144 results match your criteria: "Charles Perrens Hospital[Affiliation]"

Article Synopsis
  • * Of the women surveyed, 63% responded, revealing a postpartum depression prevalence of 16.4% when using a specific scoring scale (EPDS score of 13 or higher), which rose to 23.1% with a slightly lower cutoff (score of 11 or higher).
  • * Key risk factors identified included younger maternal age and being born in a non-European country, highlighting the need for tailored support and interventions for at-risk populations after cesarean delivery.
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Article Synopsis
  • Clozapine is effective for treatment-resistant schizophrenia but can cause significant side effects, notably excessive daytime sleepiness, which is a form of hypersomnolence.
  • A systematic review examined how clozapine affects objective measures of hypersomnolence, analyzing six studies using various testing methods like polysomnography (PSG).
  • Initial findings showed clozapine led to longer sleep times and quicker sleep onset, but these effects did not last beyond 4-6 weeks, indicating a need for further long-term research on sleep patterns and wakefulness in clozapine-treated patients.
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Background: Adverse childhood experiences (ACEs) have been associated with volume alterations of stress-related brain structures among aging and clinical populations, however, existing studies have predominantly assessed only one type of ACE, with small sample sizes, and it is less clear if these associations exist among a general population of young adults.

Objective: The aims were to describe structural hippocampal volumetric differences by ACEs exposure and investigate the association between ACEs exposure and left and right hippocampal volume in a student sample of young adults.

Methods: 959 young adult students (18-24 years old) completed an online questionnaire on ACEs, mental health conditions, and sociodemographic characteristics.

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Hair cortisol concentrations across pregnancy and maternal postpartum depressive symptoms - The ELFE cohort.

J Psychiatr Res

October 2024

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Equipe de Recherche en Epidémiologie Sociale (ERES), 75012, Paris, France. Electronic address:

Postpartum depression and depressive symptoms have a major impact on maternal and infant health and well-being, yet to date their aetiology remains unclear. One hypothesis suggests a link between these symptoms and variations in prenatal cortisol levels, but existing evidence is limited and inconclusive. This study aims to provide additional evidence to disentangle the relationship between prenatal cortisol concentrations and subsequent occurrence of postpartum depressive symptoms.

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Aim: The anticholinergic properties of medications are associated with poorer cognitive performance in schizophrenia. Numerous scales have been developed to assess anticholinergic burden and yet, there is no consensus indicating which anticholinergic burden scale is more relevant for patients with schizophrenia. We aimed to identify valid scales for estimating the risk of iatrogenic cognitive impairment in schizophrenia.

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Prevalence and correlates of depressive symptoms among undergraduate health science students at the University of Parakou, Benin.

J Epidemiol Popul Health

August 2024

University of Parakou, ENATSE - National School of Public Health and Epidemiology, Parakou, Benin; University of Parakou, Department of Neurology, Parakou, Benin.

Objectives: Research on psychological distress in African students is scarce. This study aimed at exploring the epidemiology (prevalence and correlates) of depressive symptoms among undergraduate health sciences students at the University of Parakou (Benin).

Methods: We conducted a cross-sectional survey from June to July 2022 at the University of Parakou, the second-largest university in the Republic of Benin.

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Assisted reproductive technologies could be associated with higher risk of parenting difficulties in women with postpartum major depression.

Arch Womens Ment Health

October 2024

University Department of Child and Adolescent Psychiatry, Charles-Perrens Hospital, Bordeaux, France, INSERM, Bordeaux Population Health Research Center, U1219, Bordeaux University, Bordeaux, France.

No increased risk of postpartum major depression (PPMD) was reported in women conceiving through assisted reproductive technologies (ART). However, ART may be associated with a higher risk of parenting difficulties in women with PPMD. In 359 women with a PPMD admitted to a Mother-Baby Unit (MBU), ART-women (4.

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Purpose: The French Society for Biological Psychiatry and Neuropsychopharmacology and the French-speaking Marcé Society have joined forces to establish expert recommendations on the prescription of psychotropic drugs before, during, and after pregnancy in women with major depressive disorder (MDD) and bipolar disorder (BD).

Methods: To elaborate recommendations, we used the RAND/UCLA Appropriateness Method, which combines scientific evidence and expert clinicians' opinions. A written survey was completed by 48 psychiatrists, who have expertise in the management of mood disorders and/or in perinatal psychiatry.

