1,928 results match your criteria: "Charite-University Hospital[Affiliation]"

Article Synopsis
  • The study explores how self-rated health (SRH) relates to sleep patterns in people who had COVID-19, suggesting that COVID-19 negatively impacts SRH and sleep quality.
  • Participants from 16 countries were surveyed, with findings indicating that those infected with COVID-19 reported lower SRH scores, especially if their illness was severe.
  • Changes in sleep duration after infection—both decreases and increases—were significantly linked to lower SRH scores, as well as increased fatigue and other health issues, highlighting the importance of sleep in recovery.
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Patients with Alzheimer's disease (AD) can now be treated with monoclonal antibodies aiming at clearing amyloid plaques from the brain parenchyma. Weeks after initiation of this drug therapy, patients may develop so-called amyloid-related imaging abnormalities (ARIA) on MRI. ARIA comprise vasogenic edema and leptomeningeal effusions (ARIA-E) as well as microbleeds and superficial hemosiderosis (ARIA-H).

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Background: Increased coracoclavicular distance due to acute acromioclavicular joint (ACJ) instability is often described as a pseudoelevation of the clavicle due to inferior hanging of the scapula, while the distal clavicle remains in its position. The aim of this study was to analyze whether the elevation of the distal clavicle, depression of the scapula, or both are associated with vertical instability and to evaluate the impact of weighted stress radiographs on the clavicle and scapular position in acute ACJ instabilities.

Methods: The cohort consisted of 505 patients (f = 52, m = 453; mean age 46 years) which presented to our emergency department or outpatient clinic and treated in our institution from 2006 to 2019 displaying an acute ACJ injury.

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Introduction: Allogeneic stem cell transplantation is used to cure hematologic malignancies or deficiencies of the hematopoietic system. It is associated with severe immunodeficiency of the host early after transplant and therefore early reactivation of latent herpesviruses such as CMV and EBV within the first 100 days are frequent. Small studies and case series indicated that application of herpes virus specific T cells can control and prevent disease in this patient population.

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Objective: To investigate the prognostic value of cancer antigen 125 (CA125) related variables on progression free survival and overall survival in primary and recurrent ovarian cancers.

Method: A comprehensive review of the Medline, Embase, and Cochrane Library databases was conducted to identify relevant literature on survival outcomes according to the ELIMination Rate Constant K (KELIM), Gynecologic Cancer InterGroup (GCIG) CA125 response criteria, CA125 half-life, and CA125 nadir levels during first line or later line chemotherapy. The search included articles published before February 2023.

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Mapping regional funding for COVID-19 research in the Asia-Pacific region.

BMJ Glob Health

November 2023

GloPID-R Research and Policy Team, Policy and Practice Research Group, Pandemic Sciences Institute, University of Oxford, Oxford, UK.

Introduction: The Global Research Collaboration for Infectious Disease Preparedness (GloPID-R) is a network of funders supporting research on infectious diseases of epidemic/pandemic potential. GloPID-R is establishing regional hubs to strengthen stakeholder engagement particularly among low-income and middle-income countries. The first pilot hub, led from Republic of Korea (South Korea), has been launched in the Asia-Pacific region, a region highly prone to outbreaks of emerging infectious diseases.

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The association of insomnia with long COVID: An international collaborative study (ICOSS-II).

Sleep Med

December 2023

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway.

Objective: There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection.

Methods: Data were collected cross-sectionally (May-Dec 2021) as part of an international collaborative study involving participants from 16 countries.

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Optimal conditioning prior to allogeneic hematopoietic stem cell transplantation for children with non-malignant diseases is subject of ongoing research. This prospective, randomized, phase 2 trial compared safety and efficacy of busulfan with treosulfan based preparative regimens. Children with non-malignant diseases received fludarabine and either intravenous (IV) busulfan (4.

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Intersections between HIV and obesity in emerging economies.

Curr Opin HIV AIDS

January 2024

Department of Pharmacology and Therapeutics, Liverpool University, Liverpool, UK.

Purpose Of Review: HIV epidemics are increasing in many emerging economy countries, whilst the very process of 'economic emergence' is obesogenic. Annual deaths related to obesity and overweight are now four times more than for HIV globally. We describe the intersections between HIV and obesity in emerging economies, and highlight potential mitigation options, including antiobesity medications (AOMs), which are safe and effective, but inaccessibly priced.

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Neuroimmunology of rabies: New insights into an ancient disease.

J Med Virol

October 2023

Department of Pharmaceutical Sciences, Postgraduate Program of Physiopathology and Toxicology, University of São Paulo, São Paulo, Brazil.

Rabies is an ancient neuroinvasive viral (genus Lyssavirus, family Rhabdoviridae) disease affecting approximately 59,000 people worldwide. The central nervous system (CNS) is targeted, and rabies has a case fatality rate of almost 100% in humans and animals. Rabies is entirely preventable through proper vaccination, and thus, the highest incidence is typically observed in developing countries, mainly in Africa and Asia.

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In the absence of randomized controlled trials comparing tisagenlecleucel vs. standard of care (SOC) in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (r/r ALL), the objective was to compare the efficacy of tisagenlecleucel with historical controls from multiple disease registries using patient-level adjustment of the historical controls. The analysis is based on patient-level data of three tisagenlecleucel studies (ELIANA, ENSIGN and CCTL019B2001X) vs.

