5 results match your criteria: "Charles University and University Hospital Motol in Prague[Affiliation]"
Acupuncture and dry needling for physical therapy of scar: a systematic review.
BMC Complement Med Ther
January 2024
Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University and University Hospital Motol in Prague, V Úvalu 84, Prague 5, 150 06, Czech Republic.
Background: There is a continuing interest in finding effective methods for scar treatment. Dry needling is gaining popularity in physiotherapy and is defined by Western medicine as a type of acupuncture. The terms acupuncture and dry needling have been used interchangeably so we have focused on the efficacy of dry needling or acupuncture in scar treatment.
View Article and Find Full Text PDFMERCURY-3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open-angle glaucoma and ocular hypertension.
Graefes Arch Clin Exp Ophthalmol
January 2024
Tutkimusz Ltd, Solymár, Hungary.
Article Synopsis
- The purpose of the study was to compare the safety and effectiveness of a fixed-dose combination of netarsudil and latanoprost (NET/LAT) with bimatoprost and timolol (BIM/TIM) in treating open-angle glaucoma and ocular hypertension.
- Conducted as a six-month randomized study, participants over 18 years with uncontrolled intraocular pressure were assigned to either NET/LAT or BIM/TIM, with efficacy and safety monitored over the period.
- Results showed that NET/LAT was non-inferior to BIM/TIM, maintaining a similar intraocular pressure at various time points, with both treatments demonstrating comparable safety profiles.
Impaired intestinal permeability in patients with multiple sclerosis.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
August 2023
Department of Internal Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol in Prague, Czech Republic.
Background: A number of recent studies have shown that the intestinal microbiome, part of the brain-gut axis, is implicated in the pathophysiology of multiple sclerosis. An essential part of this axis, is the intestinal barrier and gastrointestinal disorders with intestinal barrier dysregulation appear to be linked to CNS demyelination, and hence involved in the etiopathogenesis of multiple sclerosis (MS).
Objective: The aim of this study was to evaluate the integrity of the intestinal barrier in patients with clinically definite multiple sclerosis (CDMS) and clinically isolated syndrome (CIS) using two serum biomarkers, claudin-3 (CLDN3), a component of tight epithelial junctions, and intestinal fatty acid binding protein (I-FABP), a cytosolic protein in enterocytes.
Comparison of MicroRNA Content in Plasma and Urine Indicates the Existence of a Transrenal Passage of Selected MicroRNAs.
Adv Exp Med Biol
September 2017
Department of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General Faculty Hospital in Prague, Prague, Czech Republic.
MicroRNAs (miRNAs) in urine are examined as potential biomarkers. We examined the urine samples from 70 individuals (45 males, 25 females, mean age 65 years, range 20-84 years). Of the urine donors, 15 were healthy volunteers, 5 were patients with non-cancer diseases, 50 were patients with different stages of bladder cancer.
View Article and Find Full Text PDFAnti-GAD65 reactive peripheral blood mononuclear cells in the pathogenesis of cystic fibrosis related diabetes mellitus.
Autoimmunity
June 2005
Department of Paediatrics, 2nd Medical Faculty of Charles University and University Hospital Motol in Prague, V Uvalu 84, Prague 5, Motol, 15006, Czech Republic.
Objective: A role of autoreactive T cells for type 1 diabetes pathogenesis is considered crucial. In our pilot study we addressed if autoreactive mononuclear cells are present also in peripheral blood of patients with other specific forms of diabetes as cystic fibrosis related diabetes (CFRD).
Methods: Cellular immune responses to a known beta-cell autoantigen (GAD65 and GAD65 derived peptides) were analysed by ELISPOT (IFN-gamma) and by protein microarray analysis in four patients suffering from CFRD, in four cystic fibrosis (CF) patients without diabetes, in eight type 1 diabetes patients (without CF) and in four healthy controls.