Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with -mutated AML.

This study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with -mutated ( ) AML. Targeted DNA sequencing of 263 genes was performed in 568 AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were (49.

Urbanization Impacts Top Predators and Alters Biotic Interactions in Predator-Prey-Mutualistic Communities of Urban Dry Grasslands.

Urbanization as a major driver of global change modifies biodiversity patterns and the abundance and interactions among species or functional species groups. For example, urbanization can negatively impact both predator-prey and mutualistic relationships. However, empirical studies on how urbanization modifies biotic, particularly multitrophic, interactions are still limited.

Excessive Supraventricular Ectopic Activity in Patients With Acute Ischemic Stroke Is Associated With Atrial Fibrillation Detection Within 24 Months After Stroke: A Predefined Analysis of the MonDAFIS Study.

Background: Excessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection.

Methods And Results: The investigator-initiated, prospective, open, multicenter MonDAFIS (Impact of Standardized Monitoring for Detection of Atrial Fibrillation in Ischemic Stroke) study randomized 3465 patients with acute ischemic stroke without known AF 1:1 to usual diagnostic procedures for AF detection or additive Holter monitoring in hospital for up to 7 days, analyzed in a core laboratory. Secondary study objectives include the comparison of recurrent stroke, myocardial infarction, major bleeding, and all-cause death within 24 months in patients with ESVEA (defined as ectopic supraventricular beats ≥480/day or atrial runs of 10-29 seconds or both) versus patients with newly diagnosed AF versus patients without ESVEA or AF (non-ESVEA/AF), randomized to the intervention group.

Management of an Intraparenchymal Struvite Stone Using Laparoscopic Nephrolithotomy: A Case Report.

This study aims to present a case of laparoscopic nephrolithotomy and highlight its successful outcome. The patient was a 65-year-old male who experienced intermittent colicky flank pain. Imaging revealed the presence of a 20-mm round-shaped stone in a hydronephrotic calyx located in the mid-pole of the left kidney, possibly with a parenchymal component.

Degradable starch microspheres transarterial chemoembolization (DSM-TACE) in patients with unresectable hepatocellular carcinoma: results from the Prospective Multicenter Observational HepaStar Trial.

Objectives: Despite increasing interest, prospective data on the use of degradable starch microsphere-transarterial chemoembolization (DSM-TACE) in the management of patients with unresectable HCC are still scarce. The objective of the HepaStar study was to collect prospective safety and effectiveness data in a prospective multicenter observational study.

Materials And Methods: Between January 2017 and December 2022, consecutive participants with unresectable or recurrent HCC treated with DSM-TACE as standard of care at 6 participating centers in Europe were enrolled.

Artificial intelligence-based rapid brain volumetry substantially improves differential diagnosis in dementia.

Introduction: This study evaluates the clinical value of a deep learning-based artificial intelligence (AI) system that performs rapid brain volumetry with automatic lobe segmentation and age- and sex-adjusted percentile comparisons.

Methods: Fifty-five patients-17 with Alzheimer's disease (AD), 18 with frontotemporal dementia (FTD), and 20 healthy controls-underwent cranial magnetic resonance imaging scans. Two board-certified neuroradiologists (BCNR), two board-certified radiologists (BCR), and three radiology residents (RR) assessed the scans twice: first without AI support and then with AI assistance.

Improving Food-Related Inhibitory Control Through an mHealth Intervention-A Secondary Outcome Analysis of an RCT.

Background: Experimental studies reveal that deficits in food-related inhibitory control, rather than general impulsiveness, are closely linked to overweight and obesity. To date, the real-world implications remain unknown, and it is unclear whether these results are supported in the clinical field.

Objective: To examine the effectiveness of a mobile health (mHealth) intervention with cognitive and behavioral therapeutic elements in altering impulsiveness and food-related inhibitory control.

Parsonage-Turner-syndrome associated with infection.

Neurological complications in the course of community-acquired pneumonia indicate that may be the causative pathogen. Parsonage-Turner-Syndrome, characterized by neuralgic shoulder pain and amyotrophy, has rarely been reported in this context.

Veni, Vidi, Vici-When Is Home Video Seizure Monitoring Helpful?

Seizure detection is vital for managing epilepsy as seizures can lead to injury and even death, in addition to impacting quality of life. Prompt detection of seizures and intervention can help prevent injury and improve outcomes for individuals with epilepsy. Wearable sensors show promising results for automated detection of certain seizures, but they have limitations such as patient tolerance, impracticality for newborns, and the need for recharging.

Upregulation vs. loss of function of NTRK2 in 44 affected individuals leads to two distinct neurodevelopmental disorders.

Introduction: Heterozygous pathogenic variants in NTRK2 (HGNC: 8032) have been associated with global developmental delay. However, only scattered cases have been described in small or general studies. The aim of our work was to consolidate our understanding of NTRK2-related disorders and to delineate the clinical presentation METHODS: We report extended cohort of 44 affected individuals, of whom 19 are from the literature and 25 were previously unreported.

