5 results match your criteria: "Charité-Freie Universität Berlin[Affiliation]"
Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Hypertension
August 2019
From the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Article Synopsis
- - The study investigates how subendocardial damage due to hypertension impacts the structure and function of the heart, highlighting early signs of cardiac problems even in asymptomatic individuals.
- - Mice induced with subendocardial scarring showed diastolic dysfunction, changes in myocardial deformation, and increased expression of specific biomarkers, while systolic function remained normal.
- - Advanced imaging techniques indicated that alterations in myocardial microstructure, particularly in subepicardial myofibers, can serve as early indicators for subendocardial fibrosis, with high sensitivity and specificity for predicting cardiac damage.
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Nucleic Acids Res
January 2018
Structural Bioinformatics Group, Experimental and Clinical Research Center (ECRC), Charité - University Medicine Berlin, Berlin, Germany.
Regular monitoring of drug regulatory agency web sites and similar resources for information on new drug approvals and changes to legal status of marketed drugs is impractical. It requires navigation through several resources to find complete information about a drug as none of the publicly accessible drug databases provide all features essential to complement in silico drug discovery. Here, we propose SuperDRUG2 (http://cheminfo.
View Article and Find Full Text PDFWhole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies.
Sci Rep
May 2016
Department of Genomics and Human Genetics, Laboratory of Evolutionary Genomics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, Russia.
Tumors of the jaws may represent different human disorders and frequently associate with pathologic bone fractures. In this report, we analyzed two affected siblings from a family of Russian origin, with a history of dental tumors of the jaws, in correspondence to original clinical diagnosis of cementoma consistent with gigantiform cementoma (GC, OMIM: 137575). Whole exome sequencing revealed the heterozygous missense mutation c.
View Article and Find Full Text PDF[Endoventricular patch-plasty for reconstruction of ventricular geometry and pump function in myocardial aneurysm].
Z Kardiol
February 1997
Universitáatsklinik und Poliklinik für Herzchirurgie, Humboldt Universitáat Berlin, Charité.
This report deals with the first experience with endoventricular patch plasty in patients suffering from left ventricular aneurysm. The early postoperative results in 18 patients operated upon during January and May 1995 are encouraging. All patients survived the procedure.
View Article and Find Full Text PDFReduction of exit-site infections in peritoneal dialysis by local application of metallic silver: a preliminary report.
Perit Dial Int
September 1994
Department of Nephrology, Klinikum Rudolf Virchow Freie Universitaät Berlin, Germany.