1,146 results match your criteria: "Charles-Nicolle hospital[Affiliation]"

Introduction: Spondyloarthritis (SpA) is a common rheumatic inflammatory disease and can impact patients' work productivity. We aimed to evaluate the impact of pain catastrophizing and central sensitization on work outcomes in young SpA patients and determine the predictive factors of work productivity loss.

Material And Methods: We performed a cross-sectional study over 6 months.

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Purpose: Right-sided diverticulitis is a rare entity in North Africa. Therefore, it is usually misdiagnosed, and the management of cecal diverticulitis is aggressive in most cases, whereas nowadays, most studies recommend a conservative approach with promising results. This study aims to describe the presentation, management, and outcomes of right-sided diverticulitis (RSD) and to present the experience of one surgical center in Tunisia.

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Introduction: Pediatric end-stage renal disease is a rare but severe condition that causes numerous complications and impairs the quality of life of children. Kidney transplantation is the therapy of choice in pediatric end-stage renal disease.

Aim: Our study aimed to identify the predictive factors of renal graft failure after kidney transplantation in Tunisian children and young adults.

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[Not Available].

Tunis Med

March 2024

Cardiology department, Charles Nicolle hospital, Tunis, Tunisia. Faculty of medicine of Tunis, Tunis El Manar university.

Introduction: Despite the demonstrated efficacy of cardiovascular (CV) preventive measures, data from international literature indicate that control of CV risk factors (RF) remains insufficient in very high-risk patients.

Aim: This study aimed to assess prevalence of achievement of recommended therapeutic targets for the major and modifiable CVRF 12 months after myocardial infarction (MI).

Methods: From 1st January to 30th April 2023, we collected consecutive patients with type 1 MI who had completed 12 months follow-up.

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Introduction: To date, the discussion is still ongoing whether the Siewert II adenocarcinoma of the esophagogastric junction (AEG) should be resected either by thoracoabdominal esophagectomy or gastrectomy with resection of the distal esophagus by transhiatal extension. The aim of our study was to compare the oncological and perioperative outcomes of the transthoracic approach (TTA) and the transabdominal approach (TAA).

Methods: Searches of electronic databases identifying studies from Cochrane, PubMed and Google Scholar were performed.

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Laparoscopic sleeve gastrectomy with omentopexy (O-LSG) has been compared to laparoscopic sleeve gastrectomy with no-omentopexy (NO-LSG) in terms of postoperative outcomes and one-year anthropometric results. This systematic review with meta-analysis aimed to compare the utility of omentopexy in sleeve gastrectomy. We performed a systematic review with meta-analysis according to PRISMA 2020 and AMSTAR 2 guidelines.

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Introduction: Longer survival in dialysis led to a higher incidence of vascular access complications and failure. With the limited access to kidney transplantation programs and peritoneal dialysis, exhaustion of vascular access for hemodialysis is an increasingly common situation. Among the available options, atrial tunneled dialysis catheter (ATDC) has been reported as an effective vascular access in this population.

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Impact of IL-10 gene promoter polymorphisms on treatment response in HCV patients: A systematic review, a meta-analysis, and a meta-regression.

Int J Immunopathol Pharmacol

March 2024

Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia.

The impact of interleukin-10 (IL-10) gene promoter polymorphisms (SNPs) on treatment response in HCV patients was dissimilarly estimated. Hence, the aim of this meta-analysis was to robustly assess the effect of IL-10 SNPs on treatment response in HCV patients. An electronic literature search was carried out through PubMed, EMBASE, Web of science, and Scopus databases.

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Gastrointestinal mesenchymal tumors (GIST) are the most prevalent sarcoma tumors affecting the digestive tract. GIST originates from Cajal cells located within the digestive tract's wall. These cells play a crucial role in regulating digestive peristaltism as they are considered pacemaker cells.

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Becker Nevus Syndrome: A Rare Entity but Important to Recognize.

J Clin Aesthet Dermatol

March 2024

Drs. Litaiem, Chabbouh, Chabchoub, and Zeglaoui are with the Department of Dermatology at Charles Nicolle Hospital in Tunis, Tunisia. Additionally, Drs. Litaiem, Chabbouh, Chabchoub, and Zeglaoui are with the Faculty of Medicine of Tunis at the University of Tunis El Manar in Tunis, Tunisia.

Becker's nevus syndrome is defined by the association of a Becker nevus with homolateral breast hypoplasia or more rarely skeletal cutaneous or muscle deformities. Early diagnosis is important, especially in female patients to prevent and treat breast hypoplasia. We report two cases of Becker nevus syndrome with serious functional impairment and discuss possible treatment options.

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Dynamic of SARS-CoV-2 variants circulation in Tunisian pediatric population, during successive waves, from March 2020 to September 2022.

Virus Res

June 2024

Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institute Pasteur of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74 1002 le Belvédère, Tunis, Tunisia; Laboratory of Virus, Host and Vectors (LR 20 IPT 02), Institute Pasteur of Tunis, University of Tunis El Manar, Tunis, Tunisia. Electronic address:

Article Synopsis
  • * It finds that adolescents made up over half of the cases, identified 23 viral lineages, and noted that seven were newly reported in Tunisia.
  • * The research indicates that children play a significant role in virus transmission and emphasizes the importance of vaccinating kids, including booster doses, to control future outbreaks.
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Background: Healthcare workers (HCW) may experience anxiety and prolonged work schedules during pandemics. The mental health status after a COVID-19 infection and the work ability of HCW are interesting criteria in assessing their fitness to work at the return to work (RTW) medical visit.

