to explore the prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) metabolic parameters of immune organs and hematological immune-related markers for patients with locally advanced cervical cancer (LACC) undergoing concurrent chemoradiotherapy (CCRT), and to establish prognostic nomograms based on these potential biomarkers.

Methods: A total of 180 patients with LACC undergoing CCRT were retrospectively reviewed and randomly divided into training and validation groups at a 7:3 ratio. Cox regression analysis was performed to identify independent prognostic factors for progression-free survival (PFS) and overall survival (OS) from hematological immune-related markers and F-FDG PET/CT metabolic parameters of the primary tumor, spleen, and bone marrow (BM).