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Impact of paternal psychiatric disorders on parents-baby separation after mother-baby unit care.

Child Abuse Negl

March 2024

University Department of Child and Adolescent Psychiatry, Charles-Perrens Hospital, Bordeaux, France; INSERM, Bordeaux Population Health Research Center, U 1219, Bordeaux University, Bordeaux, France.

Background: Paternal mental health may have an impact on parenthood especially in case of maternal postpartum severe psychiatric illness.

Objective: The aim of this study was to search for an association between paternal psychiatric disorder and parents-baby separation after a maternal joint hospitalization for a severe postpartum psychiatric episode.

Participants And Settings: In an observational, naturalist and multicentric study, 787 fathers whose partner was hospitalized in a mother-baby unit were included.

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Background: While studies have demonstrated the negative impact of adverse childhood experiences (ACEs) on lifelong health, less is known about the relationship between ACEs and illegal drug use. Thus, the objective of the study was to examine the relationship between ACEs and illegal drug use among college students.

Methods: French college students between 18 and 30 years enrolled in a university cohort study were eligible for inclusion.

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Social determinants in prenatal antidepressant use and continuation: Systematic review and meta-analysis.

Acta Psychiatr Scand

November 2024

Institut Pierre Louis d'Epidémiologie et de Santé Publique, Équipe de Recherche en Épidémiologie Sociale, Paris, France.

Introduction: Depression is one of the most common co-morbidities during pregnancy; with severe symptoms, antidepressants are sometimes recommended. Social determinants are often linked with antidepressant use in the general population, and it is not known if this is the case for pregnant populations. Our objective was to determine if social determinants are associated with prenatal antidepressant intake via a systematic review and meta-analysis.

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Clinical and cognitive characteristics of subjects with schizophrenia and childhood attention-deficit/hyperactivity disorder: Results from the multicentric FACE-SZ cross-sectional dataset.

Schizophr Res

February 2024

Fondation Fondamental, Créteil, France; Université de Paris, INSERM UMR1266, Institute of Psychiatry and Neuroscience of Paris, France; AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, France.

Background: Childhood Attention-deficit/hyperactivity disorder (C-ADHD) is a neurodevelopmental disorder, associated with an increased risk of subsequent schizophrenia. The objective of the present study was to determine the prevalence of C-ADHD in schizophrenia and the clinical and cognitive characteristics associated with C-ADHD history in schizophrenia.

Methods: 569 subjects with schizophrenia (74 % men, mean age 30.

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Adverse Childhood Experiences and ADHD Symptoms Among French College Students.

J Child Adolesc Trauma

December 2023

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, U1219, CHU Bordeaux, 146 Rue Léo Saignat, F-33000 Bordeaux, France.

To examine the relationship between adverse childhood experiences (ACEs) and Attention-deficit Hyperactivity Disorder (ADHD) among college students. We investigated the association between ACEs and ADHD symptoms among French college students enrolled in the i-Share cohort using multivariate logistic regression models. The sample comprised of 1062 participants with a mean age of 20.

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Article Synopsis
  • The study investigates repetitive and restricted behaviors and interests (RRBI) in autism, classifying them into 'motor-driven' and 'cognitively driven' categories while considering the roles of clinical contexts and neuroanatomy.
  • Researchers analyzed data from 792 participants, including autistic individuals, their relatives, and typically developing individuals, using standardized scales and MRI to assess RRBI patterns and brain volumes.
  • The analysis revealed three main RRBI factors, with 'motor-driven' symptoms linked to lower putamen volumes, while 'cognitively driven' symptoms showed different associations with brain structure, highlighting the complexity of RRBI in autism.
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Emerging evidence suggests that the higher prevalence of autism in individuals who are assigned male than assigned female at birth results from both biological factors and identification biases. Autistic individuals who are assigned female at birth (AFAB) and those who are gender diverse experience health disparities and clinical inequity, including late or missed diagnosis and inadequate support. In this Viewpoint, an international panel of clinicians, scientists, and community members with lived experiences of autism reviewed the challenges in identifying autism in individuals who are AFAB and proposed clinical and research directions to promote the health, development, and wellbeing of autistic AFAB individuals.

