1,146 results match your criteria: "Charles-Nicolle hospital[Affiliation]"

Background: To explore how urologists manage prostate cancer (PCa) screening and treatment in patients undergoing endoscopic enucleation of the prostate (EEP).

Methods: A team of experts in EEP collaboratively formulated the survey questions through an interactive process. The survey opened in January 2024 and closed in February 2024.

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Background: Managing postoperative setting, regarding pain and anxiety after cesarean delivery is crucial for the mother's recovery, her emotional well-being, mother-infant bonding and initiating breastfeeding. Although some research have suggested that aromatherapy with lavender essential oil can be effective in reducing pain and anxiety in various medical settings, the efficacy of lavender aromatherapy in the postoperative setting after cesarean delivery is less well-studied. We aimed to assess the effectiveness of lavender essential oil therapy in the management of pain and anxiety after cesarean delivery.

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Association of four CTLA-4 gene polymorphisms with pemphigus risk: a systematic review, meta-analysis, and meta-regression.

J Int Med Res

October 2024

Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunisia.

Article Synopsis
  • - The review focused on the impact of four specific single nucleotide polymorphisms (SNPs) in the CTLA-4 gene on the risk of developing pemphigus, an autoimmune skin disease.
  • - An extensive literature search was conducted across several databases, and meta-analyses determined that the SNPs rs5742909*C and rs733618*C significantly increased the risk of pemphigus, while the other two SNPs did not.
  • - The findings indicate a potential genetic link to pemphigus susceptibility, with implications for understanding the disease's biological mechanisms.
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Background: Deficiency in vitamin D is widely prevalent around the world. Oral vitamin D supplementation is suggested for older adults to sustain appropriate 25-hydroxyvitamin D (25(OH)D) levels throughout the year. At present, cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are the most commonly used compounds.

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. Breastfeeding practices fall short of optimal levels globally, despite its known health benefits and World Health Organization endorsements. We aimed through this study to firstly estimate the global prevalence of principal indicators of breastfeeding practice in Tunisia.

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Chronic asymptomatic retention of an intragastric foreign body can pose a life-threatening scenario. In the event of migration, it may result in perforation, as shown in our unique case of pericardial perforation through the fundus. Beyond illustrating a rare condition, this case prompts us to engage in a debate about whether to retain or remove asymptomatic foreign bodies in the gastrointestinal tract.

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Novel Inflammatory Markers Associated With Cutaneous Leukocytoclastic Vasculitis Etiology.

Indian Dermatol Online J

August 2024

Department of Internal Medicine, University of Tunis El Manar, Faculty of Medicine of Tunis, Department of Internal Medicine, 1007, Tunis, Tunisia.

Article Synopsis
  • The study aimed to compare inflammatory markers to help differentiate between secondary leukocytoclastic vasculitis (SLV) and idiopathic leukocytoclastic vasculitis (ILV).
  • Researchers analyzed clinical and laboratory data from 77 patients diagnosed with cutaneous leukocytoclastic vasculitis, calculating various ratios including PLR, NLR, CAR, and FAR.
  • Significant differences in these ratios were found between SLV and ILV groups, indicating that elevated ratios may suggest SLV, which warrants thorough evaluation in affected patients.
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Pneumothorax following rigid bronchoscopy for foreign body removal in a child: A case report.

Int J Surg Case Rep

November 2024

ENT Department, Charles Nicolle Hospital, Boulevard du 9-Avril 1938, 1006 Tunis, Tunisia; Faculty of Medicine of Tunis, University Tunis el Manar, Tunisia.

Introduction: Rigid bronchoscopy is an effective tool for the management of pediatric airway foreign bodies. However, it is not exempt from complications that can be fatal, such as pneumothorax.

Case Presentation: A 20-month-old child was admitted to our department after inhaling a foreign body (peanut).

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Article Synopsis
  • - The study investigates how a personalized dietary plan affects kidney stone formation (urolithiasis) and related urinary parameters over 3 months in patients with different types of kidney stones.
  • - It involved 69 patients with various types of stones and measured changes in urinary components like calcium, oxalate, and uric acid before and after the dietary intervention.
  • - Results showed significant reductions in urinary oxalate levels and improvements in crystalluria for some stone types, highlighting the positive impact of diet in managing kidney stones.
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Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene.

Calcif Tissue Int

November 2024

Rare Disease Genomic Medicine Department, CHU Necker-Enfants Malades, INSERM UMR1163, Institut Imagine, Université Paris-Cité, Paris, France.

Osteoporosis is a skeletal disorder characterized by abnormal bone microarchitecture and low bone mineral density (BMD), responsible for an increased risk of fractures and skeletal fragility. It is a common pathology of the aging population. However, when osteoporosis occurs in children or young adults, it strongly suggests an underlying genetic etiology.

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Article Synopsis
  • Many faculties worldwide are implementing mentoring programs to enhance student learning, skills, belonging, and well-being.
  • This review aims to discuss the principles and recommendations of effective mentoring projects in academic settings.
  • It also presents the Faculty of Medicine of Tunis's perspective on adopting this mentoring approach.
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A regression predictive model for QuantiFERON-TB Gold Plus indeterminate results in immunosuppressed patients.

SAGE Open Med

September 2024

Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia.

Background: Screening for latent tuberculosis infection using Interferon-Gamma Release Assays is a routine procedure prior to the initiation of anti-tumor necrosis factor (TNF) biotherapy or immunosuppressive therapy. However, indeterminate results are relatively frequent and are an obstacle to treatment initiation.