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Article Synopsis
  • VA-ECMO therapy helps patients with cardiogenic shock by restoring circulation but can lead to various complications affecting survival and neurological outcomes.
  • A study analyzed data from 501 patients across 16 centers, revealing that over half experienced complications, especially women, with 40% mortality within 30 days.
  • The findings indicate a need for better identification of patients at risk for complications to improve treatment strategies, as most adverse events correlate with worse prognosis.
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Article Synopsis
  • Testing for mismatch repair deficiency (dMMR) and high-grade microsatellite instability (MSI-H) is crucial for diagnosing colorectal cancer and predicting response to immune therapies.
  • Originally linked to Lynch syndrome, MSI is now important in the treatment of various cancers beyond CRC, including endometrial and gastric cancers.
  • The review highlights the importance of quality assurance measures in testing, the challenges of assessing results, and the potential of Next Generation Sequencing in improving diagnostic accuracy.
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Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID.

J Clin Sleep Med

January 2024

Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Study Objectives: Preliminary evidence suggests that the risk of Long COVID is higher among people with pre-existing medical conditions. Based on its proven adjuvant role in immunity, habitual sleep duration may alter the risk of developing Long COVID. The objective of this study was to determine whether the odds of Long COVID are higher among those with pre-existing medical conditions, and whether the strength of this association varies by habitual sleep duration.

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Multitask Learning with Convolutional Neural Networks and Vision Transformers Can Improve Outcome Prediction for Head and Neck Cancer Patients.

Cancers (Basel)

October 2023

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, Germany.

Neural-network-based outcome predictions may enable further treatment personalization of patients with head and neck cancer. The development of neural networks can prove challenging when a limited number of cases is available. Therefore, we investigated whether multitask learning strategies, implemented through the simultaneous optimization of two distinct outcome objectives (multi-outcome) and combined with a tumor segmentation task, can lead to improved performance of convolutional neural networks (CNNs) and vision transformers (ViTs).

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Background And Purpose: The study compares early outcomes after simultaneous and staged knee arthroplasty in patients with bilateral knee osteoarthritis (OA) to evaluate whether simultaneous bilateral TKA shows comparable early outcomes and complication rates to staged bilateral TKA.

Methods: A retrospective cohort study including all patients scheduled for primary TKA for bilateral knee OA (n = 127) was conducted. Patients received either simultaneous (n = 53, 41.

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Aims: Accurate skeletal age and final adult height prediction methods in paediatric orthopaedics are crucial for determining optimal timing of growth-guiding interventions and minimizing complications in treatments of various conditions. This study aimed to evaluate the accuracy of final adult height predictions using the central peak height (CPH) method with long leg X-rays and four different multiplier tables.

Methods: This study included 31 patients who underwent temporary hemiepiphysiodesis for varus or valgus deformity of the leg between 2014 and 2020.

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Article Synopsis
  • A study was conducted on patients with autoinflammatory diseases who received anti-IL-1 therapy, analyzing clinical symptoms and genetic variants over a nine-year period from 2013 to 2022 in Germany, involving 152 patients with various conditions.
  • Results showed that inflammatory attacks commonly began before age 18 (over 61% of patients), with an average delay of 17.8 years before starting anti-IL-1 treatment; genetic analysis confirmed diagnoses in the majority of patients.
  • The presence of variants of unknown significance (VUS) was notably high in patients, associated with older age at disease onset, suggesting a milder phenotype, and Turkish-Armenian ancestry was linked to more severe disease activity in familial
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Implementation of a new surveillance system for dialysis-associated infection events in outpatient dialysis facilities in Germany.

J Hosp Infect

December 2023

Institute of Hygiene and Environmental Medicine, Charité - University Hospital Berlin, Berlin, Germany; National Reference Centre for the Surveillance of Nosocomial Infections, Charité - University Hospital Berlin, Berlin, Germany.

Introduction: Patients receiving maintenance haemodialysis are at risk of catheter-related infections. Up to now, there has been no standardized surveillance tool in Germany to evaluate infection events in haemodialysis outpatients. As such, this study aimed to implement an online-based surveillance tool in outpatient dialysis facilities, and to report the first national surveillance data for haemodialysis patients in Germany from October 2019 until September 2021.

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The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied "explainable" machine learning, univariate, multivariate and mediation analyses of fasting plasma TMAO concentration and a multitude of phenotypes in 1,741 adult Europeans of the MetaCardis study. Here we show that next to age, kidney function is the primary variable predicting circulating TMAO, with microbiota composition and diet playing minor, albeit significant, roles.

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Introduction: Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling.

Methods: Blood samples from 54 patients included in the EuroHYP-1 study (27 treated with hypothermia, and 27 controls) were obtained at baseline, 24 ± 2 h, and 72 ± 4 h.

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Germline pathogenic variants in isocitrate dehydrogenase 1 (IDH1) can lead to a rare neurodevelopmental disorder called metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria, including severe skeletal and cerebral anomalies. To the best of our knowledge, no prenatal case of an IDH1 pathogenic variant has been reported in literature. Somatic sequence variants in IDH1/2 genes are described in distinct cancers, premalignant diseases and rare inherited metabolic disorders.

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Article Synopsis
  • The article explores the unique brain activity patterns associated with voluntary actions and inhibitory control in individuals with Tourette syndrome.
  • It highlights the increased representational similarity in brain responses when these individuals perform actions versus suppressing them.
  • The findings suggest that understanding these neural mechanisms could improve treatments and interventions for Tourette syndrome.
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