3 results match your criteria: "Charles University and Hospital Na Bulovce in Prague[Affiliation]"
Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals.
Clin Epigenetics
April 2016
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic.
Background: Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (5' LTR) restricts HIV-1 reactivation and, together with chromatin conformation, represents an important mechanism of HIV-1 latency maintenance. Here, we explored the new issue of temporal development of DNA methylation in latent HIV-1 5' LTR.
View Article and Find Full Text PDFHIV resistance testing and detected drug resistance in Europe.
AIDS
July 2015
aDepartment of Infection and Population Health, University College London, London, UK bFundacions irsiCaixa i Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain cDivision of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Switzerland dUniversitäts Klinik, Bonn, Germany eDepartment of Infectious Diseases, Third Faculty of Medicine, Charles University and Hospital Na Bulovce in Prague, Czech Republic fClinic for Infectious Diseases, University Medical Centre, Ljubljana, Slovenia gService des Maladies Infectieuses, APHP, Hôpital St Antoine and INSERM, UMR_S1136, Paris, France hState Agency Infectology Center of Latvia, Riga, Latvia iRigshospitalet, University of Copenhagen, CHIP at Department of Infectious Diseases, Copenhagen, Denmark.
Objectives: To describe regional differences and trends in resistance testing among individuals experiencing virological failure and the prevalence of detected resistance among those individuals who had a genotypic resistance test done following virological failure.
Design: Multinational cohort study.
Methods: Individuals in EuroSIDA with virological failure (>1 RNA measurement >500 on ART after >6 months on ART) after 1997 were included.
Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients.
Epidemiol Infect
February 2015
Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University and Hospital Na Bulovce in Prague,Czech Republic.
To determine changes in incidence of reactivation of Toxoplasma gondii infection, manifesting as toxoplasmic encephalitis, and to assess the immunological mechanisms controlling reactivation in HIV-infected patients, a Czech cohort of 502 HIV/T. gondii co-infected patients was followed for 2909·3 person-years. The incidence of toxoplasmic encephalitis between the periods before and after the introduction of combination antiretroviral therapy (cART) was compared.
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