Aim: The aim of this cross-sectional study was to estimate the frequency of indeterminate QuantiFERON-TB Gold Plus test results in Tunisian patients, and to analyze the potential clinico-biological risk factors associated with these indeterminate results.

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Towards implementing telemedicine in Tunisia: A knowledge, attitude and practice study among medical doctors.

F1000Res

September 2024

Gynaecology and Obstetrics Department, Regional Hospital of Ben Arous, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, 1006, Tunisia.

The use of information and communication technology such as telemedicine occupies nowadays a huge place in modern medicine practice all over the world, mainly after the COVID-19 pandemic. However, its implementation in Tunisia and other developing countries has achieved little success with low utilization and can be challenging for several reasons. In this study, our aim was to assess the knowledge, attitudes and practice of Tunisian medical doctors regarding telemedicine.

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Purpose: Globally, colorectal cancer (CRC) is among the most prevalent cancers. One distinctive feature of colorectal cancer is its close relationship to the gut microbiota, which is a crucial component of the tumor microenvironment. Over the last ten years, research has demonstrated that colorectal cancer is accompanied with dysbiosis of gut bacteria, fungi, viruses, and Archaea, and that these alterations may be causal.

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Article Synopsis
  • Cystic lymphangioma is a rare, benign growth in the lymphatic system, typically found in children but can occur in young adults, with varying management and prognosis based on the location.
  • A case study reported a young adult with chronic swelling in the neck, diagnosed through physical examination and imaging, with histopathology confirming cystic lymphangioma.
  • Treatment involved sclerotherapy and surgical removal, highlighting the need for increased awareness and understanding of this condition in adult patients.
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COVID-19, caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can lead to severe infection and has been suggested to induce autoimmune phenomena. We report three cases of rheumatoid arthritis (RA) occurring after COVID-19 infection and we present a systematic review of the literature of cases of RA post COVID-19. Our findings suggest that RA may be trigged by COVID-19 infection in genetically predisposed individuals.

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It is well known that modifiers play a role in ameliorating or exacerbating disease phenotypes in patients and carriers of recessively inherited disorders such as sickle cell disease and thalassemia. Here, we give an overview of the literature concerning a recently described association in carriers of Loss-of-Function variants with a beta-thalassemia-like phenotype including the characteristic elevated levels of HbA. That acts as modifier in beta-thalassemia carriers became evident from three reported cases in whom combined heterozygosity of and gene variants was observed to resemble a mild beta-thalassemia intermedia phenotype.

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Genome Tunisia Project: paving the way for precision medicine in North Africa.

Genome Med

August 2024

Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia.

Article Synopsis
  • The Genome Tunisia Project is a two-phase initiative (2022-2035) aimed at sequencing the Tunisian Genome and advancing personalized medicine in Tunisia, a diverse North African country affected by human migration patterns from various continents.
  • A multidisciplinary team of Tunisian experts is focused on addressing key priorities, such as determining the reference genome sequence, enhancing education and awareness, and improving infrastructure for personalized medicine integration.
  • The project involves collaboration among various stakeholders, including healthcare providers and policymakers, and aims to boost research and innovation in genomics while improving healthcare practices in the region.
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Case report of an abdominal wet gangrene caused by Acidaminococcus.

Acta Microbiol Immunol Hung

September 2024

1Charles Nicolle Hospital, Laboratory of Microbiology, National Reference Laboratory on Antibicrobial Resistance Surveillance, 1006, Tunis, Tunisia.

The Acidaminococcus genus is a part of the normal flora in gastrointestinal tract. It is a strictly anaerob Gram-negative coccus that is rarely pathogenic. We report the case of a 58-year-old man, who presented to surgery department A of the Charles Nicolle hospital, complaining of a wide inflammatory lesion in the anterior abdominal wall evolving for two weeks.

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Foreign body (FB) ingestion leading to appendicular perforation, although rare in adults, presents a complex clinical challenge. The clinical presentation may not always be straightforward, necessitating a comprehensive array of diagnostic examinations. In fact, accurate and timely diagnosis is crucial to prevent severe complications.

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Introduction: During the COVID-19 pandemic, single use medical devices' supply (SUMD) was marked by repetitive and unforeseen interruptions. The present study aimed to determine the risks related to the processes of management of medical devices in our CHU according to a method of failure mode, effect and criticality analysis (FMECA).

Methods: Qualified healthcare professionals were recruited to form a multidisciplinary consensus committee.

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Nail Alterations From Musical Instruments: Insights for Dermatologists Treating Musicians.

Cutis

July 2024

Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia. Drs. Ghannem, Litaiem, and Zeglaoui also are from the Department of Dermatology, Charles Nicolle Hospital, Tunis. Dr. Slouma also is from the Department of Rheumatology, Military Hospital of Tunis.

Long-term practice and performance with a musical instrument predispose musicians to several skin conditions and nail disorders. We conducted a comprehensive literature search of the PubMed, Scopus, and Google Scholar databases for articles on nail alterations in musicians. Complications were divided into modifications of the nail surface and nail plate, soft-tissue abnormalities, and periungual tissue and distal pulp disorders.

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Objective: For patients with T1b gallbladder cancer or greater, an adequate lymphadenectomy should include at least 6 nodes. Studies comparing short- and long-term outcomes of the open approach with those of laparoscopy and robotic approaches are limited, with small sample sizes, and there are none comparing laparoscopic and robotic approaches. This study compared patients who underwent robotic, laparoscopic, and open resection of gallbladder cancer, evaluating short- and long-term outcomes.

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