Functional and Character Disparity Are Decoupled in Turtle Mandibles.

Turtles have high shape variation of their mandibles, likely reflecting adaptations to a broad variety of food items and ingestion strategies. Here, we compare functional disparity measured by biomechanical proxies and character disparity measured by discrete morphological characters. Functional and character disparities vary between clades and ecological groups and are thus decoupled.

Multitasking practice eliminates modality-based interference by separating task representations in sensory brain regions.

The debate on the neural basis of multitasking costs evolves around neural overlap between concurrently performed tasks. Recent evidence suggests that training-related reductions in representational overlap in fronto-parietal brain regions predict multitasking improvements. Cognitive theories assume that overlap of task representations may lead to unintended information exchange between tasks (i.

Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry.

Background: Patients with Kawasaki disease (KD) with coronary artery involvement require long-term cardiac care. Although respective evidence-based recommendations are missing, cardiac catheterization is still considered the gold standard for diagnosing detailed coronary pathology. Therefore, to better understand coronary artery pathology development, we conducted a survey to document and evaluate cardiac catheterization data in a European population.

Globally Distributed Arbuscular Mycorrhizal Fungi Associated With Invasive on Santa Cruz Island, Galápagos.

The presence of arbuscular mycorrhizal fungi (AMF) is essential for the survival and establishment of most plant species in nature. The reproductive success of invasive plant species in a particular habitat could also depend on these AM fungi. , commonly known as quinine, is highly invasive on Santa Cruz Island, Galápagos, but at the same time severely endangered in its native range on mainland Ecuador due to overexploitation in the past.

Association Between Stroke Lesion Size and Atrial Fibrillation Detected After Stroke: An Observational Cohort Study.

Background: Atrial fibrillation detected after stroke (AFDAS) is considered to be a distinct entity influenced by cardiogenic and neurogenic factors. We hypothesized that patients with AFDAS have larger stroke lesions than patients without atrial fibrillation (AF) and with known AF (KAF).

Methods And Results: Consecutive patients with magnetic resonance imaging-confirmed acute ischemic stroke admitted to a university hospital between October 2020 and January 2023 were prospectively registered.

Translating efficacy of liver transplantation in liver-limited metastatic colorectal cancer into clinical practice: the TransMet trial.

Pioneer studies suggested that liver transplantation (LT) has the potential to provide long-term survival in patients with liver-limited metastatic colorectal cancer (mCRC) not amenable for surgery of metastases. Evidence, however, was limited to single-arm studies with few patients enrolled and suboptimal selection criteria, with concerns over access to organ availability overcoming the potential efficacy of LT in this setting. Recently, 5-year survival rates with chemotherapy followed by LT (73%) compared with chemotherapy alone (9%) have been demonstrated by the randomized TransMet trial, enrolling 94 definitively unresectable strictly selected liver-limited mCRC patients.

New phenanthrenequinones from roots and their anti-inflammatory activity on lipopolysaccharide-activated BV2 microglial cells.

The roots of yielded a total of 17 compounds, comprising two new compounds (1-2), one new natural product (3), and 14 known compounds (4-17). The structures of new compounds were determined through the analysis of their spectroscopic data, including NMR, MS, UV, FT-IR, optical rotation, and CD. The anti-inflammatory activity of the isolated pure compounds was assessed using lipopolysaccharide-activated BV2 microglial cells.

Interplay of physical and recognition performance using hierarchical continuous-time dynamic modeling and a dual-task training regime in Alzheimer's patients.

Unlabelled: Training studies typically investigate the cumulative rather than the analytically challenging immediate effect of exercise on cognitive outcomes. We investigated the dynamic interplay between single-session exercise intensity and time-locked recognition speed-accuracy scores in older adults with Alzheimer's dementia ( = 17) undergoing a 24-week dual-task regime. We specified a state-of-the-art hierarchical Bayesian continuous-time dynamic model with fully connected state variables to analyze the bi-directional effects between physical and recognition scores over time.

Enhancing the oxygen evolution reaction activity of CuCo based hydroxides with VCT MXene.

The oxygen evolution reaction (OER) is a key reaction in the production of green hydrogen by water electrolysis. In alkaline media, the current state of the art catalysts used for the OER are based on non-noble metal oxides. However, despite their huge potential as OER catalysts, these materials exhibit various disadvantages including lack of stability and conductivity that hinder the wide-spread utilization of these materials in alkaline electrolyzer devices.

Chemical and transcriptomic diversity do not correlate with ascending levels of social complexity in the insect order Blattodea.

Eusocial insects, such as ants and termites, are characterized by high levels of coordinated social organization. This is contrasted by solitary insects that display more limited forms of collective behavior. It has been hypothesized that this gradient in sociobehavioral sophistication is positively correlated with chemical profile complexity, due to a potentially increased demand for diversity in chemical communication mechanisms in insects with higher levels of social complexity.