Objectives: To assess mental health and work ability after a COVID-19 infection among HCW at the RTW medical visit.

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Introduction: Vitamin D plays a role in regulating the immune response through an immunomodulatory effect, and is probably involved in the pathophysiology of Crohn's disease (CD).

Aim: to assess vitamin D status in patients with CD as well as in healthy controls and to determine associated factors of vitamin D deficiency in patients with CD.

Methods: We conducted a prospective study over 18 months, including CD patients with age and sex matched with healthy controls.

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Unlabelled: Currently, clinical biomarkers are urgently needed to improve patient management to guide personal therapy for cancer. In this study, we investigate the deregulation of in prostate cancer (PC) Tunisian patients. Expression patterns of the were investigated in prostate adenocarcinoma and benign prostate biopsies using quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR) and 2-ΔΔCt method.

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[Not Available].

Tunis Med

October 2023

Department of Internal Medicine A, Charles Nicolle hospital, Tunis, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Introduction: Sarcoidosis is a systemic granulomatosis that can be associated with large-scale physical and mental disability, affecting the health related quality-of-life (HRQoL) of patients.

Aim: To evaluate the HRQoL of tunisian patients with sarcoidosis and to identify the factors that influence it.

Methods: We conducted an analytical, cross-sectional study collecting 31 patients with sarcoidosis according to the ATS/ERS/WASOG criteria.

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[Not Available].

Tunis Med

October 2023

Department of Epidemiology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Introduction: Oncologists are often confronted with patients at the end of their lives who are suffering. This can lead to anxiety and depressive disorders (ADD), affecting the quality of the doctors's quality of life.

Aim: To compare the level of ADD among doctors practicing at Salah Azaiez Institute (SAI) in Tunis with doctors who do not treat cancer patients, while identifying any factors associated with these disorders.

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Article Synopsis
  • Tacrolimus shows variability in how it works in different individuals and has a small window between effective and harmful doses, with ongoing debate about the effect of a specific genetic variant (CYP3A5 6986A>G) on this variability.
  • A study on Tunisian kidney transplant recipients examined the effects of this SNP on tacrolimus levels, adverse drug reactions (ADRs), and kidney graft outcomes over five years.
  • Results indicated that patients with the CYP3A5*3 variant had higher tacrolimus concentrations and more ADRs, but this genetic variant did not affect the success of the kidney transplant.
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[Not Available].

Tunis Med

October 2023

Department of Pediatric Surgery A, Béchir Hamza Children's Hospital, Tunis, Tunisia.

Introduction: Peritoneal dialysis (PD) is the method of choice for extra-renal replacement therapy (ERT) for children with end-stage renal disease (ESRD), because of its various advantages. However, it presents different infectious and non-infectious complications, causes of important morbidity and mortality.

Aim: To determine the mechanical complications of PD in our center and to identify risk factors of their occurrence.

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Article Synopsis
  • - Gastrosplenic fistula is a rare and serious condition often caused by lymphoma, which can develop spontaneously or post-chemotherapy, and is commonly mistaken for a splenic abscess.
  • - Accurate diagnosis relies on identifying the fistulous tract through computed tomography, and treatment options typically include surgical resection and chemotherapy.
  • - In a case study, two patients with diffuse large B cell lymphoma experienced lethal outcomes, highlighting the poor prognosis of gastrosplenic fistula even after surgical intervention.
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Article Synopsis
  • The study aimed to compare the effectiveness of targeted antibiotic prophylaxis (TAP) based on rectal swab culture versus standard empiric prophylaxis with ciprofloxacin in patients undergoing transrectal ultrasound-guided needle biopsy of the prostate (TRUS-BP).
  • A total of 157 patients were randomized into two groups, with G1 receiving TAP and G2 receiving standard empiric treatment; findings indicated a prevalent resistance to Fluoroquinolone-resistant Enterobacterales (FQRE) in the G2 group.
  • The results revealed that TAP led to a significantly lower rate of febrile urinary tract infections after the procedure (3.8% in G2 compared to 13% in G1), illustrating its effectiveness in
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Quality assessment of rectal cancer surgery: How are we doing?

Tunis Med

July 2023

Department B of surgery, Charles Nicolle Hospital, Tunis, Tunisia/ Faculty of medicine, University Tunis-El Manar.

Introduction: Surgery remains a cornerstone in the treatment of rectal cancer. Optimal surgical resection implies respect for carcinologic principles. The best way to evaluate a good quality of resection requires certainly an exhaustive evaluation of the surgical specimen by the surgeon and the pathologist.

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[Not Available].

Tunis Med

July 2023

Department of Biochemistry, Sahloul Hospital, Tunisia.

Introduction: There are three types of primary hyperoxaluria, with type 1 considered the most severe.

Aim: To analyze the clinical, genetic, and evolutionary characteristics of type 1 primary hyperoxaluria with pediatric onset.

Methods: This was a retrospective, descriptive study that included Tunisian children under the age of 18 at the time of diagnosis over a period of 25 years (January 1, 1996, to December 31, 2022).

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