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Schizophrenia is characterized by the most salient medication adherence problems among severe mental disorders, but limited prospective data are available to predict and improve adherence in this population. This investigation aims to identify predictors of medication adherence over a 1-year period in a large national cohort using clustering analysis. Outpatients were recruited from ten Schizophrenia Expert Centers and were evaluated with a day-long standardized battery including clinician and patient-rated medication adherence measures.

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Background: Children's mental health is a public health priority, with 1 in 5 European children younger than 12 years having a behavioral, developmental, or psychological disorder. Mental health literacy (MHL) is a modifiable determinant of mental health, promoting psychological well-being and reducing mental health problems. Despite its significance, no interventions or scales currently exist for increasing and measuring MHL in this population.

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Attention deficit hyperactivity disorder symptoms and lifetime use of psychoactive substances among French university students: A cross-sectional study.

Psychiatry Res

October 2023

University of Bordeaux, Bordeaux, France; Bordeaux Population Heltch Research Center, UMR1219, HEALTHY Team, National Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale - INSERM), Bordeaux, France; Charles Perrens Hospital, Bordeaux, France. Electronic address:

In a cross sectional study of 13,837 university students, we aimed to explore the association between attention deficit hyperactivity disorder (ADHD) symptoms and lifetime psychoactive substance use (LPSU) on a wide range of illicit substances. Logistic and Hurdel multivariable regressions were used. ADHD symptoms were significantly associated with the lifetime use of ketamine, magic mushrooms, poppers, and nine other psychoactive substances.

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Objective: Fully automated digital interventions show promise for disseminating evidence-based strategies to manage insomnia complaints. However, an important concept often overlooked concerns the extent to which users adopt the recommendations provided in these programs into their daily lives. Our objectives were evaluating users' adherence to the behavioral recommendations provided by an app, and exploring whether users' perceptions of the app had an impact on their adherence behavior.

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Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age.

Int J Mol Sci

July 2023

Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences (IAB), University Grenoble Alpes, INSERM, 38700 La Tronche, France.

The placenta is a key organ for fetal and brain development. Its epigenome can be regarded as a biochemical record of the prenatal environment and a potential mechanism of its association with the future health of the fetus. We investigated associations between placental DNA methylation levels and child behavioral and emotional difficulties, assessed at 3 years of age using the Strengths and Difficulties Questionnaire (SDQ) in 441 mother-child dyads from the EDEN cohort.

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Introduction: Schizophrenia is recognized for its severe impact on both patients and caregivers. In a 12-month follow-up randomized clinical trial, we aimed to measure the efficacy of a brief family psychoeducation program in terms of reducing relapse risk and improving medication adherence in patients, as well as reducing caregiver burden, depression and increasing knowledge of the illness.

Methods: A total of 25 days of patients with schizophrenia (DSM-IV-TR) and family primary caregivers were recruited in a single regional psychiatric outpatient facility located in Bordeaux.

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Purpose: Although attention deficit hyperactivity disorder (ADHD) has been associated with illicit stimulants use, less is known about their prospective association in university students. We aimed to examine the association between ADHD symptoms at inclusion and illicit stimulants use following 1 year among university students.

Methods: The i-Share cohort recruited French students from February 2013 to July 2020.

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Objective: The risk factors for postnatal depressive symptoms (PNDS) are numerous, but little is known about the protective factors or the interactions between different exposures. The present study explored the pathways between maternal, infant and parenthood vulnerabilities or risk/protective factors and PNDS at 2 months postpartum (PP) in a large sample of women from the general population.

Methods: We used data from the French ELFE cohort, a nationally representative cohort of children followed-up from birth.

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Benefits of video games for people with schizophrenia: a literature review.

Curr Opin Psychiatry

May 2023

University Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, Bordeaux, France.

Purpose Of Review: In spite of the overwhelming concerns about the deleterious impact of exposure to video games, a growing body of evidence suggests that it may be of potential interest for therapeutic purposes, particularly in schizophrenia. As literature is rapidly evolving, we carried out a systematic review of recent articles on this issue.

Recent Findings: We identified seven studies published from 2017 to 2022 exploring the benefits of commercial video games in people with schizophrenia and related disorders regarding symptoms, cognition and functional outcome.

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